AU2014290454A1 - Specific nucleic acid amplification with compounded selectivity - Google Patents

Specific nucleic acid amplification with compounded selectivity Download PDF

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Publication number
AU2014290454A1
AU2014290454A1 AU2014290454A AU2014290454A AU2014290454A1 AU 2014290454 A1 AU2014290454 A1 AU 2014290454A1 AU 2014290454 A AU2014290454 A AU 2014290454A AU 2014290454 A AU2014290454 A AU 2014290454A AU 2014290454 A1 AU2014290454 A1 AU 2014290454A1
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AU
Australia
Prior art keywords
domain
nucleic acid
target
strand
pseudo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2014290454A
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English (en)
Inventor
Xi Chen
Peng Yin
David Yu Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
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Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of AU2014290454A1 publication Critical patent/AU2014290454A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2014290454A 2013-07-18 2014-07-18 Specific nucleic acid amplification with compounded selectivity Abandoned AU2014290454A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361856028P 2013-07-18 2013-07-18
US61/856,028 2013-07-18
PCT/US2014/047196 WO2015010020A1 (en) 2013-07-18 2014-07-18 Specific nucleic acid amplification with compounded selectivity

Publications (1)

Publication Number Publication Date
AU2014290454A1 true AU2014290454A1 (en) 2016-01-28

Family

ID=52346754

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014290454A Abandoned AU2014290454A1 (en) 2013-07-18 2014-07-18 Specific nucleic acid amplification with compounded selectivity

Country Status (7)

Country Link
US (1) US10745746B2 (enExample)
EP (1) EP3022323B1 (enExample)
JP (1) JP2016524917A (enExample)
CN (1) CN105492629A (enExample)
AU (1) AU2014290454A1 (enExample)
CA (1) CA2917627A1 (enExample)
WO (1) WO2015010020A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2633071T3 (en) 2010-10-27 2017-01-30 Harvard College COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE
WO2012151328A2 (en) 2011-05-02 2012-11-08 President And Fellows Of Harvard College Spatial sequestration of dynamic nucleic acid circuits
WO2013119888A1 (en) 2012-02-09 2013-08-15 President And Fellows Of Harvard College Selective nucleic acid amplification from nucleic acid pools
EP3022323B1 (en) 2013-07-18 2019-04-24 President and Fellows of Harvard College Specific nucleic acid amplification with compounded selectivity
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物,以及包括其的组合物和方法
WO2016161237A1 (en) * 2015-04-03 2016-10-06 President And Fellows Of Harvard College Nucleic acid retro-activated primers
WO2017147585A1 (en) 2016-02-26 2017-08-31 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic translation-sensing riboswitches and uses thereof
WO2017193025A1 (en) * 2016-05-06 2017-11-09 William Marsh Rice University Stoichiometric nucleic acid purification using randomer capture probe libraries
CN109312337B (zh) 2016-05-27 2022-10-04 哈佛学院院长及董事 用于单分子检测的条件性引物延伸
WO2018075502A1 (en) * 2016-10-17 2018-04-26 Arizona Board Of Regents On Behalf Of Arizona State University Unimolecular aptamer-based sensors for pathogen detection
US11434540B2 (en) 2016-11-15 2022-09-06 Arizona Board Of Regents On Behalf Of Arizona State University Ultraspecific nucleic acid sensors for low-cost liquid biopsies
WO2019014656A1 (en) 2017-07-14 2019-01-17 Han Si Ping METALLIC OLIGONUCLEOTIDE JONCTIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS
EP3665281A4 (en) 2017-08-10 2021-05-05 City of Hope CONDITIONAL SIRNA AND ITS USE IN THE TREATMENT OF CARDIAC HYERTROPHY
JP7566741B2 (ja) 2018-08-10 2024-10-15 シティ・オブ・ホープ プログラム可能なsiRNA及びその使用
US11104941B2 (en) * 2018-09-28 2021-08-31 Bioo Scientific Corporation 5′ adapter comprising an internal 5′-5′ linkage
WO2020092255A1 (en) * 2018-10-29 2020-05-07 Kutyavin Igor V Accelerated polymerase chain reaction
KR20230002943A9 (ko) * 2020-04-22 2024-04-26 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 검출을 위한 등온 방법, 조성물, 키트, 및 시스템
CN118302819A (zh) * 2021-07-06 2024-07-05 斯威齐治疗公司 产生条件可激活核酸复合物中的核心链的方法
CN115125292B (zh) * 2022-06-02 2025-02-07 武汉大学 一种内切酶辅助的rna中肌苷修饰的单碱基分辨率定位分析方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436149A (en) * 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US20030087239A1 (en) 2000-09-13 2003-05-08 Marty Stanton Target activated nucleic acid biosensor and methods of using same
EP2292787B1 (en) * 2002-05-10 2017-03-22 City of Hope Pyrophosphorolysis activated polymerization (PAP)
US20040086892A1 (en) 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
JP5101288B2 (ja) 2004-10-05 2012-12-19 カリフォルニア インスティテュート オブ テクノロジー アプタマー調節される核酸及びその利用
WO2007106534A2 (en) 2006-03-14 2007-09-20 Harbor-Ucla Research And Education Institute Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides
GB0703996D0 (en) 2007-03-01 2007-04-11 Oxitec Ltd Nucleic acid detection
GB0703997D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
WO2010120853A2 (en) 2009-04-16 2010-10-21 Padma Arunachalam Methods and compositions to detect and differentiate small rnas in rna maturation pathway
JP4528885B1 (ja) * 2009-06-29 2010-08-25 株式会社東芝 検体解析方法およびそれに用いるアッセイキット
US8815514B2 (en) 2009-07-02 2014-08-26 Co-Diagnostics, Inc. Detection primers for nucleic acid extension or amplification reactions
DK2633071T3 (en) 2010-10-27 2017-01-30 Harvard College COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
WO2012149154A1 (en) 2011-04-26 2012-11-01 Swift Biosciences, Inc. Polynucleotide primers and probes
WO2012151328A2 (en) 2011-05-02 2012-11-08 President And Fellows Of Harvard College Spatial sequestration of dynamic nucleic acid circuits
WO2013119888A1 (en) 2012-02-09 2013-08-15 President And Fellows Of Harvard College Selective nucleic acid amplification from nucleic acid pools
WO2014014988A2 (en) 2012-07-17 2014-01-23 Dna Logix, Inc. Cooperative primers, probes, and applications thereof
EP3022323B1 (en) 2013-07-18 2019-04-24 President and Fellows of Harvard College Specific nucleic acid amplification with compounded selectivity
WO2016161237A1 (en) 2015-04-03 2016-10-06 President And Fellows Of Harvard College Nucleic acid retro-activated primers
CN109312337B (zh) 2016-05-27 2022-10-04 哈佛学院院长及董事 用于单分子检测的条件性引物延伸

Also Published As

Publication number Publication date
CA2917627A1 (en) 2015-01-22
EP3022323B1 (en) 2019-04-24
US20160153036A1 (en) 2016-06-02
WO2015010020A1 (en) 2015-01-22
EP3022323A4 (en) 2017-05-03
EP3022323A1 (en) 2016-05-25
CN105492629A (zh) 2016-04-13
US10745746B2 (en) 2020-08-18
JP2016524917A (ja) 2016-08-22

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Legal Events

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application