JP2017025071A5 - - Google Patents
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- Publication number
- JP2017025071A5 JP2017025071A5 JP2016159713A JP2016159713A JP2017025071A5 JP 2017025071 A5 JP2017025071 A5 JP 2017025071A5 JP 2016159713 A JP2016159713 A JP 2016159713A JP 2016159713 A JP2016159713 A JP 2016159713A JP 2017025071 A5 JP2017025071 A5 JP 2017025071A5
- Authority
- JP
- Japan
- Prior art keywords
- anticancer agent
- agent according
- group
- hydrogen
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002246 antineoplastic agent Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000004005 microsphere Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 239000010419 fine particle Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- -1 camptothecin compound Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000007942 carboxylates Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 239000006194 liquid suspension Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 238000010526 radical polymerization reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04255411.3 | 2004-09-07 | ||
| EP04255411 | 2004-09-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015080262A Division JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017025071A JP2017025071A (ja) | 2017-02-02 |
| JP2017025071A5 true JP2017025071A5 (https=) | 2017-03-09 |
Family
ID=34930630
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529390A Expired - Lifetime JP5221134B2 (ja) | 2004-09-07 | 2005-09-06 | 塞栓剤からの薬物送達 |
| JP2012167295A Expired - Lifetime JP5792691B2 (ja) | 2004-09-07 | 2012-07-27 | 塞栓剤からの薬物送達 |
| JP2015080262A Pending JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
| JP2016159713A Pending JP2017025071A (ja) | 2004-09-07 | 2016-08-16 | 塞栓剤からの薬物送達 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529390A Expired - Lifetime JP5221134B2 (ja) | 2004-09-07 | 2005-09-06 | 塞栓剤からの薬物送達 |
| JP2012167295A Expired - Lifetime JP5792691B2 (ja) | 2004-09-07 | 2012-07-27 | 塞栓剤からの薬物送達 |
| JP2015080262A Pending JP2015180625A (ja) | 2004-09-07 | 2015-04-09 | 塞栓剤からの薬物送達 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20070275991A1 (https=) |
| EP (3) | EP1796644B1 (https=) |
| JP (4) | JP5221134B2 (https=) |
| CN (2) | CN103860479A (https=) |
| AT (1) | ATE505185T1 (https=) |
| AU (1) | AU2005281483B2 (https=) |
| CA (1) | CA2579533C (https=) |
| DE (1) | DE602005027477D1 (https=) |
| ES (1) | ES2361919T3 (https=) |
| HK (1) | HK1198691A1 (https=) |
| WO (1) | WO2006027567A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100872884B1 (ko) | 2000-03-24 | 2008-12-10 | 바이오스피어 메디칼 인코포레이티드 | 능동 색전화용 미소구 |
| WO2006013376A2 (en) * | 2004-08-04 | 2006-02-09 | Biocompatibles Uk Limited | Drug delivery of a cox inhibitor from embolic agents |
| KR101429774B1 (ko) | 2005-05-09 | 2014-10-02 | 바이오스피어 메디칼 에스.에이. | 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법 |
| US9107833B2 (en) | 2006-06-22 | 2015-08-18 | Biocompatibles Uk Limited | Rehydratable pharmaceutical product |
| EP1985286A1 (en) * | 2007-04-24 | 2008-10-29 | Biocompatibles UK Limited | Microspheres for treatment of brain tumours |
| JP2010536738A (ja) * | 2007-08-16 | 2010-12-02 | バイオコンパティブルズ ユーケー リミテッド | 薬剤の組み合わせの送達 |
| CA2745238A1 (en) * | 2008-12-02 | 2010-06-10 | Biocompatibles Uk Limited | Pancreatic tumour treatment |
| US9724421B2 (en) | 2010-11-29 | 2017-08-08 | Centre Hospitalier Universitaire Vaudois | Chemoembolization composition comprising anti-angiogenic agents |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| CN102336904B (zh) * | 2011-09-29 | 2013-03-27 | 成都一平医药科技发展有限公司 | 一种喜树碱及其衍生物的多价peg修饰物及其用途 |
| CN102397593B (zh) * | 2011-11-11 | 2013-12-18 | 北京大学 | X线下可显影的栓塞微粒及其制备方法和应用 |
| EP2921166B1 (en) * | 2012-11-15 | 2017-06-14 | Utah-Inha DDS & Advanced Therapeutics Research Center | Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| CN104994841B (zh) | 2012-11-27 | 2018-11-16 | 犹他-仁荷Dds及新医疗技术开发共同研究所 | 包含阴离子性高分子的抗癌药吸附能力得到提高的生物降解性微珠及其的制备方法 |
| EP3046952B1 (en) | 2013-09-19 | 2021-05-12 | Terumo Corporation | Polymer particles |
| JP6641265B2 (ja) | 2013-09-19 | 2020-02-05 | マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． | ポリマーフィルム |
| EP3065719A4 (en) | 2013-11-08 | 2017-08-09 | Terumo Corporation | Polymer particles |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| JP2016124818A (ja) * | 2014-12-26 | 2016-07-11 | 日本化薬株式会社 | 転移性肝癌治療薬及び転移性肝癌の治療方法 |
| WO2016154592A1 (en) | 2015-03-26 | 2016-09-29 | Microvention, Inc. | Embiolic particles |
| WO2016203352A2 (en) * | 2015-06-14 | 2016-12-22 | Mohan M Alapati | Compositions and methods for the treatment of cancer |
| WO2016203337A2 (en) * | 2015-06-14 | 2016-12-22 | Mohan M Alapati | Compositions and methods for the treatment of cancer |
| GB201515602D0 (en) | 2015-09-03 | 2015-10-21 | Biocompatibles Uk Ltd | Polymers and microspheres |
| EP4279139A3 (en) | 2016-09-28 | 2024-01-24 | Terumo Corporation | Polymer particles |
| RU2019138742A (ru) | 2017-05-26 | 2021-06-28 | Бруин Байосаенсис, Инк. | Средства для химиоэмболизации |
| CN107812232A (zh) * | 2017-11-08 | 2018-03-20 | 华威（深圳）医疗器械有限责任公司 | 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺 |
| EP3888708B1 (en) * | 2018-11-30 | 2024-01-03 | Nextbiomedical Co., Ltd. | Hydrogel particles for chemoembolization comprising biodegradable polymer |
| GB201918300D0 (en) * | 2019-12-12 | 2020-01-29 | Extruded Pharmaceuticals Ltd | Chemotherapeutic drug implant |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032561A (en) * | 1975-05-27 | 1977-06-28 | The Upjohn Company | 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds |
| US4224427A (en) | 1978-06-01 | 1980-09-23 | Ciba-Geigy Corporation | Process for preparing hydrogels as spherical beads of large size |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4978713A (en) | 1987-12-16 | 1990-12-18 | Ciba-Geigy Corporation | Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom |
| GB9023498D0 (en) | 1990-10-29 | 1990-12-12 | Biocompatibles Ltd | Soft contact lens material |
| US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
| GB9301702D0 (en) | 1993-01-28 | 1993-03-17 | Biocompatibles Ltd | New materials |
| GB9301701D0 (en) | 1993-01-28 | 1993-03-17 | Biocompatibles Ltd | New zwitterionic materials |
| TW272976B (https=) | 1993-08-06 | 1996-03-21 | Ciba Geigy Ag | |
| GB9415926D0 (en) | 1994-08-04 | 1994-09-28 | Biocompatibles Ltd | New materials |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| JP4790125B2 (ja) | 1998-11-13 | 2011-10-12 | バイオコンパテイブルズ・ユーケイ・リミテツド | 両性イオン性モノマー成分を含んでなるアニオン性−カチオン性ポリイオンコンプレックス |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| DE19905639A1 (de) * | 1999-02-11 | 2000-08-17 | Clariant Gmbh | Wasserlösliche oder wasserquellbare Polymerisate |
| FR2793684B1 (fr) | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant |
| US6191119B1 (en) * | 1999-10-15 | 2001-02-20 | Supergen, Inc. | Combination therapy including 9-nitro-20(S)-camptothecin |
| JP2002154963A (ja) * | 2000-11-14 | 2002-05-28 | Yakult Honsha Co Ltd | 徐放性抗腫瘍剤 |
| US7838699B2 (en) * | 2002-05-08 | 2010-11-23 | Biosphere Medical | Embolization using degradable crosslinked hydrogels |
| DE10230991A1 (de) | 2002-07-10 | 2004-02-12 | Robert Bosch Gmbh | Werkzeugaufnahme für eine Werkzeugmaschine |
| US20040076582A1 (en) * | 2002-08-30 | 2004-04-22 | Dimatteo Kristian | Agent delivery particle |
| CN103393605B (zh) * | 2003-02-12 | 2018-05-29 | 生物相容英国有限公司 | 用于实体瘤的化学栓塞治疗的组合物 |
| US20040161466A1 (en) * | 2003-02-14 | 2004-08-19 | Biocompatibles Uk Limited | Chemoembolisation |
-
2005
- 2005-09-06 US US11/574,703 patent/US20070275991A1/en not_active Abandoned
- 2005-09-06 CN CN201410016386.5A patent/CN103860479A/zh active Pending
- 2005-09-06 CN CNA2005800374691A patent/CN101052378A/zh active Pending
- 2005-09-06 WO PCT/GB2005/003431 patent/WO2006027567A2/en not_active Ceased
- 2005-09-06 AT AT05777645T patent/ATE505185T1/de active
- 2005-09-06 AU AU2005281483A patent/AU2005281483B2/en not_active Ceased
- 2005-09-06 DE DE602005027477T patent/DE602005027477D1/de not_active Expired - Lifetime
- 2005-09-06 EP EP05777645A patent/EP1796644B1/en not_active Expired - Lifetime
- 2005-09-06 EP EP10174312A patent/EP2269580A3/en not_active Ceased
- 2005-09-06 CA CA2579533A patent/CA2579533C/en not_active Expired - Lifetime
- 2005-09-06 EP EP15159809.1A patent/EP3085361A1/en not_active Ceased
- 2005-09-06 ES ES05777645T patent/ES2361919T3/es not_active Expired - Lifetime
- 2005-09-06 JP JP2007529390A patent/JP5221134B2/ja not_active Expired - Lifetime
-
2011
- 2011-10-27 US US13/282,953 patent/US20120276151A1/en not_active Abandoned
-
2012
- 2012-04-20 US US13/452,493 patent/US20120201867A1/en not_active Abandoned
- 2012-07-27 JP JP2012167295A patent/JP5792691B2/ja not_active Expired - Lifetime
-
2014
- 2014-12-04 HK HK14112213.0A patent/HK1198691A1/xx unknown
-
2015
- 2015-04-09 JP JP2015080262A patent/JP2015180625A/ja active Pending
-
2016
- 2016-08-16 JP JP2016159713A patent/JP2017025071A/ja active Pending
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