JP2016533740A5 - - Google Patents
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- JP2016533740A5 JP2016533740A5 JP2016531774A JP2016531774A JP2016533740A5 JP 2016533740 A5 JP2016533740 A5 JP 2016533740A5 JP 2016531774 A JP2016531774 A JP 2016531774A JP 2016531774 A JP2016531774 A JP 2016531774A JP 2016533740 A5 JP2016533740 A5 JP 2016533740A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid substitution
- group
- aspergillus
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 148
- 238000006467 substitution reaction Methods 0.000 claims 146
- 229910052717 sulfur Inorganic materials 0.000 claims 27
- 229910052700 potassium Inorganic materials 0.000 claims 25
- 229910052731 fluorine Inorganic materials 0.000 claims 20
- 229910052740 iodine Inorganic materials 0.000 claims 19
- 229910052720 vanadium Inorganic materials 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 16
- 229910052727 yttrium Inorganic materials 0.000 claims 14
- 229910052698 phosphorus Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 229910052721 tungsten Inorganic materials 0.000 claims 7
- 241000122821 Aspergillus kawachii Species 0.000 claims 5
- 241000221960 Neurospora Species 0.000 claims 5
- 241000223259 Trichoderma Species 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000223261 Trichoderma viride Species 0.000 claims 4
- 230000002538 fungal effect Effects 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 241000228212 Aspergillus Species 0.000 claims 3
- 241000499912 Trichoderma reesei Species 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 241000351920 Aspergillus nidulans Species 0.000 claims 2
- 241000123346 Chrysosporium Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241000223198 Humicola Species 0.000 claims 2
- 108090000604 Hydrolases Proteins 0.000 claims 2
- 102000004157 Hydrolases Human genes 0.000 claims 2
- 241001507755 Neosartorya Species 0.000 claims 2
- 241000221961 Neurospora crassa Species 0.000 claims 2
- 241000228143 Penicillium Species 0.000 claims 2
- 241000223260 Trichoderma harzianum Species 0.000 claims 2
- 241000378866 Trichoderma koningii Species 0.000 claims 2
- 241000306527 Trichoderma orientale Species 0.000 claims 2
- 241000209149 Zea Species 0.000 claims 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 235000005822 corn Nutrition 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 125000003147 glycosyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000010907 stover Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical group C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 claims 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 1
- 241001513093 Aspergillus awamori Species 0.000 claims 1
- 241000228193 Aspergillus clavatus Species 0.000 claims 1
- 241000228197 Aspergillus flavus Species 0.000 claims 1
- 241000228245 Aspergillus niger Species 0.000 claims 1
- 240000006439 Aspergillus oryzae Species 0.000 claims 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 1
- 241001465318 Aspergillus terreus Species 0.000 claims 1
- 108010059892 Cellulase Proteins 0.000 claims 1
- 241000228138 Emericella Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000223218 Fusarium Species 0.000 claims 1
- 241001149475 Gaeumannomyces graminis Species 0.000 claims 1
- 241000896533 Gliocladium Species 0.000 claims 1
- 102220604087 Homeobox protein SIX3_Y49W_mutation Human genes 0.000 claims 1
- 241000223199 Humicola grisea Species 0.000 claims 1
- 241001480714 Humicola insolens Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000121264 Neurospora tetrasperma Species 0.000 claims 1
- 102220492441 Selenoprotein V_F43Y_mutation Human genes 0.000 claims 1
- 206010041736 Sporotrichosis Diseases 0.000 claims 1
- 102220577295 Stromal cell-derived factor 1_P23G_mutation Human genes 0.000 claims 1
- 241001100181 Thermothelomyces heterothallica Species 0.000 claims 1
- 241000894120 Trichoderma atroviride Species 0.000 claims 1
- 241000223262 Trichoderma longibrachiatum Species 0.000 claims 1
- 241000223263 Trichoderma saturnisporum Species 0.000 claims 1
- 241001149558 Trichoderma virens Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 239000003674 animal food additive Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 102220515765 cAMP-dependent protein kinase inhibitor alpha_N10D_mutation Human genes 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 229940106157 cellulase Drugs 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102220245301 rs1555596673 Human genes 0.000 claims 1
- 102220005535 rs41322954 Human genes 0.000 claims 1
- 102200069353 rs8103142 Human genes 0.000 claims 1
- 102220106669 rs879255364 Human genes 0.000 claims 1
- 239000004173 sunset yellow FCF Substances 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361859721P | 2013-07-29 | 2013-07-29 | |
| US201361859680P | 2013-07-29 | 2013-07-29 | |
| US201361859735P | 2013-07-29 | 2013-07-29 | |
| US201361859630P | 2013-07-29 | 2013-07-29 | |
| US201361859666P | 2013-07-29 | 2013-07-29 | |
| US201361859704P | 2013-07-29 | 2013-07-29 | |
| US201361859712P | 2013-07-29 | 2013-07-29 | |
| US61/859,680 | 2013-07-29 | ||
| US61/859,735 | 2013-07-29 | ||
| US61/859,666 | 2013-07-29 | ||
| US61/859,704 | 2013-07-29 | ||
| US61/859,712 | 2013-07-29 | ||
| US61/859,721 | 2013-07-29 | ||
| US61/859,630 | 2013-07-29 | ||
| PCT/US2014/048075 WO2015017255A1 (en) | 2013-07-29 | 2014-07-24 | Variant enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016533740A JP2016533740A (ja) | 2016-11-04 |
| JP2016533740A5 true JP2016533740A5 (https=) | 2017-08-31 |
Family
ID=51299060
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016531775A Pending JP2016533741A (ja) | 2013-07-29 | 2014-07-24 | 酵素の変異体 |
| JP2016531773A Pending JP2016533739A (ja) | 2013-07-29 | 2014-07-24 | 変異酵素 |
| JP2016531774A Pending JP2016533740A (ja) | 2013-07-29 | 2014-07-24 | 酵素変異体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016531775A Pending JP2016533741A (ja) | 2013-07-29 | 2014-07-24 | 酵素の変異体 |
| JP2016531773A Pending JP2016533739A (ja) | 2013-07-29 | 2014-07-24 | 変異酵素 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10479983B2 (https=) |
| EP (3) | EP3027741B1 (https=) |
| JP (3) | JP2016533741A (https=) |
| CN (3) | CN105683369A (https=) |
| AU (3) | AU2014296572A1 (https=) |
| BR (3) | BR112016002038A2 (https=) |
| DK (2) | DK3027742T3 (https=) |
| MX (3) | MX2016001315A (https=) |
| WO (3) | WO2015017256A1 (https=) |
| ZA (3) | ZA201600632B (https=) |
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| US20140134677A1 (en) | 2011-03-17 | 2014-05-15 | Danisco Us Inc. | Method for reducing viscosity in saccharification process |
| EP3027741B1 (en) | 2013-07-29 | 2019-10-23 | Danisco US Inc. | Gh61 enzyme variants |
| US10294466B2 (en) | 2015-02-25 | 2019-05-21 | Danisco Us Inc. | Alpha-glucosidase, compositions and methods |
| EP3711773A1 (en) | 2015-09-02 | 2020-09-23 | DuPont Nutrition Biosciences ApS | Glycoside hydrolases and their use in preventing and/or treating a pathogenic infection in an animal |
| MX2018015534A (es) | 2016-06-15 | 2019-03-14 | Codexis Inc | Beta-glucosidasas dise?adas y metodos de glucosilacion. |
| WO2018005225A1 (en) | 2016-06-30 | 2018-01-04 | Danisco Us Inc | Aspartic proteases |
| WO2018053058A1 (en) | 2016-09-14 | 2018-03-22 | Danisco Us Inc. | Lignocellulosic biomass fermentation-based processes |
| JP7569475B2 (ja) | 2016-09-23 | 2024-10-18 | インターナショナル エヌアンドエイチ デンマーク エーピーエス | デンプンの消化を促進するための、反芻動物用の飼料添加物としての、低ｐＨ活性アルファ－１，４；／１，６－グリコシドヒドロラーゼの使用 |
| WO2018106656A1 (en) * | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
| BR112019012291A2 (pt) | 2016-12-15 | 2019-11-19 | Danisco Us Inc. | método para aumentar a produção de etanol a partir de fibra de milho em um processo de hidrólise de amido |
| DK3558026T3 (da) | 2016-12-21 | 2026-01-12 | Int N&H Denmark Aps | Fremgangsmåder til anvendelse af termostabile serinproteaser |
| ES2680196B1 (es) * | 2017-02-01 | 2019-07-30 | Abengoa Bioenergia Nuevas Tecnologias Sa | Polipeptidos con actividad polisacarido monooxigenasa y su usopara la produccion de azucares fermentables |
| BR112019018381A2 (pt) | 2017-03-06 | 2020-04-07 | Dupont Nutrition Biosci Aps | fucosidases fúngicas e seu uso na prevenção e/ou no tratamento de uma infecção patogênica em um animal |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| HUE057832T2 (hu) * | 2017-10-27 | 2022-06-28 | Procter & Gamble | Polipeptid-variánsokat tartalmazó mosószerkészítmények |
| EP3710580A1 (en) | 2017-11-14 | 2020-09-23 | Danisco US Inc. | Alpha-amylase, composition and method |
| AU2018387151B2 (en) | 2017-12-19 | 2024-05-02 | International N&H Denmark Aps | Improved enzymatic modification of phospholipids in food |
| AU2020228355B2 (en) | 2019-02-25 | 2026-01-29 | International N&H Denmark Aps | Protein hydrolysates with increased yield of N-terminal amino acid |
| CN110846294B (zh) * | 2019-11-29 | 2022-05-17 | 怀化学院 | 重组果胶酶及其基因、重组载体、制备方法和应用 |
| CN110747212B (zh) * | 2019-11-29 | 2022-05-17 | 怀化学院 | 一种新果胶酶的基因及其蛋白表达、载体和应用 |
| CN110846332B (zh) * | 2019-11-29 | 2022-05-17 | 怀化学院 | 一种果胶酶人工序列及其表达方法和应用 |
| CN111154743B (zh) * | 2020-04-01 | 2021-01-05 | 黑龙江省农业科学院畜牧兽医分院 | 突变型纤维素酶及其在玉米青贮中的应用 |
| EP4355872A2 (en) | 2021-06-18 | 2024-04-24 | International N&H Denmark ApS | Proteases for beer haze reduction |
| CN113913412B (zh) * | 2021-10-13 | 2023-10-03 | 湖北大学 | 蛋白酶k突变体及其制备方法 |
| CN114480146B (zh) * | 2022-04-15 | 2022-06-24 | 中国科学院天津工业生物技术研究所 | 一种米曲霉菌株在富集铜铁锰锌中的应用 |
| AU2023306398A1 (en) | 2022-07-15 | 2025-01-23 | International N&H Denmark Aps | Improved enzymatic modification of phospholipids in food |
| US20260092088A1 (en) | 2022-09-20 | 2026-04-02 | International N&H Denmark Aps | Variant anti-viral polypeptides |
| CN116121434B (zh) * | 2022-09-26 | 2023-12-12 | 四川农业大学 | 一种控制小麦zip3a锌转运功能的氨基酸位点及分子标记 |
| AU2024331645A1 (en) | 2023-09-01 | 2026-03-12 | International N&H Denmark Aps | Proteases and aldc enzymes for beer haze and diacetyl reduction |
| CN116970591B (zh) * | 2023-09-19 | 2023-12-05 | 中国科学院天津工业生物技术研究所 | 一种嗜热内切纤维素酶突变体及制备方法 |
| CN117925577B (zh) * | 2024-03-19 | 2024-06-14 | 金堂佰信维科技有限公司 | 提高木聚糖酶活性的方法和木聚糖酶及其应用 |
| CN118910014B (zh) * | 2024-09-03 | 2025-04-25 | 广州青囊生物科技有限公司 | 一种生产稀有人参皂苷CK的β-葡萄糖苷酶突变体及其应用 |
| WO2026060195A2 (en) | 2024-09-13 | 2026-03-19 | International N&H Denmark Aps | Glutaminase and methods of use thereof |
| CN120464599B (zh) * | 2025-07-11 | 2025-09-12 | 南京工业大学 | Pet水解酶突变体及其应用 |
| CN120758467B (zh) * | 2025-09-11 | 2025-12-16 | 中国科学院天津工业生物技术研究所 | 裂解性多糖单加氧酶突变体及纤维素协同水解方法 |
| CN121204003A (zh) * | 2025-10-17 | 2025-12-26 | 珠海宝锐生物科技有限公司 | 一种mmlv酶突变体、制备方法及其应用 |
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