JP2016513709A5 - - Google Patents
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- Publication number
- JP2016513709A5 JP2016513709A5 JP2016502520A JP2016502520A JP2016513709A5 JP 2016513709 A5 JP2016513709 A5 JP 2016513709A5 JP 2016502520 A JP2016502520 A JP 2016502520A JP 2016502520 A JP2016502520 A JP 2016502520A JP 2016513709 A5 JP2016513709 A5 JP 2016513709A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- chloro
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QLOLLPPRFVBYSM-QMMMGPOBSA-N C=Nc1ccccc1C(C[C@@H](C(O)=O)N)=O Chemical compound C=Nc1ccccc1C(C[C@@H](C(O)=O)N)=O QLOLLPPRFVBYSM-QMMMGPOBSA-N 0.000 description 1
- PPIMFXHQDQRWGJ-UHFFFAOYSA-N CC(NC(CC(c1ccccc1N)=O)C(O)=O)=O Chemical compound CC(NC(CC(c1ccccc1N)=O)C(O)=O)=O PPIMFXHQDQRWGJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785807P | 2013-03-14 | 2013-03-14 | |
| US61/785,807 | 2013-03-14 | ||
| PCT/US2014/027694 WO2014152752A1 (en) | 2013-03-14 | 2014-03-14 | Methods for the synthesis of chiral kynurenine compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018093249A Division JP6618569B2 (ja) | 2013-03-14 | 2018-05-14 | キラルキヌレニン化合物の合成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513709A JP2016513709A (ja) | 2016-05-16 |
| JP2016513709A5 true JP2016513709A5 (https=) | 2017-10-05 |
| JP6340409B2 JP6340409B2 (ja) | 2018-06-06 |
Family
ID=51581307
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502520A Expired - Fee Related JP6340409B2 (ja) | 2013-03-14 | 2014-03-14 | キラルキヌレニン化合物の合成方法 |
| JP2018093249A Expired - Fee Related JP6618569B2 (ja) | 2013-03-14 | 2018-05-14 | キラルキヌレニン化合物の合成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018093249A Expired - Fee Related JP6618569B2 (ja) | 2013-03-14 | 2018-05-14 | キラルキヌレニン化合物の合成方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9834801B2 (https=) |
| EP (1) | EP2970097B1 (https=) |
| JP (2) | JP6340409B2 (https=) |
| CN (2) | CN107417558A (https=) |
| CA (1) | CA2941559A1 (https=) |
| WO (1) | WO2014152752A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107417558A (zh) * | 2013-03-14 | 2017-12-01 | 维斯塔津治疗公司 | 用于合成手性犬尿氨酸化合物的方法 |
| KR20240068766A (ko) | 2015-05-22 | 2024-05-17 | 비스타젠 쎄라퓨틱스, 인크. | L-４-클로로키누레닌의 치료적 용도 |
| WO2017044516A1 (en) * | 2015-09-08 | 2017-03-16 | Cephalon, Inc. | Prodrugs of chlorokynurenines |
| WO2018044724A1 (en) * | 2016-08-31 | 2018-03-08 | Ampio Pharmaceuticals, Inc. | Treatment of disease with n-acetyl kynurenine |
| CN110446950B (zh) | 2017-03-29 | 2021-12-28 | 富士胶片株式会社 | 结构体及光传感器 |
| CN112236412B (zh) * | 2018-02-09 | 2024-01-30 | 维斯塔津治疗公司 | 4-氯代犬尿氨酸及中间体的合成 |
| CN113549662B (zh) * | 2020-04-26 | 2022-06-03 | 赤壁市高质量发展研究院有限公司 | 一种用MOF载酶技术高效制备抗抑郁药前药L-4-Cl-犬尿氨酸的方法及应用 |
| CN113549661B (zh) * | 2020-04-26 | 2022-08-30 | 赤壁生合元科技有限公司 | 生物催化合成L-4-Cl-犬尿氨酸或L-4-Br-犬尿氨酸的方法及应用 |
| KR20250011960A (ko) | 2022-06-30 | 2025-01-22 | 가부시키가이샤 에이클립켄규쇼 | 혈관염으로의 이환 상태 또는 covid-19의 중증화 위험을 검사하는 방법, 검사용 키트, 컴패니언 진단약 및 검사용 마커 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3702255A (en) * | 1970-08-21 | 1972-11-07 | Us Agriculture | Kynurenine derivatives as sweetening agents |
| US3766261A (en) | 1970-08-21 | 1973-10-16 | Us Agriculture | Process of producing kynurenine |
| US3765261A (en) * | 1973-01-02 | 1973-10-16 | Hurst Performance | Unitary stick transfer case shifter |
| US5519055A (en) | 1993-08-06 | 1996-05-21 | University Of Maryland At Baltimore | Substituted kynurenines and process for their preparation |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| GB9522615D0 (en) * | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
| ITMI20041626A1 (it) | 2004-08-06 | 2004-11-06 | Roberto Pellicciari | Inibitori della chinurenina-ammino-trasferasi |
| US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| US8728771B2 (en) * | 2008-12-11 | 2014-05-20 | Toyo Boseki Kabushiki Kaisha | L-succinylaminoacylase and process for producing L-amino acid using it |
| CN107417558A (zh) | 2013-03-14 | 2017-12-01 | 维斯塔津治疗公司 | 用于合成手性犬尿氨酸化合物的方法 |
-
2014
- 2014-03-14 CN CN201710718531.8A patent/CN107417558A/zh active Pending
- 2014-03-14 CA CA2941559A patent/CA2941559A1/en not_active Abandoned
- 2014-03-14 US US14/775,287 patent/US9834801B2/en active Active
- 2014-03-14 WO PCT/US2014/027694 patent/WO2014152752A1/en not_active Ceased
- 2014-03-14 EP EP14770640.2A patent/EP2970097B1/en not_active Not-in-force
- 2014-03-14 JP JP2016502520A patent/JP6340409B2/ja not_active Expired - Fee Related
- 2014-03-14 CN CN201480023992.8A patent/CN105164100B/zh not_active Expired - Fee Related
-
2017
- 2017-11-14 US US15/812,599 patent/US10294502B2/en active Active
-
2018
- 2018-05-14 JP JP2018093249A patent/JP6618569B2/ja not_active Expired - Fee Related
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