JP2017502253A5 - - Google Patents
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- Publication number
- JP2017502253A5 JP2017502253A5 JP2016521777A JP2016521777A JP2017502253A5 JP 2017502253 A5 JP2017502253 A5 JP 2017502253A5 JP 2016521777 A JP2016521777 A JP 2016521777A JP 2016521777 A JP2016521777 A JP 2016521777A JP 2017502253 A5 JP2017502253 A5 JP 2017502253A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- ibs
- vinculin
- cdt
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 32
- 239000012472 biological sample Substances 0.000 claims description 20
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 10
- 102000003970 Vinculin Human genes 0.000 claims description 10
- 108090000384 Vinculin Proteins 0.000 claims description 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 101710182223 Toxin B Proteins 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 231100000518 lethal Toxicity 0.000 claims description 3
- 230000001665 lethal effect Effects 0.000 claims description 3
- 241000589877 Campylobacter coli Species 0.000 claims description 2
- 241000589875 Campylobacter jejuni Species 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 230000022534 cell killing Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361888658P | 2013-10-09 | 2013-10-09 | |
| US61/888,658 | 2013-10-09 | ||
| PCT/US2014/059957 WO2015054529A1 (en) | 2013-10-09 | 2014-10-09 | Diagnosis and treatment of irritable bowel syndrome and inflammatory bowel disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017502253A JP2017502253A (ja) | 2017-01-19 |
| JP2017502253A5 true JP2017502253A5 (OSRAM) | 2017-11-16 |
| JP6567509B2 JP6567509B2 (ja) | 2019-08-28 |
Family
ID=52813648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521777A Active JP6567509B2 (ja) | 2013-10-09 | 2014-10-09 | 過敏性腸症候および炎症性腸疾患の診断および治療 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9851361B2 (OSRAM) |
| EP (1) | EP3054977B1 (OSRAM) |
| JP (1) | JP6567509B2 (OSRAM) |
| KR (1) | KR102259588B1 (OSRAM) |
| CN (1) | CN105744956B (OSRAM) |
| AU (2) | AU2014331841B2 (OSRAM) |
| BR (1) | BR112016007474A2 (OSRAM) |
| CA (1) | CA2923651C (OSRAM) |
| CL (1) | CL2016000820A1 (OSRAM) |
| ES (1) | ES2892905T3 (OSRAM) |
| IL (1) | IL244971B2 (OSRAM) |
| MX (1) | MX383423B (OSRAM) |
| NZ (1) | NZ717633A (OSRAM) |
| PE (1) | PE20160882A1 (OSRAM) |
| PL (1) | PL3054977T3 (OSRAM) |
| PT (1) | PT3054977T (OSRAM) |
| RU (1) | RU2683781C2 (OSRAM) |
| SG (1) | SG11201601733VA (OSRAM) |
| WO (1) | WO2015054529A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11693009B2 (en) | 2009-02-11 | 2023-07-04 | Cedars-Sinai Medical Center | Methods for detecting post-infectious irritable bowel syndrome |
| DK2396652T3 (da) | 2009-02-11 | 2018-01-29 | Cedars Sinai Medical Center | Diagnose af inflammatorisk tarmsyndrom baseret på cytoletalt udspilende toksin |
| MX383428B (es) | 2012-09-17 | 2025-03-13 | Cedars Sinai Medical Center | Determinaciòn de trastornos de la motilidad de los intestinos y la vejiga, y de la fibromialgia. |
| US9851361B2 (en) | 2013-10-09 | 2017-12-26 | Cedars-Sinai Medical Center | Methods of comparing anti-vinculin and anti-cytolethal distending toxin antibodies as they relate to irritable bowel syndrome |
| RU2706361C2 (ru) | 2014-10-09 | 2019-11-18 | Седарс-Синаи Медикал Сентер | Способы и системы для отличия синдрома раздраженного кишечника от воспалительного заболевания кишечника и глютеновой болезни |
| CN106053827A (zh) * | 2016-05-17 | 2016-10-26 | 上海凯璟生物科技有限公司 | 一种肠易激综合症标志物Vinculin抗体检测试剂盒及其制备方法 |
| CN105784989A (zh) * | 2016-05-17 | 2016-07-20 | 上海凯璟生物科技有限公司 | 一种肠易激综合症标志物CdtB抗体检测试剂盒及其制备方法 |
| KR20230003433A (ko) * | 2016-05-20 | 2023-01-05 | 세다르스-신나이 메디칼 센터 | 유전자에 기반한 염증성 장 질환의 진단 |
| EP3573650A4 (en) | 2017-01-30 | 2020-12-09 | Cedars-Sinai Medical Center | DIAGNOSIS OF SCLERODERMIA |
| RU2763258C1 (ru) * | 2020-07-13 | 2021-12-28 | Евгения Николаевна Воронина | Способ дифференциальной диагностики воспалительных заболеваний кишечника у детей по комплексу клинико-анамнестических, лабораторных и инструментальных критериев |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5691151A (en) * | 1994-10-07 | 1997-11-25 | Regents Of University Of California | Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
| FR2806805A1 (fr) | 2000-03-22 | 2001-09-28 | Centre Nat Rech Scient | SEQUENCE PEPTIDIQUES COMPRENANT UN OU PLUSIEURS MOTIFS DE LIAISON AUX PROTEINES DE LA FAMILLE Ena/VASP, ET LEURS UTILISATIONS |
| WO2003097854A2 (en) * | 2002-05-17 | 2003-11-27 | Sugen, Inc. | Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals |
| CA2498274A1 (en) | 2002-09-16 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the diagnosis of immune related diseases using pro7 |
| US7595386B2 (en) | 2003-01-24 | 2009-09-29 | William Beaumont Hospital | Methods and compositions for heat activated gene therapy using cytolethal distending toxin |
| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| ATE491953T1 (de) * | 2003-09-15 | 2011-01-15 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| ES2456710T3 (es) | 2003-12-05 | 2014-04-23 | Fuso Pharmaceutical Industries Ltd. | Genes de toxinas de distensión citoletales como dianas para la detección de bacterias Campylobacter |
| US8148067B2 (en) | 2006-11-09 | 2012-04-03 | Xdx, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
| US20110183337A1 (en) | 2007-12-20 | 2011-07-28 | Petra Von Stein | Method and Kit for Use in the Differentiation of IBD and IBS and Further Distinction Between Disease Types of IBD |
| ES2529060T3 (es) | 2008-11-24 | 2015-02-16 | Cedars-Sinai Medical Center | Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos |
| EP2396029A4 (en) | 2009-02-11 | 2012-08-08 | Cedars Sinai Medical Center | ANTIBIOTIC THERAPY FOR REDUCING THE PROBABILITY OF THE DEVELOPMENT OF POST-INFECTIOUS REIZDARY SYNDROME |
| DK2396652T3 (da) | 2009-02-11 | 2018-01-29 | Cedars Sinai Medical Center | Diagnose af inflammatorisk tarmsyndrom baseret på cytoletalt udspilende toksin |
| FR2942541A1 (fr) | 2009-02-25 | 2010-08-27 | Assist Publ Hopitaux De Paris | Procede de diagnostic d'une vascularite |
| RU2397178C1 (ru) * | 2009-02-27 | 2010-08-20 | Федеральное государственное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Диагностическая тест-система в формате иммуночипа и способ серологической дифференциальной диагностики сифилиса |
| IT1400989B1 (it) | 2010-07-13 | 2013-07-05 | Segix Italia S R L Ora Istituto Biochimico Naz Savio S R L | Forme di somministrazione orale a rilascio controllato di rifampicina per il trattamento di infezioni batteriche dell' apparato intestinale. |
| GB201017520D0 (en) | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
| MX383428B (es) | 2012-09-17 | 2025-03-13 | Cedars Sinai Medical Center | Determinaciòn de trastornos de la motilidad de los intestinos y la vejiga, y de la fibromialgia. |
| US9851361B2 (en) | 2013-10-09 | 2017-12-26 | Cedars-Sinai Medical Center | Methods of comparing anti-vinculin and anti-cytolethal distending toxin antibodies as they relate to irritable bowel syndrome |
| RU2706361C2 (ru) | 2014-10-09 | 2019-11-18 | Седарс-Синаи Медикал Сентер | Способы и системы для отличия синдрома раздраженного кишечника от воспалительного заболевания кишечника и глютеновой болезни |
| CN106091069A (zh) | 2016-06-15 | 2016-11-09 | 安徽省绿巨人环境技术有限公司 | 一种废水再利用装置 |
| EP3573650A4 (en) | 2017-01-30 | 2020-12-09 | Cedars-Sinai Medical Center | DIAGNOSIS OF SCLERODERMIA |
-
2014
- 2014-10-09 US US15/021,850 patent/US9851361B2/en active Active
- 2014-10-09 BR BR112016007474A patent/BR112016007474A2/pt not_active Application Discontinuation
- 2014-10-09 PE PE2016000430A patent/PE20160882A1/es unknown
- 2014-10-09 JP JP2016521777A patent/JP6567509B2/ja active Active
- 2014-10-09 KR KR1020167011774A patent/KR102259588B1/ko active Active
- 2014-10-09 WO PCT/US2014/059957 patent/WO2015054529A1/en not_active Ceased
- 2014-10-09 IL IL244971A patent/IL244971B2/en unknown
- 2014-10-09 CA CA2923651A patent/CA2923651C/en active Active
- 2014-10-09 AU AU2014331841A patent/AU2014331841B2/en active Active
- 2014-10-09 ES ES14851688T patent/ES2892905T3/es active Active
- 2014-10-09 PT PT14851688T patent/PT3054977T/pt unknown
- 2014-10-09 RU RU2016116766A patent/RU2683781C2/ru active
- 2014-10-09 EP EP14851688.3A patent/EP3054977B1/en active Active
- 2014-10-09 SG SG11201601733VA patent/SG11201601733VA/en unknown
- 2014-10-09 PL PL14851688T patent/PL3054977T3/pl unknown
- 2014-10-09 MX MX2016004167A patent/MX383423B/es unknown
- 2014-10-09 CN CN201480055994.5A patent/CN105744956B/zh active Active
- 2014-10-09 NZ NZ717633A patent/NZ717633A/en unknown
-
2016
- 2016-04-08 CL CL2016000820A patent/CL2016000820A1/es unknown
-
2017
- 2017-12-12 US US15/839,366 patent/US10352944B2/en active Active
-
2020
- 2020-05-27 AU AU2020203468A patent/AU2020203468A1/en not_active Abandoned
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