JP2016516026A - Ｒｅａｒｒａｎｇｅｄｄｕｒｉｎｇｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）キナーゼ阻害剤としてのピリジン誘導体 - Google Patents

Ｒｅａｒｒａｎｇｅｄｄｕｒｉｎｇｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）キナーゼ阻害剤としてのピリジン誘導体 Download PDF

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Publication number
JP2016516026A
JP2016516026A JP2015562529A JP2015562529A JP2016516026A JP 2016516026 A JP2016516026 A JP 2016516026A JP 2015562529 A JP2015562529 A JP 2015562529A JP 2015562529 A JP2015562529 A JP 2015562529A JP 2016516026 A JP2016516026 A JP 2016516026A
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Japan
Prior art keywords
alkyl
ethoxy
fluorophenyl
acetamide
trifluoromethyl
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Pending
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JP2015562529A
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English (en)
Japanese (ja)
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JP2016516026A5 (OSRAM
Inventor
ヒラリー、シェンク、アイダム
マイケル、ピー．デマーティノ
ゴン、ゼン
エイミー、ホイピン、グアン
カウシク、ラハ
チェンデ、ウー
ヤン、ハイイン
ユ、ハイユ
チャン、ジリウ
ムイ、チュン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Publication of JP2016516026A publication Critical patent/JP2016516026A/ja
Publication of JP2016516026A5 publication Critical patent/JP2016516026A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
JP2015562529A 2013-03-15 2014-03-14 Ｒｅａｒｒａｎｇｅｄｄｕｒｉｎｇｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）キナーゼ阻害剤としてのピリジン誘導体 Pending JP2016516026A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/072683 2013-03-15
CN2013072683 2013-03-15
CNPCT/CN2013/090059 2013-12-20
CN2013090059 2013-12-20
CNPCT/CN2014/072449 2014-02-24
CN2014072449 2014-02-24
PCT/IB2014/059817 WO2014141187A1 (en) 2013-03-15 2014-03-14 Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2016516026A true JP2016516026A (ja) 2016-06-02
JP2016516026A5 JP2016516026A5 (OSRAM) 2017-04-13

Family

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JP2015562529A Pending JP2016516026A (ja) 2013-03-15 2014-03-14 Ｒｅａｒｒａｎｇｅｄｄｕｒｉｎｇｔｒａｎｓｆｅｃｔｉｏｎ（ｒｅｔ）キナーゼ阻害剤としてのピリジン誘導体

Country Status (33)

Country Link
US (2) US9382238B2 (OSRAM)
EP (1) EP2970191B1 (OSRAM)
JP (1) JP2016516026A (OSRAM)
CN (1) CN105051027A (OSRAM)
AU (1) AU2014229233B2 (OSRAM)
BR (1) BR112015023618A2 (OSRAM)
CA (1) CA2905627A1 (OSRAM)
CL (1) CL2015002514A1 (OSRAM)
CR (1) CR20150490A (OSRAM)
CY (1) CY1118730T1 (OSRAM)
DK (1) DK2970191T3 (OSRAM)
DO (1) DOP2015000244A (OSRAM)
EA (1) EA029296B1 (OSRAM)
ES (1) ES2616655T3 (OSRAM)
HR (1) HRP20170363T1 (OSRAM)
HU (1) HUE033423T2 (OSRAM)
IL (1) IL241161A0 (OSRAM)
LT (1) LT2970191T (OSRAM)
ME (1) ME02664B (OSRAM)
MX (1) MX2015012286A (OSRAM)
NZ (1) NZ628388A (OSRAM)
PE (1) PE20151538A1 (OSRAM)
PH (1) PH12015502044A1 (OSRAM)
PL (1) PL2970191T3 (OSRAM)
PT (1) PT2970191T (OSRAM)
RS (1) RS55710B1 (OSRAM)
SG (1) SG11201506695UA (OSRAM)
SI (1) SI2970191T1 (OSRAM)
SM (1) SMT201700152T1 (OSRAM)
TW (1) TW201524958A (OSRAM)
UA (1) UA115264C2 (OSRAM)
UY (1) UY35465A (OSRAM)
WO (1) WO2014141187A1 (OSRAM)

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PT3191450T (pt) * 2014-09-10 2019-05-29 Glaxosmithkline Ip Dev Ltd Derivados de piridona como inibidores da quinase rearranjada durante a transfecção (ret)
EA032030B1 (ru) 2014-09-10 2019-03-29 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
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WO2017019804A2 (en) 2015-07-28 2017-02-02 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
EP3571203B1 (en) 2017-01-18 2023-06-07 Array BioPharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
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CN110891573A (zh) 2017-05-15 2020-03-17 缆图药品公司 Ret抑制剂和mtorc1抑制剂的组合及其用于治疗由异常ret活性介导的癌症的用途
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TWI876442B (zh) * 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
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Publication number Priority date Publication date Assignee Title
JP2023512546A (ja) * 2020-02-20 2023-03-27 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 キノリン系化合物
JP7461605B2 (ja) 2020-02-20 2024-04-04 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 キノリン系化合物

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RS55710B1 (sr) 2017-07-31
CL2015002514A1 (es) 2016-02-05
DOP2015000244A (es) 2015-12-31
US9382238B2 (en) 2016-07-05
PE20151538A1 (es) 2015-11-18
US20160271123A1 (en) 2016-09-22
PL2970191T3 (pl) 2017-07-31
IL241161A0 (en) 2015-11-30
EA029296B1 (ru) 2018-03-30
EP2970191B1 (en) 2016-12-21
SMT201700152T1 (it) 2017-05-08
HRP20170363T1 (hr) 2017-04-21
SG11201506695UA (en) 2015-09-29
DK2970191T3 (en) 2017-03-20
EA201591738A1 (ru) 2016-01-29
CN105051027A (zh) 2015-11-11
AU2014229233A1 (en) 2015-09-24
US20160002215A1 (en) 2016-01-07
BR112015023618A2 (pt) 2017-07-18
LT2970191T (lt) 2017-03-10
PT2970191T (pt) 2017-03-23
EP2970191A1 (en) 2016-01-20
SI2970191T1 (sl) 2017-04-26
UA115264C2 (uk) 2017-10-10
US9789100B2 (en) 2017-10-17
AU2014229233B2 (en) 2016-08-11
PH12015502044A1 (en) 2016-01-18
ES2616655T3 (es) 2017-06-13
NZ628388A (en) 2016-09-30
MX2015012286A (es) 2016-05-31
HUE033423T2 (en) 2017-11-28
CA2905627A1 (en) 2014-09-18
UY35465A (es) 2014-10-31
CR20150490A (es) 2015-11-20
WO2014141187A1 (en) 2014-09-18
TW201524958A (zh) 2015-07-01
CY1118730T1 (el) 2017-07-12
ME02664B (me) 2017-06-20

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