JP2016514686A5 - - Google Patents
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- Publication number
- JP2016514686A5 JP2016514686A5 JP2016503003A JP2016503003A JP2016514686A5 JP 2016514686 A5 JP2016514686 A5 JP 2016514686A5 JP 2016503003 A JP2016503003 A JP 2016503003A JP 2016503003 A JP2016503003 A JP 2016503003A JP 2016514686 A5 JP2016514686 A5 JP 2016514686A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- matrix
- dosage form
- wax
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 45
- 239000011159 matrix material Substances 0.000 claims 45
- 239000002245 particle Substances 0.000 claims 42
- 239000001993 wax Substances 0.000 claims 32
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 24
- 229960004394 topiramate Drugs 0.000 claims 24
- 239000011230 binding agent Substances 0.000 claims 20
- 239000004094 surface-active agent Substances 0.000 claims 18
- 229920001577 copolymer Polymers 0.000 claims 12
- 239000007788 liquid Substances 0.000 claims 9
- 239000007884 disintegrant Substances 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 235000003599 food sweetener Nutrition 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 239000003765 sweetening agent Substances 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 238000007639 printing Methods 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 229920000831 ionic polymer Polymers 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 238000010146 3D printing Methods 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 235000012489 doughnuts Nutrition 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791592P | 2013-03-15 | 2013-03-15 | |
| US61/791,592 | 2013-03-15 | ||
| PCT/US2014/029168 WO2014144661A1 (en) | 2013-03-15 | 2014-03-14 | Rapidly dispersible dosage form of topiramate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016514686A JP2016514686A (ja) | 2016-05-23 |
| JP2016514686A5 true JP2016514686A5 (OSRAM) | 2017-04-06 |
| JP6466399B2 JP6466399B2 (ja) | 2019-02-06 |
Family
ID=51537752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503003A Active JP6466399B2 (ja) | 2013-03-15 | 2014-03-14 | トピラマートの急速分散性の剤形 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9492380B2 (OSRAM) |
| EP (1) | EP2968181B1 (OSRAM) |
| JP (1) | JP6466399B2 (OSRAM) |
| CN (1) | CN105050588B (OSRAM) |
| AU (2) | AU2014228861B2 (OSRAM) |
| CA (1) | CA2906172C (OSRAM) |
| ES (1) | ES2761407T3 (OSRAM) |
| HK (1) | HK1213473A1 (OSRAM) |
| MX (1) | MX365914B (OSRAM) |
| WO (1) | WO2014144661A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105534936B (zh) * | 2007-08-13 | 2020-07-31 | Ohemo 生命科学股份有限公司 | 抗滥用药物、使用方法和制备方法 |
| EP3431141B1 (en) | 2013-03-15 | 2021-12-08 | Aprecia Pharmaceuticals LLC | Three-dimensional printing method |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| CN104586871B (zh) * | 2014-12-27 | 2018-01-16 | 北京罗诺强施医药技术研发中心有限公司 | 包含托吡酯的药物组合物 |
| US20160243036A1 (en) * | 2015-02-25 | 2016-08-25 | Intelgenx Corp. | Film dosage forms containing amorphous active agents |
| WO2016192680A1 (en) | 2015-06-03 | 2016-12-08 | Triastek, Inc. | Dosage forms and use thereof |
| ES2992002T3 (es) * | 2016-04-06 | 2024-12-05 | Astellas Pharma Inc | Moldeo tridimensional de elución rápida, filamento para moldeo tridimensional de elución rápida y material para moldeo tridimensional de elución rápida |
| WO2018041312A1 (en) | 2016-09-02 | 2018-03-08 | Novo Futura Ivs | Disposable grill and method of manufacturing a disposable grill |
| EP3573602A4 (en) | 2017-01-26 | 2020-09-16 | Triastek, Inc. | DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES |
| CN107213126B (zh) * | 2017-05-17 | 2020-06-23 | 西安棣加生物科技有限公司 | 一种3d打印技术制备治疗高磷血症的口腔速崩片的方法 |
| CN107252418B (zh) * | 2017-05-17 | 2020-06-23 | 西安棣加生物科技有限公司 | 一种3d打印技术制备治疗低钾血症的口腔速崩片的方法 |
| US10703549B2 (en) | 2017-06-30 | 2020-07-07 | The Procter And Gamble Company | Water soluble containers and methods of making them |
| MX2020004403A (es) * | 2017-11-02 | 2020-08-06 | Zambon Spa | Composiciones farmaceuticas que comprenden safinamida. |
| JP7360949B2 (ja) * | 2017-12-26 | 2023-10-13 | 東和薬品株式会社 | 環状口腔内崩壊錠 |
| WO2019137200A1 (en) | 2018-01-09 | 2019-07-18 | Triastek, Inc. | Oral drug dosage forms comprising a fixed-dose of an adhd non-stimulant and an adhd stimulant |
| CA3096124A1 (en) | 2018-04-10 | 2019-10-17 | Panacea Biomatx, Inc. | Method and system for making personalized nutritional and pharmaceutical formulations using additive manufacturing |
| CA3112618A1 (en) * | 2018-09-14 | 2020-03-19 | Merck Patent Gmbh | Process for the preparation of a coated solid pharmaceutical dosage form |
| CN112867482B (zh) | 2018-10-15 | 2023-04-25 | 阿普雷奇亚制药有限责任公司 | 在包装内形成剂型的方法和系统 |
| US12419857B2 (en) * | 2018-11-21 | 2025-09-23 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
| HUE064472T2 (hu) | 2019-02-22 | 2024-03-28 | Catalent Uk Swindon Zydis Ltd | Agglomeráció, aeráció minimalizálása, és ibuprofent tartalmazó gyógyszerészeti készítmények bevonatának védelme |
| CN113507923B (zh) | 2019-02-22 | 2024-03-26 | 康特伦英国斯温顿捷迪斯有限公司 | 在线混合期间混悬液的曝气最小化 |
| PL3927314T3 (pl) | 2019-02-22 | 2024-02-19 | Catalent U.K. Swindon Zydis Limited | Minimalizacja aglomeracji materiału powlekającego cząstki leku podczas przechowywania dla ustabilizowania czasów rozpadu produktów farmaceutycznych |
| AR118159A1 (es) | 2019-02-22 | 2021-09-22 | Catalent Uk Swindon Zydis Ltd | Minimización de aglomeración, aireación y conservación del revestimiento de composiciones farmacéuticas que comprenden ibuprofeno |
| US20220408745A1 (en) * | 2019-09-13 | 2022-12-29 | Meiji Co., Ltd. | Solid food and solid milk having hole penetrating first face and second face |
| MX2022016117A (es) | 2020-06-26 | 2023-04-05 | Aprecia Pharmaceuticals LLC | Tabletas rapidamente orodispersables que tienen una cavidad interior. |
| CA3189404A1 (en) | 2020-07-31 | 2022-02-03 | Catalent U.K. Swindon Zydis Limited | Pharmaceutical compositions comprising coated api |
| WO2024108082A1 (en) | 2022-11-18 | 2024-05-23 | Aprecia Pharmaceuticals LLC | Orodispersive dosage forms containing droxidopa |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4642903A (en) | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
| US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
| EP0418596A3 (en) | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| US5578322A (en) | 1990-11-30 | 1996-11-26 | Yamanouchi Pharmaceutical Co., Ltd. | Quick release coated preparation |
| DE4200821A1 (de) | 1992-01-15 | 1993-07-22 | Bayer Ag | Geschmacksmaskierte pharmazeutische mittel |
| US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| US5380473A (en) | 1992-10-23 | 1995-01-10 | Fuisz Technologies Ltd. | Process for making shearform matrix |
| US5631023A (en) | 1993-07-09 | 1997-05-20 | R.P. Scherer Corporation | Method for making freeze dried drug dosage forms |
| US5490962A (en) * | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| US5738875A (en) | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| ATE421318T1 (de) | 1997-02-20 | 2009-02-15 | Massachusetts Inst Technology | Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben |
| FR2766089B1 (fr) | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| UA65607C2 (uk) * | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| EP1194153B1 (en) | 1999-07-09 | 2004-05-06 | Ortho-McNeil Pharmaceutical, Inc. | Taste masked pharmaceutical liquid formulations |
| AU5060499A (en) * | 1999-08-04 | 2001-03-05 | Ranbaxy Laboratories Limited | Hydrodynamically balanced oral drug delivery system |
| DE19940944B4 (de) | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
| CA2408956C (en) * | 2000-05-18 | 2011-07-12 | Therics, Inc. | Method and form of a drug delivery device,such as encapsulating a toxic core within a non-toxic region in an oral dosage form |
| MXPA03008057A (es) | 2001-03-05 | 2004-10-15 | Johnson & Johnson | Composiciones farmaceuticas con sabor oculto. |
| US7931914B2 (en) * | 2001-10-29 | 2011-04-26 | Massachusetts Institute Of Technology | System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form |
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| FR2838647B1 (fr) | 2002-04-23 | 2006-02-17 | Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant | |
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| WO2004052345A1 (en) | 2002-12-11 | 2004-06-24 | Ranbaxy Laboratories Limited | Coating composition for taste masking coating and methods for their application and use |
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| BRPI0413881A (pt) | 2003-08-28 | 2006-10-24 | Sandoz Ag | composição farmacêutica compreendendo anticonvulsivante com revestimento de mascaramento de gosto |
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| JP2008507508A (ja) * | 2004-07-22 | 2008-03-13 | 株式會社アモーレパシフィック | トピラメート徐放性製剤及びその製造方法 |
| US20060127479A1 (en) | 2004-10-08 | 2006-06-15 | Natrajan Kumaraperumal | Solvent free taste masked pharmaceutical compositions |
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| US20070092553A1 (en) | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
| US9744137B2 (en) * | 2006-08-31 | 2017-08-29 | Supernus Pharmaceuticals, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| CN102218044A (zh) * | 2006-12-04 | 2011-10-19 | 苏佩努斯制药公司 | 托吡酯的增强的立即释放制剂 |
| BRPI0819231B8 (pt) * | 2007-10-31 | 2021-05-25 | Mcneil Ppc Inc | processo para preparo de forma farmacêutica de desintegração rápida por moldagem a quente na presença de sal inorgânico hidratado |
| WO2009106824A2 (en) * | 2008-02-25 | 2009-09-03 | Cipla Limited | Pharmaceutical formulations |
| EP2397161B1 (en) | 2009-02-12 | 2019-09-25 | Fuji Chemical Industry Co., Ltd. | Disintegrating particle composition and rapidly disintegrating compression-molded material comprising same |
| US20100285130A1 (en) | 2009-05-06 | 2010-11-11 | Monosol Rx, Llc | Coating of complexed actives in film formulations |
| US20120076858A1 (en) | 2009-06-04 | 2012-03-29 | Basf Se | Orally Disintegrating Dosage Forms Containing Taste-Masked Active Ingredients |
| EP2467126A1 (en) * | 2009-08-19 | 2012-06-27 | Bayer Pharma Aktiengesellschaft | Drug delivery systems (wafer) for pediatric use |
| AR079862A1 (es) * | 2010-01-08 | 2012-02-22 | Eurand Inc | Composicion de topiramato con sabor enmascarado, un comprimido desintegrable oralmente que comprende la misma y metodo de preparacion |
| JP6133009B2 (ja) * | 2010-08-11 | 2017-05-24 | 協和発酵キリン株式会社 | トピラマート顆粒 |
| US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
-
2014
- 2014-03-14 CA CA2906172A patent/CA2906172C/en active Active
- 2014-03-14 CN CN201480015723.7A patent/CN105050588B/zh active Active
- 2014-03-14 ES ES14763925T patent/ES2761407T3/es active Active
- 2014-03-14 JP JP2016503003A patent/JP6466399B2/ja active Active
- 2014-03-14 AU AU2014228861A patent/AU2014228861B2/en active Active
- 2014-03-14 EP EP14763925.6A patent/EP2968181B1/en active Active
- 2014-03-14 MX MX2015012135A patent/MX365914B/es active IP Right Grant
- 2014-03-14 WO PCT/US2014/029168 patent/WO2014144661A1/en not_active Ceased
- 2014-03-14 HK HK16101295.2A patent/HK1213473A1/zh unknown
-
2015
- 2015-08-27 US US14/837,354 patent/US9492380B2/en active Active
-
2016
- 2016-08-23 US US15/244,563 patent/US10420785B2/en active Active
-
2018
- 2018-08-22 AU AU2018220049A patent/AU2018220049B2/en active Active
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