JP2016531886A5 - - Google Patents
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- Publication number
- JP2016531886A5 JP2016531886A5 JP2016519782A JP2016519782A JP2016531886A5 JP 2016531886 A5 JP2016531886 A5 JP 2016531886A5 JP 2016519782 A JP2016519782 A JP 2016519782A JP 2016519782 A JP2016519782 A JP 2016519782A JP 2016531886 A5 JP2016531886 A5 JP 2016531886A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methylbutyl
- dichlorobenzoyl
- acetyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 9
- -1 citrate ester Chemical class 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- MXAYKZJJDUDWDS-LBPRGKRZSA-N ixazomib Chemical compound CC(C)C[C@@H](B(O)O)NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MXAYKZJJDUDWDS-LBPRGKRZSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- BMTZTBHPQACQNX-UHFFFAOYSA-N O1BOC(CC1)C(=O)O Chemical compound O1BOC(CC1)C(=O)O BMTZTBHPQACQNX-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
- YTXSYWAKVMZICI-PVCZSOGJSA-N 4-(carboxymethyl)-2-[(1r)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Chemical compound N([C@@H](CC(C)C)B1OC(CC(O)=O)(CC(=O)O1)C(O)=O)C(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl YTXSYWAKVMZICI-PVCZSOGJSA-N 0.000 description 1
- CDFSNHZUTLZCTK-LBPRGKRZSA-N ClC1=C(C(=O)NCC(=O)N[C@@H](CC(C)C)[B])C=C(C=C1)Cl Chemical compound ClC1=C(C(=O)NCC(=O)N[C@@H](CC(C)C)[B])C=C(C=C1)Cl CDFSNHZUTLZCTK-LBPRGKRZSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361886403P | 2013-10-03 | 2013-10-03 | |
| US61/886,403 | 2013-10-03 | ||
| PCT/US2014/058738 WO2015051067A1 (en) | 2013-10-03 | 2014-10-02 | Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016531886A JP2016531886A (ja) | 2016-10-13 |
| JP2016531886A5 true JP2016531886A5 (https=) | 2017-11-02 |
Family
ID=51842818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519782A Pending JP2016531886A (ja) | 2013-10-03 | 2014-10-02 | 全身性エリテマトーデス及び／または狼瘡腎炎の予防または治療のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160250238A1 (https=) |
| EP (1) | EP3052105A1 (https=) |
| JP (1) | JP2016531886A (https=) |
| KR (1) | KR20160058886A (https=) |
| CN (1) | CN105705149A (https=) |
| BR (1) | BR112016007237A2 (https=) |
| CA (1) | CA2925935A1 (https=) |
| EA (1) | EA201690686A1 (https=) |
| MX (1) | MX2016003979A (https=) |
| WO (1) | WO2015051067A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020000092A1 (en) * | 2018-06-27 | 2020-01-02 | Algernon Pharmaceuticals Inc. | The use of actarit in the prophylaxis or treatment of renal fibrosis or kidney disease |
| JP2023525259A (ja) * | 2020-05-07 | 2023-06-15 | 諾羅瑞韋株式会社 | うつ病治療のためのシクロセリンおよびペントキシフィリンの併用療法｛Ｃｙｃｌｏｓｅｒｉｎｅ ａｎｄ Ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ Ｃｏｍｂｉｎａｔｉｏｎ Ｔｈｅｒａｐｙ ｆｏｒ Ｔｒｅａｔｍｅｎｔ ｏｆ Ｄｅｐｒｅｓｓｉｏｎ｝ |
| CN121041156A (zh) * | 2025-08-27 | 2025-12-02 | 复皙药业(上海)有限公司 | 含有替普瑞酮的具有祛红功效的膏霜及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| JP4162491B2 (ja) | 2001-01-25 | 2008-10-08 | アメリカ合衆国 | ボロン酸化合物製剤 |
| AU2007357338B2 (en) * | 2007-08-06 | 2014-03-20 | Takeda Pharmaceutical Company Limited | Proteasome inhibitors |
| US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
| CA2727862C (en) * | 2008-06-17 | 2016-04-19 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| AR077033A1 (es) | 2009-06-11 | 2011-07-27 | Hoffmann La Roche | Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas |
| US8513218B2 (en) | 2010-03-31 | 2013-08-20 | Millennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
| TW201309303A (zh) | 2011-03-03 | 2013-03-01 | Cephalon Inc | 用於治療狼瘡的蛋白酶體抑制劑 |
| US20140121182A1 (en) * | 2011-06-22 | 2014-05-01 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
-
2014
- 2014-10-02 MX MX2016003979A patent/MX2016003979A/es unknown
- 2014-10-02 US US15/026,417 patent/US20160250238A1/en not_active Abandoned
- 2014-10-02 JP JP2016519782A patent/JP2016531886A/ja active Pending
- 2014-10-02 BR BR112016007237A patent/BR112016007237A2/pt not_active IP Right Cessation
- 2014-10-02 CA CA2925935A patent/CA2925935A1/en not_active Abandoned
- 2014-10-02 WO PCT/US2014/058738 patent/WO2015051067A1/en not_active Ceased
- 2014-10-02 CN CN201480060987.4A patent/CN105705149A/zh active Pending
- 2014-10-02 EP EP14790872.7A patent/EP3052105A1/en not_active Withdrawn
- 2014-10-02 EA EA201690686A patent/EA201690686A1/ru unknown
- 2014-10-02 KR KR1020167010114A patent/KR20160058886A/ko not_active Withdrawn
-
2017
- 2017-12-12 US US15/838,595 patent/US20180099000A1/en not_active Abandoned
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