CA2917627A1 - Specific nucleic acid amplification with compounded selectivity - Google Patents
Specific nucleic acid amplification with compounded selectivity Download PDFInfo
- Publication number
- CA2917627A1 CA2917627A1 CA2917627A CA2917627A CA2917627A1 CA 2917627 A1 CA2917627 A1 CA 2917627A1 CA 2917627 A CA2917627 A CA 2917627A CA 2917627 A CA2917627 A CA 2917627A CA 2917627 A1 CA2917627 A1 CA 2917627A1
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- CA
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- Prior art keywords
- domain
- nucleic acid
- target
- strand
- pseudo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361856028P | 2013-07-18 | 2013-07-18 | |
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| DK2633071T3 (en) | 2010-10-27 | 2017-01-30 | Harvard College | COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE |
| WO2012151328A2 (en) | 2011-05-02 | 2012-11-08 | President And Fellows Of Harvard College | Spatial sequestration of dynamic nucleic acid circuits |
| WO2013119888A1 (en) | 2012-02-09 | 2013-08-15 | President And Fellows Of Harvard College | Selective nucleic acid amplification from nucleic acid pools |
| EP3022323B1 (en) | 2013-07-18 | 2019-04-24 | President and Fellows of Harvard College | Specific nucleic acid amplification with compounded selectivity |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| WO2016161237A1 (en) * | 2015-04-03 | 2016-10-06 | President And Fellows Of Harvard College | Nucleic acid retro-activated primers |
| WO2017147585A1 (en) | 2016-02-26 | 2017-08-31 | Arizona Board Of Regents On Behalf Of Arizona State University | Synthetic translation-sensing riboswitches and uses thereof |
| WO2017193025A1 (en) * | 2016-05-06 | 2017-11-09 | William Marsh Rice University | Stoichiometric nucleic acid purification using randomer capture probe libraries |
| CN109312337B (zh) | 2016-05-27 | 2022-10-04 | 哈佛学院院长及董事 | 用于单分子检测的条件性引物延伸 |
| WO2018075502A1 (en) * | 2016-10-17 | 2018-04-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Unimolecular aptamer-based sensors for pathogen detection |
| US11434540B2 (en) | 2016-11-15 | 2022-09-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Ultraspecific nucleic acid sensors for low-cost liquid biopsies |
| WO2019014656A1 (en) | 2017-07-14 | 2019-01-17 | Han Si Ping | METALLIC OLIGONUCLEOTIDE JONCTIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS |
| EP3665281A4 (en) | 2017-08-10 | 2021-05-05 | City of Hope | CONDITIONAL SIRNA AND ITS USE IN THE TREATMENT OF CARDIAC HYERTROPHY |
| JP7566741B2 (ja) | 2018-08-10 | 2024-10-15 | シティ・オブ・ホープ | プログラム可能なｓｉＲＮＡ及びその使用 |
| US11104941B2 (en) * | 2018-09-28 | 2021-08-31 | Bioo Scientific Corporation | 5′ adapter comprising an internal 5′-5′ linkage |
| WO2020092255A1 (en) * | 2018-10-29 | 2020-05-07 | Kutyavin Igor V | Accelerated polymerase chain reaction |
| KR20230002943A9 (ko) * | 2020-04-22 | 2024-04-26 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 검출을 위한 등온 방법, 조성물, 키트, 및 시스템 |
| CN118302819A (zh) * | 2021-07-06 | 2024-07-05 | 斯威齐治疗公司 | 产生条件可激活核酸复合物中的核心链的方法 |
| CN115125292B (zh) * | 2022-06-02 | 2025-02-07 | 武汉大学 | 一种内切酶辅助的rna中肌苷修饰的单碱基分辨率定位分析方法 |
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| US5436149A (en) * | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
| US20030087239A1 (en) | 2000-09-13 | 2003-05-08 | Marty Stanton | Target activated nucleic acid biosensor and methods of using same |
| EP2292787B1 (en) * | 2002-05-10 | 2017-03-22 | City of Hope | Pyrophosphorolysis activated polymerization (PAP) |
| US20040086892A1 (en) | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Universal tag assay |
| JP5101288B2 (ja) | 2004-10-05 | 2012-12-19 | カリフォルニア インスティテュート オブ テクノロジー | アプタマー調節される核酸及びその利用 |
| WO2007106534A2 (en) | 2006-03-14 | 2007-09-20 | Harbor-Ucla Research And Education Institute | Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides |
| GB0703996D0 (en) | 2007-03-01 | 2007-04-11 | Oxitec Ltd | Nucleic acid detection |
| GB0703997D0 (en) * | 2007-03-01 | 2007-04-11 | Oxitec Ltd | Methods for detecting nucleic sequences |
| WO2010120853A2 (en) | 2009-04-16 | 2010-10-21 | Padma Arunachalam | Methods and compositions to detect and differentiate small rnas in rna maturation pathway |
| JP4528885B1 (ja) * | 2009-06-29 | 2010-08-25 | 株式会社東芝 | 検体解析方法およびそれに用いるアッセイキット |
| US8815514B2 (en) | 2009-07-02 | 2014-08-26 | Co-Diagnostics, Inc. | Detection primers for nucleic acid extension or amplification reactions |
| DK2633071T3 (en) | 2010-10-27 | 2017-01-30 | Harvard College | COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| WO2012149154A1 (en) | 2011-04-26 | 2012-11-01 | Swift Biosciences, Inc. | Polynucleotide primers and probes |
| WO2012151328A2 (en) | 2011-05-02 | 2012-11-08 | President And Fellows Of Harvard College | Spatial sequestration of dynamic nucleic acid circuits |
| WO2013119888A1 (en) | 2012-02-09 | 2013-08-15 | President And Fellows Of Harvard College | Selective nucleic acid amplification from nucleic acid pools |
| WO2014014988A2 (en) | 2012-07-17 | 2014-01-23 | Dna Logix, Inc. | Cooperative primers, probes, and applications thereof |
| EP3022323B1 (en) | 2013-07-18 | 2019-04-24 | President and Fellows of Harvard College | Specific nucleic acid amplification with compounded selectivity |
| WO2016161237A1 (en) | 2015-04-03 | 2016-10-06 | President And Fellows Of Harvard College | Nucleic acid retro-activated primers |
| CN109312337B (zh) | 2016-05-27 | 2022-10-04 | 哈佛学院院长及董事 | 用于单分子检测的条件性引物延伸 |
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| EP3022323B1 (en) | 2019-04-24 |
| US20160153036A1 (en) | 2016-06-02 |
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| EP3022323A4 (en) | 2017-05-03 |
| EP3022323A1 (en) | 2016-05-25 |
| CN105492629A (zh) | 2016-04-13 |
| US10745746B2 (en) | 2020-08-18 |
| JP2016524917A (ja) | 2016-08-22 |
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| EEER | Examination request |
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