JP2016534034A5 - - Google Patents

Info

Publication number

JP2016534034A5

JP2016534034A5 JP2016519871A JP2016519871A JP2016534034A5 JP 2016534034 A5 JP2016534034 A5 JP 2016534034A5 JP 2016519871 A JP2016519871 A JP 2016519871A JP 2016519871 A JP2016519871 A JP 2016519871A JP 2016534034 A5 JP2016534034 A5 JP 2016534034A5

Authority

JP

Japan

Prior art keywords

pcv2

polypeptide

infection

sequence

amino acid

Prior art date

2014-10-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229920001184 polypeptide Polymers 0.000 claims 23
• 108090000765 processed proteins & peptides Proteins 0.000 claims 23
• 102000004196 processed proteins & peptides Human genes 0.000 claims 23
• 241001673669 Porcine circovirus 2 Species 0.000 claims 17
• 101100382437 Porcine circovirus 2 Cap gene Proteins 0.000 claims 13
• 208000015181 infectious disease Diseases 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 235000001014 amino acid Nutrition 0.000 claims 10
• 230000002163 immunogen Effects 0.000 claims 10
• 230000035772 mutation Effects 0.000 claims 9
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• 241000701447 unidentified baculovirus Species 0.000 claims 5
• 239000013612 plasmid Substances 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 229940024606 amino acid Drugs 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000006698 induction Effects 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 1
• 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
• 208000003322 Coinfection Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
• 101710113540 ORF2 protein Proteins 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 101710090523 Putative movement protein Proteins 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• 206010039101 Rhinorrhoea Diseases 0.000 claims 1
• 206010058874 Viraemia Diseases 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
• 235000021053 average weight gain Nutrition 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 210000003563 lymphoid tissue Anatomy 0.000 claims 1
• 208000010753 nasal discharge Diseases 0.000 claims 1
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1