JP2016539925A - Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 - Google Patents
Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 Download PDFInfo
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- JP2016539925A JP2016539925A JP2016525584A JP2016525584A JP2016539925A JP 2016539925 A JP2016539925 A JP 2016539925A JP 2016525584 A JP2016525584 A JP 2016525584A JP 2016525584 A JP2016525584 A JP 2016525584A JP 2016539925 A JP2016539925 A JP 2016539925A
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- tlr4
- seq
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- citrullinated
- acid sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361894042P | 2013-10-22 | 2013-10-22 | |
| US61/894,042 | 2013-10-22 | ||
| PCT/EP2014/072606 WO2015059168A1 (en) | 2013-10-22 | 2014-10-22 | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018246722A Division JP2019048895A (ja) | 2013-10-22 | 2018-12-28 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
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| JP2016539925A true JP2016539925A (ja) | 2016-12-22 |
| JP2016539925A5 JP2016539925A5 (enExample) | 2017-11-30 |
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| JP2016525584A Pending JP2016539925A (ja) | 2013-10-22 | 2014-10-22 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
| JP2018246722A Withdrawn JP2019048895A (ja) | 2013-10-22 | 2018-12-28 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
| JP2020177986A Pending JP2021006592A (ja) | 2013-10-22 | 2020-10-23 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| JP2018246722A Withdrawn JP2019048895A (ja) | 2013-10-22 | 2018-12-28 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
| JP2020177986A Pending JP2021006592A (ja) | 2013-10-22 | 2020-10-23 | Tlr4リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9688769B2 (enExample) |
| EP (1) | EP3060250A1 (enExample) |
| JP (3) | JP2016539925A (enExample) |
| CN (1) | CN105899231A (enExample) |
| AU (2) | AU2014338991B2 (enExample) |
| CA (1) | CA2928317A1 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023523096A (ja) * | 2020-04-20 | 2023-06-01 | エデサ バイオテック リサーチ インコーポレイテッド | 急性呼吸促迫症候群を治療するための組成物および方法 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6419064B2 (ja) * | 2012-03-29 | 2018-11-07 | ノビミューン エスアー | 抗tlr4抗体およびその使用 |
| AU2014338991B2 (en) | 2013-10-22 | 2020-06-11 | Novimmune S.A. | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers |
| EP3332256A1 (en) * | 2015-08-06 | 2018-06-13 | NovImmune SA | Methods and compositions for identifying patient populations for diagnosis and treatment of tlr4-dependent disorders |
| JP6872024B2 (ja) * | 2016-10-04 | 2021-05-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 合成分類指標の同定のためのシステムおよび方法 |
| JP7108638B2 (ja) * | 2017-02-07 | 2022-07-28 | ライフストーン・アーエス | 無菌性弛みによるインプラント関連のインプラント再置換リスクの診断のためのバイオマーカー |
| WO2020225549A1 (en) * | 2019-05-06 | 2020-11-12 | The Francis Crick Institute Limited | Method for preventing inflammation |
| CN113358872B (zh) * | 2021-06-03 | 2022-10-21 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 用于评估肿瘤免疫治疗疗效的标志物组及系统 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005065015A2 (en) * | 2003-12-10 | 2005-07-21 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
| US20080050366A1 (en) * | 2003-12-10 | 2008-02-28 | Greg Elson | Neutralizing antibodies and methods of use thereof |
| JP2008523048A (ja) * | 2004-12-10 | 2008-07-03 | ノビミューン エスアー | toll様レセプターを標的とする併用療法およびその使用 |
| WO2012096917A1 (en) * | 2011-01-10 | 2012-07-19 | Novimmune S.A. | Anti-tlr4 antibodies and methods of use thereof |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US7312320B2 (en) | 2003-12-10 | 2007-12-25 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
| EP1789067B8 (en) | 2004-08-12 | 2012-08-15 | Helsinn Healthcare S.A. | Use of growth hormone secretagogues for stimulating the motility of the gastrointestinal system |
| AU2006284096B2 (en) | 2005-08-25 | 2012-03-29 | Avro Life Sciences, Inc. | Polymer conjugates of K-252a and derivatives thereof |
| SI1919979T1 (sl) * | 2005-08-25 | 2014-02-28 | Creabilis Therapeutics S.P.A. | Polimerni konjugati K-252A in njihovi derivati |
| US20070148704A1 (en) * | 2005-10-06 | 2007-06-28 | Ursula Klause | Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis |
| US7712333B2 (en) | 2006-03-29 | 2010-05-11 | Asahi Glass Company, Limited | Method for smoothing a surface of a glass substrate for a reflective mask blank used in EUV lithography |
| WO2009101479A2 (en) * | 2007-05-14 | 2009-08-20 | Novimmune Sa | Fc receptor-binding polypeptides with modified effector functions |
| US8202650B2 (en) | 2007-07-24 | 2012-06-19 | Panasonic Corporation | Negative electrode material for nickel-metal hydride battery and treatment method thereof, and nickel-metal hydride battery |
| WO2009138494A2 (en) | 2008-05-15 | 2009-11-19 | Ablynx N.V. | Amino acid sequences directed against toll-like receptors and polypeptides comprising the same for the treatment of diseases related to toll-like receptors |
| US9140701B2 (en) * | 2009-08-18 | 2015-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Fibrinogen immune complexes to diagnose and guide therapy in rheumatoid arthritis |
| HRP20251174T1 (hr) * | 2010-11-05 | 2025-11-21 | Novartis Ag | Postupci za liječenje psorijatičnog artritisa uporabom il-17 antagonista |
| WO2013116590A1 (en) * | 2012-02-01 | 2013-08-08 | George Miller | Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors |
| US20160159922A1 (en) | 2013-07-24 | 2016-06-09 | Vilara Ab | Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis |
| AU2014338991B2 (en) | 2013-10-22 | 2020-06-11 | Novimmune S.A. | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers |
-
2014
- 2014-10-22 AU AU2014338991A patent/AU2014338991B2/en not_active Ceased
- 2014-10-22 WO PCT/EP2014/072606 patent/WO2015059168A1/en not_active Ceased
- 2014-10-22 CA CA2928317A patent/CA2928317A1/en not_active Abandoned
- 2014-10-22 JP JP2016525584A patent/JP2016539925A/ja active Pending
- 2014-10-22 CN CN201480070143.8A patent/CN105899231A/zh active Pending
- 2014-10-22 US US14/520,904 patent/US9688769B2/en active Active
- 2014-10-22 EP EP14793805.4A patent/EP3060250A1/en not_active Withdrawn
-
2017
- 2017-06-26 US US15/632,882 patent/US10556960B2/en active Active
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2018
- 2018-12-28 JP JP2018246722A patent/JP2019048895A/ja not_active Withdrawn
-
2020
- 2020-09-11 AU AU2020230333A patent/AU2020230333A1/en not_active Abandoned
- 2020-10-23 JP JP2020177986A patent/JP2021006592A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005065015A2 (en) * | 2003-12-10 | 2005-07-21 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
| US20080050366A1 (en) * | 2003-12-10 | 2008-02-28 | Greg Elson | Neutralizing antibodies and methods of use thereof |
| JP2008523048A (ja) * | 2004-12-10 | 2008-07-03 | ノビミューン エスアー | toll様レセプターを標的とする併用療法およびその使用 |
| WO2012096917A1 (en) * | 2011-01-10 | 2012-07-19 | Novimmune S.A. | Anti-tlr4 antibodies and methods of use thereof |
Non-Patent Citations (8)
| Title |
|---|
| ARTHRITIS RESEARCH & THERAPY, vol. 14, JPN6018025582, 2012, pages 260, ISSN: 0004010037 * |
| ARTHRITIS RESEARCH & THERAPY, vol. 8, JPN6018025585, 2006, pages 69, ISSN: 0004010038 * |
| ARTHRITIS&RHEUMATISM, vol. 56, no. 9, JPN6018025574, 2007, pages 2957 - 2967, ISSN: 0004010033 * |
| ARTHRITIS&RHEUMATISM, vol. 63, no. 1, JPN6018025578, 2011, pages 53 - 62, ISSN: 0004010035 * |
| RHEUMATOLOGY, vol. 52, JPN6018025580, April 2013 (2013-04-01), pages 1739 - 1747, ISSN: 0004010036 * |
| THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, JPN6018025576, 2008, pages 205 - 216, ISSN: 0004010034 * |
| 薬学用語解説 関節リウマチ, JPN6018025570, 2009, pages 30 - 6, ISSN: 0004010031 * |
| 関節リウマチ(RA)に対するトシリズマブ使用ガイドライン, JPN6018025571, June 2013 (2013-06-01), pages 30 - 6, ISSN: 0004010032 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023523096A (ja) * | 2020-04-20 | 2023-06-01 | エデサ バイオテック リサーチ インコーポレイテッド | 急性呼吸促迫症候群を治療するための組成物および方法 |
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|---|---|
| US20150110811A1 (en) | 2015-04-23 |
| CA2928317A1 (en) | 2015-04-30 |
| AU2014338991A1 (en) | 2016-05-26 |
| AU2014338991B2 (en) | 2020-06-11 |
| AU2020230333A1 (en) | 2020-10-01 |
| US20170298140A1 (en) | 2017-10-19 |
| EP3060250A1 (en) | 2016-08-31 |
| JP2021006592A (ja) | 2021-01-21 |
| WO2015059168A1 (en) | 2015-04-30 |
| CN105899231A (zh) | 2016-08-24 |
| US9688769B2 (en) | 2017-06-27 |
| US10556960B2 (en) | 2020-02-11 |
| JP2019048895A (ja) | 2019-03-28 |
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