JP2016527186A5 - - Google Patents
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- JP2016527186A5 JP2016527186A5 JP2016514479A JP2016514479A JP2016527186A5 JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5 JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016514479 A JP2016514479 A JP 2016514479A JP 2016527186 A5 JP2016527186 A5 JP 2016527186A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- independently
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1309248.1 | 2013-05-22 | ||
| GB201309248A GB201309248D0 (en) | 2013-05-22 | 2013-05-22 | Compounds and combinations |
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| GB1404301.2 | 2014-03-11 | ||
| PCT/GB2014/051547 WO2014188178A1 (en) | 2013-05-22 | 2014-05-21 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527186A JP2016527186A (ja) | 2016-09-08 |
| JP2016527186A5 true JP2016527186A5 (https=) | 2017-07-20 |
| JP6643758B2 JP6643758B2 (ja) | 2020-02-12 |
Family
ID=50829204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514479A Active JP6643758B2 (ja) | 2013-05-22 | 2014-05-21 | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10407467B2 (https=) |
| EP (1) | EP2999711B1 (https=) |
| JP (1) | JP6643758B2 (https=) |
| KR (1) | KR102354902B1 (https=) |
| CN (1) | CN105308065B (https=) |
| BR (1) | BR112015029309A2 (https=) |
| CA (1) | CA2939061C (https=) |
| CY (1) | CY1125479T1 (https=) |
| DK (1) | DK2999711T3 (https=) |
| ES (1) | ES2923762T3 (https=) |
| HR (1) | HRP20220898T1 (https=) |
| HU (1) | HUE059544T2 (https=) |
| LT (1) | LT2999711T (https=) |
| PL (1) | PL2999711T3 (https=) |
| PT (1) | PT2999711T (https=) |
| RS (1) | RS63484B1 (https=) |
| RU (1) | RU2730012C2 (https=) |
| SI (1) | SI2999711T1 (https=) |
| TW (1) | TWI665218B (https=) |
| WO (1) | WO2014188178A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014012016A2 (pt) | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| JP6643758B2 (ja) | 2013-05-22 | 2020-02-12 | スペロ・セラピューティクス・インコーポレーテッド | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
| US9775878B2 (en) | 2013-08-28 | 2017-10-03 | The Medicines Company | Methods for treating bacterial infections using oritavancin and polymyxins |
| RU2740190C2 (ru) * | 2014-03-11 | 2021-01-12 | Сперо Терапьютикс, Инк. | Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| US9771394B2 (en) | 2014-12-16 | 2017-09-26 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| US9763996B2 (en) | 2015-01-16 | 2017-09-19 | Northern Antibiotics, Ltd. | Polymyxin derivative and uses thereof |
| KR101790296B1 (ko) * | 2015-03-26 | 2017-10-26 | 한국생명공학연구원 | 네트롭신을 유효성분으로 포함하는 그람음성 세균에 대한 폴리믹신의 항균 활성을 증가시키는 조성물 |
| WO2016166103A1 (en) * | 2015-04-13 | 2016-10-20 | Xellia Pharmaceuticals Aps | Polymyxin derivatives |
| EP3356387B1 (en) * | 2015-09-29 | 2024-06-26 | Monash University | Antimicrobial polymyxin derivative compounds |
| CN109789125B (zh) * | 2016-08-16 | 2022-10-18 | 罗切斯特大学 | 含有基于多粘菌素b/甲氧苄啶的治疗剂的药物组合物 |
| CN106631902A (zh) * | 2016-09-23 | 2017-05-10 | 上海步越化工科技有限公司 | 一种特拉万星侧链癸基(2‑氧代乙基)氨基甲酸9h‑芴‑9‑甲基酯的制备方法 |
| WO2019018286A1 (en) * | 2017-07-17 | 2019-01-24 | President And Fellows Of Harvard College | METHODS OF TREATING BACTERIAL INFECTIONS |
| WO2019085926A1 (zh) * | 2017-10-31 | 2019-05-09 | 上海医药工业研究院 | 多黏菌素类似物及其制备方法 |
| AU2018359018B2 (en) | 2017-11-02 | 2022-11-24 | The University Of Queensland | Peptide antibiotics |
| US11713335B2 (en) | 2018-03-12 | 2023-08-01 | President And Fellows Of Harvard College | Aminocoumarin compounds and methods of their use |
| MD3810633T2 (ro) | 2018-06-25 | 2024-05-31 | Spero Therapeutics Inc | Compuşi |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| US20220395555A1 (en) * | 2020-06-11 | 2022-12-15 | Boris Farber | Derivatives of antibiotics |
| US12472195B2 (en) | 2020-07-02 | 2025-11-18 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
| TW202233649A (zh) | 2020-11-06 | 2022-09-01 | 美商斯佩羅治療學股份有限公司 | 化合物 |
| CN116847735B (zh) * | 2021-02-02 | 2026-02-03 | 韩国生命工学研究院 | 含有联苯基衍生物化合物作为有效成分的抗菌佐剂及其用途 |
| AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| WO2024003042A1 (en) | 2022-06-28 | 2024-01-04 | Breakthrough Biotech Drift Aps | Novel combinations of sesquiterpene alcohols, polymyxins and nisin compounds as antimicobial and/or antifungal compounds |
| JP2026506767A (ja) * | 2022-11-14 | 2026-02-26 | シプラ・リミテッド | 新規眼科用組成物 |
| CN116212004A (zh) * | 2022-12-07 | 2023-06-06 | 东南大学 | 一种复合抗生素吸入用粉剂及其制备方法与应用 |
| WO2025030169A2 (en) * | 2023-08-03 | 2025-02-06 | Arcum Vision Inc. | Enhanced formulation of polymyxin b/ trimethoprim and rifampin and methods for ophthalmic uses |
| KR20250037611A (ko) * | 2023-09-07 | 2025-03-18 | 웰펩 주식회사 | 그람 음성균 및 다제내성 그람 음성균에 우수한 항균 활성을 갖는 신규 폴리믹신 유사체, 이를 포함하는 항균용 조성물 |
| WO2025236916A1 (en) * | 2024-05-16 | 2025-11-20 | Brii Biosciences, Inc. | Compositions and methods for treating infections |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| WO1988000950A2 (fr) | 1986-08-06 | 1988-02-11 | Fauchere Jean Luc | Fabrication de conjugues a liaisons de covalence a partir d'un antibiotique et d'un derive non toxique de la polymyxine b |
| US20010021697A1 (en) | 1987-09-14 | 2001-09-13 | Henning Lowenstein | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components |
| TW274552B (https=) | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| JP4583559B2 (ja) * | 2000-07-24 | 2010-11-17 | 栄研化学株式会社 | Ｍｒｓａスクリーニング用培地 |
| AU2004277977B2 (en) | 2003-09-30 | 2010-10-28 | Biomechanisms Inc. | Compositions and methods for treating burns |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2008001773A1 (fr) | 2006-06-27 | 2008-01-03 | Toyo Tire & Rubber Co., Ltd. | pneu apte à rouler dégonflé |
| HUE028271T2 (en) * | 2006-08-11 | 2016-12-28 | Northern Antibiotics Oy | Polymixin derivatives and their applications |
| FI20085469A0 (fi) | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| US8193148B2 (en) | 2008-02-08 | 2012-06-05 | Northern Antibiotics Ltd. | Short fatty acid tail polymyxin derivatives and uses thereof |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| ES2334547B1 (es) | 2008-09-10 | 2010-12-03 | Universidad De Barcelona | Compuestos peptidicos antibacterianos. |
| TW201035111A (en) * | 2008-12-23 | 2010-10-01 | Biosource Pharm Inc | Antibiotic compositions for the treatment of gram negative infections |
| JP5493387B2 (ja) * | 2009-02-25 | 2014-05-14 | 国立大学法人 東京大学 | 選択培地の製造方法及びその利用 |
| CN101851270A (zh) | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| US9226786B2 (en) * | 2011-03-22 | 2016-01-05 | Lexion Medical Llc | Medical devices for clearing a surgical site |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| BR112014012016A2 (pt) * | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| JP6643758B2 (ja) | 2013-05-22 | 2020-02-12 | スペロ・セラピューティクス・インコーポレーテッド | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
-
2014
- 2014-05-21 JP JP2016514479A patent/JP6643758B2/ja active Active
- 2014-05-21 BR BR112015029309A patent/BR112015029309A2/pt active Search and Examination
- 2014-05-21 LT LTEPPCT/GB2014/051547T patent/LT2999711T/lt unknown
- 2014-05-21 HU HUE14726731A patent/HUE059544T2/hu unknown
- 2014-05-21 EP EP14726731.4A patent/EP2999711B1/en active Active
- 2014-05-21 DK DK14726731.4T patent/DK2999711T3/da active
- 2014-05-21 US US14/892,757 patent/US10407467B2/en active Active
- 2014-05-21 KR KR1020157035048A patent/KR102354902B1/ko active Active
- 2014-05-21 WO PCT/GB2014/051547 patent/WO2014188178A1/en not_active Ceased
- 2014-05-21 SI SI201431984T patent/SI2999711T1/sl unknown
- 2014-05-21 HR HRP20220898TT patent/HRP20220898T1/hr unknown
- 2014-05-21 CA CA2939061A patent/CA2939061C/en active Active
- 2014-05-21 PL PL14726731.4T patent/PL2999711T3/pl unknown
- 2014-05-21 TW TW103117787A patent/TWI665218B/zh active
- 2014-05-21 PT PT147267314T patent/PT2999711T/pt unknown
- 2014-05-21 CN CN201480029145.2A patent/CN105308065B/zh active Active
- 2014-05-21 RS RS20220760A patent/RS63484B1/sr unknown
- 2014-05-21 RU RU2015148032A patent/RU2730012C2/ru active
- 2014-05-21 ES ES14726731T patent/ES2923762T3/es active Active
-
2022
- 2022-08-11 CY CY20221100550T patent/CY1125479T1/el unknown
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