JP2022177142A5 - - Google Patents
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- Publication number
- JP2022177142A5 JP2022177142A5 JP2022145714A JP2022145714A JP2022177142A5 JP 2022177142 A5 JP2022177142 A5 JP 2022177142A5 JP 2022145714 A JP2022145714 A JP 2022145714A JP 2022145714 A JP2022145714 A JP 2022145714A JP 2022177142 A5 JP2022177142 A5 JP 2022177142A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- angptl3
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662328823P | 2016-04-28 | 2016-04-28 | |
| US62/328,823 | 2016-04-28 | ||
| US201662348001P | 2016-06-09 | 2016-06-09 | |
| US62/348,001 | 2016-06-09 | ||
| US201762451310P | 2017-01-27 | 2017-01-27 | |
| US62/451,310 | 2017-01-27 | ||
| PCT/US2017/029782 WO2017189813A1 (en) | 2016-04-28 | 2017-04-27 | Methods for treating patients with familial hypercholesterolemia |
| JP2018556273A JP7201437B2 (ja) | 2016-04-28 | 2017-04-27 | 家族性高コレステロール血症を有する患者を処置するための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556273A Division JP7201437B2 (ja) | 2016-04-28 | 2017-04-27 | 家族性高コレステロール血症を有する患者を処置するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022177142A JP2022177142A (ja) | 2022-11-30 |
| JP2022177142A5 true JP2022177142A5 (https=) | 2023-05-09 |
| JP7404471B2 JP7404471B2 (ja) | 2023-12-25 |
Family
ID=58692626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556273A Active JP7201437B2 (ja) | 2016-04-28 | 2017-04-27 | 家族性高コレステロール血症を有する患者を処置するための方法 |
| JP2022145714A Active JP7404471B2 (ja) | 2016-04-28 | 2022-09-14 | 家族性高コレステロール血症を有する患者を処置するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556273A Active JP7201437B2 (ja) | 2016-04-28 | 2017-04-27 | 家族性高コレステロール血症を有する患者を処置するための方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20170312359A1 (https=) |
| EP (1) | EP3448426B1 (https=) |
| JP (2) | JP7201437B2 (https=) |
| KR (3) | KR20190003679A (https=) |
| CN (1) | CN109069641A (https=) |
| AU (1) | AU2017258105B2 (https=) |
| CA (1) | CA3021884A1 (https=) |
| DK (1) | DK3448426T3 (https=) |
| ES (1) | ES3032667T3 (https=) |
| FI (1) | FI3448426T3 (https=) |
| HR (1) | HRP20250797T1 (https=) |
| HU (1) | HUE071912T2 (https=) |
| IL (2) | IL293308B2 (https=) |
| LT (1) | LT3448426T (https=) |
| MA (1) | MA44764B1 (https=) |
| MD (1) | MD3448426T2 (https=) |
| MX (1) | MX2018012741A (https=) |
| PL (1) | PL3448426T3 (https=) |
| PT (1) | PT3448426T (https=) |
| RS (1) | RS66975B1 (https=) |
| SI (1) | SI3448426T1 (https=) |
| SM (1) | SMT202500230T1 (https=) |
| WO (1) | WO2017189813A1 (https=) |
| ZA (1) | ZA201806557B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| CN110944675B9 (zh) | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| EP3719126B1 (en) | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| DK3719128T3 (da) | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719127A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CA3083970A1 (en) | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| WO2020038377A1 (zh) | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| WO2020135581A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020135673A1 (zh) | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| KR20220011689A (ko) | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| US12559551B2 (en) | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| EP4054625A4 (en) * | 2019-11-07 | 2026-01-07 | Medimmune Llc | Endothelial Lipase Antibodies for the Treatment of Cardiovascular Diseases |
| WO2021154079A1 (en) | 2020-01-29 | 2021-08-05 | Rijksuniversiteit Groningen | Means and methods for modulating lipid metabolism |
| CA3186856A1 (en) | 2020-07-29 | 2022-02-03 | Ruth NALLEN | Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients |
| CA3188213A1 (en) * | 2020-08-07 | 2022-02-10 | Robert C. Pordy | Methods for treating refractory hypercholesterolemia involving an angptl3 inhibitor |
| CN112656792B (zh) * | 2021-01-26 | 2022-07-05 | 首都医科大学宣武医院 | 洛美他派在制备用于治疗脑卒中引起的神经损伤药物中的用途 |
| CN116948030B (zh) * | 2022-04-25 | 2024-11-19 | 武汉大学 | 抗asgr1单克隆抗体及其应用 |
| IL316249A (en) | 2022-05-02 | 2024-12-01 | Novo Nordisk As | Novel anti-angptl3 antibodies suitable for high concentration compositions and subcutaneous administration |
| CN119192369A (zh) * | 2023-06-25 | 2024-12-27 | 百奥泰生物制药股份有限公司 | 抗angptl3抗体及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US730654A (en) * | 1902-04-17 | 1903-06-09 | John W Hornsey | Hot-air furnace. |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| NZ527408A (en) * | 2001-02-22 | 2005-04-29 | Skyepharma Canada Inc | Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia |
| WO2008073300A2 (en) * | 2006-12-08 | 2008-06-19 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
| US20130064834A1 (en) * | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| EP2216016A1 (en) * | 2009-02-06 | 2010-08-11 | LEK Pharmaceuticals d.d. | Process for the preparation of a pharmaceutical composition comprising ezetimibe |
| CN102753186B (zh) * | 2010-01-08 | 2016-09-14 | Isis制药公司 | 血管生成素样3表达的调节 |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| AR087329A1 (es) * | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EA039663B1 (ru) | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| HK1224186A1 (zh) * | 2013-11-20 | 2017-08-18 | Cymabay Therapeutics, Inc. | 纯阖家族型高胆固醇血症的治疗 |
| PT3087183T (pt) * | 2013-12-24 | 2020-10-08 | Ionis Pharmaceuticals Inc | Modulação da expressão da proteína relacionada com angiopoietina 3 |
| US9382540B2 (en) * | 2014-05-01 | 2016-07-05 | Isis Pharmaceuticals, Inc | Compositions and methods for modulating angiopoietin-like 3 expression |
| MA43734A (fr) * | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| RS62769B1 (sr) * | 2016-04-08 | 2022-01-31 | Regeneron Pharma | Postupci za lečenje hiperlipidemije inhibitorom angptl8 i inhibitorom angptl3 |
-
2017
- 2017-04-27 FI FIEP17722604.0T patent/FI3448426T3/fi active
- 2017-04-27 WO PCT/US2017/029782 patent/WO2017189813A1/en not_active Ceased
- 2017-04-27 US US15/498,687 patent/US20170312359A1/en not_active Abandoned
- 2017-04-27 PL PL17722604.0T patent/PL3448426T3/pl unknown
- 2017-04-27 SI SI201731609T patent/SI3448426T1/sl unknown
- 2017-04-27 MA MA44764A patent/MA44764B1/fr unknown
- 2017-04-27 PT PT177226040T patent/PT3448426T/pt unknown
- 2017-04-27 JP JP2018556273A patent/JP7201437B2/ja active Active
- 2017-04-27 MX MX2018012741A patent/MX2018012741A/es unknown
- 2017-04-27 KR KR1020187034616A patent/KR20190003679A/ko not_active Ceased
- 2017-04-27 KR KR1020227036013A patent/KR20220148299A/ko not_active Ceased
- 2017-04-27 IL IL293308A patent/IL293308B2/en unknown
- 2017-04-27 HU HUE17722604A patent/HUE071912T2/hu unknown
- 2017-04-27 RS RS20250643A patent/RS66975B1/sr unknown
- 2017-04-27 HR HRP20250797TT patent/HRP20250797T1/hr unknown
- 2017-04-27 DK DK17722604.0T patent/DK3448426T3/da active
- 2017-04-27 KR KR1020247003356A patent/KR20240019856A/ko active Pending
- 2017-04-27 CN CN201780026147.XA patent/CN109069641A/zh active Pending
- 2017-04-27 MD MDE20190270T patent/MD3448426T2/ro unknown
- 2017-04-27 LT LTEPPCT/US2017/029782T patent/LT3448426T/lt unknown
- 2017-04-27 AU AU2017258105A patent/AU2017258105B2/en active Active
- 2017-04-27 SM SM20250230T patent/SMT202500230T1/it unknown
- 2017-04-27 CA CA3021884A patent/CA3021884A1/en active Pending
- 2017-04-27 EP EP17722604.0A patent/EP3448426B1/en active Active
- 2017-04-27 IL IL262591A patent/IL262591B/en unknown
- 2017-04-27 ES ES17722604T patent/ES3032667T3/es active Active
-
2018
- 2018-10-03 ZA ZA2018/06557A patent/ZA201806557B/en unknown
-
2019
- 2019-11-07 US US16/677,319 patent/US20200061189A1/en not_active Abandoned
-
2022
- 2022-07-07 US US17/859,996 patent/US20230000976A1/en not_active Abandoned
- 2022-09-14 JP JP2022145714A patent/JP7404471B2/ja active Active
-
2025
- 2025-07-14 US US19/268,651 patent/US20250332254A1/en active Pending
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