JP5656183B2 - 滑膜由来間葉幹細胞(MSCs)の軟骨・半月板再生への応用 - Google Patents

滑膜由来間葉幹細胞(MSCs)の軟骨・半月板再生への応用 Download PDF

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JP5656183B2
JP5656183B2 JP2009525260A JP2009525260A JP5656183B2 JP 5656183 B2 JP5656183 B2 JP 5656183B2 JP 2009525260 A JP2009525260 A JP 2009525260A JP 2009525260 A JP2009525260 A JP 2009525260A JP 5656183 B2 JP5656183 B2 JP 5656183B2
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mesenchymal stem
stem cells
cartilage
defect
cells
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JP2010501547A5 (enExample
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一郎 関矢
一郎 関矢
宗田 大
大 宗田
森尾 友宏
友宏 森尾
清水 則夫
則夫 清水
黒岩 保幸
保幸 黒岩
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Tokyo Medical and Dental University NUC
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655Chondrocytes; Cartilage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0668Mesenchymal stem cells from other natural sources
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

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JP2009525260A 2006-08-22 2007-08-22 滑膜由来間葉幹細胞(MSCs)の軟骨・半月板再生への応用 Active JP5656183B2 (ja)

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US82313806P 2006-08-22 2006-08-22
US60/823,138 2006-08-22
PCT/JP2007/066708 WO2008023829A1 (en) 2006-08-22 2007-08-22 Application of synovium-derived mesenchymal stem cells (mscs) for cartilage or meniscus regeneration

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JP2014145146A Active JP5928961B2 (ja) 2006-08-22 2014-07-15 滑膜由来間葉幹細胞(MSCs)の軟骨・半月板再生への応用

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022004878A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022004879A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022075294A1 (ja) 2020-10-07 2022-04-14 富士フイルム株式会社 関節治療用細胞製剤の製造方法、関節治療用細胞製剤および間葉系幹細胞の培養方法
WO2023286305A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 細胞の品質管理方法及び細胞を製造する方法
WO2023286819A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 特定細胞の品質管理方法及び特定細胞を製造する方法
WO2023032945A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 関節症治療剤、及び関節症治療剤の製造方法
WO2023249104A1 (ja) 2022-06-24 2023-12-28 富士フイルム株式会社 細胞製品を提供するためのシステム
WO2025206252A1 (ja) * 2024-03-29 2025-10-02 富士フイルム株式会社 滑膜由来間葉系幹細胞、その製造方法、およびその利用

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US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
JP5843189B2 (ja) * 2011-03-15 2016-01-13 国立大学法人名古屋大学 Sdf−1阻害剤を含有した軟骨組織再生用組成物
JP6502857B2 (ja) * 2013-01-14 2019-04-17 スクリップス ヘルス 組織アレイプリンティング
CN105392489B (zh) 2013-08-01 2019-11-22 智再如股份有限公司 软骨损伤治疗剂及其制造方法
US11497830B2 (en) 2014-03-14 2022-11-15 Scripps Health Electrospinning of cartilage and meniscus matrix polymers
KR101641770B1 (ko) * 2014-06-23 2016-07-22 씨제이제일제당 (주) O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법
CN104357385A (zh) * 2014-11-17 2015-02-18 四川大学华西医院 一种半月板组织来源的间充质干细胞及其制备方法和鉴定
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US11497831B2 (en) 2016-05-26 2022-11-15 Scripps Health Systems and methods to repair tissue defects
WO2018131673A1 (ja) * 2017-01-13 2018-07-19 公立大学法人首都大学東京 新規組織再生材料およびその製造方法
US12453743B2 (en) 2018-05-30 2025-10-28 Direct Biologics, Llc Mesenchymal stem cell (MSC) growth factor and extracellular vesicle preparation in frozen or powdered form and methods of use
KR102223043B1 (ko) * 2018-09-28 2021-03-08 주식회사 히에라바이오 활액막 유래 중간엽 줄기세포 및 그의 용도
WO2020196233A1 (ja) * 2019-03-26 2020-10-01 国立大学法人東京医科歯科大学 軟骨組織の再生を促進するための組成物
EP3999083A4 (en) 2019-07-18 2023-07-26 Direct Biologics LLC Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN117355314A (zh) * 2021-03-12 2024-01-05 富士胶片株式会社 关节病治疗剂的制造方法及关节病治疗剂
CN119235920B (zh) * 2024-12-06 2025-06-24 浙江大学 一种用于关节软骨损伤修复的mfap5阳性滑膜衬里层干细胞及其鉴定方法

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NZ527916A (en) * 2001-01-30 2006-10-27 Orthogene Inc Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
JP2003199816A (ja) * 2002-01-10 2003-07-15 Takehisa Matsuda 軟骨組織再生用補助材、軟骨組織再生用キット及び軟骨組織再生方法
CA2530421C (en) * 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells

Cited By (11)

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Publication number Priority date Publication date Assignee Title
WO2022004878A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
WO2022004879A1 (ja) 2020-07-03 2022-01-06 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法
KR20230025800A (ko) 2020-07-03 2023-02-23 후지필름 가부시키가이샤 활막 유래 간엽계 줄기 세포의 제조 방법 및 관절 치료용 세포 제제의 제조 방법
KR20230025801A (ko) 2020-07-03 2023-02-23 후지필름 가부시키가이샤 활막 유래 간엽계 줄기 세포의 제조 방법 및 관절 치료용 세포 제제의 제조 방법
WO2022075294A1 (ja) 2020-10-07 2022-04-14 富士フイルム株式会社 関節治療用細胞製剤の製造方法、関節治療用細胞製剤および間葉系幹細胞の培養方法
KR20230058721A (ko) 2020-10-07 2023-05-03 후지필름 가부시키가이샤 관절 치료용 세포 제제의 제조 방법, 관절 치료용 세포 제제 및 간엽계 줄기세포의 배양 방법
WO2023286305A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 細胞の品質管理方法及び細胞を製造する方法
WO2023286819A1 (ja) 2021-07-15 2023-01-19 富士フイルム株式会社 特定細胞の品質管理方法及び特定細胞を製造する方法
WO2023032945A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 関節症治療剤、及び関節症治療剤の製造方法
WO2023249104A1 (ja) 2022-06-24 2023-12-28 富士フイルム株式会社 細胞製品を提供するためのシステム
WO2025206252A1 (ja) * 2024-03-29 2025-10-02 富士フイルム株式会社 滑膜由来間葉系幹細胞、その製造方法、およびその利用

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US20100178274A1 (en) 2010-07-15
JP2010501547A (ja) 2010-01-21
JP5928961B2 (ja) 2016-06-01
WO2008023829A1 (en) 2008-02-28

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