JP2010501547A5 - - Google Patents

Info

Publication number

JP2010501547A5

JP2010501547A5 JP2009525260A JP2009525260A JP2010501547A5 JP 2010501547 A5 JP2010501547 A5 JP 2010501547A5 JP 2009525260 A JP2009525260 A JP 2009525260A JP 2009525260 A JP2009525260 A JP 2009525260A JP 2010501547 A5 JP2010501547 A5 JP 2010501547A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

defect

stem cells

mesenchymal stem

synovial

Prior art date

2007-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 21
• 230000007547 defect Effects 0.000 claims 18
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 15
• 238000004519 manufacturing process Methods 0.000 claims 13
• 210000000845 cartilage Anatomy 0.000 claims 10
• 239000000463 material Substances 0.000 claims 7
• 206010061762 Chondropathy Diseases 0.000 claims 6
• 230000005499 meniscus Effects 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 239000000499 gel Substances 0.000 claims 3
• 210000000130 stem cell Anatomy 0.000 claims 3
• 206010007710 Cartilage injury Diseases 0.000 claims 2
• 108010010803 Gelatin Proteins 0.000 claims 2
• 208000003947 Knee Osteoarthritis Diseases 0.000 claims 2
• 201000009859 Osteochondrosis Diseases 0.000 claims 2
• 206010031264 Osteonecrosis Diseases 0.000 claims 2
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 210000002449 bone cell Anatomy 0.000 claims 2
• 239000000512 collagen gel Substances 0.000 claims 2
• 210000004748 cultured cell Anatomy 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
• 229960003957 dexamethasone Drugs 0.000 claims 2
• 230000004069 differentiation Effects 0.000 claims 2
• 210000000968 fibrocartilage Anatomy 0.000 claims 2
• 239000008273 gelatin Substances 0.000 claims 2
• 229920000159 gelatin Polymers 0.000 claims 2
• 235000019322 gelatine Nutrition 0.000 claims 2
• 235000011852 gelatine desserts Nutrition 0.000 claims 2
• 210000003035 hyaline cartilage Anatomy 0.000 claims 2
• 210000003559 hypertrophic chondrocyte Anatomy 0.000 claims 2
• 239000007943 implant Substances 0.000 claims 2
• 208000014674 injury Diseases 0.000 claims 2
• 201000008482 osteoarthritis Diseases 0.000 claims 2
• 230000001172 regenerating effect Effects 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• 210000001258 synovial membrane Anatomy 0.000 claims 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• 230000000472 traumatic effect Effects 0.000 claims 2
• 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
• 102000056172 Transforming growth factor beta-3 Human genes 0.000 claims 1
• 108090000097 Transforming growth factor beta-3 Proteins 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1