JP2017119638A - 泡吐出容器入り液体口腔用組成物 - Google Patents
泡吐出容器入り液体口腔用組成物 Download PDFInfo
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- JP2017119638A JP2017119638A JP2015256340A JP2015256340A JP2017119638A JP 2017119638 A JP2017119638 A JP 2017119638A JP 2015256340 A JP2015256340 A JP 2015256340A JP 2015256340 A JP2015256340 A JP 2015256340A JP 2017119638 A JP2017119638 A JP 2017119638A
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Landscapes
- Cosmetics (AREA)
Abstract
Description
(A)両性界面活性剤 0.25質量%以上1.5質量%以下、
(B)ポリオキシエチレン硬化ヒマシ油 0.2質量%以上2質量%以下、
(C)香料 0.1質量%以上1.5質量%以下、
(D)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(E)水
を含有し、成分(A)と成分(B)の合計含有量と成分(C)の含有量との質量比((A)+(B))/(C)が1.5以上20以下であり、
アニオン界面活性剤の含有量が0.3質量%未満であり、成分(B)以外のノニオン界面活性剤の含有量が成分(B)の含有量以下であり、ショ糖脂肪酸エステルの含有量が0.5質量%以下であり、かつ研磨性紛体の含有量が0.5質量%以下である泡吐出容器入り液体口腔用組成物に関する。
本発明の泡吐出容器入り液体口腔用組成物は、成分(A)として、両性界面活性剤を0.25質量%以上1.5質量%以下含有する。成分(A)をかかる量で含有することにより、アニオン界面活性剤の含有量が減じられるなかでも、容器から吐出された際における良好な泡の形成を可能とし、また後述するように、その余の界面活性剤が特定の量的関係を有することとも相まって、低温安定性を有効に高め、低温における粘度上昇を抑制することができる。
成分(D)として用いるポリエチレングリコールの質量平均分子量は、低温保存安定性をより高める観点から、1000以下であって、好ましくは850以下であり、良好な泡質を保持する観点から、好ましくは200以上であり、より好ましくは400以上である。
なお、吸油量とは、シリカが担持できる油量を示したものであり、測定方法はJIS K5101−13−2(2004年制定)に基づく方法により、吸収される煮あまに油の量により特定する。
表1に示す処方にしたがって、液体口腔用組成物を調製した。次いで、得られた各液体口腔用組成物を用い、以下の方法にしたがって各測定及び評価を行った。
結果を表1に示す。
また、本発明の液体口腔用組成物において、成分(C)の香料として用い得る具体的な香料を表5〜7に示す。なお、実施例1〜30、比較例1〜8では、全て表6に示す香料を用いた。
得られた各液体口腔用組成物をガラス瓶に充填し、充填直後と、−5℃で1週間保存した後との双方において、ガラス瓶の外側から内容物の液体口腔用組成物を目視により観察し、以下の内容にしたがって評価した。「透明」である以外、安定性に問題があることを意味する。
透明:透明で均一であった
析出:析出物が確認された
針状結晶:針状結晶の存在が確認された
得られた各液体口腔用組成物をガラス瓶に充填し、充填直後と、−5℃で1週間保存した後との双方において、BL粘度計(東機産業(株)社製、M1ローター、回転数:30rpm/1分間)を用い、−5℃に保持したままでの液粘度(mPa・s)を測定した。
得られた各液体口腔用組成物100gをポンプフォーマー容器(大和製罐(株)、F5ポンプフォーマー、メッシュ:2枚、メッシュサイズ:#255/#255)に充填し、吐出口から内容物を吐出させ、BH粘度計(東機産業(株)社製、H2ローター、回転数:5rpm/1分間)を用い、室温(25℃)にて泡粘度(mPa・s)を測定した。
表2に示す処方にしたがって、液体口腔用組成物を調製した。次いで、得られた各液体口腔用組成物を用い、−5℃での保存期間を1ヶ月間とした以外、上記実施例1における方法にしたがって各測定及び評価を行った。
結果を表2に示す。
表3に示す処方にしたがって、液体口腔用組成物を調製した。次いで、得られた各液体口腔用組成物を用い、上記実施例1における方法(−5℃での保存期間=1週間)にしたがって各測定及び評価を行った。
結果を表3に示す。
表4に示す処方にしたがって、液体口腔用組成物を調製した。次いで、得られた各液体口腔用組成物を用い、−5℃での保存期間を1ヶ月間とした以外、上記実施例1における方法にしたがって各測定及び評価を行った。
結果を表4に示す。
Claims (7)
- 次の成分(A)、(B)、(C)、(D)並びに(E):
(A)両性界面活性剤 0.25質量%以上1.5質量%以下、
(B)ポリオキシエチレン硬化ヒマシ油 0.2質量%以上2質量%以下、
(C)香料 0.1質量%以上1.5質量%以下、
(D)グリセリン、プロピレングリコール、ブチレングリコール、及び平均分子量1000以下のポリエチレングリコールから選ばれる1種又は2種以上のポリオール 合計で10質量%以上40質量%以下、並びに
(E)水
を含有し、成分(A)と成分(B)の合計含有量と成分(C)の含有量との質量比((A)+(B))/(C)が1.5以上20以下であり、
アニオン界面活性剤の含有量が0.3質量%未満であり、成分(B)以外のノニオン界面活性剤の含有量が成分(B)の含有量以下であり、ショ糖脂肪酸エステルの含有量が0.5質量%以下であり、かつ研磨性紛体の含有量が0.5質量%以下である泡吐出容器入り液体口腔用組成物。 - ポリグリセリン脂肪酸エステルの含有量が、1質量%以下である請求項1に記載の泡吐出容器入り液体口腔用組成物。
- 成分(C)の含有量と成分(B)の含有量との質量比((C)/(B))が、0.05以上5以下である請求項1又は2に記載の泡吐出容器入り液体口腔用組成物。
- 成分(C)の含有量が、0.15質量%以上1質量%以下である請求項1〜3のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 20℃において固体の糖アルコールの含有量が、5質量%以下である請求項1〜4のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(A)、成分(B)及び成分(C)の合計含有量が、0.8質量%以上3.5質量%以下である請求項1〜5のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
- 成分(B)以外のノニオン界面活性剤の含有量が、成分(B)の含有量に対して0.8倍以下である請求項1〜6のいずれか1項に記載の泡吐出容器入り液体口腔用組成物。
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Publication number | Priority date | Publication date | Assignee | Title |
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JP2017119636A (ja) * | 2015-12-28 | 2017-07-06 | 花王株式会社 | 液体口腔用組成物 |
JP2020002023A (ja) * | 2018-06-25 | 2020-01-09 | ロート製薬株式会社 | 液体口腔用組成物 |
JP7336476B2 (ja) | 2021-02-26 | 2023-08-31 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08333226A (ja) * | 1995-06-02 | 1996-12-17 | Lion Corp | 泡状口腔用組成物 |
JPH1087457A (ja) * | 1996-09-14 | 1998-04-07 | Sunstar Inc | 口腔用組成物 |
JPH11130647A (ja) * | 1997-10-28 | 1999-05-18 | Lion Corp | 泡状口腔用組成物 |
JP2003089641A (ja) * | 2001-07-12 | 2003-03-28 | Lion Corp | 偏性嫌気性菌抑制剤及び偏性嫌気性菌抑制用組成物 |
JP2013209311A (ja) * | 2012-03-30 | 2013-10-10 | Sunstar Inc | 保存安定性に優れたステイン形成阻害用液体口腔用組成物 |
WO2015016057A1 (ja) * | 2013-08-02 | 2015-02-05 | ライオン株式会社 | ポンプディスペンサーを有する容器充填用歯磨剤組成物及び歯磨製品 |
-
2015
- 2015-12-28 JP JP2015256340A patent/JP6669492B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08333226A (ja) * | 1995-06-02 | 1996-12-17 | Lion Corp | 泡状口腔用組成物 |
JPH1087457A (ja) * | 1996-09-14 | 1998-04-07 | Sunstar Inc | 口腔用組成物 |
JPH11130647A (ja) * | 1997-10-28 | 1999-05-18 | Lion Corp | 泡状口腔用組成物 |
JP2003089641A (ja) * | 2001-07-12 | 2003-03-28 | Lion Corp | 偏性嫌気性菌抑制剤及び偏性嫌気性菌抑制用組成物 |
JP2013209311A (ja) * | 2012-03-30 | 2013-10-10 | Sunstar Inc | 保存安定性に優れたステイン形成阻害用液体口腔用組成物 |
WO2015016057A1 (ja) * | 2013-08-02 | 2015-02-05 | ライオン株式会社 | ポンプディスペンサーを有する容器充填用歯磨剤組成物及び歯磨製品 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017119636A (ja) * | 2015-12-28 | 2017-07-06 | 花王株式会社 | 液体口腔用組成物 |
JP2020002023A (ja) * | 2018-06-25 | 2020-01-09 | ロート製薬株式会社 | 液体口腔用組成物 |
JP7336476B2 (ja) | 2021-02-26 | 2023-08-31 | 花王株式会社 | 泡吐出容器入り液体口腔用組成物 |
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