JP2017502669A5 - - Google Patents

Info

Publication number

JP2017502669A5

JP2017502669A5 JP2016543567A JP2016543567A JP2017502669A5 JP 2017502669 A5 JP2017502669 A5 JP 2017502669A5 JP 2016543567 A JP2016543567 A JP 2016543567A JP 2016543567 A JP2016543567 A JP 2016543567A JP 2017502669 A5 JP2017502669 A5 JP 2017502669A5

Authority

JP

Japan

Prior art keywords

nucleic acid

pharmaceutical composition

utr

composition according

reading frame

Prior art date

2014-12-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000007523 nucleic acids Chemical group 0.000 claims 21
• 239000008194 pharmaceutical composition Substances 0.000 claims 20
• 108020005345 3' Untranslated Regions Proteins 0.000 claims 17
• 108700026244 Open Reading Frames Proteins 0.000 claims 17
• 108020004707 nucleic acids Proteins 0.000 claims 14
• 102000039446 nucleic acids Human genes 0.000 claims 14
• 101150081848 FIG4 gene Proteins 0.000 claims 8
• 239000013598 vector Substances 0.000 claims 8
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 108020004999 messenger RNA Proteins 0.000 claims 4
• 108020003589 5' Untranslated Regions Proteins 0.000 claims 3
• 108700008625 Reporter Genes Proteins 0.000 claims 3
• 230000014616 translation Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 2
• 108020004705 Codon Proteins 0.000 claims 2
• 108091034057 RNA (poly(A)) Proteins 0.000 claims 2
• 239000002671 adjuvant Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000013600 plasmid vector Substances 0.000 claims 2
• 230000008488 polyadenylation Effects 0.000 claims 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
• 102100024321 Alkaline phosphatase, placental type Human genes 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 1
• 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 1
• 108010033040 Histones Proteins 0.000 claims 1
• 101100012903 Homo sapiens FIG4 gene Proteins 0.000 claims 1
• 101000827703 Homo sapiens Polyphosphoinositide phosphatase Proteins 0.000 claims 1
• 108060001084 Luciferase Proteins 0.000 claims 1
• 239000005089 Luciferase Substances 0.000 claims 1
• 108010047357 Luminescent Proteins Proteins 0.000 claims 1
• 102000006830 Luminescent Proteins Human genes 0.000 claims 1
• 102100023591 Polyphosphoinositide phosphatase Human genes 0.000 claims 1
• 108091036066 Three prime untranslated region Proteins 0.000 claims 1
• 102000005936 beta-Galactosidase Human genes 0.000 claims 1
• 108010005774 beta-Galactosidase Proteins 0.000 claims 1
• 108091005948 blue fluorescent proteins Proteins 0.000 claims 1
• 238000007865 diluting Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 108091006047 fluorescent proteins Proteins 0.000 claims 1
• 102000034287 fluorescent proteins Human genes 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000001415 gene therapy Methods 0.000 claims 1
• 239000005090 green fluorescent protein Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 101150066555 lacZ gene Proteins 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108010031345 placental alkaline phosphatase Proteins 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 108010054624 red fluorescent protein Proteins 0.000 claims 1
• 230000000087 stabilizing effect Effects 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 239000003981 vehicle Substances 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1