JP2016516562A - マイクロ流体処理のための方法およびシステム - Google Patents

マイクロ流体処理のための方法およびシステム Download PDF

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JP2016516562A
JP2016516562A JP2015560397A JP2015560397A JP2016516562A JP 2016516562 A JP2016516562 A JP 2016516562A JP 2015560397 A JP2015560397 A JP 2015560397A JP 2015560397 A JP2015560397 A JP 2015560397A JP 2016516562 A JP2016516562 A JP 2016516562A
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cartridge
fluid
microfluidic
actuator
molecule
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JP2016516562A5 (de
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ダニエル レーザー
ダニエル レーザー
エイミー ドロワクール
エイミー ドロワクール
ハイルマリアム ネグシー
ハイルマリアム ネグシー
ウィリアム ベーンケ‐パークス
ウィリアム ベーンケ‐パークス
Original Assignee
ウェーブ ８０ バイオサイエンシズ インコーポレイテッド
ウェーブ ８０ バイオサイエンシズ インコーポレイテッド
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Publication of JP2016516562A publication Critical patent/JP2016516562A/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2015560397A 2013-03-01 2014-03-03 マイクロ流体処理のための方法およびシステム Pending JP2016516562A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771708P 2013-03-01 2013-03-01
US61/771,708 2013-03-01
PCT/US2014/020029 WO2014137940A1 (en) 2013-03-01 2014-03-03 Methods and systems for enhanced microfluidic processing

Related Child Applications (1)

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JP2019063904A Division JP2019162623A (ja) 2013-03-01 2019-03-28 マイクロ流体処理のための方法およびシステム

Publications (2)

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JP2016516562A true JP2016516562A (ja) 2016-06-09
JP2016516562A5 JP2016516562A5 (de) 2017-04-06

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EP (1) EP2962092A4 (de)
JP (2) JP2016516562A (de)
CA (1) CA2903382A1 (de)
WO (1) WO2014137940A1 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018025899A1 (ja) * 2016-08-03 2018-02-08 和光純薬工業株式会社 プラスチック製マイクロ流体デバイス充填用溶液
JP2018028437A (ja) * 2016-08-15 2018-02-22 住友ゴム工業株式会社 マイクロ流路チップ
CN108927229A (zh) * 2017-05-24 2018-12-04 住友橡胶工业株式会社 微流路芯片
JP2020513762A (ja) * 2016-12-21 2020-05-21 ゲノムテック、スプウカ、アクツィーナＧｅｎｏｍｔｅｃ Ｓａ 生体サンプル中の遺伝物質を検出する方法及びその実施のための装置
KR20210094385A (ko) * 2020-01-21 2021-07-29 (주)옵토레인 푸시타입 pcr용 카트리지

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105758942B (zh) * 2014-12-16 2019-01-04 中国科学院大连化学物理研究所 基于多种核酸适体的多蛋白同时在线富集检测方法
CN105241941A (zh) * 2015-09-06 2016-01-13 常州大学 一种毛细管内快速检测酶浓度的方法
WO2017066884A1 (en) * 2015-10-23 2017-04-27 The Royal Institution For The Advancement Of Learning/Mcgill University Fluidic circuits and methods for bacterial screening
WO2018057005A1 (en) * 2016-09-23 2018-03-29 Hewlett-Packard Development Company, L.P. Microfluidic device
US11162130B2 (en) * 2017-11-09 2021-11-02 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
US10046322B1 (en) * 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
CN109576345A (zh) * 2018-10-17 2019-04-05 西人马（厦门）科技有限公司 一种用于dna提取的微流控芯片及其检测方法
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
CN116930298B (zh) * 2023-09-14 2023-12-26 古镜科技(深圳)有限公司 用于检测hiv的电化学生物传感器及其制备方法和应用

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000513813A (ja) * 1996-07-03 2000-10-17 カリパー テクノロジーズ コーポレイション 流体含有構造体内における電気力を介した電気浸透力および／または電気泳動力の可変制御
JP2001502790A (ja) * 1996-06-28 2001-02-27 カリパー テクノロジーズ コーポレイション 微小スケール流体装置の高処理能力スクリーニングアッセイシステム
JP2004508837A (ja) * 2000-09-14 2004-03-25 カリパー・テクノロジーズ・コープ． 温度介在反応を行うためのマイクロ流体装置及び方法
JP2004340962A (ja) * 2003-05-13 2004-12-02 Berkin Bv 液体流路内の液流の質量流量を制御するための装置
JP2006022807A (ja) * 2004-06-07 2006-01-26 Science Solutions International Laboratory Inc 電気浸透流ポンプシステム及び電気浸透流ポンプ
JP2011509658A (ja) * 2008-01-10 2011-03-31 ヒューレル コーポレーション 免疫システムモデリング・デバイスおよび方法
JP2012508894A (ja) * 2008-11-13 2012-04-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体システムの流入口と毛細管チャネルとの接続
JP2012511156A (ja) * 2008-12-05 2012-05-17 ナノアイヴイディー，インコーポレイテッド ポイント・オブ・ケア分析器用マイクロ流体ベースのラボオンテストカード
JP2012527622A (ja) * 2009-05-19 2012-11-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多方向マイクロ流体装置および方法
JP2012251927A (ja) * 2011-06-06 2012-12-20 National Institute Of Advanced Industrial & Technology 標的物質検出用マイクロチップ
JP2013520298A (ja) * 2010-02-22 2013-06-06 ルナマイクロ・エービー 動電学的流体システム

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391622B1 (en) * 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US7235164B2 (en) * 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7316543B2 (en) * 2003-05-30 2008-01-08 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic micropump with planar features
US20050034990A1 (en) * 2003-08-12 2005-02-17 Crooks Richard M. System and method for electrokinetic trapping and concentration enrichment of analytes in a microfluidic channel
EP2411148B1 (de) * 2009-03-23 2018-02-21 Raindance Technologies, Inc. Manipulation von mikrofluidiktröpfchen

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502790A (ja) * 1996-06-28 2001-02-27 カリパー テクノロジーズ コーポレイション 微小スケール流体装置の高処理能力スクリーニングアッセイシステム
JP2000513813A (ja) * 1996-07-03 2000-10-17 カリパー テクノロジーズ コーポレイション 流体含有構造体内における電気力を介した電気浸透力および／または電気泳動力の可変制御
JP2004508837A (ja) * 2000-09-14 2004-03-25 カリパー・テクノロジーズ・コープ． 温度介在反応を行うためのマイクロ流体装置及び方法
JP2004340962A (ja) * 2003-05-13 2004-12-02 Berkin Bv 液体流路内の液流の質量流量を制御するための装置
JP2006022807A (ja) * 2004-06-07 2006-01-26 Science Solutions International Laboratory Inc 電気浸透流ポンプシステム及び電気浸透流ポンプ
JP2011509658A (ja) * 2008-01-10 2011-03-31 ヒューレル コーポレーション 免疫システムモデリング・デバイスおよび方法
JP2012508894A (ja) * 2008-11-13 2012-04-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体システムの流入口と毛細管チャネルとの接続
JP2012511156A (ja) * 2008-12-05 2012-05-17 ナノアイヴイディー，インコーポレイテッド ポイント・オブ・ケア分析器用マイクロ流体ベースのラボオンテストカード
JP2012527622A (ja) * 2009-05-19 2012-11-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多方向マイクロ流体装置および方法
JP2013520298A (ja) * 2010-02-22 2013-06-06 ルナマイクロ・エービー 動電学的流体システム
JP2012251927A (ja) * 2011-06-06 2012-12-20 National Institute Of Advanced Industrial & Technology 標的物質検出用マイクロチップ

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018025899A1 (ja) * 2016-08-03 2018-02-08 和光純薬工業株式会社 プラスチック製マイクロ流体デバイス充填用溶液
JP2018028437A (ja) * 2016-08-15 2018-02-22 住友ゴム工業株式会社 マイクロ流路チップ
US10799866B2 (en) 2016-08-15 2020-10-13 Sumitomo Rubber Industries, Ltd. Microfluidic chip
JP2020513762A (ja) * 2016-12-21 2020-05-21 ゲノムテック、スプウカ、アクツィーナＧｅｎｏｍｔｅｃ Ｓａ 生体サンプル中の遺伝物質を検出する方法及びその実施のための装置
CN108927229A (zh) * 2017-05-24 2018-12-04 住友橡胶工业株式会社 微流路芯片
JP2018197694A (ja) * 2017-05-24 2018-12-13 住友ゴム工業株式会社 マイクロ流路チップ
KR20210094385A (ko) * 2020-01-21 2021-07-29 (주)옵토레인 푸시타입 pcr용 카트리지
KR102329337B1 (ko) * 2020-01-21 2021-11-19 (주)옵토레인 푸시타입 pcr용 카트리지

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Publication number Publication date
CA2903382A1 (en) 2014-09-12
JP2019162623A (ja) 2019-09-26
EP2962092A4 (de) 2016-08-24
WO2014137940A1 (en) 2014-09-12
EP2962092A1 (de) 2016-01-06

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