JP2016515526A5 - - Google Patents

Download PDF

Info

Publication number
JP2016515526A5
JP2016515526A5 JP2016503224A JP2016503224A JP2016515526A5 JP 2016515526 A5 JP2016515526 A5 JP 2016515526A5 JP 2016503224 A JP2016503224 A JP 2016503224A JP 2016503224 A JP2016503224 A JP 2016503224A JP 2016515526 A5 JP2016515526 A5 JP 2016515526A5
Authority
JP
Japan
Prior art keywords
compound
independently
group
heteroaryl
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2016503224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016515526A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/029806 external-priority patent/WO2014145116A2/en
Publication of JP2016515526A publication Critical patent/JP2016515526A/ja
Publication of JP2016515526A5 publication Critical patent/JP2016515526A5/ja
Ceased legal-status Critical Current

Links

JP2016503224A 2013-03-15 2014-03-14 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 Ceased JP2016515526A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361798937P 2013-03-15 2013-03-15
US61/798,937 2013-03-15
PCT/US2014/029806 WO2014145116A2 (en) 2013-03-15 2014-03-14 Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders

Publications (2)

Publication Number Publication Date
JP2016515526A JP2016515526A (ja) 2016-05-30
JP2016515526A5 true JP2016515526A5 (enExample) 2017-04-20

Family

ID=50588910

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016503224A Ceased JP2016515526A (ja) 2013-03-15 2014-03-14 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体

Country Status (6)

Country Link
US (1) US10189830B2 (enExample)
EP (1) EP2970158B1 (enExample)
JP (1) JP2016515526A (enExample)
CA (1) CA2906145A1 (enExample)
HK (1) HK1220451A1 (enExample)
WO (1) WO2014145116A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2564843B1 (en) 2005-06-01 2018-12-26 Bioelectron Technology Corporation Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
DK2220030T3 (en) 2007-11-06 2016-04-11 Edison Pharmaceuticals Inc 4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial
EP2237664A4 (en) 2008-01-08 2013-05-22 Edison Pharmaceuticals Inc (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
MX363223B (es) 2008-09-10 2019-03-15 Bioelectron Tech Corp Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
PL2424495T3 (pl) 2009-04-28 2018-06-29 Bioelectron Technology Corporation Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
US9464016B2 (en) 2011-06-14 2016-10-11 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ, インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
EP2892516A1 (en) 2012-09-07 2015-07-15 Edison Pharmaceuticals, Inc. Quinone derivatives for use in the modulation of redox status of individuals
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
PL3233786T3 (pl) 2014-12-16 2022-06-13 Ptc Therapeutics, Inc. Polimorficzne i amorficzne postacie (r)-2-hydroksy-2-metylo-4-(2,4,5-trimetylo-3,6-dioksocykloheksa-1,4-dienylo)butanoamidu
EP3390377A1 (en) 2015-12-16 2018-10-24 BioElectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩
BR112021007153A2 (pt) 2018-10-17 2021-07-20 Ptc Therapeutics, Inc. 2,3,5-trimetil-6-nonilcicloexa-2,5-dieno-1,4-diona para a supressão e tratamento de a-sinucleinopatias, tauopatias e outros distúrbios
CA3156499A1 (en) 2019-10-04 2021-04-08 Stealth Biotherapeutics Inc. CHINONE, HYDROCHINONE AND NAPHTOCHINONE ANALOGS OF VATIQUINONE FOR THE TREATMENT OF DISEASES WITH MITOCHONDRIAL DISORDERS
WO2021202986A1 (en) 2020-04-03 2021-10-07 Stealth Biotherapeutics Corp Compositions and methods for the prevention and/or treatment of mitochondrial disease, including friedreich's ataxia
WO2023283466A1 (en) 2021-07-08 2023-01-12 Ptc Therapeutics, Inc. Pharmaceutical compositions comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229385A (en) * 1986-01-30 1993-07-20 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
IL81264A (en) 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
JPS62223150A (ja) * 1986-02-12 1987-10-01 Otsuka Pharmaceut Co Ltd 1,4−ベンゾキノン誘導体
JP3042547B2 (ja) * 1990-05-11 2000-05-15 サントリー株式会社 ベンゾフラン誘導体及びそれを含む虚血による器質性又は機能性障害治療剤
EP0560568A3 (en) 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
CA2196426A1 (en) 1994-08-12 1996-02-22 Shinji Terao Use of quinone and hydroquinone derivatives for the teatment of cachexia
CA2224517A1 (en) 1995-06-12 1996-12-27 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
JPH0959258A (ja) 1995-08-11 1997-03-04 Ono Pharmaceut Co Ltd グアニジル誘導体
JPH09221471A (ja) 1995-12-15 1997-08-26 Takeda Chem Ind Ltd キノン誘導体の製造法および中間体
WO1997029776A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
US7034054B2 (en) 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
DE10121252A1 (de) 2001-04-30 2002-11-07 Christos C Zouboulis Behandlung der Akne
NZ513547A (en) 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
GB0204232D0 (en) 2002-02-22 2002-04-10 Isis Innovation Assay
DE60211875T2 (de) 2002-07-01 2006-10-26 Santhera Pharmaceuticals (Schweiz) Ag Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia
AU2003287250B9 (en) 2002-10-30 2010-01-28 Ptc Therapeutics, Inc. Identifying therapeutic compounds based on their physical-chemical properties
US7470798B2 (en) 2003-09-19 2008-12-30 Edison Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
US7067659B2 (en) 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
MX2007010721A (es) 2005-03-01 2007-11-13 Pfizer Ltd Nuevo uso de inhibidores de fosfodiesterasa 7 para el tratamiento de dolor neuropatico.
EP2564843B1 (en) 2005-06-01 2018-12-26 Bioelectron Technology Corporation Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1947942B1 (en) 2005-08-18 2015-07-29 Accelalox, Inc. Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway
LT1933821T (lt) 2005-09-15 2020-11-10 Ptc Therapeutics, Inc. Šoninės grandinės variantai redoks aktyviųjų terapijos priemonių, skirtų mitochondrinių ligų ir kitokių būklių gydymui ir energijos biologinių žymenų moduliavimui
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
DK2220030T3 (en) * 2007-11-06 2016-04-11 Edison Pharmaceuticals Inc 4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial
EP2237664A4 (en) 2008-01-08 2013-05-22 Edison Pharmaceuticals Inc (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
WO2009105723A2 (en) 2008-02-22 2009-08-27 Accelalox, Inc. Novel methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway
CA2717741C (en) 2008-03-05 2018-04-03 Edison Pharmaceuticals, Inc. Treatment of hearing and balance impairments with redox-active therapeutics
EP2262508B1 (en) * 2008-03-05 2018-10-03 BioElectron Technology Corporation SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
CA2729227C (en) * 2008-06-25 2018-05-22 Andrew W. Hinman 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
JP2012500260A (ja) * 2008-08-18 2012-01-05 イェール・ユニヴァーシティー Mifモジュレーター
MX363223B (es) 2008-09-10 2019-03-15 Bioelectron Tech Corp Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
CA2740773A1 (en) 2008-10-14 2010-04-22 Edison Pharmaceuticals, Inc. Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
PL2424495T3 (pl) 2009-04-28 2018-06-29 Bioelectron Technology Corporation Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
US20100273892A1 (en) 2009-04-28 2010-10-28 Miller Guy M Formulations of tocotrienol quinones for the treatment of ophthalmic diseases
HUE037592T2 (hu) 2009-08-26 2018-09-28 Bioelectron Tech Corp Eljárások cerebrális ischemia megelõzésére és kezelésére
EP2519232A1 (en) 2009-12-31 2012-11-07 Edison Pharmaceuticals, Inc. Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
AU2011245384C1 (en) 2010-04-27 2016-09-01 Bioelectron Technology Corporation Formulations of quinones for the treatment of ophthalmic diseases
US20130345312A1 (en) 2010-08-06 2013-12-26 Orion D. Jankowski Treatment of mitochondrial diseases with naphthoquinones
WO2012022467A2 (en) * 2010-08-16 2012-02-23 Santhera Pharmaceuticals (Schweiz) Ag Novel benzoquinone derivatives and use thereof as modulators of mitochondrial function
US20120076795A1 (en) 2010-09-27 2012-03-29 Sutter West Bay Hospitals D/B/A California Pacific Medical Center Anti-PECAM Therapy, Compositions, Methods, and Uses
US9464016B2 (en) 2011-06-14 2016-10-11 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
WO2013006737A1 (en) 2011-07-06 2013-01-10 Edison Pharmaceuticals, Inc. Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ, インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
RS56226B1 (sr) 2012-03-14 2017-11-30 Levicept Ltd P75ntr neurotrofin vezujući protein za terapijsku primenu
WO2014031586A2 (en) 2012-08-20 2014-02-27 Tallikut Pharmaceuticals, Inc. Methods for treating cardiovascular diseases
EP2892516A1 (en) 2012-09-07 2015-07-15 Edison Pharmaceuticals, Inc. Quinone derivatives for use in the modulation of redox status of individuals
US20140275045A1 (en) 2013-03-15 2014-09-18 Edison Pharmaceuticals, Inc. Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
HK1223369A1 (zh) 2013-05-31 2017-07-28 Bioelectron Technology Corporation 用於治疗氧化应激障碍的羧酸衍生物

Similar Documents

Publication Publication Date Title
JP2016515526A5 (enExample)
JP2019504018A5 (enExample)
JP2015533794A5 (enExample)
JP2016515527A5 (enExample)
JP2016514697A5 (enExample)
JP2016520621A5 (enExample)
US10981855B2 (en) Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
US9629815B2 (en) Benzoquinone derivatives for treating oxidative stress disorders
US20220265578A1 (en) Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
EP2970158B1 (en) Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
US9296712B2 (en) Resorufin derivatives for treatment of oxidative stress disorders
JP2013541502A5 (enExample)
EP3983385B1 (en) Naphthoquinone derivatives for treatment of oxidative stress disorders
CA2906154A1 (en) Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
JP2011525926A5 (enExample)
US9868711B2 (en) Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
CA2912871A1 (en) Carboxylic acid derivatives for treatment of oxidative stress disorders
WO2018129411A1 (en) Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders
RU2009148821A (ru) Производные [1,10]фенантролина для лечения нейродегенеративных или гематологических заболеваний
RU2006112573A (ru) Соединения карбоновых кислот и медицинские композиции, содержащие их в качестве активного ингредиента
PE20121682A1 (es) Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
RU2021122694A (ru) Способы и композиции для лечения митохондриальной дисфункции
NZ740846A (en) Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof