JP2017506218A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017506218A5 JP2017506218A5 JP2016546971A JP2016546971A JP2017506218A5 JP 2017506218 A5 JP2017506218 A5 JP 2017506218A5 JP 2016546971 A JP2016546971 A JP 2016546971A JP 2016546971 A JP2016546971 A JP 2016546971A JP 2017506218 A5 JP2017506218 A5 JP 2017506218A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- mccs
- recombinant
- proteins
- chromatographic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004587 chromatography analysis Methods 0.000 description 13
- 239000012528 membrane Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000010977 unit operation Methods 0.000 description 8
- 229960000160 recombinant therapeutic protein Drugs 0.000 description 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 5
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010005716 Interferon beta-1a Proteins 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 108010039650 imiglucerase Proteins 0.000 description 2
- 229960004461 interferon beta-1a Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229960001972 panitumumab Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960003989 tocilizumab Drugs 0.000 description 2
- 102000003390 tumor necrosis factor Human genes 0.000 description 2
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 108010019673 Darbepoetin alfa Proteins 0.000 description 1
- 108010074604 Epoetin Alfa Proteins 0.000 description 1
- 108010008165 Etanercept Proteins 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 description 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 description 1
- 101001018026 Homo sapiens Lysosomal alpha-glucosidase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000003996 Interferon-beta Human genes 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 102100033342 Lysosomal acid glucosylceramidase Human genes 0.000 description 1
- 208000015439 Lysosomal storage disease Diseases 0.000 description 1
- 108010039185 Tenecteplase Proteins 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229950005186 abagovomab Drugs 0.000 description 1
- 229960003697 abatacept Drugs 0.000 description 1
- 229960000446 abciximab Drugs 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229960002964 adalimumab Drugs 0.000 description 1
- 229950009084 adecatumumab Drugs 0.000 description 1
- 229960004470 agalsidase beta Drugs 0.000 description 1
- 108010056760 agalsidase beta Proteins 0.000 description 1
- 108010030291 alpha-Galactosidase Proteins 0.000 description 1
- 102000005840 alpha-Galactosidase Human genes 0.000 description 1
- 229960003318 alteplase Drugs 0.000 description 1
- 229950009106 altumomab Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 229950003145 apolizumab Drugs 0.000 description 1
- 229950005122 atinumab Drugs 0.000 description 1
- 229940049197 cerezyme Drugs 0.000 description 1
- 229940105774 coagulation factor ix Drugs 0.000 description 1
- 229960005029 darbepoetin alfa Drugs 0.000 description 1
- 108010067396 dornase alfa Proteins 0.000 description 1
- 229960001776 edrecolomab Drugs 0.000 description 1
- 229960000284 efalizumab Drugs 0.000 description 1
- KUBARPMUNHKBIQ-VTHUDJRQSA-N eliglustat tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.C([C@@H](NC(=O)CCCCCCC)[C@H](O)C=1C=C2OCCOC2=CC=1)N1CCCC1.C([C@@H](NC(=O)CCCCCCC)[C@H](O)C=1C=C2OCCOC2=CC=1)N1CCCC1 KUBARPMUNHKBIQ-VTHUDJRQSA-N 0.000 description 1
- 229960003388 epoetin alfa Drugs 0.000 description 1
- 229950008579 ertumaxomab Drugs 0.000 description 1
- 229960000403 etanercept Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229960005390 galsulfase Drugs 0.000 description 1
- 108010089296 galsulfase Proteins 0.000 description 1
- 229960001743 golimumab Drugs 0.000 description 1
- 102000044890 human EPO Human genes 0.000 description 1
- 102000045921 human GAA Human genes 0.000 description 1
- 229960002127 imiglucerase Drugs 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 229960002486 laronidase Drugs 0.000 description 1
- 229940103023 myozyme Drugs 0.000 description 1
- 229960005027 natalizumab Drugs 0.000 description 1
- 229960000470 omalizumab Drugs 0.000 description 1
- 229960000402 palivizumab Drugs 0.000 description 1
- 229960002087 pertuzumab Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229960003876 ranibizumab Drugs 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 229960000216 tenecteplase Drugs 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461928906P | 2014-01-17 | 2014-01-17 | |
| US61/928,906 | 2014-01-17 | ||
| PCT/US2015/011698 WO2015109146A1 (en) | 2014-01-17 | 2015-01-16 | Sterile chromatography and manufacturing processes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020070132A Division JP7055161B2 (ja) | 2014-01-17 | 2020-04-09 | 無菌クロマトグラフィーおよび製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506218A JP2017506218A (ja) | 2017-03-02 |
| JP2017506218A5 true JP2017506218A5 (enExample) | 2018-02-08 |
| JP6691047B2 JP6691047B2 (ja) | 2020-04-28 |
Family
ID=52630479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546971A Active JP6691047B2 (ja) | 2014-01-17 | 2015-01-16 | 無菌クロマトグラフィーおよび製造方法 |
| JP2020070132A Active JP7055161B2 (ja) | 2014-01-17 | 2020-04-09 | 無菌クロマトグラフィーおよび製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020070132A Active JP7055161B2 (ja) | 2014-01-17 | 2020-04-09 | 無菌クロマトグラフィーおよび製造方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US10087214B2 (enExample) |
| EP (1) | EP3094640B1 (enExample) |
| JP (2) | JP6691047B2 (enExample) |
| KR (1) | KR102326354B1 (enExample) |
| CN (1) | CN106103464B (enExample) |
| AU (1) | AU2015206422B2 (enExample) |
| BR (1) | BR112016016329B1 (enExample) |
| CA (1) | CA2936951C (enExample) |
| CY (1) | CY1124062T1 (enExample) |
| DK (1) | DK3094640T3 (enExample) |
| ES (1) | ES2841141T3 (enExample) |
| HK (1) | HK1227042B (enExample) |
| HU (1) | HUE052611T2 (enExample) |
| IL (1) | IL246774B (enExample) |
| MX (1) | MX376882B (enExample) |
| RU (1) | RU2679133C2 (enExample) |
| SG (1) | SG11201605626SA (enExample) |
| TW (2) | TWI709570B (enExample) |
| WO (1) | WO2015109146A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105209603A (zh) | 2013-02-22 | 2015-12-30 | 建新公司 | 微载体灌注培养方法及其用途 |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| AU2014226126B2 (en) | 2013-03-08 | 2019-02-14 | Genzyme Corporation | Continuous purification of therapeutic proteins |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| KR102769649B1 (ko) | 2014-12-22 | 2025-02-19 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| DE102015005244A1 (de) | 2015-04-24 | 2016-11-10 | Sartorius Stedim Biotech Gmbh | Verfahren zur Sterilisierung eines Chromatographiematerials und danach sterilisiertes Chromatographiematerial |
| GB201711249D0 (en) * | 2017-07-13 | 2017-08-30 | Ge Healthcare Bioprocess R&D Ab | Chromatography column |
| WO2019086463A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| US12292448B2 (en) * | 2018-05-24 | 2025-05-06 | Sigma-Aldrich Co. Llc | Quantitative analysis of proteins |
| JP7699537B2 (ja) | 2018-08-31 | 2025-06-27 | ジェンザイム・コーポレーション | 無菌クロマトグラフィー樹脂および製造方法におけるその使用 |
| CN113825840A (zh) * | 2019-04-03 | 2021-12-21 | 建新公司 | 重组蛋白的连续生产 |
| CA3155216A1 (en) | 2019-10-22 | 2021-04-29 | Robert Snow | In-line product monitoring in integrated continuous bio-manufacturing |
| CN115475258A (zh) * | 2022-09-06 | 2022-12-16 | 江苏丰华生物制药有限公司 | 一种注射用替奈普酶纯化工艺 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4401108A (en) | 1980-02-13 | 1983-08-30 | Thomas Jefferson University | Radioactive material loading, calibration and injection systems |
| SU1033181A1 (ru) | 1982-02-02 | 1983-08-07 | Томское Отделение Охтинского Ордена Ленина И Ордена Трудового Красного Знамени Научно-Производственного Объединения "Пластполимер" | Способ обработки полимерного сорбента дл хроматографии |
| JPS6075530A (ja) | 1983-09-30 | 1985-04-27 | Asahi Chem Ind Co Ltd | 金属元素の新しい分離精製方法 |
| US4559175A (en) | 1984-04-19 | 1985-12-17 | The United States Of America As Represented By The Secretary Of The Air Force | Halo-substituted diphospha-s-triazines and their derivatives |
| US4885250A (en) | 1987-03-02 | 1989-12-05 | E. I. Du Pont De Nemours And Company | Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports |
| US5612016A (en) | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| US5169936A (en) | 1989-04-14 | 1992-12-08 | Biogen, Inc. | Protein purification on immobilized metal affinity resins effected by elution using a weak ligand |
| WO1991002049A1 (en) | 1989-08-04 | 1991-02-21 | Peter Grandics | An integrated cell culture-protein purification system for the automated production and purification of cell culture products |
| US5244816A (en) | 1989-10-11 | 1993-09-14 | Akzo N.V. | Method for purifying chelator conjugated compounds |
| AU1742092A (en) | 1991-04-05 | 1992-11-02 | Brigham Young University | Support bonded polyalkylene-polyamine-poly(carboxylic acid) and extraction of metal ions therewith |
| RU2034853C1 (ru) | 1992-07-14 | 1995-05-10 | Научно-исследовательский институт строительных материалов при Томской государственной инженерно-строительной академии | Способ получения полимерного сорбента для хроматографии |
| JP2871435B2 (ja) | 1993-04-22 | 1999-03-17 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 親水性ポリマー被覆パーフルオロカーボンポリマーベースのマトリックスの製造方法 |
| JPH07110229A (ja) | 1993-10-12 | 1995-04-25 | Nkk Corp | 金属ストリップループの最下点位置検出装置 |
| US5478924A (en) | 1994-02-16 | 1995-12-26 | Cramer; Steven M. | Displacement chromatography of proteins using low molecular weight displacers |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5423982A (en) | 1994-05-31 | 1995-06-13 | Biosepra Inc. | Liquid chromatography column adapted for in situ chemical sterilization |
| US5610285A (en) | 1994-08-24 | 1997-03-11 | Bayer Corporation | Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions |
| US6359114B1 (en) | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
| US5691152A (en) | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
| AR005035A1 (es) | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
| ES2293661T3 (es) | 1996-11-27 | 2008-03-16 | Genentech, Inc. | Purificacion por afinidad de polipeptido en una matriz de proteinas a. |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| US6955917B2 (en) | 1997-06-20 | 2005-10-18 | Bayer Healthcare Llc | Chromatographic method for high yield purification and viral inactivation of antibodies |
| US6265542B1 (en) | 1997-10-24 | 2001-07-24 | Genentech, Inc. | Purification of molecules |
| US7611831B2 (en) | 1998-01-06 | 2009-11-03 | Cerus Corporation | Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix |
| ATE370961T1 (de) | 1998-05-06 | 2007-09-15 | Genentech Inc | Reinigung von antikörpern durch ionenaustauschchromatographie |
| DE19858892A1 (de) | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| GB0028879D0 (en) | 2000-11-27 | 2001-01-10 | Prometic Biosciences Ltd | Adsorbents and their use |
| EE200300408A (et) | 2001-02-23 | 2003-12-15 | Immunex Corporation | Aktiivsete valkude saagise suurendamine |
| ITBO20010426A1 (it) | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
| US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| US20030095890A1 (en) | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
| AU2002343100A1 (en) | 2001-11-27 | 2003-06-10 | Prometic Biosciences Ltd. | The use of metal-chelating adsorbents |
| US6660172B2 (en) | 2002-01-31 | 2003-12-09 | Koslow Technologies Corporation | Precoat filtration media and methods of making and using |
| EP1472275B1 (en) | 2002-02-05 | 2008-12-17 | Genentech, Inc. | Protein purification |
| SI1501369T1 (sl) | 2002-04-26 | 2015-10-30 | Genentech, Inc. | Neafinitetno čiščenje proteinov |
| US6902909B2 (en) | 2002-07-09 | 2005-06-07 | Synthecon, Inc. | Methods for efficient production of mammalian recombinant proteins |
| PT1543038T (pt) | 2002-09-11 | 2017-07-07 | Genentech Inc | Purificação de proteína |
| SI1545574T1 (sl) | 2002-09-13 | 2014-10-30 | Biogen Idec Inc. | Postopek za čiščenje polipeptidov s simulirano "moving bed" kromatografijo |
| US7157276B2 (en) | 2003-06-20 | 2007-01-02 | Biogen Idec Inc. | Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures |
| KR101150050B1 (ko) | 2004-02-27 | 2012-07-05 | 지이 헬스케어 바이오-사이언시스 에이비 | 항체 정제 방법 |
| CA2557229C (en) | 2004-02-27 | 2012-07-10 | Octapharma Ag | A method of providing a purified, virus safe antibody preparation |
| CN101001945B (zh) | 2004-06-04 | 2012-02-08 | 艾克塞勒雷克斯公司 | 一次性生物反应器系统及方法 |
| US20060004621A1 (en) | 2004-06-30 | 2006-01-05 | Malek Kamal M | Real-time selection of survey candidates |
| WO2006026248A1 (en) | 2004-08-25 | 2006-03-09 | Sigma-Aldrich Co. | Compositions and methods employing zwitterionic detergent combinations |
| WO2006039533A2 (en) | 2004-09-30 | 2006-04-13 | Sloan Kettering Institure For Cancer Research | Bcr-abl imatinib resistance-associated peptides and methods of use thereof |
| CN102794109B (zh) | 2004-09-30 | 2015-10-07 | 拜耳医药保健有限公司 | 用于集成连续生产生物分子的装置和方法 |
| KR101243425B1 (ko) | 2004-10-21 | 2013-03-13 | 지이 헬스케어 바이오-사이언시스 에이비 | 항체의 정제 방법 |
| EP1805320B1 (en) | 2004-10-22 | 2014-09-03 | Amgen Inc. | Methods for refolding of recombinant antibodies |
| JP2008525032A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
| CA2599650A1 (en) | 2005-03-07 | 2006-09-14 | Ge Healthcare Bio-Sciences Ab | Method of sterilization |
| CN1923290A (zh) | 2005-04-29 | 2007-03-07 | 成都夸常医学工业有限公司 | 一种病毒灭活方法、其中所用的处理系统以及装置 |
| WO2007055789A2 (en) | 2005-10-31 | 2007-05-18 | Neose Technologies, Inc. | Expression of soluble therapeutic proteins |
| EP1963367A4 (en) | 2005-12-06 | 2009-05-13 | Amgen Inc | POLISHING STEPS IN MULTI-STAGE PROTEIN PURIFICATION TREATMENTS |
| US7673757B2 (en) | 2006-02-17 | 2010-03-09 | Millipore Corporation | Adsorbent filter media for removal of biological contaminants in process liquids |
| WO2007116322A2 (en) | 2006-02-17 | 2007-10-18 | Novartis Ag | Purification of bacterial antigens |
| JP2010507068A (ja) | 2006-04-21 | 2010-03-04 | バイエル・コーポレーシヨン | 原位置測定のための装置、システム、方法 |
| US20080132688A1 (en) | 2006-09-22 | 2008-06-05 | Amgen Inc. | Methods for Removing Viral Contaminants During Protein Purification |
| WO2008073620A2 (en) | 2006-11-02 | 2008-06-19 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| AU2007345719A1 (en) | 2007-02-01 | 2008-08-07 | Avantor Performance Materials, Inc. | Chromatographic media and chromatographic equipment storage solutions and use thereof |
| GB0704603D0 (en) | 2007-03-09 | 2007-04-18 | Ge Healthcare Bio Sciences Ab | Packing system and method for chromatography columns |
| US9597610B2 (en) | 2007-03-09 | 2017-03-21 | Ge Healthcare Bioprocess R&D Ab | Packing system and method for chromatography columns |
| US9012212B2 (en) | 2007-04-17 | 2015-04-21 | Xendo Holding B.V. | Method and device for continuous membrane adsorption |
| EP2160227B1 (en) | 2007-06-15 | 2019-02-20 | GE Healthcare Bio-Sciences AB | Chromatography method |
| US7809258B2 (en) | 2007-07-06 | 2010-10-05 | Flir Systems Ab | Camera and method for use with camera |
| US9109193B2 (en) | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
| HUE024877T2 (en) | 2007-10-30 | 2016-02-29 | Genentech Inc | Antibody purification by cation exchange chromatography |
| KR20130133894A (ko) | 2007-12-27 | 2013-12-09 | 오츠카 세이야쿠 가부시키가이샤 | 에쿠올 합성에 관여하는 효소 |
| US8329871B2 (en) * | 2008-06-24 | 2012-12-11 | Octapharma Ag | Process of purifying coagulation factor VIII |
| CA2932207A1 (en) | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| US9441028B2 (en) | 2008-12-08 | 2016-09-13 | Novo Nordisk A/S | Counter current purification of polypeptides |
| WO2010120514A2 (en) | 2009-03-31 | 2010-10-21 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| EP2236617A1 (en) | 2009-03-31 | 2010-10-06 | Leukocare Ag | Methods of terminal sterilization of biofunctional compositions |
| CN102421858A (zh) | 2009-06-22 | 2012-04-18 | 默克专利有限公司 | 导电制剂 |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| AU2010311421B2 (en) | 2009-10-29 | 2014-11-20 | Ascendis Pharma A/S | Sterilization of biodegradable hydrogels |
| GB0922426D0 (en) | 2009-12-22 | 2010-02-03 | Ge Healthcare Bio Sciences Ab | Containers for chromatography media |
| EP2517000B1 (en) * | 2009-12-22 | 2015-12-16 | GE Healthcare Bio-Sciences AB | Method for dry packing chromatography columns |
| WO2011147762A2 (en) | 2010-05-25 | 2011-12-01 | Bayer Pharma Aktiengesellschaft | Stabilized radiopharmaceutical composition |
| US9943781B2 (en) | 2010-06-03 | 2018-04-17 | Ge Healthcare Bioprocess R&D Ab | Parallel assembly of chromatography column modules |
| CA2801332C (en) | 2010-10-15 | 2016-08-23 | Straumann Holding Ag | New emd formulation comprising pga |
| WO2012071135A2 (en) | 2010-11-23 | 2012-05-31 | Biovec Transfusion, Llc | Methods for removing pathogens from a platelet preparation |
| JP5132838B2 (ja) | 2010-11-29 | 2013-01-30 | 三菱電機株式会社 | レーザ加工機の光路構造 |
| WO2012074481A1 (en) | 2010-12-03 | 2012-06-07 | Ge Healthcare Bio-Sciences Ab | System and process for biopolymer chromatography |
| CN103562145B (zh) | 2010-12-06 | 2016-09-21 | 颇尔公司 | 生物制品的连续加工方法 |
| CN102321316B (zh) | 2011-08-25 | 2013-04-24 | 上海恒方大高分子材料科技有限公司 | 一种适用于γ射线辐照消毒的医用PVC材料及其制备方法 |
| EP2760902B1 (de) | 2011-09-30 | 2018-08-08 | Covestro Deutschland AG | Homogene extrudierte artikel aus thermoplastisch verarbeitbaren polyurethanen auf basis von polyesterdiolen aus bernsteinsäure und 1,3 -propandiol |
| EP2656892A1 (en) | 2012-04-23 | 2013-10-30 | Merck Patent GmbH | Chromatography method |
| US20140154270A1 (en) | 2012-05-21 | 2014-06-05 | Chen Wang | Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| JP6182210B2 (ja) | 2012-06-29 | 2017-08-16 | イー・エム・デイー・ミリポア・コーポレイシヨン | タンパク質精製プロセス中のウイルスの不活性化方法 |
| MX379269B (es) | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| AU2014226126B2 (en) | 2013-03-08 | 2019-02-14 | Genzyme Corporation | Continuous purification of therapeutic proteins |
| CN103223333B (zh) | 2013-04-15 | 2015-01-14 | 河海大学 | 一种含双偕胺肟基的改性硅胶吸附剂及其制备方法 |
| EP3094391B1 (en) | 2014-01-17 | 2024-11-20 | Repligen Corporation | Sterilizing chromatography columns |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| US20240100450A9 (en) | 2014-01-17 | 2024-03-28 | Repligen Corporation | Sterilizing chromatography columns |
| CA3233933A1 (en) | 2017-01-30 | 2018-08-02 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for reducing bioburden in chromatography |
| JP7699537B2 (ja) | 2018-08-31 | 2025-06-27 | ジェンザイム・コーポレーション | 無菌クロマトグラフィー樹脂および製造方法におけるその使用 |
-
2015
- 2015-01-15 TW TW108121669A patent/TWI709570B/zh active
- 2015-01-15 TW TW104101335A patent/TWI671312B/zh active
- 2015-01-16 MX MX2016009295A patent/MX376882B/es active IP Right Grant
- 2015-01-16 RU RU2016133483A patent/RU2679133C2/ru active
- 2015-01-16 BR BR112016016329-0A patent/BR112016016329B1/pt active IP Right Grant
- 2015-01-16 HU HUE15708622A patent/HUE052611T2/hu unknown
- 2015-01-16 DK DK15708622.4T patent/DK3094640T3/da active
- 2015-01-16 EP EP15708622.4A patent/EP3094640B1/en active Active
- 2015-01-16 US US14/598,450 patent/US10087214B2/en active Active
- 2015-01-16 WO PCT/US2015/011698 patent/WO2015109146A1/en not_active Ceased
- 2015-01-16 ES ES15708622T patent/ES2841141T3/es active Active
- 2015-01-16 CA CA2936951A patent/CA2936951C/en active Active
- 2015-01-16 SG SG11201605626SA patent/SG11201605626SA/en unknown
- 2015-01-16 CN CN201580012458.1A patent/CN106103464B/zh active Active
- 2015-01-16 JP JP2016546971A patent/JP6691047B2/ja active Active
- 2015-01-16 HK HK17100550.3A patent/HK1227042B/en unknown
- 2015-01-16 AU AU2015206422A patent/AU2015206422B2/en active Active
- 2015-01-16 KR KR1020167022264A patent/KR102326354B1/ko active Active
- 2015-02-23 US US14/629,356 patent/US20150203532A1/en not_active Abandoned
-
2016
- 2016-07-14 IL IL246774A patent/IL246774B/en active IP Right Grant
-
2018
- 2018-08-21 US US16/107,203 patent/US20180354986A1/en not_active Abandoned
-
2020
- 2020-04-09 JP JP2020070132A patent/JP7055161B2/ja active Active
- 2020-08-14 US US16/993,654 patent/US11912739B2/en active Active
-
2021
- 2021-01-21 CY CY20211100048T patent/CY1124062T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017508135A5 (enExample) | ||
| JP6783767B2 (ja) | 組換えタンパク質を精製する方法 | |
| Chollangi et al. | Development of robust antibody purification by optimizing protein‐A chromatography in combination with precipitation methodologies | |
| EP3500586B1 (en) | Continuous process for reducing heterogeneity of therapeutic protein | |
| CA3034092A1 (en) | Methods of processing a fluid including a recombinant therapeutic protein and use thereof | |
| WO2003057158A3 (en) | Method of treating apoptosis and compositions thereof | |
| JP7817743B2 (ja) | タンパク質の精製の改善されたプロセス | |
| ES2942024T3 (es) | Métodos para caracterizar enlaces disulfuro | |
| CN103333244B (zh) | 利用GST 表达体系制备的hZimp10-N 端高效价抗体及应用 | |
| US8895237B2 (en) | Enhancing of hepatitis B virus vaccine and its gene | |
| CN105602915A (zh) | 一种多价ezh2肿瘤相关抗原肽及其制备 | |
| CN103524625B (zh) | 一种新型诱导抗体产生的方法 | |
| Shimada et al. | Development of a two‐step chromatography procedure that allows the purification of a high‐purity anti‐histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity | |
| RU2230573C2 (ru) | Способ получения очищенной вакцины клещевого энцефалита | |
| AU2017329865B2 (en) | Polypeptide construct comprising fragments of allergens | |
| Zhou et al. | Implementation of advanced technologies in commercial monoclonal antibody production | |
| Isu et al. | Process-and Product-Related Foulants in Virus Filtration. Bioengineering 2022, 9, 155 | |
| EA047061B1 (ru) | Непрерывный способ для снижения гетерогенности терапевтического белка | |
| CA3231514A1 (en) | Peptides for metabolic syndrome | |
| CN112079915A (zh) | 一种多肽及其制备方法和用途 | |
| RU2021112040A (ru) | Полипептиды для лечения синдромов стресса, иммунной реакции и инсульта | |
| CN117778363A (zh) | 一种α-烯醇化酶肿瘤抗原多肽及其肿瘤多肽疫苗及其应用 | |
| CN117343172A (zh) | 一种抗TGFβ的人源化纳米抗体及其制备方法 | |
| WO2005053740A1 (ja) | 免疫増強剤およびこれを用いた強化抗原 | |
| Morrow | Inventive Approaches Redefine Downstream Ops |