RU2750211C2 - Продукт и способ для нормализации вязкости слизи - Google Patents

Продукт и способ для нормализации вязкости слизи Download PDF

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Publication number
RU2750211C2
RU2750211C2 RU2015143953A RU2015143953A RU2750211C2 RU 2750211 C2 RU2750211 C2 RU 2750211C2 RU 2015143953 A RU2015143953 A RU 2015143953A RU 2015143953 A RU2015143953 A RU 2015143953A RU 2750211 C2 RU2750211 C2 RU 2750211C2
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seq
thioredoxin
protein
mucus
monocysteine
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RU2015143953A
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English (en)
Russian (ru)
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RU2015143953A (ru
RU2015143953A3 (enExample
Inventor
Питер Б. ХЕЙФЕТЦ
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Орпро Терапьютикс, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/04—Oxidoreductases acting on sulfur groups as donors (1.8) with a disulfide as acceptor (1.8.4)
    • C12Y108/0401—Adenylyl-sulfate reductase (thioredoxin) (1.8.4.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
    • C12Y108/01009—Thioredoxin-disulfide reductase (1.8.1.9), i.e. thioredoxin-reductase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Analytical Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2015143953A 2013-03-15 2014-03-17 Продукт и способ для нормализации вязкости слизи RU2750211C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792198P 2013-03-15 2013-03-15
US61/792,198 2013-03-15
PCT/US2014/030545 WO2014145735A2 (en) 2013-03-15 2014-03-17 Product and process for mucus viscosity normalization

Publications (3)

Publication Number Publication Date
RU2015143953A RU2015143953A (ru) 2017-04-21
RU2015143953A3 RU2015143953A3 (enExample) 2018-04-02
RU2750211C2 true RU2750211C2 (ru) 2021-06-24

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US (4) US9168290B2 (enExample)
EP (1) EP2968481B1 (enExample)
JP (1) JP6672139B2 (enExample)
KR (2) KR20210068606A (enExample)
CN (1) CN105188738B (enExample)
AU (1) AU2014232520B2 (enExample)
CA (1) CA2906868A1 (enExample)
IL (1) IL241320B (enExample)
MX (1) MX377653B (enExample)
RU (1) RU2750211C2 (enExample)
WO (1) WO2014145735A2 (enExample)

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LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
MX377653B (es) * 2013-03-15 2025-03-11 Orpro Therapeutics Inc Producto y uso para normalización de la viscoelasticidad del moco.
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
CN106868090B (zh) * 2017-03-28 2020-09-29 王绪友 一种医学检验用痰液处理方法
CN107630065A (zh) * 2017-11-02 2018-01-26 蔡慧娜 一种在支原体液体培养时使标本均匀分散的方法
WO2019222665A1 (en) * 2018-05-17 2019-11-21 Orpro Therapeutics, Inc. Thiol-based multivalent drug delivery compositions
WO2021138682A1 (en) * 2020-01-03 2021-07-08 Orpro Therapeutics, Inc. Compositions having thioredoxin activity and related methods
CN115200954B (zh) * 2022-06-28 2025-05-06 珠海大略科技有限公司 一种降低唾液粘度的方法及其应用

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RU2253484C1 (ru) * 2003-09-30 2005-06-10 Российский научный центр восстановительной медицины и курортологии Министерства здравоохранения Российской Федерации Способ лечения хронического бронхолегочного процесса при врожденных пороках развития легких у детей
US20090311231A1 (en) * 2002-09-10 2009-12-17 National Jewish Health Product and process for liquefaction of mucus or sputum

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US4771036A (en) 1986-02-10 1988-09-13 Trustees Of Columbia University In The City Of New York Method and ophthalmic composition for the prevention and reversal of cataracts
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WO2021138682A1 (en) 2020-01-03 2021-07-08 Orpro Therapeutics, Inc. Compositions having thioredoxin activity and related methods

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683069A (en) * 1970-02-19 1972-08-08 Michel Hooreman Enzymatic products which optimize the viscosity of mucuses and their applications
US20090311231A1 (en) * 2002-09-10 2009-12-17 National Jewish Health Product and process for liquefaction of mucus or sputum
RU2253484C1 (ru) * 2003-09-30 2005-06-10 Российский научный центр восстановительной медицины и курортологии Министерства здравоохранения Российской Федерации Способ лечения хронического бронхолегочного процесса при врожденных пороках развития легких у детей

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BALIGA V. et al. Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study. // J Indian Med Assoc 2010; 108: 313-314, 316-318, 320. *
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Publication number Publication date
US20210254025A1 (en) 2021-08-19
JP6672139B2 (ja) 2020-03-25
KR20210068606A (ko) 2021-06-09
CA2906868A1 (en) 2014-09-18
US20140271599A1 (en) 2014-09-18
JP2016517446A (ja) 2016-06-16
EP2968481A2 (en) 2016-01-20
US9168290B2 (en) 2015-10-27
MX2015013040A (es) 2016-05-24
AU2014232520A1 (en) 2015-09-24
IL241320B (en) 2022-02-01
US20260027189A1 (en) 2026-01-29
RU2015143953A (ru) 2017-04-21
MX377653B (es) 2025-03-11
WO2014145735A9 (en) 2015-05-07
CN105188738B (zh) 2025-11-07
AU2014232520B2 (en) 2019-04-04
HK1220354A1 (zh) 2017-05-05
KR20160007496A (ko) 2016-01-20
RU2015143953A3 (enExample) 2018-04-02
WO2014145735A3 (en) 2014-12-31
US12390511B2 (en) 2025-08-19
EP2968481B1 (en) 2020-11-04
IL241320A0 (en) 2015-11-30
NZ711983A (en) 2021-09-24
WO2014145735A2 (en) 2014-09-18
EP2968481A4 (en) 2016-07-13
CN105188738A (zh) 2015-12-23
US20160230149A1 (en) 2016-08-11

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