JP2016524917A5 - - Google Patents
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- Publication number
- JP2016524917A5 JP2016524917A5 JP2016527125A JP2016527125A JP2016524917A5 JP 2016524917 A5 JP2016524917 A5 JP 2016524917A5 JP 2016527125 A JP2016527125 A JP 2016527125A JP 2016527125 A JP2016527125 A JP 2016527125A JP 2016524917 A5 JP2016524917 A5 JP 2016524917A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- nucleic acid
- specificity
- stranded
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 38
- 102000039446 nucleic acids Human genes 0.000 claims 38
- 150000007523 nucleic acids Chemical class 0.000 claims 38
- 238000000034 method Methods 0.000 claims 22
- 230000037452 priming Effects 0.000 claims 13
- 230000000295 complement effect Effects 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 5
- 102000053602 DNA Human genes 0.000 claims 5
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 5
- 230000002860 competitive effect Effects 0.000 claims 5
- 238000009396 hybridization Methods 0.000 claims 5
- 229920002477 rna polymer Polymers 0.000 claims 5
- 239000005546 dideoxynucleotide Substances 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361856028P | 2013-07-18 | 2013-07-18 | |
| US61/856,028 | 2013-07-18 | ||
| PCT/US2014/047196 WO2015010020A1 (en) | 2013-07-18 | 2014-07-18 | Specific nucleic acid amplification with compounded selectivity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016524917A JP2016524917A (ja) | 2016-08-22 |
| JP2016524917A5 true JP2016524917A5 (enExample) | 2017-08-31 |
Family
ID=52346754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527125A Pending JP2016524917A (ja) | 2013-07-18 | 2014-07-18 | 複合的な選択性を有する特異的核酸増幅 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10745746B2 (enExample) |
| EP (1) | EP3022323B1 (enExample) |
| JP (1) | JP2016524917A (enExample) |
| CN (1) | CN105492629A (enExample) |
| AU (1) | AU2014290454A1 (enExample) |
| CA (1) | CA2917627A1 (enExample) |
| WO (1) | WO2015010020A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011319755B2 (en) | 2010-10-27 | 2017-02-23 | President And Fellows Of Harvard College | Compositions of toehold primer duplexes and methods of use |
| WO2012151328A2 (en) | 2011-05-02 | 2012-11-08 | President And Fellows Of Harvard College | Spatial sequestration of dynamic nucleic acid circuits |
| WO2013119888A1 (en) | 2012-02-09 | 2013-08-15 | President And Fellows Of Harvard College | Selective nucleic acid amplification from nucleic acid pools |
| JP2016524917A (ja) | 2013-07-18 | 2016-08-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 複合的な選択性を有する特異的核酸増幅 |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| US20180094309A1 (en) * | 2015-04-03 | 2018-04-05 | President And Fellows Of Harvard College | Nucleic acid retro-activated primers |
| US10550440B2 (en) | 2016-02-26 | 2020-02-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Synthetic translation-sensing riboswitches and uses thereof |
| CN109563506A (zh) * | 2016-05-06 | 2019-04-02 | 威廉马歇莱思大学 | 使用随机捕获探针文库的化学计量核酸纯化 |
| WO2017205719A1 (en) | 2016-05-27 | 2017-11-30 | President And Fellows Of Harvard College | Conditional primer extension for single-molecule detection |
| US11773430B2 (en) | 2016-10-17 | 2023-10-03 | Arizona Board Of Regents On Behalf Of Arizona State University | Unimolecular aptamer-based sensors for pathogen detection |
| US11434540B2 (en) | 2016-11-15 | 2022-09-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Ultraspecific nucleic acid sensors for low-cost liquid biopsies |
| US12054711B2 (en) | 2017-07-14 | 2024-08-06 | City Of Hope | Meta-stable oligonucleotides junctions for delivery of therapeutics |
| WO2019033079A1 (en) | 2017-08-10 | 2019-02-14 | City Of Hope | CONDITIONAL RNAIDS AND THEIR USES IN THE TREATMENT OF CARDIAC HYPERTROPHY |
| CN113166750B (zh) | 2018-08-10 | 2025-02-18 | 希望之城 | 可编程的条件性sirna及其用途 |
| US11104941B2 (en) * | 2018-09-28 | 2021-08-31 | Bioo Scientific Corporation | 5′ adapter comprising an internal 5′-5′ linkage |
| WO2020092268A2 (en) * | 2018-10-29 | 2020-05-07 | Kutyavin Igor V | Thermokinetically balanced isothermal amplification of nucleic acid sequences |
| EP4139456A4 (en) * | 2020-04-22 | 2024-05-22 | President And Fellows Of Harvard College | ISOTHERMAL METHODS, COMPOSITIONS, KITS AND SYSTEMS FOR THE DETECTION OF NUCLEIC ACIDS |
| CN118302819A (zh) * | 2021-07-06 | 2024-07-05 | 斯威齐治疗公司 | 产生条件可激活核酸复合物中的核心链的方法 |
| EP4490316A4 (en) * | 2022-03-11 | 2026-03-04 | Harvard College | Multiplex Fluorescent Cell and Tissue Imaging with DNA-Encoded Thermal Channels and Their Uses |
| CN115125292B (zh) * | 2022-06-02 | 2025-02-07 | 武汉大学 | 一种内切酶辅助的rna中肌苷修饰的单碱基分辨率定位分析方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436149A (en) * | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
| EP1354062A2 (en) | 2000-09-13 | 2003-10-22 | Archemix Corporation | Target activated nucleic acid biosensor and methods of using same |
| CA2485596C (en) * | 2002-05-10 | 2013-04-16 | City Of Hope | Pyrophosphorolysis activated polymerization (pap) |
| US20040086892A1 (en) | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Universal tag assay |
| ATE514776T1 (de) | 2004-10-05 | 2011-07-15 | California Inst Of Techn | Aptamer-regulierte nukleinsäuren und verwendungen davon |
| US20100009355A1 (en) * | 2006-03-14 | 2010-01-14 | Kolodney Michael S | Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides |
| GB0703997D0 (en) * | 2007-03-01 | 2007-04-11 | Oxitec Ltd | Methods for detecting nucleic sequences |
| GB0703996D0 (en) | 2007-03-01 | 2007-04-11 | Oxitec Ltd | Nucleic acid detection |
| WO2010120853A2 (en) | 2009-04-16 | 2010-10-21 | Padma Arunachalam | Methods and compositions to detect and differentiate small rnas in rna maturation pathway |
| CN102459630B (zh) * | 2009-06-29 | 2014-04-30 | 株式会社东芝 | 样本分析方法和用于该方法的检测试剂盒 |
| US8815514B2 (en) | 2009-07-02 | 2014-08-26 | Co-Diagnostics, Inc. | Detection primers for nucleic acid extension or amplification reactions |
| AU2011319755B2 (en) | 2010-10-27 | 2017-02-23 | President And Fellows Of Harvard College | Compositions of toehold primer duplexes and methods of use |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| WO2012149154A1 (en) * | 2011-04-26 | 2012-11-01 | Swift Biosciences, Inc. | Polynucleotide primers and probes |
| WO2012151328A2 (en) | 2011-05-02 | 2012-11-08 | President And Fellows Of Harvard College | Spatial sequestration of dynamic nucleic acid circuits |
| WO2013119888A1 (en) | 2012-02-09 | 2013-08-15 | President And Fellows Of Harvard College | Selective nucleic acid amplification from nucleic acid pools |
| EP2875132A4 (en) | 2012-07-17 | 2016-02-24 | Dna Logix Inc | COOPERATIVE PRIMERS, PROBES AND APPLICATIONS THEREOF |
| JP2016524917A (ja) | 2013-07-18 | 2016-08-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 複合的な選択性を有する特異的核酸増幅 |
| US20180094309A1 (en) | 2015-04-03 | 2018-04-05 | President And Fellows Of Harvard College | Nucleic acid retro-activated primers |
| WO2017205719A1 (en) | 2016-05-27 | 2017-11-30 | President And Fellows Of Harvard College | Conditional primer extension for single-molecule detection |
-
2014
- 2014-07-18 JP JP2016527125A patent/JP2016524917A/ja active Pending
- 2014-07-18 AU AU2014290454A patent/AU2014290454A1/en not_active Abandoned
- 2014-07-18 CA CA2917627A patent/CA2917627A1/en not_active Abandoned
- 2014-07-18 CN CN201480045718.0A patent/CN105492629A/zh active Pending
- 2014-07-18 WO PCT/US2014/047196 patent/WO2015010020A1/en not_active Ceased
- 2014-07-18 US US14/905,021 patent/US10745746B2/en active Active
- 2014-07-18 EP EP14826920.2A patent/EP3022323B1/en not_active Not-in-force
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