JP2017500017A5 - - Google Patents
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- JP2017500017A5 JP2017500017A5 JP2016532136A JP2016532136A JP2017500017A5 JP 2017500017 A5 JP2017500017 A5 JP 2017500017A5 JP 2016532136 A JP2016532136 A JP 2016532136A JP 2016532136 A JP2016532136 A JP 2016532136A JP 2017500017 A5 JP2017500017 A5 JP 2017500017A5
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- JP
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- Prior art keywords
- culture
- cells
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- item
- viable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 93
- 210000004027 cell Anatomy 0.000 claims description 67
- 230000001186 cumulative effect Effects 0.000 claims description 28
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 229910052742 iron Inorganic materials 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 claims description 11
- 238000010899 nucleation Methods 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 9
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- 229910052802 copper Inorganic materials 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 8
- 230000010412 perfusion Effects 0.000 claims description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 5
- 108010050904 Interferons Proteins 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 102100023961 ADP-ribosylation factor-like protein 2-binding protein Human genes 0.000 claims description 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 2
- 108010008165 Etanercept Proteins 0.000 claims description 2
- 101000757692 Homo sapiens ADP-ribosylation factor-like protein 2-binding protein Proteins 0.000 claims description 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 2
- 101000934823 Homo sapiens Barttin Proteins 0.000 claims description 2
- 108010005716 Interferon beta-1a Proteins 0.000 claims description 2
- 229960002964 adalimumab Drugs 0.000 claims description 2
- 102000003802 alpha-Synuclein Human genes 0.000 claims description 2
- 108090000185 alpha-Synuclein Proteins 0.000 claims description 2
- 229940003504 avonex Drugs 0.000 claims description 2
- 229960000397 bevacizumab Drugs 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
- 229960002806 daclizumab Drugs 0.000 claims description 2
- 229960000403 etanercept Drugs 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 229960000598 infliximab Drugs 0.000 claims description 2
- 229950005751 ocrelizumab Drugs 0.000 claims description 2
- 239000012716 precipitator Substances 0.000 claims description 2
- 229960004641 rituximab Drugs 0.000 claims description 2
- 229960000575 trastuzumab Drugs 0.000 claims description 2
- 210000003501 vero cell Anatomy 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims 1
- 229960003347 obinutuzumab Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919629P | 2013-12-20 | 2013-12-20 | |
| US61/919,629 | 2013-12-20 | ||
| PCT/US2014/071701 WO2015095809A1 (en) | 2013-12-20 | 2014-12-19 | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000268A Division JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017500017A JP2017500017A (ja) | 2017-01-05 |
| JP2017500017A5 true JP2017500017A5 (cg-RX-API-DMAC7.html) | 2018-02-08 |
Family
ID=52347449
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532136A Withdrawn JP2017500017A (ja) | 2013-12-20 | 2014-12-19 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2020000268A Withdrawn JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2022197095A Pending JP2023022317A (ja) | 2013-12-20 | 2022-12-09 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020000268A Withdrawn JP2020054388A (ja) | 2013-12-20 | 2020-01-06 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| JP2022197095A Pending JP2023022317A (ja) | 2013-12-20 | 2022-12-09 | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20160289633A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3083933A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2017500017A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015095809A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3083933A1 (en) | 2013-12-20 | 2016-10-26 | Biogen MA Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TW202246486A (zh) | 2014-06-09 | 2022-12-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| US20180312802A1 (en) * | 2015-11-02 | 2018-11-01 | Ares Trading S.A. | Methods for modulating production profiles of recombinant proteins in perfusion mode |
| KR102739324B1 (ko) | 2016-01-26 | 2024-12-09 | 베링거 인겔하임 인터내셔날 게엠베하 | 연결된 관류 대 연속-유동식 교반-탱크 반응기 세포 배양 시스템 |
| EP3504315A4 (en) | 2016-08-27 | 2020-04-15 | 3D Biotek, LLC | BIOREACTOR |
| US20200255785A1 (en) * | 2017-09-15 | 2020-08-13 | Bristol-Myers Squibb Company | Online biomass capacitance monitoring during large scale production of polypeptides of interest |
| CN111344558A (zh) | 2017-10-06 | 2020-06-26 | 龙沙有限公司 | 使用拉曼光谱法自动控制细胞培养 |
| EA202090740A1 (ru) | 2017-10-16 | 2020-07-07 | Ридженерон Фармасьютикалз, Инк. | Перфузионный биореактор и связанные с ним способы применения |
| WO2019094333A1 (en) * | 2017-11-13 | 2019-05-16 | Amgen Inc. | Methods for producing protein products |
| KR20250111232A (ko) * | 2017-12-11 | 2025-07-22 | 암젠 인크 | 이중특이적 항체 생성물의 연속 제조 공정 |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| CA3098565A1 (en) * | 2018-04-29 | 2019-11-07 | Claire G. ZHANG | Scalable clarification process for recombinant aav production |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
| JP7453151B2 (ja) * | 2018-11-02 | 2024-03-19 | 協和キリン株式会社 | 液体培地の調製方法 |
| AU2020212042A1 (en) * | 2019-01-25 | 2021-08-26 | Biogen Ma Inc. | Seed culture process for AAV production |
| AR118617A1 (es) * | 2019-04-11 | 2021-10-20 | Merck Patent Gmbh | Medios de cultivo celular que comprenden cetoácidos |
| JP7680418B2 (ja) * | 2019-07-16 | 2025-05-20 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 高密度連続接種の細胞培養方法及びその応用 |
| KR20220039777A (ko) * | 2019-08-01 | 2022-03-29 | 브리스톨-마이어스 스큅 컴퍼니 | 유가식 세포 배양에서 단백질 생산성을 개선시키는 방법 |
| CA3201327A1 (en) * | 2020-12-08 | 2022-06-16 | Partner Therapeutics, Inc. | Manufacture of granulocyte macrophage-colony stimulating factor |
| TW202309087A (zh) * | 2021-05-03 | 2023-03-01 | 德商百靈佳殷格翰國際股份有限公司 | 製備spesolimab之方法 |
| US20230279433A1 (en) | 2021-12-15 | 2023-09-07 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| CA3245327A1 (en) * | 2022-03-07 | 2023-09-14 | Ultragenyx Pharmaceutical Inc. | MODIFIED BATCH-BASED AAV PRODUCTION SYSTEMS AND PROCESSES |
| WO2024054414A1 (en) * | 2022-09-06 | 2024-03-14 | Amgen Inc. | Lean perfusion cell culture methods |
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| KR20110015551A (ko) | 2008-04-16 | 2011-02-16 | 바이엘 헬스케어 엘엘씨 | 제ｉｘ인자의 부위-지정 변형 |
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| EA201291482A1 (ru) | 2010-07-09 | 2013-10-30 | Байоджен Айдек Хемофилия Инк. | Химерные факторы коагуляции |
| CN103415610B (zh) | 2011-03-18 | 2016-10-19 | 通用电气健康护理生物科学股份公司 | 用于培养细胞的弹性袋 |
| LT2837680T (lt) | 2011-07-01 | 2020-07-10 | Amgen Inc. | Žinduolių ląstelių kultūra |
| EP3083933A1 (en) | 2013-12-20 | 2016-10-26 | Biogen MA Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
-
2014
- 2014-12-19 EP EP14827357.6A patent/EP3083933A1/en active Pending
- 2014-12-19 JP JP2016532136A patent/JP2017500017A/ja not_active Withdrawn
- 2014-12-19 US US15/038,698 patent/US20160289633A1/en not_active Abandoned
- 2014-12-19 WO PCT/US2014/071701 patent/WO2015095809A1/en not_active Ceased
-
2020
- 2020-01-06 JP JP2020000268A patent/JP2020054388A/ja not_active Withdrawn
-
2022
- 2022-12-09 JP JP2022197095A patent/JP2023022317A/ja active Pending
-
2025
- 2025-01-17 US US19/027,281 patent/US20250382568A1/en active Pending
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