JP2016517446A5 - - Google Patents

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Publication number
JP2016517446A5
JP2016517446A5 JP2016503417A JP2016503417A JP2016517446A5 JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5 JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016503417 A JP2016503417 A JP 2016503417A JP 2016517446 A5 JP2016517446 A5 JP 2016517446A5
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JP
Japan
Prior art keywords
seq
composition
patient
mucus
protein
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Application number
JP2016503417A
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English (en)
Japanese (ja)
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JP6672139B2 (ja
JP2016517446A (ja
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Priority claimed from PCT/US2014/030545 external-priority patent/WO2014145735A2/en
Publication of JP2016517446A publication Critical patent/JP2016517446A/ja
Publication of JP2016517446A5 publication Critical patent/JP2016517446A5/ja
Application granted granted Critical
Publication of JP6672139B2 publication Critical patent/JP6672139B2/ja
Active legal-status Critical Current
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JP2016503417A 2013-03-15 2014-03-17 粘液の粘性の正常化のための組成物 Active JP6672139B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792198P 2013-03-15 2013-03-15
US61/792,198 2013-03-15
PCT/US2014/030545 WO2014145735A2 (en) 2013-03-15 2014-03-17 Product and process for mucus viscosity normalization

Publications (3)

Publication Number Publication Date
JP2016517446A JP2016517446A (ja) 2016-06-16
JP2016517446A5 true JP2016517446A5 (enExample) 2017-04-20
JP6672139B2 JP6672139B2 (ja) 2020-03-25

Family

ID=51527945

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016503417A Active JP6672139B2 (ja) 2013-03-15 2014-03-17 粘液の粘性の正常化のための組成物

Country Status (11)

Country Link
US (4) US9168290B2 (enExample)
EP (1) EP2968481B1 (enExample)
JP (1) JP6672139B2 (enExample)
KR (2) KR20210068606A (enExample)
CN (1) CN105188738B (enExample)
AU (1) AU2014232520B2 (enExample)
CA (1) CA2906868A1 (enExample)
IL (1) IL241320B (enExample)
MX (1) MX377653B (enExample)
RU (1) RU2750211C2 (enExample)
WO (1) WO2014145735A2 (enExample)

Families Citing this family (9)

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LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
KR20210068606A (ko) * 2013-03-15 2021-06-09 오프로 테라퓨틱스 인코퍼레이션 점액 점도 정상화를 위한 생성물 및 방법
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
CN106868090B (zh) * 2017-03-28 2020-09-29 王绪友 一种医学检验用痰液处理方法
CN107630065A (zh) * 2017-11-02 2018-01-26 蔡慧娜 一种在支原体液体培养时使标本均匀分散的方法
US20210213134A1 (en) * 2018-05-17 2021-07-15 Orpro Therapeutics, Inc. Thiol-based multivalent drug delivery compositions
CA3163157A1 (en) * 2020-01-03 2021-07-08 Orpro Therapeutics, Inc. Compositions having thioredoxin activity and related methods
CN115200954B (zh) * 2022-06-28 2025-05-06 珠海大略科技有限公司 一种降低唾液粘度的方法及其应用

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US3683069A (en) * 1970-02-19 1972-08-08 Michel Hooreman Enzymatic products which optimize the viscosity of mucuses and their applications
US4738841A (en) * 1985-08-28 1988-04-19 Repligen Corporation Use of thioredoxin, thioredoxin-derived, or thioredoxin-like dithiol peptides in hair care preparations
US4771036A (en) 1986-02-10 1988-09-13 Trustees Of Columbia University In The City Of New York Method and ophthalmic composition for the prevention and reversal of cataracts
SE8903003D0 (sv) 1989-09-12 1989-09-12 Astra Ab Novel medical use
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AU3643497A (en) 1996-06-28 1998-01-21 National Jewish Center For Immunology And Respiratory Medicine Use of thioredoxin-like molecules for induction of mnsod to treat oxidative damage
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DE19711052C2 (de) 1997-03-03 1999-09-23 Hans Rommelspacher Verwendung von 2-Methyl-thiazolidin-2,4-dicarbonsäure als Mukolytikum
US7585645B2 (en) 1997-05-27 2009-09-08 Sembiosys Genetics Inc. Thioredoxin and thioredoxin reductase containing oil body based products
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DE60233040D1 (de) 2001-03-29 2009-09-03 Synergy Pharmaceuticals Inc Guanylat-cyclase-rezeptor-agonisten zur behandlung von gewebeentzündung und karzinogenese
CA2447407A1 (en) 2001-05-04 2002-11-14 Xencor Nucleic acids and proteins with thioredoxin reductase activity
US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US20060148057A1 (en) * 2002-08-02 2006-07-06 Wang Min Thioredoxin mutants and uses thereof
KR20050072743A (ko) 2002-09-10 2005-07-12 내셔날 쥬이쉬 메디칼 앤드 리서치 센터 점액 또는 타액의 액화를 위한 생성물 및 방법
CN1694726A (zh) * 2002-09-10 2005-11-09 国家杰威什医疗及研究中心 用于液化粘液或痰液的产品和方法
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RU2253484C1 (ru) * 2003-09-30 2005-06-10 Российский научный центр восстановительной медицины и курортологии Министерства здравоохранения Российской Федерации Способ лечения хронического бронхолегочного процесса при врожденных пороках развития легких у детей
WO2005094269A2 (en) 2004-03-24 2005-10-13 National Jewish Medical And Research Center Mucolytic and anti-elastase compounds and methods of use thereof
JP2008501772A (ja) 2004-06-11 2008-01-24 シンジェンタ リミテッド 炎症性皮膚状態を寛解するための方法
GB2416122A (en) 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
GB0503640D0 (en) 2005-02-22 2005-03-30 Syngenta Ltd Improvements in or relating to organic compounds
KR20210068606A (ko) 2013-03-15 2021-06-09 오프로 테라퓨틱스 인코퍼레이션 점액 점도 정상화를 위한 생성물 및 방법
US20210213134A1 (en) 2018-05-17 2021-07-15 Orpro Therapeutics, Inc. Thiol-based multivalent drug delivery compositions
CA3163157A1 (en) 2020-01-03 2021-07-08 Orpro Therapeutics, Inc. Compositions having thioredoxin activity and related methods

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