JP2016523847A5 - - Google Patents
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- JP2016523847A5 JP2016523847A5 JP2016518018A JP2016518018A JP2016523847A5 JP 2016523847 A5 JP2016523847 A5 JP 2016523847A5 JP 2016518018 A JP2016518018 A JP 2016518018A JP 2016518018 A JP2016518018 A JP 2016518018A JP 2016523847 A5 JP2016523847 A5 JP 2016523847A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 102000025171 antigen binding proteins Human genes 0.000 claims 10
- 108091000831 antigen binding proteins Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 3
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 3
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 229940030627 lipid modifying agent Drugs 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 229940122392 PCSK9 inhibitor Drugs 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 229940127355 PCSK9 Inhibitors Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 229960005110 cerivastatin Drugs 0.000 claims 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229960000815 ezetimibe Drugs 0.000 claims 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- -1 fibrates Substances 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 229960002797 pitavastatin Drugs 0.000 claims 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832459P | 2013-06-07 | 2013-06-07 | |
| US61/832,459 | 2013-06-07 | ||
| EP13305762.0 | 2013-06-07 | ||
| EP13305762.0A EP2810955A1 (en) | 2013-06-07 | 2013-06-07 | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| US201361892215P | 2013-10-17 | 2013-10-17 | |
| US61/892,215 | 2013-10-17 | ||
| EP20130306436 EP2862877A1 (en) | 2013-10-18 | 2013-10-18 | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| EP13306436.0 | 2013-10-18 | ||
| US201461944855P | 2014-02-26 | 2014-02-26 | |
| US61/944,855 | 2014-02-26 | ||
| US201462002508P | 2014-05-23 | 2014-05-23 | |
| US62/002,508 | 2014-05-23 | ||
| PCT/US2014/041204 WO2014197752A1 (en) | 2013-06-07 | 2014-06-06 | Methods fo inhibting atherosclerosis by administering an inhibitor of pcsk9 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019033436A Division JP7112975B2 (ja) | 2013-06-07 | 2019-02-27 | Ｐｃｓｋ９のインヒビターの投与によりアテローム性動脈硬化を阻害する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523847A JP2016523847A (ja) | 2016-08-12 |
| JP2016523847A5 true JP2016523847A5 (https=) | 2017-07-20 |
Family
ID=52008606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518018A Pending JP2016523847A (ja) | 2013-06-07 | 2014-06-06 | Ｐｃｓｋ９のインヒビターの投与によりアテローム性動脈硬化を阻害する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10494442B2 (https=) |
| EP (1) | EP3004171B1 (https=) |
| JP (1) | JP2016523847A (https=) |
| KR (1) | KR20160024906A (https=) |
| CN (2) | CN111920954A (https=) |
| AU (2) | AU2014274844B2 (https=) |
| CA (1) | CA2914721A1 (https=) |
| EA (1) | EA201592267A1 (https=) |
| HK (1) | HK1222865A1 (https=) |
| MX (1) | MX2015016887A (https=) |
| TW (2) | TW202021614A (https=) |
| WO (1) | WO2014197752A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3672B1 (ar) * | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| SG192117A1 (en) | 2011-01-28 | 2013-08-30 | Sanofi Sa | Human antibodies to pcsk9 for use in methods of treating particular groups of subjects |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| HUE069234T2 (hu) | 2011-09-16 | 2025-02-28 | Regeneron Pharma | Eljárások lipoprotein(a)-szint csökkentésére proprotein-konvertáz szubtilizin/kexin 9 (PCSK9) inhibitorának beadásával |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| US10494442B2 (en) | 2013-06-07 | 2019-12-03 | Sanofi Biotechnology | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| CN118105480A (zh) | 2013-11-12 | 2024-05-31 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| AU2015289874A1 (en) * | 2014-07-14 | 2017-02-02 | Amgen Inc. | Crystalline antibody formulations |
| KR20230074283A (ko) | 2014-07-16 | 2023-05-26 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| JP2018523684A (ja) | 2015-08-18 | 2018-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗ｐｃｓｋ９阻害抗体 |
| WO2017053734A1 (en) | 2015-09-25 | 2017-03-30 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of atherosclerosis |
| CN105214087B (zh) | 2015-10-29 | 2017-12-26 | 陈敏 | Pcsk9单克隆抗体在制备治疗炎症免疫性疾病药物中的应用 |
| MA44234B1 (fr) * | 2016-02-17 | 2023-10-31 | Regeneron Pharma | Procédés de traitement ou de prévention de l'athérosclérose par administration d'un inhibiteur d'angptl3 |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| JP7110124B2 (ja) * | 2016-06-24 | 2022-08-01 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 心血管疾患を治療するための組成物及び方法 |
| KR20190049866A (ko) | 2016-09-20 | 2019-05-09 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 항-ｐｃｓｋ９ 항체 |
| JP7050807B2 (ja) | 2017-04-13 | 2022-04-08 | カディラ ヘルスケア リミティド | 新規ペプチドベースのｐｃｓｋ９ワクチン |
| WO2020049026A1 (en) * | 2018-09-05 | 2020-03-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating asthma and allergic diseases |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| MX2021008661A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
| US12559551B2 (en) | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| WO2021058597A1 (en) * | 2019-09-24 | 2021-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of determining whether a subject is at risk of developing arterial plaques |
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-
2014
- 2014-06-06 US US14/896,196 patent/US10494442B2/en active Active
- 2014-06-06 CN CN202010812439.XA patent/CN111920954A/zh active Pending
- 2014-06-06 CA CA2914721A patent/CA2914721A1/en not_active Abandoned
- 2014-06-06 JP JP2016518018A patent/JP2016523847A/ja active Pending
- 2014-06-06 TW TW108126132A patent/TW202021614A/zh unknown
- 2014-06-06 HK HK16111037.4A patent/HK1222865A1/zh unknown
- 2014-06-06 EP EP14737087.8A patent/EP3004171B1/en active Active
- 2014-06-06 TW TW103119641A patent/TW201534324A/zh unknown
- 2014-06-06 CN CN201480032506.9A patent/CN105705521A/zh active Pending
- 2014-06-06 AU AU2014274844A patent/AU2014274844B2/en not_active Ceased
- 2014-06-06 MX MX2015016887A patent/MX2015016887A/es unknown
- 2014-06-06 WO PCT/US2014/041204 patent/WO2014197752A1/en not_active Ceased
- 2014-06-06 KR KR1020167000010A patent/KR20160024906A/ko not_active Ceased
- 2014-06-06 EA EA201592267A patent/EA201592267A1/ru unknown
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2018
- 2018-01-18 US US15/874,807 patent/US20180244801A1/en not_active Abandoned
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2019
- 2019-07-08 US US16/505,074 patent/US10995150B2/en active Active
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2020
- 2020-02-19 AU AU2020201191A patent/AU2020201191A1/en not_active Abandoned
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