|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
|
JP2648897B2
(ja)
|
1991-07-01 |
1997-09-03 |
塩野義製薬株式会社 |
ピリミジン誘導体
|
|
AU2309692A
(en)
|
1991-07-03 |
1993-02-11 |
Cryolife, Inc. |
Method for stabilization of biomaterials
|
|
DE69333928T2
(de)
|
1992-04-30 |
2006-08-17 |
Probitas Pharma Inc., Los Angeles |
Verbesserte solubilisierung und stabilisierung des faktor viii-komplexes
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
GB9410534D0
(en)
|
1994-05-26 |
1994-07-13 |
Lynxvale Ltd |
Improvements in or relating to growth factor inhibitors
|
|
US6685940B2
(en)
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
JPH09154588A
(ja)
|
1995-10-07 |
1997-06-17 |
Toagosei Co Ltd |
Ｖｅｇｆ結合性ポリペプチド
|
|
JP2000509018A
(ja)
|
1996-03-26 |
2000-07-18 |
イーライ・リリー・アンド・カンパニー |
肥満タンパク質製剤
|
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
EP0852951A1
(de)
|
1996-11-19 |
1998-07-15 |
Roche Diagnostics GmbH |
Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
|
|
US7312196B2
(en)
|
1997-01-08 |
2007-12-25 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
US20070224663A1
(en)
|
1997-03-07 |
2007-09-27 |
Human Genome Sciences, Inc. |
Human Secreted Proteins
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
JP4549529B2
(ja)
|
1998-01-30 |
2010-09-22 |
サイオス，インコーポレーテッド |
ペプチドまたはタンパク質の制御放出送達
|
|
US7001892B1
(en)
|
1999-06-11 |
2006-02-21 |
Purdue Research Foundation |
Pharmaceutical materials and methods for their preparation and use
|
|
EP1514933A1
(en)
|
1999-07-08 |
2005-03-16 |
Research Association for Biotechnology |
Secretory protein or membrane protein
|
|
US7129338B1
(en)
|
1999-07-08 |
2006-10-31 |
Research Association For Biotechnology |
Secretory protein or membrane protein
|
|
US7029895B2
(en)
|
1999-09-27 |
2006-04-18 |
Millennium Pharmaceuticals, Inc. |
27411, a novel human PGP synthase
|
|
AU2001241461A1
(en)
|
2000-02-07 |
2001-08-14 |
Millennium Pharmaceuticals, Inc. |
Narc-1, novel subtilase-like homologs
|
|
US6659982B2
(en)
|
2000-05-08 |
2003-12-09 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
US6629949B1
(en)
|
2000-05-08 |
2003-10-07 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
PT1317537E
(pt)
|
2000-09-08 |
2007-02-28 |
Massachusetts Inst Technology |
Composições e métodos de análogos de g-csf
|
|
ATE442862T2
(de)
|
2000-10-12 |
2009-10-15 |
Genentech Inc |
Niederviskose konzentrierte proteinformulierungen
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
DE60235013D1
(de)
|
2001-07-25 |
2010-02-25 |
Facet Biotech Corp |
Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab
|
|
US20040101920A1
(en)
|
2002-11-01 |
2004-05-27 |
Czeslaw Radziejewski |
Modification assisted profiling (MAP) methodology
|
|
US20040191243A1
(en)
|
2002-12-13 |
2004-09-30 |
Bei Chen |
System and method for stabilizing antibodies with histidine
|
|
BRPI0403964B8
(pt)
|
2003-04-04 |
2021-05-25 |
Genentech Inc |
formulações líquidas estáveis, artigo manufaturado e uso dessas formulações para o tratamento de disfunção mediada por ige
|
|
EP1471152A1
(en)
|
2003-04-25 |
2004-10-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Mutations in the human PCSK9 gene associated to hypercholesterolemia
|
|
EP1740946B1
(en)
|
2004-04-20 |
2013-11-06 |
Genmab A/S |
Human monoclonal antibodies against cd20
|
|
US20110313024A1
(en)
|
2004-08-20 |
2011-12-22 |
Leonid Beigelman |
RNA INTERFERENCE MEDIATED INHIBITION OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20060147945A1
(en)
|
2005-01-06 |
2006-07-06 |
Edmonds Brian T |
Novel secreted proteins and their uses
|
|
CN101489565A
(zh)
|
2006-05-05 |
2009-07-22 |
Isis药物公司 |
调节pcsk9表达的化合物和方法
|
|
EP2015758B1
(en)
|
2006-05-05 |
2014-04-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression apob
|
|
EP2835429B1
(en)
|
2006-05-11 |
2017-12-13 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibiting expression of the PCSK9 gene
|
|
RU2432155C3
(ru)
|
2006-06-16 |
2017-11-17 |
Ридженерон Фармасьютикалз, Инк. |
Составы антагониста vegf, подходящие для интравитреального введения
|
|
US7572618B2
(en)
|
2006-06-30 |
2009-08-11 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel PCSK9 variants
|
|
US7608693B2
(en)
|
2006-10-02 |
2009-10-27 |
Regeneron Pharmaceuticals, Inc. |
High affinity human antibodies to human IL-4 receptor
|
|
WO2008133647A2
(en)
|
2006-11-07 |
2008-11-06 |
Merck & Co., Inc. |
Antagonists of pcsk9
|
|
EP2083859A4
(en)
|
2006-11-07 |
2010-11-24 |
Merck Sharp & Dohme |
PCSK9 ANTAGONISTS
|
|
EP2083860A4
(en)
|
2006-11-07 |
2010-05-26 |
Merck Sharp & Dohme |
PCSK9 ANTAGONISTS
|
|
EP2083861A4
(en)
|
2006-11-07 |
2010-11-24 |
Merck Sharp & Dohme |
ANTAGONISTS OF PCSK9
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
CN101589143A
(zh)
*
|
2006-11-27 |
2009-11-25 |
Isis药物公司 |
用于治疗高胆固醇血症的方法
|
|
CN101679527A
(zh)
|
2007-04-13 |
2010-03-24 |
诺瓦提斯公司 |
用于调节前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)的分子和方法
|
|
JOP20080381B1
(ar)
|
2007-08-23 |
2023-03-28 |
Amgen Inc |
بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
|
|
US20100286021A1
(en)
|
2007-09-25 |
2010-11-11 |
Qun-Yong Zhou |
Methods of Modulating Prokineticin 2 for Treatment of Stress Response and Anxiety-Related Disorders
|
|
JP2011501952A
(ja)
|
2007-10-26 |
2011-01-20 |
シェーリング コーポレイション |
脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法
|
|
AR070315A1
(es)
|
2008-02-07 |
2010-03-31 |
Merck & Co Inc |
Anticuerpos 1b20 antagonistas de pcsk9
|
|
AR070316A1
(es)
|
2008-02-07 |
2010-03-31 |
Merck & Co Inc |
Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
|
|
KR102269708B1
(ko)
|
2008-04-11 |
2021-06-25 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
TWI445716B
(zh)
|
2008-09-12 |
2014-07-21 |
Rinat Neuroscience Corp |
Ｐｃｓｋ９拮抗劑類
|
|
EP2331090B1
(en)
|
2008-09-19 |
2018-01-03 |
Pfizer Inc. |
Stable liquid antibody formulation
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
WO2010068526A1
(en)
|
2008-12-12 |
2010-06-17 |
Merck Sharp & Dohme Corp. |
Pcsk9 immunoassay
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
US8357371B2
(en)
|
2008-12-15 |
2013-01-22 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia using antibodies to PCSK9
|
|
US20130064834A1
(en)
|
2008-12-15 |
2013-03-14 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia using antibodies to pcsk9
|
|
AU2010221156A1
(en)
|
2009-03-06 |
2011-09-22 |
Genentech, Inc. |
Antibody formulation
|
|
NZ597504A
(en)
|
2009-06-15 |
2013-10-25 |
Alnylam Pharmaceuticals Inc |
Lipid formulated dsrna targeting the pcsk9 gene
|
|
WO2010148337A1
(en)
|
2009-06-18 |
2010-12-23 |
Wyeth Llc |
Lyophilized formulations for small modular immunopharmaceuticals
|
|
WO2011006000A1
(en)
|
2009-07-08 |
2011-01-13 |
Haiyan Liu |
Berberine derivatives useful for modulating lipid levels and their methods of synthesis
|
|
EP2456870A1
(en)
|
2009-07-21 |
2012-05-30 |
Santaris Pharma A/S |
Antisense oligomers targeting pcsk9
|
|
WO2011028938A1
(en)
|
2009-09-02 |
2011-03-10 |
Alnylam Pharmaceuticals, Inc. |
Methods for lowering serum cholestrol in a subject using inhibition of pcsk9
|
|
US20120219558A1
(en)
|
2009-09-25 |
2012-08-30 |
Yan Ni |
Antagonists of pcsk9
|
|
WO2011039578A1
(en)
|
2009-10-02 |
2011-04-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination of spla2 activity and lp(a) cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event
|
|
CN102639150A
(zh)
|
2009-10-30 |
2012-08-15 |
默沙东公司 |
Ax213和ax132 pcsk9拮抗剂和变体
|
|
WO2011053759A1
(en)
|
2009-10-30 |
2011-05-05 |
Merck Sharp & Dohme Corp. |
Ax1 and ax189 pcsk9 antagonists and variants
|
|
CN102770157B
(zh)
|
2009-11-20 |
2017-05-17 |
拜康有限公司 |
抗体的配制品
|
|
AR079336A1
(es)
|
2009-12-11 |
2012-01-18 |
Irm Llc |
Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
AU2011225716A1
(en)
|
2010-03-11 |
2012-09-27 |
Pfizer Inc. |
Antibodies with pH dependent antigen binding
|
|
GB201005005D0
(en)
|
2010-03-25 |
2010-05-12 |
Angeletti P Ist Richerche Bio |
New vaccine
|
|
AU2011202239C1
(en)
|
2010-05-19 |
2017-03-16 |
Sanofi |
Long-acting formulations of insulins
|
|
DE102010024698A1
(de)
|
2010-06-23 |
2011-12-29 |
Eads Deutschland Gmbh |
Verfahren, Vorrichtung und Anordnung zur Entfernung organischer Verschmutzung von Anströmbereichen eines Luftfahrzeugs
|
|
PH12013500672A1
(en)
|
2010-10-06 |
2013-06-03 |
Regeneron Pharma |
Stabilized formulations containing anti-interleukin-4-receptor (il-4r) antibodies
|
|
WO2012054438A1
(en)
|
2010-10-22 |
2012-04-26 |
Schering Corporation |
Anti-pcsk9
|
|
US9518132B2
(en)
|
2010-11-09 |
2016-12-13 |
Altimab Therapeutics, Inc. |
Protein complexes for antigen binding and methods of use
|
|
US20120195910A1
(en)
|
2010-12-22 |
2012-08-02 |
Genentech, Inc. |
Anti-pcsk9 antibodies and methods of use
|
|
AR084938A1
(es)
|
2011-01-28 |
2013-07-10 |
Sanofi Sa |
Anticuerpos humanos contra la proproteina convertasa subtilisina/kexina tipo 9 (anti pcsk9) para usar en metodos para tratar grupos de pacientes
|
|
JP2014511378A
(ja)
|
2011-02-11 |
2014-05-15 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
Ｐｃｓｋ９アンタゴニスト
|
|
AR088782A1
(es)
|
2011-04-29 |
2014-07-10 |
Sanofi Sa |
Sistemas de ensayo y metodos para identificar y caracterizar farmacos hipolipemiantes
|
|
US20140004122A1
(en)
|
2011-05-10 |
2014-01-02 |
Amgen Inc. |
Methods for treating or preventing cholesterol related disorders
|
|
JOP20200043A1
(ar)
|
2011-05-10 |
2017-06-16 |
Amgen Inc |
طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
|
|
EP2731623A1
(en)
|
2011-07-14 |
2014-05-21 |
Pfizer Inc |
Treatment with anti-pcsk9 antibodies
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
AR087715A1
(es)
|
2011-09-16 |
2014-04-09 |
Lilly Co Eli |
Anticuerpos anti pcsk9 y usos de los mismos
|
|
ES2773111T3
(es)
|
2011-09-16 |
2020-07-09 |
Regeneron Pharma |
Inhibidor de la proproteína convertasa subtilisina/kexina 9 (PCSK9) para su uso en la reducción de los niveles de lipoproteína (a)
|
|
EP2839037B1
(en)
|
2012-04-19 |
2018-12-26 |
Acetylon Pharmaceuticals, Inc. |
Biomarkers to identify patients that will respond to treatment and treating such patients
|
|
EA039663B1
(ru)
|
2012-05-03 |
2022-02-24 |
Амген Инк. |
Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
|
|
KR20150041662A
(ko)
|
2012-08-13 |
2015-04-16 |
리제너론 파아마슈티컬스, 인크. |
Ｐｈ-의존적 결합 특성을 갖는 항-ｐｃｓｋ9 항체
|
|
EP2703008A1
(en)
|
2012-08-31 |
2014-03-05 |
Sanofi |
Human antibodies to PCSK9 for use in methods of treating particular groups of subjects
|
|
EP2703009A1
(en)
|
2012-08-31 |
2014-03-05 |
Sanofi |
Combination treatments involving antibodies to human PCSK9
|
|
EP2706070A1
(en)
|
2012-09-06 |
2014-03-12 |
Sanofi |
Combination treatments involving antibodies to human PCSK9
|
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
|
TWI682780B
(zh)
|
2013-05-30 |
2020-01-21 |
美商再生元醫藥公司 |
醫藥組成物用於製造治療與ｐｃｓｋ９功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
|
|
TW201534324A
(zh)
|
2013-06-07 |
2015-09-16 |
Sanofi Sa |
藉由投與ｐｃｓｋ９抑制劑抑制動脈粥狀硬化的方法
|
|
EA037526B1
(ru)
|
2013-10-11 |
2021-04-08 |
Санофи Байотекнолоджи |
Применение ингибитора pcsk9 для лечения гиперлипидемии
|
|
CN106062003A
(zh)
|
2013-11-12 |
2016-10-26 |
赛诺菲生物技术公司 |
用于与pcsk9抑制剂一起使用的给药方案
|
|
US8945560B1
(en)
|
2014-07-15 |
2015-02-03 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
US8883157B1
(en)
|
2013-12-17 |
2014-11-11 |
Kymab Limited |
Targeting rare human PCSK9 variants for cholesterol treatment
|
|
US9034332B1
(en)
|
2014-07-15 |
2015-05-19 |
Kymab Limited |
Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
|
|
WO2015123423A2
(en)
|
2014-02-14 |
2015-08-20 |
Regeneron Pharmaceuticals, Inc |
Methods for treating patients with hypercholesterolemia that is not adequately controlled by moderate-dose statin therapy
|
|
CA2942549A1
(en)
|
2014-03-17 |
2015-09-24 |
Sanofi Biotechnology |
Methods for reducing cardiovascular risk
|
|
US20150283236A1
(en)
|
2014-03-17 |
2015-10-08 |
Marie Baccara-Dinet |
Methods for treating subjects with primary hypercholesterolemia that is not adequately controlled
|
|
KR20240017117A
(ko)
|
2014-07-16 |
2024-02-06 |
사노피 바이오테크놀로지 |
이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법
|
|
EP3753575A1
(en)
|
2014-07-16 |
2020-12-23 |
Sanofi Biotechnology |
Methods for treating high cardiovascular risk patients with hypercholesterolemia using inhibitors of pcsk9
|
|
EA201890519A1
(ru)
|
2015-08-18 |
2018-07-31 |
Ридженерон Фармасьютикалз, Инк. |
Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов
|
|
US20190031774A1
(en)
|
2017-06-09 |
2019-01-31 |
Sanofi Biotechnology |
Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor
|