JP2016514091A - トランスサイレチン抗体およびその使用 - Google Patents

トランスサイレチン抗体およびその使用 Download PDF

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Publication number
JP2016514091A
JP2016514091A JP2015557148A JP2015557148A JP2016514091A JP 2016514091 A JP2016514091 A JP 2016514091A JP 2015557148 A JP2015557148 A JP 2015557148A JP 2015557148 A JP2015557148 A JP 2015557148A JP 2016514091 A JP2016514091 A JP 2016514091A
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ttr
mutation
antibody
subject
native
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Japanese (ja)
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JP2016514091A5 (enExample
Inventor
シン ジャン，
シン ジャン，
ジェフリー ダブリュー． ケリー，
ジェフリー ダブリュー． ケリー，
ジャスティン チャプマン，
ジャスティン チャプマン，
Original Assignee
ミスフォールディング ダイアグノスティクス， インコーポレイテッド
ミスフォールディング ダイアグノスティクス， インコーポレイテッド
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Publication of JP2016514091A publication Critical patent/JP2016514091A/ja
Publication of JP2016514091A5 publication Critical patent/JP2016514091A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015557148A 2013-02-08 2014-02-07 トランスサイレチン抗体およびその使用 Pending JP2016514091A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361762750P 2013-02-08 2013-02-08
US61/762,750 2013-02-08
US201361863818P 2013-08-08 2013-08-08
US61/863,818 2013-08-08
PCT/US2014/015421 WO2014124334A2 (en) 2013-02-08 2014-02-07 Transthyretin antibodies and uses thereof

Publications (2)

Publication Number Publication Date
JP2016514091A true JP2016514091A (ja) 2016-05-19
JP2016514091A5 JP2016514091A5 (enExample) 2017-03-02

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JP2015557148A Pending JP2016514091A (ja) 2013-02-08 2014-02-07 トランスサイレチン抗体およびその使用

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US (2) US9790269B2 (enExample)
EP (1) EP2953970A4 (enExample)
JP (1) JP2016514091A (enExample)
WO (1) WO2014124334A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020188700A (ja) * 2019-05-21 2020-11-26 国立大学法人 熊本大学 アミロイドーシス治療薬の新規スクリーニング方法及びアミロイドーシスのための医薬組成物
JP2020536532A (ja) * 2017-10-06 2020-12-17 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
US11873332B2 (en) 2017-11-29 2024-01-16 Novo Nordisk A/S Lyophilized formulation of a monoclonal antibody against transthyretin
US11912759B2 (en) 2015-01-28 2024-02-27 Novo Nordisk A/S Anti-transthyretin antibodies
US12247985B2 (en) 2017-10-06 2025-03-11 Novo Nordisk A/S Methods of detecting transthyretin

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US20160168235A1 (en) * 2013-07-19 2016-06-16 Board Of Regents Of The University Of Texas System Transthyretin amyloid-selective and polyreactive catabodies
WO2015092077A1 (en) 2013-12-20 2015-06-25 Neurimmune Holding Ag Antibody-based therapy of transthyretin (ttr) amyloidosis and human-derived antibodies therefor
KR102240417B1 (ko) 2014-01-29 2021-04-13 케이엠 바이올로직스 가부시키가이샤 항-트랜스티레틴 인간 항체
CN106574258B (zh) * 2014-01-29 2021-03-30 Km生物医药股份公司 抗-运甲状腺素蛋白人源化抗体
TWI781507B (zh) * 2015-01-28 2022-10-21 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
TWI718122B (zh) * 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
TWI711631B (zh) * 2015-01-28 2020-12-01 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
JP7016470B2 (ja) * 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
EP3478714A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7017013B2 (ja) * 2016-07-02 2022-02-08 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
CN116600392A (zh) * 2016-09-10 2023-08-15 Lg电子株式会社 执行副链路操作的方法和用户设备以及控制该设备的设备
EP3515482A4 (en) 2016-09-19 2020-09-30 The Wistar Institute Of Anatomy And Biology ASSOCIATION OF NEW ZIKA VIRUS VACCINES AND ANTI-DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST ZIKA VIRUS
WO2019241497A1 (en) * 2018-06-13 2019-12-19 The Wistar Institute Of Anatomy And Biology Dna antibody constructs for use against zika virus
US20210400932A1 (en) 2018-11-09 2021-12-30 Neurimmune Ag Patient-derived amyloid xenograft non-human animal model
US20220241247A1 (en) * 2019-05-31 2022-08-04 Plex Pharmaceuticals, Inc. Pharmacological agents for treating protein aggregation diseases of the eye
EP3988122A4 (en) * 2019-12-17 2023-01-18 Yizhou (Shanghai) Biological Medicine Co, Ltd. USE OF TRANSTHYRETIN FOR INTRODUCTION TO THE EYE AND MAKING DROPS
US11998237B2 (en) 2020-06-03 2024-06-04 Bard Access Systems, Inc. Intraosseous device including a sensing obturator
CN114098918B (zh) 2020-08-25 2025-12-12 巴德阿克塞斯系统股份有限公司 成角度的骨内进入系统
EP4203821B1 (en) 2020-09-01 2025-10-29 Bard Access Systems, Inc. Retractable intraosseous access system
CN215839325U (zh) * 2020-09-09 2022-02-18 巴德阿克塞斯系统股份有限公司 用于骨内进入系统的抽吸设备
CN117062527A (zh) 2021-01-19 2023-11-14 埃里莫斯制药有限责任公司 作为冠状病毒抗病毒剂的Terameprocol和去甲二氢愈创木酸（NDGA）衍生物
CN114903553A (zh) 2021-02-08 2022-08-16 巴德阿克塞斯系统股份有限公司 骨内进入系统和用于钻入穿过骨骼的方法
CN117916599A (zh) 2021-09-07 2024-04-19 美国西门子医学诊断股份有限公司 生物标记物组合物及其使用方法
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
EP4296279A1 (en) * 2022-06-23 2023-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti-transthyretin (ttr) binding proteins and uses thereof
JP2025540181A (ja) 2022-12-05 2025-12-11 ニューリミューン アーゲー 環状化合物及び抗体を検出するためのアッセイにおけるその使用
CN116396392B (zh) * 2023-01-17 2023-10-27 珠海重链生物科技有限公司 一种特异性针对异羟基洋地黄毒甙元的抗体及其相关应用
SE2350342A1 (en) * 2023-03-27 2024-09-28 Anders Olofsson Composition for use in prevention and/or treatment of human transthyretin amyloidosis
EP4713354A1 (en) * 2023-05-19 2026-03-25 Neurimmune AG Novel immunotherapy for musculoskeletal disorders and conditions
CN121646476A (zh) 2023-06-07 2026-03-10 神经免疫有限公司 用于治疗淀粉样变性的疫苗
TW202528347A (zh) 2023-11-15 2025-07-16 瑞士商紐立慕公司 抗運甲狀腺素蛋白抗體、包含所述抗體之組成物及用於治療或預防運甲狀腺素蛋白介導之澱粉樣變性的方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11912759B2 (en) 2015-01-28 2024-02-27 Novo Nordisk A/S Anti-transthyretin antibodies
JP2020536532A (ja) * 2017-10-06 2020-12-17 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
JP7357609B2 (ja) 2017-10-06 2023-10-06 ノボ ノルディスク エー／エス 抗トランスサイレチン抗体
US12247985B2 (en) 2017-10-06 2025-03-11 Novo Nordisk A/S Methods of detecting transthyretin
US11873332B2 (en) 2017-11-29 2024-01-16 Novo Nordisk A/S Lyophilized formulation of a monoclonal antibody against transthyretin
JP2020188700A (ja) * 2019-05-21 2020-11-26 国立大学法人 熊本大学 アミロイドーシス治療薬の新規スクリーニング方法及びアミロイドーシスのための医薬組成物
JP7360142B2 (ja) 2019-05-21 2023-10-12 国立大学法人 熊本大学 アミロイドーシス治療薬の新規スクリーニング方法

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EP2953970A2 (en) 2015-12-16
WO2014124334A3 (en) 2014-12-24
WO2014124334A2 (en) 2014-08-14
EP2953970A4 (en) 2016-06-29
US20160039916A1 (en) 2016-02-11
US20180022797A1 (en) 2018-01-25
US9790269B2 (en) 2017-10-17

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