JP2016529324A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016529324A5 JP2016529324A5 JP2016540848A JP2016540848A JP2016529324A5 JP 2016529324 A5 JP2016529324 A5 JP 2016529324A5 JP 2016540848 A JP2016540848 A JP 2016540848A JP 2016540848 A JP2016540848 A JP 2016540848A JP 2016529324 A5 JP2016529324 A5 JP 2016529324A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- solvate
- acceptable salt
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CP(*)(N(*)CC(O)=O)=[U] Chemical compound CP(*)(N(*)CC(O)=O)=[U] 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351026 | 2013-09-04 | ||
| SE1351026-8 | 2013-09-04 | ||
| SE1351169 | 2013-10-03 | ||
| SE1351169-6 | 2013-10-03 | ||
| SE1450152 | 2014-02-12 | ||
| SE1450152-2 | 2014-02-12 | ||
| PCT/SE2014/051005 WO2015034420A1 (en) | 2013-09-04 | 2014-09-02 | Hcv polymerase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193251A Division JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529324A JP2016529324A (ja) | 2016-09-23 |
| JP2016529324A5 true JP2016529324A5 (OSRAM) | 2017-10-19 |
| JP6456958B2 JP6456958B2 (ja) | 2019-01-23 |
Family
ID=52628746
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540848A Active JP6456958B2 (ja) | 2013-09-04 | 2014-09-02 | Ｈｃｖポリメラーゼ阻害剤 |
| JP2018193251A Ceased JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193251A Ceased JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9481703B2 (OSRAM) |
| EP (2) | EP3041855B1 (OSRAM) |
| JP (2) | JP6456958B2 (OSRAM) |
| KR (1) | KR20160078337A (OSRAM) |
| CN (3) | CN105705510B (OSRAM) |
| AU (2) | AU2014315715B2 (OSRAM) |
| BR (1) | BR112016004919A2 (OSRAM) |
| CA (1) | CA2921899A1 (OSRAM) |
| CL (2) | CL2016000493A1 (OSRAM) |
| CR (1) | CR20160123A (OSRAM) |
| CY (1) | CY1119587T1 (OSRAM) |
| DK (1) | DK3041855T3 (OSRAM) |
| EA (1) | EA028974B1 (OSRAM) |
| HR (1) | HRP20171435T1 (OSRAM) |
| HU (1) | HUE036365T2 (OSRAM) |
| IL (2) | IL244389B (OSRAM) |
| ME (1) | ME02875B (OSRAM) |
| MX (1) | MX2016002849A (OSRAM) |
| MY (1) | MY177804A (OSRAM) |
| PH (2) | PH12016500402A1 (OSRAM) |
| PL (1) | PL3041855T3 (OSRAM) |
| PT (1) | PT3041855T (OSRAM) |
| RS (1) | RS56383B1 (OSRAM) |
| SA (1) | SA516370684B1 (OSRAM) |
| SG (2) | SG10201700647PA (OSRAM) |
| SI (1) | SI3041855T1 (OSRAM) |
| UA (1) | UA117375C2 (OSRAM) |
| WO (1) | WO2015034420A1 (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596979B (zh) | 2009-09-21 | 2014-12-10 | 吉里德科学公司 | 用于制备1’-取代碳核苷类似物的方法和中间体 |
| BR112013001553B1 (pt) | 2010-07-22 | 2021-01-12 | Gilead Sciences, Inc. | compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem |
| CN110156838A (zh) * | 2013-05-14 | 2019-08-23 | 北京美倍他药物研究有限公司 | 磷酸/膦酸衍生物及其医药用途 |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| US20170198005A1 (en) * | 2013-11-27 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| JP2017504572A (ja) | 2013-11-27 | 2017-02-09 | アイデニクス・ファーマシューティカルズ・エルエルシー | 肝臓癌治療のためのヌクレオチド類 |
| WO2015164812A1 (en) * | 2014-04-24 | 2015-10-29 | Cocrystal Pharma, Inc. | 2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| CN105315319B (zh) * | 2014-07-30 | 2020-11-20 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| CA2972034A1 (en) | 2014-12-30 | 2016-07-07 | Dow Agrosciences Llc | Picolinamides with fungicidal activity |
| RU2708392C2 (ru) | 2014-12-30 | 2019-12-06 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Соединения пиколинамида с фунгицидной активностью |
| JP2018500362A (ja) * | 2014-12-30 | 2018-01-11 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌活性を有するピコリンアミド化合物の使用 |
| EP3240419B1 (en) | 2014-12-30 | 2020-05-06 | Dow Agrosciences LLC | Picolinamide compounds with fungicidal activity |
| WO2016134057A1 (en) * | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
| US20180036330A1 (en) * | 2015-03-02 | 2018-02-08 | Medivir Ab | Nucleotide phosphoramidate formulation |
| EP3271371A4 (en) * | 2015-03-02 | 2018-12-05 | Medivir Aktiebolag | Nucleotide derivatives which are hcv inhibitors for use in the treatment of hepatitis c |
| US10618926B2 (en) | 2015-04-02 | 2020-04-14 | Merck Sharp & Dohme | Process for making phosphoramidate protected nucleoside compounds |
| CN107709344B (zh) * | 2015-05-01 | 2022-07-15 | 共晶制药股份有限公司 | 用于治疗黄病毒科病毒和癌症的核苷类似物 |
| MX2018002707A (es) | 2015-09-02 | 2018-08-01 | Abbvie Inc | Derivados de tetrahidrofurano antivirales. |
| WO2017040898A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040895A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040892A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040896A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040889A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| ES2918585T3 (es) | 2015-09-16 | 2022-07-19 | Gilead Sciences Inc | Métodos para el tratamiento de infecciones por el virus Arenaviridae |
| CN105367505A (zh) * | 2015-12-01 | 2016-03-02 | 苏利制药科技江阴有限公司 | 一种新型合成3,6-二甲基-2,5-哌嗪二酮的方法 |
| AU2017208970A1 (en) | 2016-01-18 | 2018-08-02 | Arisan Therapeutics | Adamatane derivatives for the treatment of filovirus infection |
| AU2017314148A1 (en) * | 2016-08-19 | 2019-02-28 | Sandoz Ag | Sofosbuvir derivatives for the treatment of Hepatitis C |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| TW201842851A (zh) | 2017-05-02 | 2018-12-16 | 美商陶氏農業科學公司 | 用於穀類中的真菌防治之協同性混合物 |
| KR102659552B1 (ko) | 2017-05-02 | 2024-04-23 | 코르테바 애그리사이언스 엘엘씨 | 잔디풀 상의 진균 질환에 대한 살진균제로서의 비고리형 피콜린아미드 화합물의 용도 |
| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| CA3077489A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
| KR102665499B1 (ko) | 2018-03-09 | 2024-05-14 | 메디비르 아베 | (2,2-비스하이드록시메틸)메틸렌사이클로프로판 뉴클레오티드로의 암 치료 |
| EP3866597A4 (en) | 2018-10-15 | 2022-06-29 | Corteva Agriscience LLC | Methods for sythesis of oxypicolinamides |
| CN109762040A (zh) * | 2019-01-14 | 2019-05-17 | 歌礼生物制药(杭州)有限公司 | 一种核苷类ns5b聚合酶抑制剂的制备方法 |
| BR112022007354A2 (pt) | 2019-10-18 | 2022-08-23 | Corteva Agriscience Llc | Processo para síntese de picolinamidas |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ， インコーポレイテッド | ＳＡＲＳ ＣｏＶ－２感染を治療するための方法 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN111269263A (zh) * | 2020-03-09 | 2020-06-12 | 上海龙翔生物医药开发有限公司 | 一种瑞德西韦侧链中间体及其制备方法 |
| AU2021234308C1 (en) | 2020-03-12 | 2024-02-22 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| CN111848679A (zh) * | 2020-04-17 | 2020-10-30 | 山东科巢生物制药有限公司 | 一种利用微通道反应技术合成瑞德西韦的方法 |
| PL4157272T3 (pl) | 2020-05-29 | 2025-10-20 | Gilead Sciences, Inc. | Remdesiwir do leczenia zakażeń wirusowych |
| TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
| WO2022047065A2 (en) | 2020-08-27 | 2022-03-03 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| TWI867455B (zh) | 2022-03-02 | 2024-12-21 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| CN116199679A (zh) * | 2022-12-23 | 2023-06-02 | 吉斯凯(苏州)制药有限公司 | 一种拉米夫定的工业化制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0727419B1 (en) | 1992-12-29 | 2002-02-27 | Abbott Laboratories | Intermediates for the preparation of retroviral protease inhibiting compounds |
| IL110752A (en) | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| US5559158A (en) | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| IL111991A (en) | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| EP2251015B1 (en) * | 2000-10-18 | 2013-02-20 | Gilead Pharmasset LLC | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| WO2008022469A1 (en) * | 2006-08-23 | 2008-02-28 | Mcgill University | 2'-DEOXY-2'-FLUORO-β-D-ARABINONUCLEOSIDE 5'-TRIPHOSPHATES AND THEIR USE IN ENZYMATIC NUCLEIC ACID SYNTHESIS |
| ATE493428T1 (de) * | 2006-10-10 | 2011-01-15 | Medivir Ab | Hcv-nukleosidinhibitor |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US20100298256A1 (en) | 2007-12-27 | 2010-11-25 | Steven Dong | Antiviral compounds |
| US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| EP2408306A4 (en) * | 2009-03-20 | 2012-11-07 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGUES |
| CN101591371B (zh) * | 2009-06-30 | 2012-05-30 | 连云港金康医药科技有限公司 | 一种通过卤交换氟化制备吉西他滨或其类似物的方法 |
| UY33312A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidato de nucleosido de purina |
| US8402690B2 (en) | 2010-09-09 | 2013-03-26 | Sterling International Inc. | Bedbug trap |
| WO2012040126A1 (en) * | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| BR112013005872A2 (pt) * | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| EP2696681B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| GEP20166496B (en) | 2011-12-22 | 2016-06-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| WO2014078427A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of rp-nucleoside analog |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| US20170198005A1 (en) * | 2013-11-27 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| JP2017504572A (ja) * | 2013-11-27 | 2017-02-09 | アイデニクス・ファーマシューティカルズ・エルエルシー | 肝臓癌治療のためのヌクレオチド類 |
| WO2015164812A1 (en) | 2014-04-24 | 2015-10-29 | Cocrystal Pharma, Inc. | 2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
-
2014
- 2014-02-09 UA UAA201602085A patent/UA117375C2/uk unknown
- 2014-09-02 PT PT147894349T patent/PT3041855T/pt unknown
- 2014-09-02 HU HUE14789434A patent/HUE036365T2/hu unknown
- 2014-09-02 PL PL14789434T patent/PL3041855T3/pl unknown
- 2014-09-02 MY MYPI2016700722A patent/MY177804A/en unknown
- 2014-09-02 KR KR1020167008381A patent/KR20160078337A/ko not_active Withdrawn
- 2014-09-02 WO PCT/SE2014/051005 patent/WO2015034420A1/en not_active Ceased
- 2014-09-02 MX MX2016002849A patent/MX2016002849A/es unknown
- 2014-09-02 CA CA2921899A patent/CA2921899A1/en not_active Abandoned
- 2014-09-02 HR HRP20171435TT patent/HRP20171435T1/hr unknown
- 2014-09-02 DK DK14789434.9T patent/DK3041855T3/en active
- 2014-09-02 BR BR112016004919A patent/BR112016004919A2/pt not_active Application Discontinuation
- 2014-09-02 EP EP14789434.9A patent/EP3041855B1/en active Active
- 2014-09-02 EA EA201690452A patent/EA028974B1/ru not_active IP Right Cessation
- 2014-09-02 JP JP2016540848A patent/JP6456958B2/ja active Active
- 2014-09-02 AU AU2014315715A patent/AU2014315715B2/en not_active Ceased
- 2014-09-02 ME MEP-2017-229A patent/ME02875B/me unknown
- 2014-09-02 RS RS20170949A patent/RS56383B1/sr unknown
- 2014-09-02 SI SI201430401T patent/SI3041855T1/sl unknown
- 2014-09-02 SG SG10201700647PA patent/SG10201700647PA/en unknown
- 2014-09-02 CN CN201480060874.4A patent/CN105705510B/zh active Active
- 2014-09-02 CN CN201810472644.9A patent/CN108676047B/zh active Active
- 2014-09-02 CN CN201810473163.XA patent/CN108558973A/zh active Pending
- 2014-09-02 EP EP17176973.0A patent/EP3252066B1/en active Active
- 2014-09-02 SG SG11201601474UA patent/SG11201601474UA/en unknown
-
2015
- 2015-02-27 US US14/634,449 patent/US9481703B2/en active Active
-
2016
- 2016-02-29 PH PH12016500402A patent/PH12016500402A1/en unknown
- 2016-03-02 IL IL244389A patent/IL244389B/en not_active IP Right Cessation
- 2016-03-03 CL CL2016000493A patent/CL2016000493A1/es unknown
- 2016-03-06 SA SA516370684A patent/SA516370684B1/ar unknown
- 2016-03-10 CR CR20160123A patent/CR20160123A/es unknown
- 2016-07-14 US US15/210,500 patent/US9540411B2/en not_active Expired - Fee Related
- 2016-11-23 US US15/360,360 patent/US9828408B2/en not_active Expired - Fee Related
-
2017
- 2017-06-13 AU AU2017203954A patent/AU2017203954B2/en not_active Ceased
- 2017-10-04 CY CY20171101032T patent/CY1119587T1/el unknown
- 2017-11-27 US US15/823,224 patent/US10106571B2/en not_active Expired - Fee Related
-
2018
- 2018-05-02 PH PH12018500931A patent/PH12018500931A1/en unknown
- 2018-09-12 IL IL261702A patent/IL261702B/en not_active IP Right Cessation
- 2018-10-12 JP JP2018193251A patent/JP2019065011A/ja not_active Ceased
- 2018-10-22 US US16/166,578 patent/US20190085010A1/en not_active Abandoned
-
2019
- 2019-02-01 CL CL2019000271A patent/CL2019000271A1/es unknown