JP2019526580A5 - - Google Patents
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- JP2019526580A5 JP2019526580A5 JP2019512191A JP2019512191A JP2019526580A5 JP 2019526580 A5 JP2019526580 A5 JP 2019526580A5 JP 2019512191 A JP2019512191 A JP 2019512191A JP 2019512191 A JP2019512191 A JP 2019512191A JP 2019526580 A5 JP2019526580 A5 JP 2019526580A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- seq
- administered
- weeks
- primer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims description 74
- 239000013598 vector Substances 0.000 claims description 55
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 49
- 239000000427 antigen Substances 0.000 claims description 35
- 102000036639 antigens Human genes 0.000 claims description 35
- 108091007433 antigens Proteins 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 24
- 238000011225 antiretroviral therapy Methods 0.000 claims description 20
- 230000002163 immunogen Effects 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 6
- 206010000807 Acute HIV infection Diseases 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 241000701161 unidentified adenovirus Species 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000003612 virological effect Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 241001212582 Ancara Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 description 2
- 108010078428 env Gene Products Proteins 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662383140P | 2016-09-02 | 2016-09-02 | |
| US62/383,140 | 2016-09-02 | ||
| PCT/US2017/049817 WO2018045267A1 (en) | 2016-09-02 | 2017-09-01 | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019526580A JP2019526580A (ja) | 2019-09-19 |
| JP2019526580A5 true JP2019526580A5 (OSRAM) | 2020-10-15 |
Family
ID=59887395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512191A Pending JP2019526580A (ja) | 2016-09-02 | 2017-09-01 | 抗レトロウイルス処置を受けている対象においてヒト免疫不全ウイルス感染に対する免疫応答を誘発するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10307477B2 (OSRAM) |
| EP (1) | EP3506937A1 (OSRAM) |
| JP (1) | JP2019526580A (OSRAM) |
| CN (1) | CN110494159A (OSRAM) |
| AU (1) | AU2017318689A1 (OSRAM) |
| CA (1) | CA3035759A1 (OSRAM) |
| WO (1) | WO2018045267A1 (OSRAM) |
| ZA (1) | ZA201901899B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202092521A1 (ru) * | 2014-09-26 | 2021-05-31 | Бет Изрейэл Диконисс Медикал Сентер, Инк. | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
| SMT202100623T1 (it) | 2015-12-15 | 2022-01-10 | Janssen Vaccines & Prevention Bv | Antigeni del virus dell'immunodeficienza umana, vettori, composizioni, e metodi di utilizzo degli stessi |
| BR112018075785A2 (pt) | 2016-06-16 | 2019-04-02 | Janssen Vaccines & Prevention B.V. | formulação de vacina para o hiv |
| CA3035759A1 (en) | 2016-09-02 | 2018-03-08 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| KR102513146B1 (ko) | 2016-09-15 | 2023-03-23 | 얀센 백신스 앤드 프리벤션 비.브이. | 삼량체를 안정화하는 hiv 엔벨로프 단백질 돌연변이 |
| CA3066573A1 (en) | 2017-06-15 | 2018-12-20 | Janssen Vaccines & Prevention B.V. | Poxvirus vectors encoding hiv antigens, and methods of use thereof |
| MA49616A (fr) | 2017-07-19 | 2020-05-27 | Janssen Vaccines & Prevention Bv | Mutations de protéine d'enveloppe du vih stabilisant la forme trimère |
| US20190083620A1 (en) * | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| WO2020237052A1 (en) * | 2019-05-22 | 2020-11-26 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| CA3141454A1 (en) * | 2019-05-22 | 2020-11-26 | Aelix Therapeutics, S.L. | Dosage regimens for vaccines |
| IL293051A (en) | 2019-11-18 | 2022-07-01 | Janssen Biotech Inc | Vaccines based on mutant calr and jak2 and their uses |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| JP2023521194A (ja) | 2020-04-13 | 2023-05-23 | ヤンセン バイオテツク，インコーポレーテツド | Ｐｓｍａ及びｓｔｅａｐ１ワクチン並びにそれらの使用 |
| EP4175721A1 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022009051A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | A method for determining responsiveness to prostate cancer treatment |
| US20220118081A1 (en) | 2020-10-20 | 2022-04-21 | Janssen Vaccines & Prevention B.V. | HIV vaccine regimens |
| WO2022272275A1 (en) * | 2021-06-25 | 2022-12-29 | Janssen Vaccines & Prevention B.V. | Combinations of vaccines and neutralizing antibodies for treating human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
| WO2024036217A2 (en) * | 2022-08-09 | 2024-02-15 | Fred Hutchinson Cancer Center | Immunization strategies to more naturally guide the maturation of antibodies against human immunodeficiency virus (hiv) in hiv-infected subjects |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| US5298416A (en) | 1989-01-18 | 1994-03-29 | British Technology Group Ltd. | Attenuated polioviruses |
| US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
| UA68327C2 (en) | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| US6479258B1 (en) | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| GB0023203D0 (en) | 2000-09-21 | 2000-11-01 | Isis Innovation | Vaccination method |
| US6710173B1 (en) | 1999-06-25 | 2004-03-23 | Progenics Pharmaceuticals, Inc. | Stabilized viral envelope proteins and uses thereof |
| CA2384271A1 (en) | 1999-09-17 | 2001-03-22 | Joseph G. Sodroski | Stabilized soluble glycoprotein trimers |
| UA76731C2 (uk) | 2000-11-23 | 2006-09-15 | Баваріан Нордік А/С | Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації |
| CN1602316A (zh) | 2001-12-04 | 2005-03-30 | 巴法里安诺迪克有限公司 | 黄病毒ns1亚单位疫苗 |
| ATE447037T1 (de) | 2002-04-25 | 2009-11-15 | Crucell Holland Bv | Mittel und verfahren zur herstellung von adenovirusvektoren |
| WO2004044155A2 (en) | 2002-11-07 | 2004-05-27 | Beth Israel Deaconess Medical Center | MIP-1α AND GM-CSF AS ADJUVANTS OF IMMUNE RESPONSE |
| CA2505583C (en) | 2002-12-03 | 2014-07-15 | University Of Massachusetts | Polyvalent, primary hiv-1 glycoprotein dna vaccines and vaccination methods |
| EP2363143A3 (en) | 2003-03-28 | 2012-02-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | MVA expressing modified hiv envelope, gag, and pol genes |
| CA2539021A1 (en) | 2003-09-15 | 2005-03-31 | Chiron Corporation | Combination approaches for generating immune responses |
| US20070298051A1 (en) | 2003-11-19 | 2007-12-27 | Beth Israel Deaconess Medical Center | Adjuvants Of Immune Response |
| WO2006002079A2 (en) | 2004-06-15 | 2006-01-05 | Progenics Pharmaceuticals, Inc. | Hiv-1 neutralizing antibodies elicited by trimeric hiv-1 envelope glycoprotein complex |
| JP4772045B2 (ja) | 2004-07-16 | 2011-09-14 | アメリカ合衆国 | Ｃｍｖ／ｒ核酸コンストラクトを含むａｉｄｓに対するワクチン |
| AU2005293568B2 (en) | 2004-10-13 | 2010-10-28 | Beth Israel Deaconess Medical Center Inc. | Improved adenoviral vectors and uses thereof |
| US20100221241A1 (en) | 2005-07-06 | 2010-09-02 | University Of Maryland Biotechnology Institute | Constrained hiv envelope-based immunogen that simultaneously presents receptor and coreceptor binding sites |
| WO2007024941A2 (en) | 2005-08-23 | 2007-03-01 | The Regents Of The University Of California | Polyvalent vaccine |
| US20100143302A1 (en) | 2006-03-16 | 2010-06-10 | Crucell Holland B.V. | Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof |
| EP2040747A4 (en) | 2006-06-19 | 2010-08-25 | Progenics Pharm Inc | SOLUBLE STABILIZED TRIMERS HIV CREAM PROTEINS AND ITS USE |
| WO2008063331A2 (en) | 2006-10-23 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof |
| WO2008140579A2 (en) | 2006-11-17 | 2008-11-20 | New York University | Induction of broadly reactive neutralizing antibodies by focusing the immune response on v3 epitopes of the hiv-1 gp120 envelope |
| AU2008223951B2 (en) | 2007-03-02 | 2014-03-27 | Glaxosmithkline Biologicals S.A. | Novel method and compositions |
| SMT202000101T1 (it) | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| BRPI0921588B1 (pt) | 2008-11-18 | 2021-12-28 | Beth Israel Deaconess Medical Center | Vacina compreendendo um polipeptídeo viral e seu método de preparação, kit e uso do polipeptídeo viral |
| WO2010096561A1 (en) | 2009-02-18 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic hiv/siv gag proteins and uses thereof |
| CN102711794B (zh) | 2010-01-04 | 2015-11-25 | Kj生物科学有限公司 | 用于疫苗和诊断学的Dps融合蛋白 |
| JP5783642B2 (ja) | 2010-01-28 | 2015-09-24 | バヴァリアン・ノルディック・アクティーゼルスカブ | Ｍｖａの主なゲノム欠失を含むワクシニアウイルス変異体 |
| EP4549461A3 (en) | 2010-08-31 | 2025-08-06 | Theraclone Sciences, Inc. | Human immunodeficiency virus (hiv)-neutralizing antibodies |
| US20140348791A1 (en) | 2011-09-09 | 2014-11-27 | Beth Israel Deaconess Medical Center, Inc. | Modified adenoviral vectors and methods of treatment using same |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2766037A4 (en) | 2011-10-12 | 2015-08-05 | Scripps Research Inst | HIV-1 GP-120 MINI-V3 LOOP AND USES THEREOF |
| US9683268B2 (en) | 2012-09-19 | 2017-06-20 | Beth Israel Deaconess | Viruses associated with immunodeficiency and enteropathy and methods using same |
| CA3200425A1 (en) | 2012-11-16 | 2014-05-22 | Peter ABBINK | Recombinant adenoviruses and use thereof |
| KR102020758B1 (ko) | 2013-01-07 | 2019-09-11 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 안정화된 사람 면역결핍 바이러스 (ｈｉｖ) 외피 (ｅｎｖ) 삼량체 백신 및 이의 사용 방법 |
| US10248758B2 (en) | 2013-02-07 | 2019-04-02 | University Of Washington Through Its Center For Commercialization | Self-assembling protein nanostructures |
| EP3052132B1 (en) | 2013-09-30 | 2020-07-29 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (hiv) |
| US9750801B2 (en) * | 2014-02-28 | 2017-09-05 | Janssen Vaccines & Prevention B.V. | Replicating recombinant adenovirus vectors, compositions, and methods of use thereof |
| EP3189067B1 (en) | 2014-09-04 | 2021-05-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Recombinant hiv-1 envelope proteins and their use |
| EA202092521A1 (ru) * | 2014-09-26 | 2021-05-31 | Бет Изрейэл Диконисс Медикал Сентер, Инк. | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| SMT202100623T1 (it) | 2015-12-15 | 2022-01-10 | Janssen Vaccines & Prevention Bv | Antigeni del virus dell'immunodeficienza umana, vettori, composizioni, e metodi di utilizzo degli stessi |
| BR112018075785A2 (pt) | 2016-06-16 | 2019-04-02 | Janssen Vaccines & Prevention B.V. | formulação de vacina para o hiv |
| CA3035759A1 (en) | 2016-09-02 | 2018-03-08 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| KR102513146B1 (ko) | 2016-09-15 | 2023-03-23 | 얀센 백신스 앤드 프리벤션 비.브이. | 삼량체를 안정화하는 hiv 엔벨로프 단백질 돌연변이 |
-
2017
- 2017-09-01 CA CA3035759A patent/CA3035759A1/en active Pending
- 2017-09-01 CN CN201780067261.7A patent/CN110494159A/zh active Pending
- 2017-09-01 EP EP17768310.9A patent/EP3506937A1/en not_active Ceased
- 2017-09-01 AU AU2017318689A patent/AU2017318689A1/en not_active Abandoned
- 2017-09-01 WO PCT/US2017/049817 patent/WO2018045267A1/en not_active Ceased
- 2017-09-01 US US15/693,650 patent/US10307477B2/en active Active
- 2017-09-01 JP JP2019512191A patent/JP2019526580A/ja active Pending
-
2019
- 2019-03-27 ZA ZA2019/01899A patent/ZA201901899B/en unknown
- 2019-04-16 US US16/385,062 patent/US10525123B2/en active Active
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