CN105899231A - 用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 - Google Patents

用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 Download PDF

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Publication number
CN105899231A
CN105899231A CN201480070143.8A CN201480070143A CN105899231A CN 105899231 A CN105899231 A CN 105899231A CN 201480070143 A CN201480070143 A CN 201480070143A CN 105899231 A CN105899231 A CN 105899231A
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seq
tlr4
antibody
citrullinated
disease
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Chinese (zh)
Inventor
C.德敏
L.商
E.蒙内
G.埃尔森
E.哈特雷尔
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Novimmune SA
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Novimmune SA
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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CN201480070143.8A 2013-10-22 2014-10-22 用于在具有升高水平的tlr4配体和其它生物标记的患者中诊断和治疗病症的方法和组合物 Pending CN105899231A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361894042P 2013-10-22 2013-10-22
US61/894042 2013-10-22
PCT/EP2014/072606 WO2015059168A1 (en) 2013-10-22 2014-10-22 Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of tlr4 ligands and other biomarkers

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CN105899231A true CN105899231A (zh) 2016-08-24

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US (2) US9688769B2 (enExample)
EP (1) EP3060250A1 (enExample)
JP (3) JP2016539925A (enExample)
CN (1) CN105899231A (enExample)
AU (2) AU2014338991B2 (enExample)
CA (1) CA2928317A1 (enExample)
WO (1) WO2015059168A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397851A (zh) * 2019-12-20 2022-11-25 哈德森医学研究院 Cxcl10结合蛋白及其用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6419064B2 (ja) * 2012-03-29 2018-11-07 ノビミューン エスアー 抗ｔｌｒ４抗体およびその使用
AU2014338991B2 (en) 2013-10-22 2020-06-11 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers
EP3332256A1 (en) * 2015-08-06 2018-06-13 NovImmune SA Methods and compositions for identifying patient populations for diagnosis and treatment of tlr4-dependent disorders
JP6872024B2 (ja) * 2016-10-04 2021-05-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 合成分類指標の同定のためのシステムおよび方法
JP7108638B2 (ja) * 2017-02-07 2022-07-28 ライフストーン・アーエス 無菌性弛みによるインプラント関連のインプラント再置換リスクの診断のためのバイオマーカー
WO2020225549A1 (en) * 2019-05-06 2020-11-12 The Francis Crick Institute Limited Method for preventing inflammation
CA3174429A1 (en) * 2020-04-20 2021-10-28 Edesa Biotech Research Inc. Compositions and methods for treatment of acute respiratory distress syndrome
CN113358872B (zh) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于评估肿瘤免疫治疗疗效的标志物组及系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065015A2 (en) * 2003-12-10 2005-07-21 Novimmune Sa Neutralizing antibodies and methods of use thereof
CN101248105A (zh) * 2005-08-25 2008-08-20 克雷毕里斯治疗股份公司 K-252a及其衍生物的聚合物缀合物
CN101283278A (zh) * 2005-10-06 2008-10-08 霍夫曼-拉罗奇有限公司 在类风湿性关节炎的诊断中的抗ccp和抗核抗体
US20120177648A1 (en) * 2011-01-10 2012-07-12 Marie Kosco-Vilbois Anti-tlr4 antibodies and methods of use thereof
CN103189074A (zh) * 2010-11-05 2013-07-03 诺华有限公司 使用il-17拮抗剂治疗类风湿性关节炎的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7674884B2 (en) * 2003-12-10 2010-03-09 Novimmune S.A. Neutralizing antibodies and methods of use thereof
US7312320B2 (en) 2003-12-10 2007-12-25 Novimmune Sa Neutralizing antibodies and methods of use thereof
EP1789067B8 (en) 2004-08-12 2012-08-15 Helsinn Healthcare S.A. Use of growth hormone secretagogues for stimulating the motility of the gastrointestinal system
ES2348792T3 (es) * 2004-12-10 2010-12-14 Novimmune Sa TERAPIAS COMBINADAS DIRIGIDAS A MÚLTIPLES RECEPTORES TIPO TOLL Y USO DE LAS MISMAS.
AU2006284096B2 (en) 2005-08-25 2012-03-29 Avro Life Sciences, Inc. Polymer conjugates of K-252a and derivatives thereof
US7712333B2 (en) 2006-03-29 2010-05-11 Asahi Glass Company, Limited Method for smoothing a surface of a glass substrate for a reflective mask blank used in EUV lithography
WO2009101479A2 (en) * 2007-05-14 2009-08-20 Novimmune Sa Fc receptor-binding polypeptides with modified effector functions
US8202650B2 (en) 2007-07-24 2012-06-19 Panasonic Corporation Negative electrode material for nickel-metal hydride battery and treatment method thereof, and nickel-metal hydride battery
WO2009138494A2 (en) 2008-05-15 2009-11-19 Ablynx N.V. Amino acid sequences directed against toll-like receptors and polypeptides comprising the same for the treatment of diseases related to toll-like receptors
US9140701B2 (en) * 2009-08-18 2015-09-22 The Board Of Trustees Of The Leland Stanford Junior University Fibrinogen immune complexes to diagnose and guide therapy in rheumatoid arthritis
WO2013116590A1 (en) * 2012-02-01 2013-08-08 George Miller Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
US20160159922A1 (en) 2013-07-24 2016-06-09 Vilara Ab Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis
AU2014338991B2 (en) 2013-10-22 2020-06-11 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065015A2 (en) * 2003-12-10 2005-07-21 Novimmune Sa Neutralizing antibodies and methods of use thereof
CN101248105A (zh) * 2005-08-25 2008-08-20 克雷毕里斯治疗股份公司 K-252a及其衍生物的聚合物缀合物
CN101283278A (zh) * 2005-10-06 2008-10-08 霍夫曼-拉罗奇有限公司 在类风湿性关节炎的诊断中的抗ccp和抗核抗体
CN103189074A (zh) * 2010-11-05 2013-07-03 诺华有限公司 使用il-17拮抗剂治疗类风湿性关节炎的方法
US20120177648A1 (en) * 2011-01-10 2012-07-12 Marie Kosco-Vilbois Anti-tlr4 antibodies and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MASAHIROHASEGAWA ET AL.: "Expression of Large Tenascin-C SpliceVariantsin Synovial Fluid of Patients with Rheumatoid Arthritis", 《JOURNAL OF ORTHOPAEDIC RESEARCH》 *
XIAOYAN ZHAO ET AL.: "Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis", 《ARTHRITIS RESEARCH & THERAPY》 *
彭双清等: "《毒理学替代法》", 31 December 2009 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397851A (zh) * 2019-12-20 2022-11-25 哈德森医学研究院 Cxcl10结合蛋白及其用途

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CA2928317A1 (en) 2015-04-30
AU2014338991A1 (en) 2016-05-26
JP2016539925A (ja) 2016-12-22
AU2014338991B2 (en) 2020-06-11
AU2020230333A1 (en) 2020-10-01
US20170298140A1 (en) 2017-10-19
EP3060250A1 (en) 2016-08-31
JP2021006592A (ja) 2021-01-21
WO2015059168A1 (en) 2015-04-30
US9688769B2 (en) 2017-06-27
US10556960B2 (en) 2020-02-11
JP2019048895A (ja) 2019-03-28

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Application publication date: 20160824