JP2016523847A5 - - Google Patents
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- JP2016523847A5 JP2016523847A5 JP2016518018A JP2016518018A JP2016523847A5 JP 2016523847 A5 JP2016523847 A5 JP 2016523847A5 JP 2016518018 A JP2016518018 A JP 2016518018A JP 2016518018 A JP2016518018 A JP 2016518018A JP 2016523847 A5 JP2016523847 A5 JP 2016523847A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 102000025171 antigen binding proteins Human genes 0.000 claims 10
- 108091000831 antigen binding proteins Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 3
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 3
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 229940030627 lipid modifying agent Drugs 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 229940122392 PCSK9 inhibitor Drugs 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 229940127355 PCSK9 Inhibitors Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 229960005110 cerivastatin Drugs 0.000 claims 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229960000815 ezetimibe Drugs 0.000 claims 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims 1
- 229940125753 fibrate Drugs 0.000 claims 1
- -1 fibrates Substances 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 229960002797 pitavastatin Drugs 0.000 claims 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832459P | 2013-06-07 | 2013-06-07 | |
| EP13305762.0A EP2810955A1 (en) | 2013-06-07 | 2013-06-07 | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| EP13305762.0 | 2013-06-07 | ||
| US61/832,459 | 2013-06-07 | ||
| US201361892215P | 2013-10-17 | 2013-10-17 | |
| US61/892,215 | 2013-10-17 | ||
| EP13306436.0 | 2013-10-18 | ||
| EP20130306436 EP2862877A1 (en) | 2013-10-18 | 2013-10-18 | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| US201461944855P | 2014-02-26 | 2014-02-26 | |
| US61/944,855 | 2014-02-26 | ||
| US201462002508P | 2014-05-23 | 2014-05-23 | |
| US62/002,508 | 2014-05-23 | ||
| PCT/US2014/041204 WO2014197752A1 (en) | 2013-06-07 | 2014-06-06 | Methods fo inhibting atherosclerosis by administering an inhibitor of pcsk9 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019033436A Division JP7112975B2 (ja) | 2013-06-07 | 2019-02-27 | Ｐｃｓｋ９のインヒビターの投与によりアテローム性動脈硬化を阻害する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523847A JP2016523847A (ja) | 2016-08-12 |
| JP2016523847A5 true JP2016523847A5 (cg-RX-API-DMAC7.html) | 2017-07-20 |
Family
ID=52008606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518018A Pending JP2016523847A (ja) | 2013-06-07 | 2014-06-06 | Ｐｃｓｋ９のインヒビターの投与によりアテローム性動脈硬化を阻害する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10494442B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3004171B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2016523847A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20160024906A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105705521A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014274844B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2914721A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201592267A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1222865A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2015016887A (cg-RX-API-DMAC7.html) |
| TW (2) | TW201534324A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014197752A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| AR084938A1 (es) | 2011-01-28 | 2013-07-10 | Sanofi Sa | Anticuerpos humanos contra la proproteina convertasa subtilisina/kexina tipo 9 (anti pcsk9) para usar en metodos para tratar grupos de pacientes |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| ES2773111T3 (es) | 2011-09-16 | 2020-07-09 | Regeneron Pharma | Inhibidor de la proproteína convertasa subtilisina/kexina 9 (PCSK9) para su uso en la reducción de los niveles de lipoproteína (a) |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| TW201534324A (zh) | 2013-06-07 | 2015-09-16 | Sanofi Sa | 藉由投與ｐｃｓｋ９抑制劑抑制動脈粥狀硬化的方法 |
| CN106062003A (zh) | 2013-11-12 | 2016-10-26 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| AU2015289874A1 (en) * | 2014-07-14 | 2017-02-02 | Amgen Inc. | Crystalline antibody formulations |
| KR20240017117A (ko) | 2014-07-16 | 2024-02-06 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| US10683366B2 (en) | 2015-09-25 | 2020-06-16 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of atherosclerosis |
| CN105214087B (zh) | 2015-10-29 | 2017-12-26 | 陈敏 | Pcsk9单克隆抗体在制备治疗炎症免疫性疾病药物中的应用 |
| SMT202300219T1 (it) * | 2016-02-17 | 2023-09-06 | Regeneron Pharma | Metodi per il trattamento o la prevenzione dell’aterosclerosi mediante somministrazione di un inibitore di angptl3 |
| JP7541810B2 (ja) | 2016-03-03 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ａｎｇｐｔｌ３阻害剤と組み合わせてｐｃｓｋ９阻害剤を投与することにより高脂血症を有する患者を処置するための方法 |
| MX2018016057A (es) * | 2016-06-24 | 2019-05-06 | Hoffmann La Roche | Composiciones y metodos para tratar enfermedades cardiovasculares. |
| JP2020502991A (ja) | 2016-09-20 | 2020-01-30 | ウーシー バイオロジクス アイルランド リミテッド | 新規抗ｐｃｓｋ９抗体 |
| BR112019020148A2 (pt) | 2017-04-13 | 2020-05-05 | Cadila Healthcare Ltd | peptídeo |
| US12253528B2 (en) * | 2018-09-05 | 2025-03-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating asthma and allergic diseases |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
| WO2021058597A1 (en) * | 2019-09-24 | 2021-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of determining whether a subject is at risk of developing arterial plaques |
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-
2014
- 2014-06-06 TW TW103119641A patent/TW201534324A/zh unknown
- 2014-06-06 CN CN201480032506.9A patent/CN105705521A/zh active Pending
- 2014-06-06 EP EP14737087.8A patent/EP3004171B1/en active Active
- 2014-06-06 MX MX2015016887A patent/MX2015016887A/es unknown
- 2014-06-06 EA EA201592267A patent/EA201592267A1/ru unknown
- 2014-06-06 TW TW108126132A patent/TW202021614A/zh unknown
- 2014-06-06 AU AU2014274844A patent/AU2014274844B2/en not_active Ceased
- 2014-06-06 WO PCT/US2014/041204 patent/WO2014197752A1/en not_active Ceased
- 2014-06-06 HK HK16111037.4A patent/HK1222865A1/zh unknown
- 2014-06-06 CA CA2914721A patent/CA2914721A1/en not_active Abandoned
- 2014-06-06 US US14/896,196 patent/US10494442B2/en active Active
- 2014-06-06 KR KR1020167000010A patent/KR20160024906A/ko not_active Ceased
- 2014-06-06 JP JP2016518018A patent/JP2016523847A/ja active Pending
- 2014-06-06 CN CN202010812439.XA patent/CN111920954A/zh active Pending
-
2018
- 2018-01-18 US US15/874,807 patent/US20180244801A1/en not_active Abandoned
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2019
- 2019-07-08 US US16/505,074 patent/US10995150B2/en active Active
-
2020
- 2020-02-19 AU AU2020201191A patent/AU2020201191A1/en not_active Abandoned
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