JP2017500014A5 - - Google Patents

Info

Publication number

JP2017500014A5

JP2017500014A5 JP2016528141A JP2016528141A JP2017500014A5 JP 2017500014 A5 JP2017500014 A5 JP 2017500014A5 JP 2016528141 A JP2016528141 A JP 2016528141A JP 2016528141 A JP2016528141 A JP 2016528141A JP 2017500014 A5 JP2017500014 A5 JP 2017500014A5

Authority

JP

Japan

Prior art keywords

adsorption

adsorbent

complex

infectious

examples

Prior art date

2014-11-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000001179 sorption measurement Methods 0.000 description 14
• 239000003463 adsorbent Substances 0.000 description 12
• 244000052769 pathogen Species 0.000 description 10
• 150000004676 glycans Chemical class 0.000 description 9
• 229920001282 polysaccharide Polymers 0.000 description 9
• 239000005017 polysaccharide Substances 0.000 description 9
• 208000015181 infectious disease Diseases 0.000 description 7
• 238000000034 method Methods 0.000 description 7
• 239000000758 substrate Substances 0.000 description 7
• 239000003795 chemical substances by application Substances 0.000 description 6
• 230000001717 pathogenic effect Effects 0.000 description 6
• 239000007787 solid Substances 0.000 description 6
• 230000002458 infectious effect Effects 0.000 description 5
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
• 239000000853 adhesive Substances 0.000 description 4
• 229960000633 dextran sulfate Drugs 0.000 description 4
• 229920000669 heparin Polymers 0.000 description 4
• 229960002897 heparin Drugs 0.000 description 4
• 239000000523 sample Substances 0.000 description 4
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 3
• 229920002971 Heparan sulfate Polymers 0.000 description 3
• 230000001070 adhesive effect Effects 0.000 description 3
• 150000001720 carbohydrates Chemical class 0.000 description 3
• 235000014633 carbohydrates Nutrition 0.000 description 3
• 238000001514 detection method Methods 0.000 description 3
• 238000002965 ELISA Methods 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 239000012472 biological sample Substances 0.000 description 2
• 239000013068 control sample Substances 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 239000012678 infectious agent Substances 0.000 description 2
• 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 239000002156 adsorbate Substances 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 239000007853 buffer solution Substances 0.000 description 1
• 238000001516 cell proliferation assay Methods 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• -1 dextran sulfate Chemical compound 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 239000003480 eluent Substances 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229960003160 hyaluronic acid Drugs 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 229940041290 mannose Drugs 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 238000005406 washing Methods 0.000 description 1