JP2016527225A5 - - Google Patents
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- Publication number
- JP2016527225A5 JP2016527225A5 JP2016526580A JP2016526580A JP2016527225A5 JP 2016527225 A5 JP2016527225 A5 JP 2016527225A5 JP 2016526580 A JP2016526580 A JP 2016526580A JP 2016526580 A JP2016526580 A JP 2016526580A JP 2016527225 A5 JP2016527225 A5 JP 2016527225A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- kabat
- seq
- upa
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 34
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 125000000539 amino acid group Chemical group 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 17
- 101000638886 Homo sapiens Urokinase-type plasminogen activator Proteins 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 8
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 6
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 6
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 3
- 230000002797 proteolythic effect Effects 0.000 claims 3
- 241000282567 Macaca fascicularis Species 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13176519.0 | 2013-07-15 | ||
| EP13176519 | 2013-07-15 | ||
| US201361847664P | 2013-07-18 | 2013-07-18 | |
| US61/847,664 | 2013-07-18 | ||
| PCT/EP2014/065136 WO2015007727A1 (en) | 2013-07-15 | 2014-07-15 | Antibodies that bind urokinase plasminogen activator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016527225A JP2016527225A (ja) | 2016-09-08 |
| JP2016527225A5 true JP2016527225A5 (enExample) | 2017-08-10 |
Family
ID=48783103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526580A Withdrawn JP2016527225A (ja) | 2013-07-15 | 2014-07-15 | ウロキナーゼ型プラスミノーゲン活性化因子に結合する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9908944B2 (enExample) |
| EP (1) | EP3022229A1 (enExample) |
| JP (1) | JP2016527225A (enExample) |
| CN (1) | CN105612183A (enExample) |
| TW (1) | TW201536810A (enExample) |
| WO (1) | WO2015007727A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| EP3459974B1 (en) * | 2017-09-21 | 2025-02-19 | Guy L. Reed | Specific plasmin inactivation by anticatalytic antibody |
| CA3090236A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| SG11202007482WA (en) | 2018-02-08 | 2020-09-29 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor |
| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| MA53293A (fr) | 2018-08-08 | 2021-11-17 | Dragonfly Therapeutics Inc | Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation |
| EA202091888A1 (ru) * | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CN111253486B (zh) * | 2018-09-27 | 2023-09-29 | 再鼎医药(上海)有限公司 | 抗pd-1抗体及其用途 |
| CN110343665B (zh) * | 2019-05-05 | 2023-07-14 | 吉林大学 | 一种car-t细胞及其应用 |
| US20230220112A1 (en) * | 2019-10-28 | 2023-07-13 | Monash University | Antibodies for binding plasmin |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| CN114917329B (zh) * | 2021-02-11 | 2023-07-21 | 兰州大学第二医院 | 抗cd87抗体与抗pd1抗体联合治疗胃癌 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| JP2025168320A (ja) * | 2024-04-26 | 2025-11-07 | イーライ リリー アンド カンパニー | タンパク質チロシンキナーゼ７抗体及び抗体－薬物コンジュゲート |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453269A (en) | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
| TW212184B (enExample) | 1990-04-02 | 1993-09-01 | Takeda Pharm Industry Co Ltd | |
| US8062637B2 (en) | 2000-05-08 | 2011-11-22 | Morphosys Ag | Methods of ameliorating inflammatory disease using an uPA antagonist |
| EP1406652A2 (en) | 2001-07-10 | 2004-04-14 | Omnio AB | Novel drug targets for arthritis |
| WO2003057881A1 (en) * | 2001-12-28 | 2003-07-17 | Chugai Seiyaku Kabushiki Kaisha | Method of stabilizing protein |
| WO2005048822A2 (en) | 2003-11-18 | 2005-06-02 | Attenuon Llc | Antibodies and/or conjugates thereof which bind to the amino terminal fragment of urokinase, compositions and uses thereof |
| EP1814914A2 (en) | 2004-10-29 | 2007-08-08 | The Regents of the University of Colorado | Antibodies that bind urokinase-type plasminogen activator and epitopes therefor |
| EP1876236B9 (en) * | 2005-04-08 | 2015-02-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
| JP5908972B2 (ja) * | 2011-04-07 | 2016-04-26 | アムジエン・インコーポレーテツド | 新規な抗原結合タンパク質 |
-
2014
- 2014-07-15 CN CN201480040491.0A patent/CN105612183A/zh not_active Withdrawn
- 2014-07-15 WO PCT/EP2014/065136 patent/WO2015007727A1/en not_active Ceased
- 2014-07-15 JP JP2016526580A patent/JP2016527225A/ja not_active Withdrawn
- 2014-07-15 EP EP14739165.0A patent/EP3022229A1/en not_active Withdrawn
- 2014-07-15 US US14/905,409 patent/US9908944B2/en not_active Expired - Fee Related
- 2014-07-15 TW TW103124237A patent/TW201536810A/zh unknown
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