JP2016520514A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016520514A5 JP2016520514A5 JP2016501063A JP2016501063A JP2016520514A5 JP 2016520514 A5 JP2016520514 A5 JP 2016520514A5 JP 2016501063 A JP2016501063 A JP 2016501063A JP 2016501063 A JP2016501063 A JP 2016501063A JP 2016520514 A5 JP2016520514 A5 JP 2016520514A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- humanized
- antigen
- binding construct
- lcdr1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780286P | 2013-03-13 | 2013-03-13 | |
| US61/780,286 | 2013-03-13 | ||
| PCT/US2014/022782 WO2014164553A1 (en) | 2013-03-13 | 2014-03-10 | Antigen binding constructs to cd8 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018230270A Division JP6856611B2 (ja) | 2013-03-13 | 2018-12-07 | Ｃｄ８に対する抗原結合性構築物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520514A JP2016520514A (ja) | 2016-07-14 |
| JP2016520514A5 true JP2016520514A5 (enExample) | 2017-04-13 |
| JP6815196B2 JP6815196B2 (ja) | 2021-01-20 |
Family
ID=51527868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501063A Active JP6815196B2 (ja) | 2013-03-13 | 2014-03-10 | Ｃｄ８に対する抗原結合性構築物 |
| JP2018230270A Active JP6856611B2 (ja) | 2013-03-13 | 2018-12-07 | Ｃｄ８に対する抗原結合性構築物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018230270A Active JP6856611B2 (ja) | 2013-03-13 | 2018-12-07 | Ｃｄ８に対する抗原結合性構築物 |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US10414820B2 (enExample) |
| EP (3) | EP4411378A3 (enExample) |
| JP (2) | JP6815196B2 (enExample) |
| KR (2) | KR20150131208A (enExample) |
| CN (2) | CN113045660B (enExample) |
| AU (2) | AU2014249243C1 (enExample) |
| CA (1) | CA2904969C (enExample) |
| WO (1) | WO2014164553A1 (enExample) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2598530A2 (en) | 2010-07-29 | 2013-06-05 | Xencor, Inc. | Antibodies with modified isoelectric points |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| KR102391731B1 (ko) | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| WO2014113510A1 (en) | 2013-01-15 | 2014-07-24 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd８에의 항원 결합 구조체들 |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| EP3421495A3 (en) | 2013-03-15 | 2019-05-15 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| PL3122781T3 (pl) | 2014-03-28 | 2020-06-15 | Xencor, Inc. | Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3 |
| US20160176969A1 (en) * | 2014-11-26 | 2016-06-23 | Xencor, Inc. | Heterodimeric antibodies including binding to cd8 |
| JP6696982B2 (ja) | 2014-11-26 | 2020-05-20 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | Ｃｄ３および腫瘍抗原に結合するヘテロ二量体抗体 |
| HK1245171A1 (zh) | 2014-11-26 | 2018-08-24 | Xencor, Inc. | 结合cd3和cd38的异二聚体抗体 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| US10428155B2 (en) | 2014-12-22 | 2019-10-01 | Xencor, Inc. | Trispecific antibodies |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| EP3387013B1 (en) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
| US11661455B2 (en) | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
| CN109071632B (zh) | 2016-02-05 | 2022-12-30 | 奥里尼斯生物科学私人有限公司 | 靶向性治疗剂及其用途 |
| WO2017176769A1 (en) * | 2016-04-04 | 2017-10-12 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
| MX395611B (es) | 2016-04-08 | 2025-03-25 | Adaptimmune Ltd | Receptores de celulas t. |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| CA3026151A1 (en) | 2016-06-14 | 2017-12-21 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| RU2019102008A (ru) | 2016-06-28 | 2020-07-28 | Ксенкор, Инк. | Гетеродимерные антитела, которые связывают рецептор соматостатина 2-го типа |
| JP6983824B2 (ja) * | 2016-07-04 | 2021-12-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規抗体フォーマット |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| MX2019004327A (es) | 2016-10-14 | 2019-10-14 | Xencor Inc | Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1. |
| RS67792B1 (sr) | 2016-12-01 | 2026-03-31 | Regeneron Pharma | Radio-obeležena anti-pd-l1 antitela za imuno-pet snimanje |
| KR102642385B1 (ko) | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
| WO2018147960A1 (en) * | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| BR112019016336A2 (pt) | 2017-02-10 | 2020-03-31 | Regeneron Pharmaceuticals, Inc. | Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto. |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| CN110997013B (zh) | 2017-07-24 | 2022-09-20 | 瑞泽恩制药公司 | 抗cd8抗体和其用途 |
| EP3664829A4 (en) | 2017-08-09 | 2021-05-05 | Orionis Biosciences, Inc. | LIAISON OFFICERS AT PD-1 AND PD-L1 |
| CN117924493A (zh) | 2017-08-09 | 2024-04-26 | 奥里尼斯生物科学有限公司 | Clec9a结合剂及其用途 |
| EP3665201A4 (en) * | 2017-08-09 | 2021-06-02 | Orionis Biosciences, Inc. | CD8 BINDERS |
| WO2019033043A2 (en) * | 2017-08-11 | 2019-02-14 | Genentech, Inc. | ANTI-CD8 ANTIBODIES AND USES THEREOF |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| JP7765181B2 (ja) | 2017-12-19 | 2025-11-06 | ゼンコア インコーポレイテッド | 改変されたｉｌ－２ ｆｃ融合タンパク質 |
| JP7462560B2 (ja) | 2018-01-03 | 2024-04-05 | パレオン ファーマシューティカルズ インコーポレイテッド | 組換えヒトシアリダーゼ、シアリダーゼ融合タンパク質およびそれらの使用方法 |
| US12655186B2 (en) | 2018-01-26 | 2026-06-16 | Orionis Biosciences, Inc. | Chimeric protein comprising anti-XCR1 antibody and modified interferon alpha 2 |
| CA3090406A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
| CN112469477A (zh) | 2018-04-04 | 2021-03-09 | Xencor股份有限公司 | 与成纤维细胞活化蛋白结合的异源二聚体抗体 |
| KR20210003814A (ko) | 2018-04-18 | 2021-01-12 | 젠코어 인코포레이티드 | IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질 |
| CA3097593A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
| AU2019282248A1 (en) | 2018-06-08 | 2021-01-07 | Imaginab, Inc. | Antigen binding constructs to CD4 |
| WO2020023702A1 (en) | 2018-07-25 | 2020-01-30 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| EP3833391A4 (en) | 2018-08-08 | 2022-08-10 | Orionis Biosciences, Inc. | ANTI-SIRP1ALPHA CHIMERIC PROTEINS AND USES THEREOF |
| WO2020069433A1 (en) | 2018-09-28 | 2020-04-02 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| KR102884523B1 (ko) | 2018-10-03 | 2025-11-10 | 젠코어 인코포레이티드 | IL-12 이종이량체 Fc-융합 단백질 |
| EP3890773A4 (en) | 2018-11-08 | 2022-11-09 | Orionis Biosciences, Inc. | MODULATION OF DENDRITIC CELL LINES |
| KR20210131991A (ko) | 2018-11-14 | 2021-11-03 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 구획-특이적 카고 전달을 위한 조성물 및 방법 |
| GB201819540D0 (en) * | 2018-11-30 | 2019-01-16 | Adaptimmune Ltd | T cell modification |
| EP3930850A1 (en) | 2019-03-01 | 2022-01-05 | Xencor, Inc. | Heterodimeric antibodies that bind enpp3 and cd3 |
| WO2020198665A1 (en) | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Fibroblast activation protein binding agents and use thereof |
| CN113840833B (zh) | 2019-03-28 | 2025-06-17 | 奥里尼斯生物科学股份有限公司 | 基于clec9a的嵌合蛋白复合物 |
| CN114341189A (zh) | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | 全新il-15前药及其应用 |
| BR112021026832A2 (pt) | 2019-07-02 | 2022-05-10 | Hutchinson Fred Cancer Res | Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| CN115103633B (zh) * | 2019-12-05 | 2023-09-12 | 伊麦吉纳博公司 | 使用多种成像剂的成像方法 |
| AU2021205981A1 (en) | 2020-01-11 | 2022-07-14 | AskGene Pharma, Inc. | Novel masked cytokines and methods of use thereof |
| EP4149632A1 (en) | 2020-05-14 | 2023-03-22 | Xencor, Inc. | Heterodimeric antibodies that bind msln and cd3 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| EP4186925A4 (en) * | 2020-07-21 | 2025-01-22 | Suzhou Smartnuclide Biopharmaceutical Co., Ltd. | CD8-BINDING POLYPEPTIDE AND USE THEREOF |
| US11919958B2 (en) | 2020-08-19 | 2024-03-05 | Xencor, Inc. | Anti-CD28 compositions |
| MX2023004299A (es) | 2020-10-13 | 2023-07-07 | Univ Pennsylvania | Direccionamiento de células t cd4+ in vivo para terapeuticos de arnm. |
| KR20230131236A (ko) * | 2021-01-06 | 2023-09-12 | 팔레온 파마슈티칼스 인크. | 항-pd-l1 항체 및 이의 융합 단백질 |
| KR20230151513A (ko) | 2021-01-11 | 2023-11-01 | 사나 바이오테크놀로지, 인크. | Cd8 표적 바이러스 벡터의 용도 |
| AU2022218137A1 (en) * | 2021-02-03 | 2023-08-24 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| US11859012B2 (en) | 2021-03-10 | 2024-01-02 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and GPC3 |
| JP2024532963A (ja) * | 2021-04-08 | 2024-09-11 | サナ バイオテクノロジー，インコーポレイテッド | Ｃｄ８特異的抗体コンストラクト及びその組成物 |
| WO2023010060A2 (en) | 2021-07-27 | 2023-02-02 | Novab, Inc. | Engineered vlrb antibodies with immune effector functions |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| AU2022388729A1 (en) | 2021-11-10 | 2024-05-16 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| WO2023114949A1 (en) | 2021-12-16 | 2023-06-22 | Sana Biotechnology, Inc. | Methods and systems of particle production |
| US20250082777A1 (en) | 2022-01-10 | 2025-03-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023150647A1 (en) | 2022-02-02 | 2023-08-10 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| US20260027145A1 (en) | 2022-07-27 | 2026-01-29 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
| EP4590688A1 (en) | 2022-09-21 | 2025-07-30 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| JP2026508657A (ja) | 2023-03-16 | 2026-03-11 | アイタブメッド カンパニー， リミテッド | 多重特異性抗原結合タンパク質及びその使用 |
| WO2024220597A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Digital droplet based assay for detecting replication competent lentiviral vector |
| AU2024274792A1 (en) | 2023-05-23 | 2025-10-23 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| EP4720124A1 (en) * | 2023-05-24 | 2026-04-08 | Mozart Therapeutics, Inc. | Cd8-specific binding proteins and methods of using the same |
| EP4658319A1 (en) | 2023-05-30 | 2025-12-10 | ImnoTech GmbH | Anti-cd2 single domain antibody, a pharmaceutical composition and a kit for use in the diagnosis and/or therapy of cancer |
| EP4719352A1 (en) | 2023-05-31 | 2026-04-08 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025064435A1 (en) | 2023-09-19 | 2025-03-27 | Imaginab, Inc. | Antigen binding constructs directed to integrin αvβ6 |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| EP4600270A1 (en) | 2024-02-08 | 2025-08-13 | ImnoTech GmbH | Anti-cd7 single domain antibody (sdab), a pharmaceutical composition and a kit for use in the diagnosis and/or therapy of cancer |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| CN118286410B (zh) * | 2024-06-06 | 2024-09-13 | 山东兴瑞生物科技有限公司 | 一种偶联CD8抗体的肿瘤mRNA疫苗的制备方法 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281061A (en) | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4709015A (en) | 1979-12-04 | 1987-11-24 | Ortho Pharmaceutical Corporation | Monoclonal antibody to human suppressor T cells |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| ZA936260B (en) | 1992-09-09 | 1994-03-18 | Smithkline Beecham Corp | Novel antibodies for conferring passive immunity against infection by a pathogen in man |
| CA2126967A1 (en) | 1992-11-04 | 1994-05-11 | Anna M. Wu | Novel antibody construct |
| US7435802B2 (en) | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
| WO1997000271A1 (en) * | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| CN104231078A (zh) * | 1997-04-07 | 2014-12-24 | 基因技术股份有限公司 | 抗-血管内皮生长因子的抗体 |
| DE19721700C1 (de) | 1997-05-23 | 1998-11-19 | Deutsches Krebsforsch | Mutierter OKT3-Antikörper |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| US20040209314A1 (en) | 1999-09-06 | 2004-10-21 | Institut National De La Sante Et De La Recherche Medicale France | Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA |
| RU2199115C2 (ru) | 2000-07-10 | 2003-02-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Способ прогноза развития инфекции и тяжелых инфекционных осложнений у больных гемобластозами на программной полихимиотерапии |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US8101157B2 (en) | 2001-10-03 | 2012-01-24 | Vanderbilt University | Ligands to radiation-induced molecules |
| KR101017732B1 (ko) | 2002-03-01 | 2011-02-28 | 이뮤노메딕스, 인코오포레이티드 | 내재화 항-ｃｄ74 항체 및 그 이용방법 |
| US20040018557A1 (en) | 2002-03-01 | 2004-01-29 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| DE60325564D1 (de) | 2002-03-05 | 2009-02-12 | Univ Texas | Biospezifische kontrastmittel |
| WO2003089930A1 (en) * | 2002-04-22 | 2003-10-30 | Georgetown University | Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration |
| US7993626B2 (en) | 2007-01-11 | 2011-08-09 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| US7597876B2 (en) | 2007-01-11 | 2009-10-06 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| US7563433B2 (en) | 2007-01-11 | 2009-07-21 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| CA2507080C (en) | 2002-11-27 | 2015-01-06 | Biogen Idec Ma Inc. | Humanized antibodies against monocyte chemotactic proteins |
| US7534427B2 (en) | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
| JP4874090B2 (ja) | 2003-01-31 | 2012-02-08 | イミューノメディクス、インコーポレイテッド | 治療薬および診断薬を投与するための方法および組成物 |
| EP1616016B1 (en) | 2003-03-19 | 2012-11-14 | Isogenis, Inc. | Gene therapy vectors having reduced immunogenicity based on cd8 alpha-chain |
| US9005613B2 (en) | 2003-06-16 | 2015-04-14 | Immunomedics, Inc. | Anti-mucin antibodies for early detection and treatment of pancreatic cancer |
| CA2441653A1 (en) | 2003-09-19 | 2005-03-19 | William Herman | Targeted ligands |
| WO2005086875A2 (en) * | 2004-03-11 | 2005-09-22 | City Of Hope | A humanized anti-cea t84.66 antibody and uses thereof |
| US20050281740A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
| WO2006049599A1 (en) | 2004-10-28 | 2006-05-11 | The General Hospital Corporation | Methods of detection and therapy for atheromatous plaques using immune modulation |
| WO2006050058A2 (en) | 2004-10-28 | 2006-05-11 | The General Hospital Corporation | Methods of detection and therapy of inflamed tissues using immune modulation |
| DK1841793T3 (da) | 2005-01-07 | 2010-07-19 | Diadexus Inc | Ovr110-antistofsammensætninger og fremgangsmåder til anvendelse deraf |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| ATE509033T1 (de) | 2006-03-20 | 2011-05-15 | Univ California | Manipulierte anti-prostatastammzellenantigen (psca)-antikörper für krebs-targeting |
| US8557257B2 (en) | 2006-03-24 | 2013-10-15 | Oncovac Inc. | Mycobacterial immunotherapy for cancer treatment |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| US8889100B2 (en) | 2007-01-11 | 2014-11-18 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| US8545809B2 (en) | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
| CN101568352B (zh) | 2007-01-11 | 2013-08-21 | 免疫医学股份有限公司 | 用于蛋白质、肽和其他分子的改进的f-18标记的方法和组合物 |
| US8709382B2 (en) | 2007-01-11 | 2014-04-29 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| US20160045626A1 (en) | 2007-01-11 | 2016-02-18 | Immunomedics, Inc. | Methods and Compositions for Improved Labeling of Targeting Peptides |
| US20150086482A1 (en) | 2007-01-11 | 2015-03-26 | Immunomedics, Inc. | Dye Conjugated Peptides for Fluorescent Imaging |
| US20090088578A1 (en) | 2007-01-19 | 2009-04-02 | Lascola Christopher D | Nuclear magnetic resonance imaging of selective small molecule drugs as contrast agents |
| WO2008127735A1 (en) | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
| WO2009070636A2 (en) | 2007-11-27 | 2009-06-04 | Stanford University | Engineered cells, imaging reporter gene/probe systems, and methods of imaging |
| JP5309775B2 (ja) | 2008-08-07 | 2013-10-09 | セイコーエプソン株式会社 | 放電灯の駆動装置および駆動方法、光源装置並びに画像表示装置 |
| EP2328615A2 (en) * | 2008-08-20 | 2011-06-08 | Centocor Ortho Biotech Inc. | Engineered anti-il-13 antibodies, compositions, methods and uses |
| NZ593905A (en) * | 2009-01-29 | 2013-03-28 | Abbott Lab | Il-1 binding proteins |
| DE102009030321A1 (de) | 2009-06-24 | 2011-01-05 | Siemens Aktiengesellschaft | Verfahren zur Abbildung von Tumorgewebe |
| US8416206B2 (en) | 2009-07-08 | 2013-04-09 | Smart Technologies Ulc | Method for manipulating a graphic widget in a three-dimensional environment displayed on a touch panel of an interactive input system |
| CA3040276A1 (en) * | 2009-12-02 | 2011-06-09 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| IN2012DN03177A (enExample) | 2009-12-04 | 2015-09-25 | Immunomedics Inc | |
| US20130137975A1 (en) | 2010-02-09 | 2013-05-30 | OSI Pharmaceuticals, LLC | Pet imaging |
| WO2012057697A1 (en) | 2010-10-28 | 2012-05-03 | Modmab Limited Uk Filial | New diagnostic and therapeutic target |
| EP2476754A1 (en) * | 2011-01-14 | 2012-07-18 | Bundesrepublik Deutschland, Letztvertreten Durch Den Präsidenten Des Paul-Ehrlich-Instituts | Methods for the identification and repair of amino acid residues destabilizing single-chain variable fragments (scFv) |
| EP2675485A4 (en) | 2011-02-15 | 2014-10-15 | Immunomedics Inc | ANTI-MUCIN ANTIBODY FOR THE EARLY RECOGNITION AND TREATMENT OF PANCREATIC CANCER |
| WO2012143524A2 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| CA2880791A1 (en) * | 2011-08-03 | 2013-02-07 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| CA2865774A1 (en) | 2012-02-28 | 2013-09-06 | Cornell University | Psma as a biomarker for androgen activity in prostate cancer |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| WO2013188693A1 (en) | 2012-06-15 | 2013-12-19 | Imaginab, Inc. | Antigen binding constructs to cd3 |
| US20150191543A1 (en) | 2012-08-06 | 2015-07-09 | The Regents Of The University Of California | Engineered antibody fragments for targeting and imaging cd8 expression in vivo |
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd８에의 항원 결합 구조체들 |
| WO2016145536A1 (en) | 2015-03-18 | 2016-09-22 | Immunobiochem Corporation | Conjugates for the treatment of cancer targeted at intracellular tumor-associated antigens |
| SMT202100467T1 (it) | 2015-04-17 | 2021-09-14 | Alpine Immune Sciences Inc | Proteine immunomodulatorie con affinità regolabili |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EA201792442A1 (ru) | 2015-05-06 | 2018-06-29 | Янссен Байотек, Инк. | Биспецифические агенты, связывающие простатический специфический мембранный антиген (psma), и их применение |
| US20170007727A1 (en) | 2015-07-07 | 2017-01-12 | Immunomedics, Inc. | METHODS OF IMAGING WITH Ga-68 LABELED MOLECULES |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| EP3350206A1 (en) | 2015-09-14 | 2018-07-25 | Alpine Immune Sciences, Inc. | Tunable variant immunoglobulin superfamily domains and engineered cell therapy |
| US12048753B2 (en) | 2015-10-01 | 2024-07-30 | Whitehead Institute For Biomedical Research | Labeling of antibodies |
| WO2017176769A1 (en) | 2016-04-04 | 2017-10-12 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| RU2725292C2 (ru) | 2016-04-27 | 2020-06-30 | Иммьюномедикс, Инк. | Эффективность конъюгатов антитела против trop-2 с лекарственным средством sn-38 для терапии рецидивирующих/рефрактерных к ингибиторам контрольной точки опухолей |
| US11596699B2 (en) | 2016-04-29 | 2023-03-07 | CureVac SE | RNA encoding an antibody |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP3266465A1 (en) | 2016-07-06 | 2018-01-10 | Julius-Maximilians-Universität Würzburg | Immune complexes |
| WO2018053328A1 (en) | 2016-09-16 | 2018-03-22 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| KR102568559B1 (ko) | 2016-12-14 | 2023-08-18 | 얀센 바이오테크 인코포레이티드 | Cd8a-결합 섬유결합소 iii형 도메인 |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| WO2018187215A1 (en) | 2017-04-03 | 2018-10-11 | Merrimack Pharmaceuticals, Inc. | Bispecific 4-1bb agonist molecules |
| MX421249B (es) | 2017-05-10 | 2025-02-10 | Wistar Inst | Constructos de anticuerpos de ácidos nucleicos optimizados |
| CA3067351A1 (en) | 2017-06-15 | 2018-12-20 | Nai-Kong Cheung | Anti-l1-cam antibodies and uses thereof |
| WO2019012147A1 (en) | 2017-07-13 | 2019-01-17 | Institut Gustave-Roussy | RADIOMY-BASED IMAGING TOOL FOR MONITORING INFILTRATION AND TUMOR LYMPHOCYTE AND RESULTS IN CANCER PATIENTS TREATED WITH ANTI-PD-1 / PD-L1 AGENTS |
| JP2020530554A (ja) | 2017-07-20 | 2020-10-22 | シートムエックス セラピューティクス，インコーポレイテッド | 活性化抗体の特性を定性的および／または定量的に分析する方法およびその使用 |
| CN110997013B (zh) | 2017-07-24 | 2022-09-20 | 瑞泽恩制药公司 | 抗cd8抗体和其用途 |
| EP3665201A4 (en) | 2017-08-09 | 2021-06-02 | Orionis Biosciences, Inc. | CD8 BINDERS |
| WO2019033043A2 (en) | 2017-08-11 | 2019-02-14 | Genentech, Inc. | ANTI-CD8 ANTIBODIES AND USES THEREOF |
| AU2018321893A1 (en) | 2017-08-23 | 2020-03-19 | Wayne State University | In vivo immunoimaging of interferon-gamma |
| IL273484B2 (en) | 2017-09-23 | 2025-12-01 | Memorial Sloan Kettering Cancer Center | A33 antibody compositions and methods of using the same in radioimmunotherapy |
| CA3090793C (en) | 2018-02-16 | 2024-10-08 | Kite Pharma, Inc. | MODIFIED MULTIPOTENTED STEM CELLS, AND METHODS OF PREPARATION AND USE |
| KR20200131846A (ko) | 2018-03-14 | 2020-11-24 | 메모리얼 슬로안 케터링 캔서 센터 | 항-폴리시알산 항체 및 그 용도 |
| WO2020069433A1 (en) | 2018-09-28 | 2020-04-02 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| CN115103633B (zh) | 2019-12-05 | 2023-09-12 | 伊麦吉纳博公司 | 使用多种成像剂的成像方法 |
-
2014
- 2014-03-10 KR KR1020157028748A patent/KR20150131208A/ko not_active Ceased
- 2014-03-10 EP EP24169921.4A patent/EP4411378A3/en active Pending
- 2014-03-10 EP EP14779573.6A patent/EP2968622B1/en active Active
- 2014-03-10 EP EP21171344.1A patent/EP3889182B1/en active Active
- 2014-03-10 CN CN202110297974.0A patent/CN113045660B/zh active Active
- 2014-03-10 CN CN201480024657.XA patent/CN105163765A/zh active Pending
- 2014-03-10 JP JP2016501063A patent/JP6815196B2/ja active Active
- 2014-03-10 AU AU2014249243A patent/AU2014249243C1/en active Active
- 2014-03-10 KR KR1020217003074A patent/KR102353885B1/ko active Active
- 2014-03-10 CA CA2904969A patent/CA2904969C/en active Active
- 2014-03-10 US US14/773,710 patent/US10414820B2/en active Active
- 2014-03-10 WO PCT/US2014/022782 patent/WO2014164553A1/en not_active Ceased
- 2014-03-10 US US14/202,999 patent/US20140271462A1/en not_active Abandoned
-
2016
- 2016-08-05 US US15/230,085 patent/US10377826B2/en active Active
-
2018
- 2018-12-07 JP JP2018230270A patent/JP6856611B2/ja active Active
-
2019
- 2019-04-17 AU AU2019202676A patent/AU2019202676C1/en active Active
- 2019-05-20 US US16/417,474 patent/US20190382487A1/en not_active Abandoned
- 2019-05-20 US US16/417,482 patent/US20190382488A1/en not_active Abandoned
-
2020
- 2020-01-16 US US16/745,064 patent/US12435141B2/en active Active
-
2025
- 2025-09-24 US US19/339,053 patent/US20260015422A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL290425A (en) | Humanized, murine or chimeric anti-cd47 monoclonal antibodies | |
| MX2017005987A (es) | Anticuerpos anti-interleucina(il)-1beta y metodos de uso. | |
| NZ706147A (en) | Anti-cd38 antibody and melphalan for the treatment of multiple myeloma | |
| JP2018021031A5 (enExample) | ||
| PE20181090A1 (es) | Modulacion y tratamiento inmunes de tumores solidos con anticuerpos que se unen especificamente a cd38 | |
| CL2018001177A1 (es) | Anticuerpos vinculados especificamente a pd-1 y sus usos. | |
| NZ729158A (en) | Anti-ctla4 monoclonal antibody or antigen binding fragment thereof, medicinal composition and use | |
| PH12018500708A1 (en) | Humanized anti-human cd19 antibodies and methods of use | |
| WO2015109131A3 (en) | Bi-specific cd3 and cd19 antigen-binding constructs | |
| WO2015010100A3 (en) | Humanized antibodies with ultralong complementarity determining regions | |
| ES2685424T3 (es) | Anticuerpos anti-Jagged1 y procedimientos de uso | |
| EP4249515A3 (en) | Humanized or chimeric cd3 antibodies | |
| WO2014152006A3 (en) | Anti-hepcidin antibodies and uses thereof | |
| WO2015091853A3 (en) | Human anti-cd40 human antibodies | |
| MX2023006415A (es) | Anticuerpos, usos y metodos. | |
| JP2015530399A5 (enExample) | ||
| MX2017005642A (es) | Anticuerpos anti-angiopoyetina 2 (ang2) y metodos de uso. | |
| WO2015127136A3 (en) | Ebola monoclonal antibodies | |
| NZ604464A (en) | Anti-vegf antibodies and uses thereof | |
| WO2015107331A3 (en) | Anti-light antibodies | |
| WO2015017146A3 (en) | Antibodies with ultralong complementarity determining regions | |
| WO2017021539A3 (en) | Novel anti-human gpvi antibodies and uses thereof | |
| JP2018515513A5 (enExample) | ||
| WO2016166296A3 (en) | Humanized anti-axl antibodies | |
| WO2016057683A3 (en) | Novel anti-nodal antibodies and methods of using same |