JP2017505337A - Ｉｒａｋ４阻害剤としてのインダゾール化合物 - Google Patents

Ｉｒａｋ４阻害剤としてのインダゾール化合物 Download PDF

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JP2017505337A
JP2017505337A JP2016563277A JP2016563277A JP2017505337A JP 2017505337 A JP2017505337 A JP 2017505337A JP 2016563277 A JP2016563277 A JP 2016563277A JP 2016563277 A JP2016563277 A JP 2016563277A JP 2017505337 A JP2017505337 A JP 2017505337A
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mmol
methyl
indazol
give
compound
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JP2017505337A5 (https=
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ラオ グムマディ，ヴェンカテシュワル
ラオ グムマディ，ヴェンカテシュワル
サマジダール，スサンタ
グプタ，アジャイ
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アウリジーン ディスカバリー テクノロジーズ リミテッド
アウリジーン ディスカバリー テクノロジーズ リミテッド
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Application filed by アウリジーン ディスカバリー テクノロジーズ リミテッド, アウリジーン ディスカバリー テクノロジーズ リミテッド filed Critical アウリジーン ディスカバリー テクノロジーズ リミテッド
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016563277A 2014-01-10 2015-01-07 Ｉｒａｋ４阻害剤としてのインダゾール化合物 Ceased JP2017505337A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN146/CHE/2014 2014-01-10
IN146CH2014 2014-01-10
IN3018/CHE/2014 2014-06-20
IN3018CH2014 2014-06-20
PCT/IB2015/050119 WO2015104662A1 (en) 2014-01-10 2015-01-07 Indazole compounds as irak4 inhibitors

Publications (2)

Publication Number Publication Date
JP2017505337A true JP2017505337A (ja) 2017-02-16
JP2017505337A5 JP2017505337A5 (https=) 2018-02-15

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ID=52462359

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JP2016563277A Ceased JP2017505337A (ja) 2014-01-10 2015-01-07 Ｉｒａｋ４阻害剤としてのインダゾール化合物

Country Status (16)

Country Link
US (1) US10160753B2 (https=)
EP (1) EP3092226B1 (https=)
JP (1) JP2017505337A (https=)
KR (1) KR20160115933A (https=)
CN (1) CN106458982A (https=)
AU (1) AU2015205348A1 (https=)
BR (1) BR112016015983A2 (https=)
CA (1) CA2935880A1 (https=)
CU (1) CU20160109A7 (https=)
EA (1) EA201691401A1 (https=)
HK (1) HK1231480A1 (https=)
IL (1) IL246555A0 (https=)
MX (1) MX2016009011A (https=)
PH (1) PH12016501338A1 (https=)
SG (1) SG11201605408RA (https=)
WO (1) WO2015104662A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022540464A (ja) * 2019-07-10 2022-09-15 メッドシャイン ディスカバリー インコーポレイテッド Ｉｒａｋ４及びｂｔｋマルチターゲット阻害剤としてのオキサゾール化合物
JP2024500247A (ja) * 2020-12-25 2024-01-05 メッドシャイン ディスカバリー インコーポレイテッド アミドオキサゾール系化合物
JP2025501618A (ja) * 2021-12-23 2025-01-22 ハンチョウ ポリメド バイオファーマシューティカルズ インコーポレイテッド ５員縮合６員化合物、製造方法、医薬組成物、及び応用

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SG11201605408RA (en) 2014-01-10 2016-07-28 Aurigene Discovery Tech Ltd Indazole compounds as irak4 inhibitors
FI3805233T3 (fi) 2014-01-13 2024-04-17 Aurigene Oncology Ltd N-(5-(3-hydroksipyrrolidin-1-yyli)-2-morfolinooksatsolo[4,5-b]pyridin-6-yyli)-2-(2-metylipyridin-4-yyli)okatsoli-karboksamidin (r)- (s)-enantiomeerit irak4-estäjänä syövän hoitoon
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
JP2017518348A (ja) * 2014-06-20 2017-07-06 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ Ｉｒａｋ４阻害剤としての置換インダゾール化合物
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
US10336707B2 (en) 2014-12-16 2019-07-02 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
UY36660A (es) 2015-04-30 2016-11-30 Bayer Pharma AG Combinaciones de inhibidores de irak4
BR112018000624A2 (pt) * 2015-07-15 2018-09-18 Aurigene Discovery Technologies Limited compostos de indazol e azaindazol como inibidores de irak-4
JP6994454B2 (ja) 2015-08-04 2022-01-14 ライジェル ファーマシューティカルズ， インコーポレイテッド ベンズアゾール化合物ならびに該化合物の作製方法および使用方法
ES2745284T3 (es) * 2015-09-11 2020-02-28 Boehringer Ingelheim Int Heteroarilos sustituidos con pirazolilo y su uso como medicamentos
WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
EP3423446B1 (de) 2016-03-03 2020-09-16 Bayer Pharma Aktiengesellschaft Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
UA123169C2 (uk) * 2016-04-29 2021-02-24 Байєр Фарма Акцієнгезелльшафт Поліморфна форма n-{6-(2-гідроксипропан-2-іл)-2-[2-(метилсульфоніл)етил]-2н-індазол-5-іл}-6-(трифторметил)піридин-2-карбоксаміду
KR102409105B1 (ko) * 2016-04-29 2022-06-16 바이엘 파마 악티엔게젤샤프트 인다졸의 합성
WO2017207385A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
SG10202011653WA (en) 2016-06-01 2020-12-30 Bayer Pharma AG Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
MY199070A (en) * 2016-06-01 2023-10-12 Bayer Pharma AG Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseaes in animals
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
UA125650C2 (uk) 2016-09-09 2022-05-11 Інсайт Корпорейшн Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
TW202340194A (zh) 2017-02-16 2023-10-16 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
DK3600270T3 (da) 2017-03-31 2023-07-10 Aurigene Oncology Ltd Forbindelser og sammensætninger til behandling af hæmatologiske lidelser
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
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