JP2016526374A5 - - Google Patents

Download PDF

Info

Publication number
JP2016526374A5
JP2016526374A5 JP2016501252A JP2016501252A JP2016526374A5 JP 2016526374 A5 JP2016526374 A5 JP 2016526374A5 JP 2016501252 A JP2016501252 A JP 2016501252A JP 2016501252 A JP2016501252 A JP 2016501252A JP 2016526374 A5 JP2016526374 A5 JP 2016526374A5
Authority
JP
Japan
Prior art keywords
virus
amino acid
particle
seq
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016501252A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016526374A (ja
JP6557208B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2014/069122 external-priority patent/WO2015005500A1/en
Publication of JP2016526374A publication Critical patent/JP2016526374A/ja
Publication of JP2016526374A5 publication Critical patent/JP2016526374A5/ja
Application granted granted Critical
Publication of JP6557208B2 publication Critical patent/JP6557208B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016501252A 2013-07-12 2014-07-11 Pd−1抗原またはpd−1リガンド抗原を含むウイルス様粒子 Active JP6557208B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845712P 2013-07-12 2013-07-12
US61/845,712 2013-07-12
PCT/JP2014/069122 WO2015005500A1 (en) 2013-07-12 2014-07-11 Virus like particle comprising pd-1 antigen or pd-1 ligand antigen

Publications (3)

Publication Number Publication Date
JP2016526374A JP2016526374A (ja) 2016-09-05
JP2016526374A5 true JP2016526374A5 (cg-RX-API-DMAC7.html) 2017-08-10
JP6557208B2 JP6557208B2 (ja) 2019-08-07

Family

ID=52277262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016501252A Active JP6557208B2 (ja) 2013-07-12 2014-07-11 Pd−1抗原またはpd−1リガンド抗原を含むウイルス様粒子

Country Status (13)

Country Link
US (2) US9637532B2 (cg-RX-API-DMAC7.html)
EP (2) EP3666890A1 (cg-RX-API-DMAC7.html)
JP (1) JP6557208B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160029124A (cg-RX-API-DMAC7.html)
CN (1) CN105358683A (cg-RX-API-DMAC7.html)
AR (1) AR096885A1 (cg-RX-API-DMAC7.html)
AU (1) AU2014288147B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016000303A2 (cg-RX-API-DMAC7.html)
CA (1) CA2916458A1 (cg-RX-API-DMAC7.html)
IL (1) IL243304B (cg-RX-API-DMAC7.html)
MX (1) MX364952B (cg-RX-API-DMAC7.html)
TW (1) TWI676636B (cg-RX-API-DMAC7.html)
WO (1) WO2015005500A1 (cg-RX-API-DMAC7.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249191B2 (en) 2012-02-16 2016-02-02 Vlp Therapeutics, Llc Virus like particle composition
TWI676636B (zh) 2013-07-12 2019-11-11 Vlp醫療股份有限公司 包含pd-1抗原或pd-1配體抗原的類病毒粒子
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
KR102248804B1 (ko) 2014-03-12 2021-05-11 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US9969986B2 (en) 2014-08-08 2018-05-15 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
MX383330B (es) 2014-09-11 2025-03-13 Vlp Therapeutics Inc Particula tipo virus de flavivirus.
AU2016232771B2 (en) 2015-03-18 2021-08-19 Omnicyte Fusion proteins comprising modified alpha virus surface glycoproteins and tumor associated antigen and methods thereof
US10166281B2 (en) * 2015-09-04 2019-01-01 Vlp Therapeutics, Llc Method and composition for modulating immune response
US11447550B2 (en) 2016-10-04 2022-09-20 The Curators Of The University Of Missouri Peptides for molecular detection of PD-L1
EP3589312A1 (en) 2017-03-03 2020-01-08 New York University Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins
US11357842B2 (en) * 2017-03-17 2022-06-14 Vaximm Ag PD-L1 targeting DNA vaccine for cancer immunotherapy
WO2018183488A1 (en) * 2017-03-28 2018-10-04 Ohio State Innovation Foundation Human pd1 peptide vaccines and uses thereof
MX2020006567A (es) 2017-12-20 2020-09-25 Vlp Therapeutics Llc Particula de replicon de alfavirus.
JP2021512966A (ja) * 2018-02-07 2021-05-20 イミュジーン、リミテッドImugene Limited ワクチン組成物およびその使用
US12097257B2 (en) 2018-03-05 2024-09-24 New York University Induction and enhancement of antitumor immunity involving Sindbis virus vectors expressing immune checkpoint proteins
FR3078535B1 (fr) * 2018-03-05 2024-02-09 Peptinov Sas Composition vaccinale anti-pd-l1
FR3078536A1 (fr) * 2018-03-05 2019-09-06 Peptinov Sas Composition vaccinale anti-pd-1
WO2020071869A1 (ko) * 2018-10-05 2020-04-09 알엔에이진 주식회사 표적 세포 특이적으로 결합하여 다중 면역기능이 강화된 키메라항원 및 이의용도
US12331096B2 (en) * 2019-01-04 2025-06-17 George Mason Research Foundation, Inc. Binding domain mapping and compounds, compositions, complexes, methods, and kits related thereto
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
JP7749543B2 (ja) * 2019-09-17 2025-10-06 オハイオ・ステイト・イノベーション・ファウンデーション ヒト抗pd-l1ペプチドワクチン及びその使用方法
CN111116733B (zh) * 2019-11-28 2021-11-05 广东药科大学 一种靶向程序性死亡受体1和pd-1配体1相互作用界面的抗原肽和纳米抗体
CN115175924A (zh) * 2020-02-26 2022-10-11 港大科桥有限公司 基于pd-1的针对冠状病毒感染的疫苗
TWI891771B (zh) 2020-04-17 2025-08-01 美商Vlp醫療股份有限公司 冠狀病毒疫苗
IL297564A (en) 2020-04-30 2022-12-01 Vlp Therapeutics Inc Cytokine immunotherapy
EP4624487A1 (en) * 2022-11-24 2025-10-01 Tokushima University Production of antibodies against protein

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923123D0 (en) 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
JP3954643B2 (ja) 1991-11-16 2007-08-08 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム マラリア原虫由来のCSおよびHBsAG間のハイブリッド蛋白質
US5580773A (en) 1992-06-17 1996-12-03 Korea Green Cross Corporation Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV)
CA2143491C (en) 1994-03-01 2011-02-22 Yasumasa Ishida A novel peptide related to human programmed cell death and dna encoding it
CA2232669A1 (en) 1995-09-27 1997-04-03 Frances Joanne Morling Recombinant viruses incorporating a protease cleavable protein
AU3289199A (en) 1998-02-11 1999-08-30 Maxygen, Inc. Antigen library immunization
EP1210428B1 (en) * 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
US20110262389A1 (en) 2001-02-13 2011-10-27 Mosca Joseph D Tumor-derived Biological Antigen Presenting Particles
WO2002096939A2 (en) 2001-05-30 2002-12-05 Transgene S.A. Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization
JP4790984B2 (ja) 2001-09-06 2011-10-12 アルファヴァックス,インコーポレイテッド アルファウイルスレプリコンベクター系
WO2003102166A2 (en) 2002-02-26 2003-12-11 Maxygen, Inc. Novel flavivirus antigens
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
WO2004043399A2 (en) 2002-11-13 2004-05-27 The United States Of America As Represented By The Secretary Of The Navy Methods and compositions for inducing immune responses and protective immunity by priming with alphavirus replicon vaccines
DK2290054T3 (en) 2002-12-13 2017-07-03 Alphavax Inc Alpha virus particles and processes for their preparation
NZ542353A (en) 2003-03-20 2008-07-31 Alphavax Inc Improved alphavirus replicons and helper constructs
US7790181B2 (en) 2003-05-29 2010-09-07 The United States Of America As Represented By The Secretary Of The Army Live attenuated viral vaccines for Eastern Equine Encephalitis virus
CA2547511A1 (en) * 2003-12-01 2005-07-28 Dow Global Technolgies Inc. Recombinant icosahedral virus like particle production in pseudomonads
US20050266550A1 (en) 2004-05-18 2005-12-01 Alphavax, Inc. TC-83-derived alphavirus vectors, particles and methods
MX2007004031A (es) 2004-10-14 2007-11-08 Crucell Holland Bv Vacunas de cebado/refuerzo contra el paludismo.
JP4819792B2 (ja) 2005-02-16 2011-11-24 国立大学法人東京工業大学 改変されたウイルスカプシドタンパク質及びその使用
MX349137B (es) 2005-06-08 2017-07-13 Dana-Farber Cancer Inst Metodos y composiciones para el tratamiento de infecciones persistentes y cancer por inhibicion de la ruta de muerte celular programada (pd-1).
GB0513421D0 (en) 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
US20070104689A1 (en) 2005-09-27 2007-05-10 Merck Patent Gmbh Compositions and methods for treating tumors presenting survivin antigens
CU23586A1 (es) 2005-11-22 2010-10-30 Ct Ingenieria Genetica Biotech Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus
EP1997887B1 (en) 2006-03-03 2013-09-04 Ono Pharmaceutical Co., Ltd. Multimer of extracellular domain of cell surface functional molecule
US7499304B2 (en) 2006-07-31 2009-03-03 Sandisk 3D Llc Systems for high bandwidth one time field-programmable memory
US20100120092A1 (en) 2006-08-30 2010-05-13 Hepgenics Pty Ltd. Recombinant proteins and virus like particles comprising l and s polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same
GB2453155A (en) 2007-09-26 2009-04-01 Rolls Royce Plc Co-axial pipe assembly which supplies oil to a bearing in a gas turbine engine
US20110035004A1 (en) 2007-11-14 2011-02-10 Maxwell G Interfaced medical implant
WO2009079185A2 (en) 2007-11-26 2009-06-25 Novartis Vaccines And Diagnostics, Inc. Methods of generating alphavirus particles
SG171828A1 (en) 2008-11-26 2011-07-28 Us Gov Health & Human Serv Virus like particle compositions and methods of use
CA2774640C (en) 2009-09-18 2019-11-26 Fraunhofer Usa Inc. Virus like particles comprising target proteins fused to plant viral coat proteins
US8907053B2 (en) * 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
WO2012006180A1 (en) 2010-06-29 2012-01-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv immunogens
JP5600741B2 (ja) 2010-07-13 2014-10-01 帝人株式会社 炭素繊維束及びその製造方法、ならびにそれからの成形品
WO2012023995A1 (en) 2010-08-18 2012-02-23 Takayuki Shiratsuchi Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes
US9487563B2 (en) 2011-01-31 2016-11-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Virus-like particles and methods of use
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
AU2012269907B2 (en) 2011-06-17 2017-05-18 Bharat Biotech International Limited Vaccine composition comprising an inactivated chikungunya virus strain
CA2836501A1 (en) 2011-07-12 2013-01-17 Gwong-Jen J. Chang Identification of a west nile virus cd4 t cell epitope and use thereof
CN102321639B (zh) 2011-09-08 2013-06-26 中国疾病预防控制中心病毒病预防控制所 基孔肯雅病毒病毒样颗粒的制备方法和应用
SI2768524T1 (sl) * 2011-10-17 2022-09-30 Io Biotech Aps Imunoterapija na osnovi PD-L1
HK1206366A1 (en) 2011-10-25 2016-01-08 佛罗里达海湾海岸大学理事会 Vaccines and methods for creating a vaccine for inducing immunity to all dengue virus serotypes
US9249191B2 (en) 2012-02-16 2016-02-02 Vlp Therapeutics, Llc Virus like particle composition
CN108912215A (zh) 2012-04-02 2018-11-30 北卡罗来纳-查佩尔山大学 用于登革病毒表位的方法和组合物
CN107540730B (zh) * 2012-05-16 2021-07-16 免疫设计公司 用于hsv-2的疫苗
JP6734651B2 (ja) 2013-06-03 2020-08-05 ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーVLP Therapeutics, LLC マラリアワクチン
TWI676636B (zh) 2013-07-12 2019-11-11 Vlp醫療股份有限公司 包含pd-1抗原或pd-1配體抗原的類病毒粒子
WO2015139784A1 (en) 2014-03-18 2015-09-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Distinguishing flavivirus infection using a recombinant mutant envelope protein
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US9969986B2 (en) 2014-08-08 2018-05-15 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
MX383330B (es) 2014-09-11 2025-03-13 Vlp Therapeutics Inc Particula tipo virus de flavivirus.
US9363353B1 (en) 2014-12-04 2016-06-07 Hon Man Ashley Chik Mobile phone docks with multiple circulating phone connectors
AU2015373928B2 (en) 2014-12-31 2019-10-17 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Novel multivalent nanoparticle-based vaccines
EP3309251A4 (en) 2015-06-12 2019-03-13 Mie University HUMAN PARAIN FLUENZA TYPE 2 VIRUS VIRUS VECTOR AND VACCINE
US10799575B2 (en) 2015-06-25 2020-10-13 Technovax, Inc. Flavivirus and alphavirus virus-like particles (VLPS)
CA2992531C (en) 2015-07-16 2023-09-26 Bharat Biotech International Limited Vaccine compositions
MA42502A (fr) 2015-07-21 2018-05-30 Modernatx Inc Vaccins contre une maladie infectieuse
US10166281B2 (en) 2015-09-04 2019-01-01 Vlp Therapeutics, Llc Method and composition for modulating immune response
WO2017150683A1 (en) 2016-03-04 2017-09-08 Vlp Therapeutics, Llc Zika virus virus like particle
CN106085974B (zh) 2016-06-07 2019-08-09 博奥生物集团有限公司 一种寨卡病毒假病毒颗粒及其制备方法

Similar Documents

Publication Publication Date Title
JP2016526374A5 (cg-RX-API-DMAC7.html)
Khairkhah et al. Current and future direction in treatment of HPV-related cervical disease
Zhang et al. Peptide-based nanovaccines in the treatment of cervical cancer: a review of recent advances
Cai et al. Heterologous prime-boost enhances the antitumor immune response elicited by plant-virus-based cancer vaccine
Crews et al. Prophylactic cancer vaccines engineered to elicit specific adaptive immune response
TWI676636B (zh) 包含pd-1抗原或pd-1配體抗原的類病毒粒子
Ma et al. Emerging human papillomavirus vaccines
Wu et al. Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation
Storni et al. Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles
JP6581101B2 (ja) 局所免疫刺激及び全身免疫刺激の組み合わせによる癌の免疫療法
JP7641005B2 (ja) コンジュゲート型ウイルス様粒子および抗腫瘍免疫リダイレクタとしてのその使用
JP4472724B2 (ja) パピロマウイルス偽ウイルス及びその調製方法
Daemen et al. Superior therapeutic efficacy of alphavirus-mediated immunization against human papilloma virus type 16 antigens in a murine tumour model: effects of the route of immunization
Song et al. A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity
JP2013150606A5 (cg-RX-API-DMAC7.html)
JP2017523796A (ja) 修飾エンベロープタンパク質e3を含むウイルス様粒子
Al-Barwani et al. Antigen delivery by virus-like particles for immunotherapeutic vaccination
Liu et al. Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model
Murakami et al. Human papillomavirus vaccines for cervical cancer
Kawano et al. SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier
Li et al. Surface-functionalized silica-coated calcium phosphate nanoparticles efficiently deliver DNA-based HIV-1 trimeric envelope vaccines against HIV-1
Bolhassani et al. Different spectra of therapeutic vaccine development against HPV infections
JP2014139185A5 (cg-RX-API-DMAC7.html)
Peacey et al. Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response
JP2022520467A (ja) 免疫活性もしくは癌の予防または治療用の医薬組成物