JP2010514805A5 - - Google Patents

Info

Publication number

JP2010514805A5

JP2010514805A5 JP2009544308A JP2009544308A JP2010514805A5 JP 2010514805 A5 JP2010514805 A5 JP 2010514805A5 JP 2009544308 A JP2009544308 A JP 2009544308A JP 2009544308 A JP2009544308 A JP 2009544308A JP 2010514805 A5 JP2010514805 A5 JP 2010514805A5

Authority

JP

Japan

Prior art keywords

znt8

fragment

antibody

individual

amino acid

Prior art date

2007-12-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000012634 fragment Substances 0.000 claims 38
• 150000001413 amino acids Chemical group 0.000 claims 17
• 238000000034 method Methods 0.000 claims 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 6
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 6
• 239000004475 Arginine Substances 0.000 claims 5
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 5
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 5
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
• 102000037865 fusion proteins Human genes 0.000 claims 5
• 108020001507 fusion proteins Proteins 0.000 claims 5
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 5
• 101000818846 Homo sapiens Zinc transporter 8 Proteins 0.000 claims 4
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 4
• 102000052010 human SLC30A8 Human genes 0.000 claims 4
• 208000023275 Autoimmune disease Diseases 0.000 claims 3
• 238000005259 measurement Methods 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 238000003556 assay Methods 0.000 claims 2
• 230000005784 autoimmunity Effects 0.000 claims 2
• 210000004900 c-terminal fragment Anatomy 0.000 claims 2
• 230000001066 destructive effect Effects 0.000 claims 2
• 238000002965 ELISA Methods 0.000 claims 1
• 229910052693 Europium Inorganic materials 0.000 claims 1
• 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
• 208000001280 Prediabetic State Diseases 0.000 claims 1
• 102000004248 Zinc Transporter 8 Human genes 0.000 claims 1
• 108090000702 Zinc Transporter 8 Proteins 0.000 claims 1
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
• 238000003149 assay kit Methods 0.000 claims 1
• 239000001362 calcium malate Substances 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000002860 competitive effect Effects 0.000 claims 1
• 238000003271 compound fluorescence assay Methods 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims 1
• 238000007422 luminescence assay Methods 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 210000004898 n-terminal fragment Anatomy 0.000 claims 1
• 239000013642 negative control Substances 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000002250 progressing effect Effects 0.000 claims 1
• 238000010814 radioimmunoprecipitation assay Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1