JP2016520548A5 - - Google Patents

Download PDF

Info

Publication number
JP2016520548A5
JP2016520548A5 JP2016506307A JP2016506307A JP2016520548A5 JP 2016520548 A5 JP2016520548 A5 JP 2016520548A5 JP 2016506307 A JP2016506307 A JP 2016506307A JP 2016506307 A JP2016506307 A JP 2016506307A JP 2016520548 A5 JP2016520548 A5 JP 2016520548A5
Authority
JP
Japan
Prior art keywords
cancer
antibody
inducing
composition
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016506307A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016520548A (ja
JP6361039B2 (ja
Filing date
Publication date
Priority claimed from US13/966,450 external-priority patent/US9315567B2/en
Application filed filed Critical
Priority claimed from PCT/US2013/075201 external-priority patent/WO2014163684A1/en
Publication of JP2016520548A publication Critical patent/JP2016520548A/ja
Publication of JP2016520548A5 publication Critical patent/JP2016520548A5/ja
Application granted granted Critical
Publication of JP6361039B2 publication Critical patent/JP6361039B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016506307A 2013-04-03 2013-12-14 疾患に対する免疫反応を誘導するための併用療法 Active JP6361039B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361807998P 2013-04-03 2013-04-03
US61/807,998 2013-04-03
US13/966,450 2013-08-14
US13/966,450 US9315567B2 (en) 2012-08-14 2013-08-14 T-cell redirecting bispecific antibodies for treatment of disease
PCT/US2013/075201 WO2014163684A1 (en) 2013-04-03 2013-12-14 Combination therapy for inducing immune response to disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018085760A Division JP2018135371A (ja) 2013-04-03 2018-04-26 疾患に対する免疫反応を誘導するための併用療法

Publications (3)

Publication Number Publication Date
JP2016520548A JP2016520548A (ja) 2016-07-14
JP2016520548A5 true JP2016520548A5 (https=) 2016-12-22
JP6361039B2 JP6361039B2 (ja) 2018-07-25

Family

ID=51658778

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016506307A Active JP6361039B2 (ja) 2013-04-03 2013-12-14 疾患に対する免疫反応を誘導するための併用療法
JP2018085760A Pending JP2018135371A (ja) 2013-04-03 2018-04-26 疾患に対する免疫反応を誘導するための併用療法
JP2019038757A Active JP6767029B2 (ja) 2013-04-03 2019-03-04 疾患に対する免疫反応を誘導するための併用療法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018085760A Pending JP2018135371A (ja) 2013-04-03 2018-04-26 疾患に対する免疫反応を誘導するための併用療法
JP2019038757A Active JP6767029B2 (ja) 2013-04-03 2019-03-04 疾患に対する免疫反応を誘導するための併用療法

Country Status (5)

Country Link
EP (1) EP2981281B1 (https=)
JP (3) JP6361039B2 (https=)
CN (2) CN105073128A (https=)
CA (1) CA2899577C (https=)
WO (1) WO2014163684A1 (https=)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
PL3102605T3 (pl) 2014-02-04 2019-06-28 Pfizer Inc. Połączenie antagonisty pd-1 i inhibitora vegfr do leczenia nowotworu
JP6447933B2 (ja) 2014-02-21 2019-01-09 アイビーシー ファーマスーティカルズ,インコーポレイテッド Trop−2発現細胞に対する免疫応答を誘発することによる疾患治療
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
EP4141032B1 (en) 2014-11-20 2024-05-29 F. Hoffmann-La Roche AG Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
EP3865139B1 (en) 2015-02-18 2023-05-03 Enlivex Therapeutics Rdo Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
WO2016170541A1 (en) 2015-04-21 2016-10-27 Enlivex Therapeutics Ltd. Therapeutic pooled blood apoptotic cell preparations and uses thereof
RU2714233C2 (ru) 2015-02-26 2020-02-13 Мерк Патент Гмбх Ингибиторы pd-1 / pd-l1 для лечения рака
CN114920848B (zh) * 2015-05-13 2024-10-11 埃博灵克斯股份有限公司 基于cd3反应性的t细胞募集多肽
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
JP2018516950A (ja) * 2015-06-12 2018-06-28 イミュンジーン, インコーポレイテッドImmunGene, Inc. がん治療のための集中インターフェロン免疫療法
MY193229A (en) 2015-06-16 2022-09-26 Merck Patent GmbH Pd-l1 antagonist combination treatments
JP2018519832A (ja) * 2015-06-30 2018-07-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 多重特異的結合タンパク質
TWI746449B (zh) * 2015-07-20 2021-11-21 美商Ai治療公司 使用阿吡莫德治療癌症之方法
US11045547B2 (en) 2015-12-16 2021-06-29 Merck Sharp & Dohme Corp. Anti-LAG3 antibodies and antigen-binding fragments
EP3400218A4 (en) * 2016-01-08 2019-09-18 Euclises Pharmaceuticals, Inc. COMBINATION OF A CHROME CONNECTION AND A SECOND ACTIVE SUBSTANCE
KR20180097615A (ko) 2016-01-08 2018-08-31 에프. 호프만-라 로슈 아게 Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
CN109069539A (zh) 2016-02-18 2018-12-21 恩立夫克治疗有限责任公司 用于癌症治疗的联合免疫疗法和细胞因子控制疗法
KR20180133442A (ko) * 2016-04-13 2018-12-14 비비아 바이오테크 에스.엘. 생체외 bite 활성화된 t 세포
US20190282679A1 (en) 2016-04-18 2019-09-19 Rima McLeod Toxoplasma gondii vaccines and their use
AU2017257254B2 (en) * 2016-04-27 2022-02-24 Immunomedics, Inc. Efficacy of anti-Trop-2-SN-38 antibody drug conjugates for therapy of tumors relapsed/refractory to checkpoint inhibitors
WO2017189906A1 (en) * 2016-04-27 2017-11-02 Mira Dx, Inc. Immune-based treatment of kras-variant cancer patients
CN109195992A (zh) * 2016-04-29 2019-01-11 本康生物制药(深圳)有限公司 多特异性结合偶联物、相关的药物组合物及应用
AU2017261353A1 (en) * 2016-05-05 2018-11-08 Nantomics, Llc Checkpoint failure and methods therefor
WO2017214575A1 (en) * 2016-06-10 2017-12-14 Io Therapeutics, Inc. Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy
CN105943510A (zh) * 2016-06-13 2016-09-21 佛山市腾瑞医药科技有限公司 一种艾代拉利司制剂及其应用
EP4101447A1 (en) 2016-06-30 2022-12-14 Nant Holdings IP, LLC Nant cancer vaccine
WO2018028449A1 (en) * 2016-08-08 2018-02-15 Beigene, Ltd. Method for predicting efficacy of immune checkpoint inhibitors in cancer patients
ES2981272T3 (es) 2016-09-23 2024-10-08 Merus Nv Moléculas de unión que modulan una actividad biológica expresada por una célula
US12188935B2 (en) 2016-09-30 2025-01-07 Centre National De La Recherche Scientifique Method for the evaluation of antiretroviral therapy (ART) effectiveness in HIV-1 CD4+CD89+ cellular reservoirs
EP3904880A1 (fr) * 2016-09-30 2021-11-03 Centre national de la recherche scientifique Marqueurs membranaires
KR20190062515A (ko) 2016-10-06 2019-06-05 화이자 인코포레이티드 암의 치료를 위한 아벨루맙의 투약 용법
JP6948685B2 (ja) * 2016-11-04 2021-10-13 国立大学法人金沢大学 抗癌作用増強剤及び癌治療支援方法
CA3041375A1 (en) * 2016-11-04 2018-05-11 Vaximm Ag Wt1 targeting dna vaccine for combination therapy
EP3541838A1 (en) * 2016-11-16 2019-09-25 Eli Lilly and Company Therapy for metatastic colorectal cancer using anti-vegfr-2 and anti-vegf-d antibodies
CN110573172A (zh) 2017-02-06 2019-12-13 奥里尼斯生物科学有限公司 靶向的工程化干扰素及其用途
JP2020508323A (ja) * 2017-02-23 2020-03-19 ラクテン メディカル インコーポレイテッド 光免疫療法のための治療用組成物および関連する方法
WO2018178047A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Multispecific antibody constructs binding to muc1 and cd3
CN110505883A (zh) * 2017-04-13 2019-11-26 豪夫迈·罗氏有限公司 供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂
WO2019014468A1 (en) 2017-07-13 2019-01-17 Io Therapeutics, Inc. RECEPTOR SUBTYPE AND RETINOID COMPOUNDS AND SELECTIVE REXINOIDS OF A FUNCTION IN COMBINATION WITH IMMUNE MODULATORS FOR ANTICANCER IMMUNOTHERAPY
US10363272B2 (en) 2017-08-31 2019-07-30 Io Therapeutics, Inc. RAR selective agonists in combination with immune modulators for cancer immunotherapy
CN111491665B (zh) * 2017-09-26 2024-08-06 中外制药株式会社 药物组合物
CN109954131B (zh) * 2017-12-14 2023-05-02 深圳市中科艾深医药有限公司 一种肿瘤坏死因子相关凋亡诱导配体拮抗剂作为脓毒血症治疗药物的应用
US20190184028A1 (en) * 2017-12-14 2019-06-20 Janssen Biotech, Inc. Targeting with firbronectin type iii like domain molecules
AU2019221544B2 (en) * 2018-02-13 2025-07-10 Precision Biologics, Inc. Methods and compositions for targeting Treg cells
KR102373502B1 (ko) 2018-05-14 2022-03-11 주식회사 금호에이치티 골수유래억제세포 관련 질환의 예방 및 치료 용도
EP3569617A1 (en) * 2018-05-18 2019-11-20 Trion Research GmbH Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases
EP3802595A1 (en) * 2018-06-07 2021-04-14 OncoOne Research & Development GmbH Anti-oxmif/anti-cd3 antibody for cancer treatment
JP7541930B2 (ja) * 2018-06-29 2024-08-29 ジーオー セラピューティクス,インコーポレイテッド 抗グリコmuc1抗体およびその使用
BR112021001992A2 (pt) * 2018-08-02 2021-05-04 The Board Of Regents Of The University Of Texas System efeito adjuvante do agonista tlr1/2 diprovocim sinergiza com anticorpos inibidores de checkpoint para eliminar doença
KR102817790B1 (ko) * 2018-08-29 2025-06-05 케모센트릭스, 인크. C-c 케모카인 수용체 4(ccr4) 길항제 및 하나 이상의 면역 체크포인트 억제제를 사용한 병용 요법
EP3860715A1 (en) * 2018-10-04 2021-08-11 Genmab Holding B.V. Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
KR102297440B1 (ko) * 2018-10-05 2021-09-02 알엔에이진(주) 표적 세포 특이적으로 결합하여 다중 면역기능이 강화된 키메라항원 및 이의용도
WO2020092839A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3873540A4 (en) 2018-10-31 2022-07-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
EP3897844B1 (en) * 2018-12-19 2023-11-15 Deutsches Krebsforschungszentrum Pharmaceutical combination of anti ceacam6 and tim3 antibodies
CN110846279B (zh) * 2018-12-27 2023-06-16 重庆医药高等专科学校附属第一医院 人套细胞淋巴瘤细胞株及其建立方法和应用
EP3914621A1 (en) * 2019-01-21 2021-12-01 Singapore Health Services Pte. Ltd. Treatment of hepatotoxicity
TWI899079B (zh) * 2019-05-23 2025-10-01 美商維洛斯生物公司 抗ror1/抗cd3雙特異性結合分子
KR20210021861A (ko) * 2019-08-19 2021-03-02 (주)제노팜 사람 표피성장인자수용체 2 양성 암을 치료하기 위한 인터페론-베타 변이체 면역사이토카인의 용도 및 환자 선별 방법
EP4061487A4 (en) * 2019-11-19 2023-12-20 Rootpath Genomics, Inc. COMPOSITIONS AND METHODS FOR IDENTIFYING T CELL RECEPTOR
US20230242655A1 (en) 2019-12-03 2023-08-03 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
EP4125946A4 (en) * 2020-03-27 2024-04-24 Board of Regents, The University of Texas System MONOCLONAL ANTIBODIES TARGETING HSP70 AND THEIR THERAPEUTIC USES
US20230241237A1 (en) * 2020-04-16 2023-08-03 Emory University Immune Cell Redirecting Compositions and Therapeutic Uses Thereof
CN111705013B (zh) * 2020-06-02 2021-12-07 华中农业大学 一种牛支原体Mbov_0570基因突变株及其应用
AU2021292488A1 (en) * 2020-06-15 2023-02-02 Monopar Therapeutics, Inc. Precision radioimmunotherapeutic targeting of the urokinase plasminogen activator receptor (uPAR) for treatment of severe COVID-19 disease
CN111850002B (zh) * 2020-06-22 2022-04-19 华中农业大学 牛支原体分泌蛋白MbovP570的应用
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
WO2022046658A1 (en) * 2020-08-24 2022-03-03 Janux Therapeutics, Inc. Antibodies targeting trop2 and cd3 and uses thereof
IL300835A (en) * 2020-09-02 2023-04-01 Genmab As Antibody therapy
EP4247412A4 (en) * 2020-11-18 2024-10-23 University of Florida Research Foundation, Inc. Materials and methods for sensitizing tumors to immune response
JP2022157223A (ja) * 2021-03-31 2022-10-14 国立大学法人神戸大学 抗ガン剤効果増強剤
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates
CN115671253B (zh) * 2021-07-30 2024-02-27 河北菲尼斯生物技术有限公司 Se-dr亲和肽在制备治疗风湿疾病的药物中的用途
WO2023056240A2 (en) 2021-09-28 2023-04-06 Frontaim Biomedicines, Inc. Multiple formats of molecular complexes
AU2022375782B2 (en) 2021-10-28 2026-02-26 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
JP7787991B2 (ja) 2021-10-29 2025-12-17 ギリアード サイエンシーズ, インコーポレイテッド Cd73化合物
US12122764B2 (en) 2021-12-22 2024-10-22 Gilead Sciences, Inc. IKAROS zinc finger family degraders and uses thereof
KR20240123836A (ko) 2021-12-22 2024-08-14 길리애드 사이언시즈, 인코포레이티드 이카로스 아연 핑거 패밀리 분해제 및 이의 용도
CN114209652B (zh) * 2021-12-29 2022-08-09 中山大学附属第一医院 一种微环境nk细胞免疫调控递送系统及其制备方法和应用
CN114300089B (zh) * 2022-01-04 2024-09-03 哈尔滨医科大学 一种中晚期结直肠癌治疗方案决策算法
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
US12365743B2 (en) 2022-02-23 2025-07-22 Xencor, Inc. Anti-CD28 x anti-PSMA antibodies
WO2023164640A1 (en) * 2022-02-24 2023-08-31 Xencor, Inc. Anti-cd28 x anti-trop2 antibodies
WO2023178181A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CA3256048A1 (en) 2022-04-13 2023-10-19 Arcus Biosciences, Inc. POLYTHERAPY FOR THE TREATMENT OF CANCERS EXPRESSING A TUMOR ANTIGEN
JP2025512384A (ja) 2022-04-13 2025-04-17 ギリアード サイエンシーズ, インコーポレイテッド Trop-2発現がんを治療するための併用療法
CR20240451A (es) 2022-04-21 2024-12-04 Gilead Sciences Inc Compuestos de modulación de kras g12d
KR20250028371A (ko) 2022-07-01 2025-02-28 길리애드 사이언시즈, 인코포레이티드 Cd73 화합물
TW202413405A (zh) * 2022-07-13 2024-04-01 美商翰森生物有限責任公司 抗體、其抗原結合片段及其藥物用途
WO2024097812A1 (en) 2022-11-04 2024-05-10 Gilead Sciences, Inc. Therapy for treating bladder cancer
CN115975026B (zh) * 2022-11-15 2024-06-25 青海大学 一种抗多房棘球蚴原头节的纳米抗体、重组菌及其应用
AU2023409398A1 (en) 2022-12-22 2025-06-05 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
AU2024252725A1 (en) 2023-04-11 2025-11-06 Gilead Sciences, Inc. Kras modulating compounds
CR20250446A (es) 2023-04-21 2025-12-02 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
AU2024306338A1 (en) 2023-06-30 2026-01-08 Gilead Sciences, Inc. Kras modulating compounds
KR20260046403A (ko) 2023-07-26 2026-04-07 길리애드 사이언시즈, 인코포레이티드 Parp7 저해제
CN121620513A (zh) 2023-07-26 2026-03-06 吉利德科学公司 Parp7抑制剂
WO2025027090A1 (en) * 2023-07-31 2025-02-06 Danmarks Tekniske Universitet Inhibitors of cell envelope proteinases from lactic acid bacteria
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
CN116874606B (zh) * 2023-09-08 2023-11-24 益科思特(北京)医药科技发展有限公司 一种靶向trop2和cd3的双特异性抗体及其制备方法与应用
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025184896A1 (zh) * 2024-03-08 2025-09-12 四川大学华西医院 增强免疫检查点抑制剂抗肿瘤疗效的方法和药物及其应用
WO2025245003A1 (en) 2024-05-21 2025-11-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20260098049A1 (en) 2024-08-12 2026-04-09 Gilead Sciences, Inc. Kras modulating compounds
CN120518757B (zh) * 2025-07-23 2025-09-23 中国人民解放军军事科学院军事医学研究院 一种聚乙二醇化多价抗西尼罗病毒单链抗体
CN121293363B (zh) * 2025-12-09 2026-04-21 上海玄言生物科技有限公司 一种靶向cd14和cd3的双功能t细胞衔接器及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550143B2 (en) * 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US20110020273A1 (en) * 2005-04-06 2011-01-27 Ibc Pharmaceuticals, Inc. Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof
US8481041B2 (en) * 2005-04-06 2013-07-09 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy
DK2439273T3 (da) * 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
DK1912677T3 (da) * 2005-06-20 2014-01-13 Psma Dev Company L L C PSMA-antistof-lægemiddel-konjugater
US8110194B2 (en) * 2005-12-07 2012-02-07 Medarex, Inc. CTLA-4 antibody dosage escalation regimens
WO2009070642A1 (en) * 2007-11-28 2009-06-04 Medimmune, Llc Protein formulation
AU2009279503B2 (en) * 2008-08-08 2014-05-29 Immunomedics, Inc. Anti-pancreatic cancer antibodies
CA2772572A1 (en) * 2009-08-31 2011-03-03 Ibc Pharmaceuticals, Inc. Bispecific immunocytokine dock-and-lock (dnl) complexes and therapeutic use thereof
US9249217B2 (en) * 2010-12-03 2016-02-02 Secretary, DHHS Bispecific EGFRvIII x CD3 antibody engaging molecules
AU2012245116A1 (en) * 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
MX368257B (es) * 2011-08-01 2019-09-26 Genentech Inc Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer.
CN104379169A (zh) * 2012-08-14 2015-02-25 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体

Similar Documents

Publication Publication Date Title
JP2016520548A5 (https=)
JP6767029B2 (ja) 疾患に対する免疫反応を誘導するための併用療法
JP6759508B2 (ja) Trop−2発現細胞に対する免疫応答を誘発することによる疾患治療
US10662252B2 (en) Disease therapy by inducing immune response to Trop-2 expressing cells
US10669338B2 (en) Anti-PD-1 checkpoint inhibitor antibodies that block binding of PD-L1 to PD-1
US10245321B2 (en) Combination therapy for inducing immune response to disease
US10111954B2 (en) Combination therapy for inducing immune response to disease
US10131712B2 (en) Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors
US20160361360A1 (en) Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
WO2018217227A1 (en) Novel anti-pd-1 checkpoint inhibitor antibodies that block binding of pd-l1 to pd-1
JP2012500286A5 (https=)
IL278350B (en) J-chain qualified
WO2017210058A1 (en) Combination therapy with t-cell redirecting bispecific antibodies and checkpoint inhibitors
US20220288118A1 (en) Depletion regimes for engineered t-cell or nk-cell therapy
EP3599250A1 (en) Antibody conjugate, and related pharmaceutical composition and application