JP2015199738A5 - - Google Patents
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- Publication number
- JP2015199738A5 JP2015199738A5 JP2015096425A JP2015096425A JP2015199738A5 JP 2015199738 A5 JP2015199738 A5 JP 2015199738A5 JP 2015096425 A JP2015096425 A JP 2015096425A JP 2015096425 A JP2015096425 A JP 2015096425A JP 2015199738 A5 JP2015199738 A5 JP 2015199738A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- phenyl
- alkyl
- independently
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261582760P | 2012-01-03 | 2012-01-03 | |
| US61/582,760 | 2012-01-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014551313A Division JP5747137B2 (ja) | 2012-01-03 | 2013-01-03 | Ｉａｐの阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015199738A JP2015199738A (ja) | 2015-11-12 |
| JP2015199738A5 true JP2015199738A5 (https=) | 2016-02-18 |
Family
ID=48695302
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014551313A Active JP5747137B2 (ja) | 2012-01-03 | 2013-01-03 | Ｉａｐの阻害剤 |
| JP2015096425A Pending JP2015199738A (ja) | 2012-01-03 | 2015-05-11 | Ｉａｐの阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014551313A Active JP5747137B2 (ja) | 2012-01-03 | 2013-01-03 | Ｉａｐの阻害剤 |
Country Status (41)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2755614T3 (https=) | 2012-01-03 | 2018-03-31 | ||
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN109705191B (zh) * | 2017-10-25 | 2022-04-29 | 广东东阳光药业有限公司 | Iap抑制剂及其在药物中的应用 |
| KR102707188B1 (ko) * | 2017-11-13 | 2024-09-13 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Iap 억제제로서 유용한 smac 모방물 및 그 용도 |
| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| WO2021020585A1 (ja) | 2019-07-31 | 2021-02-04 | ファイメクス株式会社 | 複素環化合物 |
| US20230029259A1 (en) * | 2019-12-02 | 2023-01-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of iap inhibitors and parp or mek inhibitors or other chemotherapeutic agents |
| JP2023510426A (ja) | 2020-01-20 | 2023-03-13 | アストラゼネカ・アクチエボラーグ | 癌を治療するための上皮細胞増殖因子受容体チロシンキナーゼ阻害剤 |
| JP2024539137A (ja) | 2021-10-22 | 2024-10-28 | ユニバーシティー オブ ヒューストン システム | 上皮組織の慢性炎症性傷害、化生、異形成、および癌を処置するための方法および組成物 |
| CN117110469B (zh) * | 2023-08-18 | 2025-12-09 | 中国检验检疫科学研究院 | 一种测定防脱发类化妆品中禁用组分的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526988A (en) | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| DE69830577T2 (de) | 1997-04-15 | 2006-05-04 | Genentech, Inc., South San Francisco | Halo-alkoxycarbonylverbindungen |
| BRPI0511350A (pt) * | 2004-07-02 | 2007-12-04 | Genentech Inc | composto, métodos de indução da apoptose em uma célula, de sensibilização de uma célula à um sinal apoptótico, de inibição da ligação de uma proteìna iap e de tratamento de uma doença e cáncer e usos de um composto |
| MX2007007195A (es) * | 2004-12-20 | 2007-10-08 | Genentech Inc | Inhibidores de pirrolidina de iap. |
| US8044209B2 (en) | 2006-10-12 | 2011-10-25 | Novartis Ag | Pyrrolydine derivatives as IAP inhibitors |
| PE20130150A1 (es) | 2007-04-30 | 2013-02-27 | Genentech Inc | Inhibidores de las iap |
| NO2755614T3 (https=) * | 2012-01-03 | 2018-03-31 | ||
| USD690416S1 (en) | 2012-12-12 | 2013-09-24 | Pharmajet, Inc. | Needle-free syringe |
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2012
- 2012-09-13 NO NO12832667A patent/NO2755614T3/no unknown
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2013
- 2013-01-02 AR ARP130100006A patent/AR089623A1/es not_active Application Discontinuation
- 2013-01-03 RU RU2016124658A patent/RU2728789C2/ru active
- 2013-01-03 SI SI201331047T patent/SI3133073T1/en unknown
- 2013-01-03 RS RS20160910A patent/RS55327B1/sr unknown
- 2013-01-03 EP EP13733613.7A patent/EP2800749B1/en active Active
- 2013-01-03 EP EP16189661.8A patent/EP3133073B1/en active Active
- 2013-01-03 TW TW102100188A patent/TWI503318B/zh active
- 2013-01-03 RS RS20180755A patent/RS57438B1/sr unknown
- 2013-01-03 PT PT161896618T patent/PT3133073T/pt unknown
- 2013-01-03 ES ES13733613.7T patent/ES2594856T3/es active Active
- 2013-01-03 WO PCT/US2013/020124 patent/WO2013103703A1/en not_active Ceased
- 2013-01-03 AU AU2013202780A patent/AU2013202780B2/en active Active
- 2013-01-03 UA UAA201408260A patent/UA114417C2/uk unknown
- 2013-01-03 PT PT137336137T patent/PT2800749T/pt unknown
- 2013-01-03 PL PL13733613T patent/PL2800749T3/pl unknown
- 2013-01-03 HR HRP20161381TT patent/HRP20161381T1/hr unknown
- 2013-01-03 HU HUE16189661A patent/HUE037760T2/hu unknown
- 2013-01-03 NZ NZ627480A patent/NZ627480A/en not_active IP Right Cessation
- 2013-01-03 SM SM20180352T patent/SMT201800352T1/it unknown
- 2013-01-03 KR KR1020157014670A patent/KR101855566B1/ko active Active
- 2013-01-03 CN CN201380012308.1A patent/CN104159897A/zh active Pending
- 2013-01-03 MY MYPI2014001966A patent/MY178390A/en unknown
- 2013-01-03 ME MEP-2016-235A patent/ME02526B/me unknown
- 2013-01-03 BR BR112014016637-4A patent/BR112014016637B1/pt active IP Right Grant
- 2013-01-03 ES ES16189661.8T patent/ES2672809T3/es active Active
- 2013-01-03 CA CA2861637A patent/CA2861637C/en active Active
- 2013-01-03 PE PE2014001069A patent/PE20142182A1/es active IP Right Grant
- 2013-01-03 PL PL16189661T patent/PL3133073T3/pl unknown
- 2013-01-03 LT LTEP16189661.8T patent/LT3133073T/lt unknown
- 2013-01-03 CN CN201711212712.XA patent/CN107915728B/zh active Active
- 2013-01-03 SG SG11201403784QA patent/SG11201403784QA/en unknown
- 2013-01-03 ME MEP-2018-161A patent/ME03084B/me unknown
- 2013-01-03 HK HK15104538.4A patent/HK1203949A1/xx unknown
- 2013-01-03 LT LTEP13733613.7T patent/LT2800749T/lt unknown
- 2013-01-03 MX MX2014007895A patent/MX336294B/es unknown
- 2013-01-03 TR TR2018/08088T patent/TR201808088T4/tr unknown
- 2013-01-03 KR KR1020147021597A patent/KR101553792B1/ko active Active
- 2013-01-03 SI SI201330343A patent/SI2800749T1/sl unknown
- 2013-01-03 KR KR1020187012124A patent/KR101917992B1/ko active Active
- 2013-01-03 HU HUE13733613A patent/HUE031305T2/hu unknown
- 2013-01-03 US US13/733,244 patent/US8716236B2/en active Active
- 2013-01-03 JP JP2014551313A patent/JP5747137B2/ja active Active
- 2013-01-03 DK DK16189661.8T patent/DK3133073T3/en active
- 2013-01-03 DK DK13733613.7T patent/DK2800749T3/en active
- 2013-01-03 RU RU2014130171/04A patent/RU2593259C2/ru active
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2014
- 2014-05-05 US US14/269,739 patent/US9238675B2/en active Active
- 2014-06-26 IL IL242314A patent/IL242314A/en active IP Right Grant
- 2014-06-26 IL IL233386A patent/IL233386A/en active IP Right Grant
- 2014-07-01 CL CL2014001770A patent/CL2014001770A1/es unknown
- 2014-07-02 PH PH12014501534A patent/PH12014501534B1/en unknown
- 2014-07-25 ZA ZA2014/05535A patent/ZA201405535B/en unknown
- 2014-07-25 CO CO14161919A patent/CO7020915A2/es unknown
- 2014-07-31 CR CR20140367A patent/CR20140367A/es not_active Application Discontinuation
- 2014-07-31 EC ECIEPI201411792A patent/ECSP14011792A/es unknown
- 2014-08-03 MA MA37254A patent/MA35895B1/fr unknown
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2015
- 2015-05-08 PH PH12015501038A patent/PH12015501038A1/en unknown
- 2015-05-11 JP JP2015096425A patent/JP2015199738A/ja active Pending
- 2015-12-18 US US14/974,140 patent/US9586991B2/en active Active
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2016
- 2016-10-06 SM SM201600357T patent/SMT201600357B/it unknown
- 2016-12-07 CY CY20161101257T patent/CY1118371T1/el unknown
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2017
- 2017-01-31 US US15/420,817 patent/US20170136084A1/en not_active Abandoned
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2018
- 2018-06-22 CY CY20181100652T patent/CY1120355T1/el unknown
- 2018-06-26 HR HRP20180976TT patent/HRP20180976T1/hr unknown
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2019
- 2019-04-02 US US16/372,940 patent/US11096982B2/en active Active
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2021
- 2021-08-03 US US17/392,724 patent/US11963994B2/en active Active
- 2021-09-17 AR ARP210102590A patent/AR123542A2/es not_active Application Discontinuation