JP2016520199A5 - - Google Patents
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- JP2016520199A5 JP2016520199A5 JP2016514524A JP2016514524A JP2016520199A5 JP 2016520199 A5 JP2016520199 A5 JP 2016520199A5 JP 2016514524 A JP2016514524 A JP 2016514524A JP 2016514524 A JP2016514524 A JP 2016514524A JP 2016520199 A5 JP2016520199 A5 JP 2016520199A5
- Authority
- JP
- Japan
- Prior art keywords
- score
- antibody
- marker
- ibs
- serotonin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 26
- 238000000034 method Methods 0.000 claims 18
- 239000003550 marker Substances 0.000 claims 13
- 206010069703 Bile acid malabsorption Diseases 0.000 claims 12
- 229940076279 serotonin Drugs 0.000 claims 12
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 11
- 210000003630 histaminocyte Anatomy 0.000 claims 10
- YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 claims 8
- 206010061218 Inflammation Diseases 0.000 claims 7
- 230000004054 inflammatory process Effects 0.000 claims 7
- 244000005700 microbiome Species 0.000 claims 7
- 230000036542 oxidative stress Effects 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 6
- 239000002771 cell marker Substances 0.000 claims 5
- VCKPUUFAIGNJHC-UHFFFAOYSA-N 3-hydroxykynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC(O)=C1N VCKPUUFAIGNJHC-UHFFFAOYSA-N 0.000 claims 4
- DUUGKQCEGZLZNO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Chemical compound C1=C(O)C=C2C(CC(=O)O)=CNC2=C1 DUUGKQCEGZLZNO-UHFFFAOYSA-N 0.000 claims 4
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims 4
- HCZHHEIFKROPDY-UHFFFAOYSA-N kynurenic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC(=O)C2=C1 HCZHHEIFKROPDY-UHFFFAOYSA-N 0.000 claims 4
- WJXSWCUQABXPFS-UHFFFAOYSA-N 3-hydroxyanthranilic acid Chemical compound NC1=C(O)C=CC=C1C(O)=O WJXSWCUQABXPFS-UHFFFAOYSA-N 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- RVWZUOPFHTYIEO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Natural products C1=C(O)C=C2C(C(=O)O)=CNC2=C1 RVWZUOPFHTYIEO-UHFFFAOYSA-N 0.000 claims 2
- 239000003310 5-hydroxyindoleacetic acid Substances 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 238000012896 Statistical algorithm Methods 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 210000004969 inflammatory cell Anatomy 0.000 claims 2
- FBZONXHGGPHHIY-UHFFFAOYSA-N xanthurenic acid Chemical compound C1=CC=C(O)C2=NC(C(=O)O)=CC(O)=C21 FBZONXHGGPHHIY-UHFFFAOYSA-N 0.000 claims 2
- LDCYZAJDBXYCGN-UHFFFAOYSA-N 5-hydroxytryptophan Chemical compound C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 claims 1
- IOIZWEJGGCZDOL-RQDYSCIWSA-N 7alpha-hydroxycholest-4-en-3-one Chemical group C([C@H]1O)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 IOIZWEJGGCZDOL-RQDYSCIWSA-N 0.000 claims 1
- 102000016950 Chemokine CXCL1 Human genes 0.000 claims 1
- 108010014419 Chemokine CXCL1 Proteins 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 1
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- 102000001400 Tryptase Human genes 0.000 claims 1
- 108060005989 Tryptase Proteins 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- JFWYSGGSCOOBGK-UHFFFAOYSA-N [3-(2-azaniumylethyl)-1h-indol-5-yl] sulfate Chemical compound C1=C(OS(O)(=O)=O)C=C2C(CCN)=CNC2=C1 JFWYSGGSCOOBGK-UHFFFAOYSA-N 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361827506P | 2013-05-24 | 2013-05-24 | |
| US61/827,506 | 2013-05-24 | ||
| PCT/IB2014/061636 WO2014188378A1 (en) | 2013-05-24 | 2014-05-22 | Pathway specific markers for diagnosing irritable bowel syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104805A Division JP2019194600A (ja) | 2013-05-24 | 2019-06-04 | 過敏性腸症候群を診断するための経路特異的マーカー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520199A JP2016520199A (ja) | 2016-07-11 |
| JP2016520199A5 true JP2016520199A5 (enExample) | 2017-06-29 |
Family
ID=50884973
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514524A Pending JP2016520199A (ja) | 2013-05-24 | 2014-05-22 | 過敏性腸症候群を診断するための経路特異的マーカー |
| JP2016514523A Pending JP2016521683A (ja) | 2013-05-24 | 2014-05-22 | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| JP2019075081A Pending JP2019151637A (ja) | 2013-05-24 | 2019-04-10 | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| JP2019104805A Pending JP2019194600A (ja) | 2013-05-24 | 2019-06-04 | 過敏性腸症候群を診断するための経路特異的マーカー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514523A Pending JP2016521683A (ja) | 2013-05-24 | 2014-05-22 | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| JP2019075081A Pending JP2019151637A (ja) | 2013-05-24 | 2019-04-10 | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| JP2019104805A Pending JP2019194600A (ja) | 2013-05-24 | 2019-06-04 | 過敏性腸症候群を診断するための経路特異的マーカー |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9891235B2 (enExample) |
| EP (2) | EP3004892B1 (enExample) |
| JP (4) | JP2016520199A (enExample) |
| KR (2) | KR20160010621A (enExample) |
| CN (2) | CN105579852B (enExample) |
| AU (3) | AU2014269961A1 (enExample) |
| BR (2) | BR112015029320A8 (enExample) |
| CA (2) | CA2912993A1 (enExample) |
| HK (1) | HK1223361A1 (enExample) |
| IL (2) | IL242597B (enExample) |
| MX (1) | MX367046B (enExample) |
| RU (2) | RU2015155552A (enExample) |
| SG (2) | SG11201509371XA (enExample) |
| WO (2) | WO2014188378A1 (enExample) |
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| CA2912993A1 (en) | 2013-05-24 | 2014-11-27 | Nestec S.A. | Pathway specific markers for diagnosing irritable bowel syndrome |
| CN119236063A (zh) | 2013-06-21 | 2025-01-03 | 翁德克控股有限公司 | 免疫治疗组合物及其用途 |
| KR20170005058A (ko) * | 2014-05-09 | 2017-01-11 | 노그라 파마 리미티드 | 염증성 장 질환을 치료하는 방법 |
| TWI690536B (zh) | 2014-11-19 | 2020-04-11 | 英商Ｎｚｐ英國有限公司 | 化合物（一） |
| CA2968338A1 (en) | 2014-11-19 | 2016-05-26 | Nestec S.A. | Antibodies against serotonin, tryptophan and kynurenine metabolites and uses thereof |
| CN107108687B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇 |
| KR102546748B1 (ko) | 2014-11-19 | 2023-06-22 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드 |
| CA2968310A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| WO2016088068A1 (en) * | 2014-12-02 | 2016-06-09 | Nestec S.A. | Methods for establishing a vedolizumab dosing regimen to treat patients with irritable bowel disease |
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2014
- 2014-05-22 CA CA2912993A patent/CA2912993A1/en not_active Abandoned
- 2014-05-22 CN CN201480041527.7A patent/CN105579852B/zh not_active Expired - Fee Related
- 2014-05-22 AU AU2014269961A patent/AU2014269961A1/en not_active Abandoned
- 2014-05-22 SG SG11201509371XA patent/SG11201509371XA/en unknown
- 2014-05-22 RU RU2015155552A patent/RU2015155552A/ru unknown
- 2014-05-22 JP JP2016514524A patent/JP2016520199A/ja active Pending
- 2014-05-22 SG SG11201509370UA patent/SG11201509370UA/en unknown
- 2014-05-22 WO PCT/IB2014/061636 patent/WO2014188378A1/en not_active Ceased
- 2014-05-22 AU AU2014269960A patent/AU2014269960B2/en not_active Ceased
- 2014-05-22 WO PCT/IB2014/061634 patent/WO2014188377A2/en not_active Ceased
- 2014-05-22 BR BR112015029320A patent/BR112015029320A8/pt not_active Application Discontinuation
- 2014-05-22 EP EP14728346.9A patent/EP3004892B1/en not_active Not-in-force
- 2014-05-22 CN CN201480041536.6A patent/CN105392780A/zh active Pending
- 2014-05-22 MX MX2015016196A patent/MX367046B/es active IP Right Grant
- 2014-05-22 CA CA2913108A patent/CA2913108A1/en not_active Abandoned
- 2014-05-22 RU RU2015155590A patent/RU2015155590A/ru not_active Application Discontinuation
- 2014-05-22 HK HK16111564.5A patent/HK1223361A1/zh unknown
- 2014-05-22 EP EP14731062.7A patent/EP3004068A2/en not_active Withdrawn
- 2014-05-22 KR KR1020157036482A patent/KR20160010621A/ko not_active Ceased
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- 2014-05-22 BR BR112015029318A patent/BR112015029318A2/pt not_active Application Discontinuation
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2015
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2017
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2018
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