CN105899231A - 用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 - Google Patents

用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 Download PDF

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Publication number
CN105899231A
CN105899231A CN201480070143.8A CN201480070143A CN105899231A CN 105899231 A CN105899231 A CN 105899231A CN 201480070143 A CN201480070143 A CN 201480070143A CN 105899231 A CN105899231 A CN 105899231A
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seq
tlr4
antibody
acid sequence
citrullinated
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Chinese (zh)
Inventor
C.德敏
L.商
E.蒙内
G.埃尔森
E.哈特雷尔
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Novimmune SA
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Novimmune SA
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • G01—MEASURING; TESTING
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    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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CN201480070143.8A 2013-10-22 2014-10-22 用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 Pending CN105899231A (zh)

Applications Claiming Priority (3)

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US201361894042P 2013-10-22 2013-10-22
US61/894042 2013-10-22
PCT/EP2014/072606 WO2015059168A1 (en) 2013-10-22 2014-10-22 Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers

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CN105899231A true CN105899231A (zh) 2016-08-24

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US (2) US9688769B2 (enExample)
EP (1) EP3060250A1 (enExample)
JP (3) JP2016539925A (enExample)
CN (1) CN105899231A (enExample)
AU (2) AU2014338991B2 (enExample)
CA (1) CA2928317A1 (enExample)
WO (1) WO2015059168A1 (enExample)

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WO2017021552A1 (en) * 2015-08-06 2017-02-09 Novimmune Sa Methods and compositions for identifying patient populations for diagnosis and treatment of tlr4-dependent disorders
WO2018065300A1 (en) * 2016-10-04 2018-04-12 F. Hoffmann-La Roche Ag System and method for identification of a synthetic classifier
EP3580571B1 (en) 2017-02-07 2023-06-07 Lyfstone B.V. Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening
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WO2021212222A1 (en) * 2020-04-20 2021-10-28 Edesa Biotech Research Inc. Compositions and methods for treatment of acute respiratory distress syndrome
CN113358872B (zh) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于评估肿瘤免疫治疗疗效的标志物组及系统

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CA2928317A1 (en) 2015-04-30
JP2016539925A (ja) 2016-12-22
EP3060250A1 (en) 2016-08-31
AU2014338991B2 (en) 2020-06-11
AU2014338991A1 (en) 2016-05-26
US20170298140A1 (en) 2017-10-19
US9688769B2 (en) 2017-06-27
US10556960B2 (en) 2020-02-11
JP2019048895A (ja) 2019-03-28
JP2021006592A (ja) 2021-01-21
WO2015059168A1 (en) 2015-04-30
US20150110811A1 (en) 2015-04-23

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