JP2016520089A5

JP2016520089A5 -

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Publication number: JP2016520089A5
Authority: JP; Japan
Prior art keywords: mammal; day; pharmaceutical composition; neuregulin; composition according
Prior art date: 2014-05-22
Legal status : Granted

Application number

JP2016514266A

Other languages

English (en)

Japanese (ja)

Other versions

JP2016520089A (ja

JP6568052B2 (ja

Filing date

2014-05-22

Publication date

2017-06-29

2014-05-22 Application filed filed Critical

2014-05-22 Priority claimed from PCT/CN2014/078154 external-priority patent/WO2014187342A1/en

2016-07-11 Publication of JP2016520089A publication Critical patent/JP2016520089A/ja

2017-06-29 Publication of JP2016520089A5 publication Critical patent/JP2016520089A5/ja

2019-09-04 Application granted granted Critical

2019-09-04 Publication of JP6568052B2 publication Critical patent/JP6568052B2/ja

Status Active legal-status Critical Current

2034-05-22 Anticipated expiration legal-status Critical

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241000124008 Mammalia Species 0.000 claims 14
239000008194 pharmaceutical composition Substances 0.000 claims 13
102000014413 Neuregulin Human genes 0.000 claims 11
108050003475 Neuregulin Proteins 0.000 claims 11
230000006698 induction Effects 0.000 claims 5
208000024172 Cardiovascular disease Diseases 0.000 claims 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
239000000203 mixture Substances 0.000 claims 3
206010019280 Heart failures Diseases 0.000 claims 2
102000004877 Insulin Human genes 0.000 claims 2
108090001061 Insulin Proteins 0.000 claims 2
201000010099 disease Diseases 0.000 claims 2
208000035475 disorder Diseases 0.000 claims 2
229940125396 insulin Drugs 0.000 claims 2
238000012423 maintenance Methods 0.000 claims 2
238000007920 subcutaneous administration Methods 0.000 claims 2
230000002861 ventricular Effects 0.000 claims 2
230000002354 daily effect Effects 0.000 claims 1
230000003203 everyday effect Effects 0.000 claims 1
238000009472 formulation Methods 0.000 claims 1
230000002459 sustained effect Effects 0.000 claims 1
238000013268 sustained release Methods 0.000 claims 1
239000012730 sustained-release form Substances 0.000 claims 1

JP2016514266A 2013-05-22 2014-05-22 心不全を治療するためのニューレグリンの徐放 Active JP6568052B2 (ja)