JP2016517446A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016517446A5 JP2016517446A5 JP2016503417A JP2016503417A JP2016517446A5 JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5 JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- patient
- mucus
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 102000002933 Thioredoxin Human genes 0.000 claims 13
- 108060008226 thioredoxin Proteins 0.000 claims 13
- 235000018417 cysteine Nutrition 0.000 claims 11
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 11
- 210000003097 mucus Anatomy 0.000 claims 9
- 235000018102 proteins Nutrition 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 206010036790 Productive cough Diseases 0.000 claims 8
- 210000003802 sputum Anatomy 0.000 claims 8
- 208000024794 sputum Diseases 0.000 claims 8
- 229940094937 thioredoxin Drugs 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000006199 nebulizer Substances 0.000 claims 3
- 239000000443 aerosol Substances 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792198P | 2013-03-15 | 2013-03-15 | |
| US61/792,198 | 2013-03-15 | ||
| PCT/US2014/030545 WO2014145735A2 (en) | 2013-03-15 | 2014-03-17 | Product and process for mucus viscosity normalization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517446A JP2016517446A (ja) | 2016-06-16 |
| JP2016517446A5 true JP2016517446A5 (enExample) | 2017-04-20 |
| JP6672139B2 JP6672139B2 (ja) | 2020-03-25 |
Family
ID=51527945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503417A Active JP6672139B2 (ja) | 2013-03-15 | 2014-03-17 | 粘液の粘性の正常化のための組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9168290B2 (enExample) |
| EP (1) | EP2968481B1 (enExample) |
| JP (1) | JP6672139B2 (enExample) |
| KR (2) | KR20160007496A (enExample) |
| CN (1) | CN105188738B (enExample) |
| AU (1) | AU2014232520B2 (enExample) |
| CA (1) | CA2906868A1 (enExample) |
| IL (1) | IL241320B (enExample) |
| MX (1) | MX377653B (enExample) |
| RU (1) | RU2750211C2 (enExample) |
| WO (1) | WO2014145735A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1993360T (pt) | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| AU2014232520B2 (en) * | 2013-03-15 | 2019-04-04 | Orpro Therapeutics, Inc. | Product and process for mucus viscosity normalization |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| CN106868090B (zh) * | 2017-03-28 | 2020-09-29 | 王绪友 | 一种医学检验用痰液处理方法 |
| CN107630065A (zh) * | 2017-11-02 | 2018-01-26 | 蔡慧娜 | 一种在支原体液体培养时使标本均匀分散的方法 |
| US20210213134A1 (en) * | 2018-05-17 | 2021-07-15 | Orpro Therapeutics, Inc. | Thiol-based multivalent drug delivery compositions |
| JP2023509462A (ja) * | 2020-01-03 | 2023-03-08 | オアプロ セラピューティクス インコーポレイテッド | チオレドキシン活性を有する組成物および関連方法 |
| CN115200954B (zh) * | 2022-06-28 | 2025-05-06 | 珠海大略科技有限公司 | 一种降低唾液粘度的方法及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3091569A (en) | 1960-08-26 | 1963-05-28 | Mead Johnson & Co | Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus |
| US3502779A (en) | 1966-08-18 | 1970-03-24 | Calbiochem | Process of mucolysis |
| US3683069A (en) * | 1970-02-19 | 1972-08-08 | Michel Hooreman | Enzymatic products which optimize the viscosity of mucuses and their applications |
| US4738841A (en) * | 1985-08-28 | 1988-04-19 | Repligen Corporation | Use of thioredoxin, thioredoxin-derived, or thioredoxin-like dithiol peptides in hair care preparations |
| US4771036A (en) | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| SE8903003D0 (sv) | 1989-09-12 | 1989-09-12 | Astra Ab | Novel medical use |
| US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5908611A (en) | 1995-05-05 | 1999-06-01 | The Scripps Research Institute | Treatment of viscous mucous-associated diseases |
| WO1998000160A1 (en) | 1996-06-28 | 1998-01-08 | Nat Jewish Ct Immun & Respirat | USE OF THIOREDOXIN-LIKE MOLECULES FOR INDUCTION OF MnSOD TO TREAT OXIDATIVE DAMAGE |
| JPH10191977A (ja) | 1997-01-14 | 1998-07-28 | Oriental Yeast Co Ltd | チオレドキシン改変体及び該改変体を含むａｐ−１の転写活性能を増強する因子 |
| DE19711052C2 (de) | 1997-03-03 | 1999-09-23 | Hans Rommelspacher | Verwendung von 2-Methyl-thiazolidin-2,4-dicarbonsäure als Mukolytikum |
| US7585645B2 (en) | 1997-05-27 | 2009-09-08 | Sembiosys Genetics Inc. | Thioredoxin and thioredoxin reductase containing oil body based products |
| US5925334A (en) | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| CA2905585C (en) | 2001-03-29 | 2020-02-18 | Synergy Pharmaceuticals, Inc. | Guanylate cyclase receptor agonists for the treatment and/or prevention of cancer or polyps |
| EP1507852A4 (en) | 2001-05-04 | 2005-12-28 | Xencor Inc | NUCLEIC ACIDS AND PROTEINS WITH THIORODOXIN REDUCED EFFECT |
| US20030194798A1 (en) | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| US20060148057A1 (en) * | 2002-08-02 | 2006-07-06 | Wang Min | Thioredoxin mutants and uses thereof |
| WO2004024868A2 (en) * | 2002-09-10 | 2004-03-25 | National Jewish Medical And Research Center | Product and process for liquefaction of mucus or sputum |
| CN1694726A (zh) * | 2002-09-10 | 2005-11-09 | 国家杰威什医疗及研究中心 | 用于液化粘液或痰液的产品和方法 |
| WO2004087917A1 (ja) | 2003-03-31 | 2004-10-14 | National Institute Of Advanced Industrial Science And Technology | チオレドキシン改変体 |
| RU2253484C1 (ru) * | 2003-09-30 | 2005-06-10 | Российский научный центр восстановительной медицины и курортологии Министерства здравоохранения Российской Федерации | Способ лечения хронического бронхолегочного процесса при врожденных пороках развития легких у детей |
| WO2005094269A2 (en) | 2004-03-24 | 2005-10-13 | National Jewish Medical And Research Center | Mucolytic and anti-elastase compounds and methods of use thereof |
| US20090203586A1 (en) | 2004-06-11 | 2009-08-13 | Syngenta Limited | Method for ameliorating an inflammatory skin condition |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| GB0503640D0 (en) | 2005-02-22 | 2005-03-30 | Syngenta Ltd | Improvements in or relating to organic compounds |
| AU2014232520B2 (en) | 2013-03-15 | 2019-04-04 | Orpro Therapeutics, Inc. | Product and process for mucus viscosity normalization |
| US20210213134A1 (en) | 2018-05-17 | 2021-07-15 | Orpro Therapeutics, Inc. | Thiol-based multivalent drug delivery compositions |
| JP2023509462A (ja) | 2020-01-03 | 2023-03-08 | オアプロ セラピューティクス インコーポレイテッド | チオレドキシン活性を有する組成物および関連方法 |
-
2014
- 2014-03-17 AU AU2014232520A patent/AU2014232520B2/en active Active
- 2014-03-17 CN CN201480024877.2A patent/CN105188738B/zh active Active
- 2014-03-17 KR KR1020157028723A patent/KR20160007496A/ko not_active Ceased
- 2014-03-17 US US14/216,568 patent/US9168290B2/en active Active
- 2014-03-17 EP EP14762649.3A patent/EP2968481B1/en active Active
- 2014-03-17 MX MX2015013040A patent/MX377653B/es active IP Right Grant
- 2014-03-17 RU RU2015143953A patent/RU2750211C2/ru active
- 2014-03-17 KR KR1020217016634A patent/KR20210068606A/ko not_active Withdrawn
- 2014-03-17 CA CA2906868A patent/CA2906868A1/en active Pending
- 2014-03-17 WO PCT/US2014/030545 patent/WO2014145735A2/en not_active Ceased
- 2014-03-17 JP JP2016503417A patent/JP6672139B2/ja active Active
-
2015
- 2015-09-08 IL IL241320A patent/IL241320B/en unknown
- 2015-09-11 US US14/852,113 patent/US20160230149A1/en not_active Abandoned
-
2020
- 2020-11-23 US US17/101,588 patent/US12390511B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016517446A5 (enExample) | ||
| Newman | Drug delivery to the lungs: challenges and opportunities | |
| Cryan et al. | In vivo animal models for drug delivery across the lung mucosal barrier | |
| JP2012176990A5 (enExample) | ||
| JP2015517489A5 (enExample) | ||
| RU2011114078A (ru) | Усовершенствование всасывания терапевтических средств через слизистые оболочки или кожу | |
| CN115701983A (zh) | 配制品 | |
| EP2277505A3 (en) | Mucoactive agents for treating a pulmonary disease | |
| HRP20130835T1 (hr) | Farmaceutske formulacije otopine za davanje kao stlaäśeni inhalat u inhalatoru | |
| ATE330589T1 (de) | Pharmazeutische zusammensetzung enthaltend resveratrol zur behandlung von entzündlichen erkrankungen der atemwege | |
| JP2008536546A5 (enExample) | ||
| CY1114157T1 (el) | Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν | |
| WO2021198115A1 (en) | Treatment | |
| RU2010108640A (ru) | Новая комбинация терапевтических агентов | |
| JP2012503668A5 (enExample) | ||
| JP2017501140A5 (enExample) | ||
| JP2014532722A5 (enExample) | ||
| WO2024169972A1 (en) | New multi-functional oligopeptides | |
| SE0302665D0 (sv) | Novel Process | |
| EA201201390A1 (ru) | Кнопочное устройство мундштука ингалятора сухого порошка | |
| MY145166A (en) | Novel tiotropium salts, process for the preparation and pharmaceutical compositions thereof | |
| Kaur | Pulmonary drug delivery system: Newer patents | |
| WO2015049519A3 (en) | Method and apparatus for making compositions for pulmonary administration | |
| RU2012156256A (ru) | Факторы трилистника (tff) для лечения хронических заболеваний легких | |
| RU2014136096A (ru) | Лекарственное средство для лечения и профилактики заболеваний верхних и нижних дыхательных путей различной этиологии, его применение и метод лечения на его основе |