JP2016513688A5 - - Google Patents

Info

Publication number

JP2016513688A5

JP2016513688A5 JP2016502370A JP2016502370A JP2016513688A5 JP 2016513688 A5 JP2016513688 A5 JP 2016513688A5 JP 2016502370 A JP2016502370 A JP 2016502370A JP 2016502370 A JP2016502370 A JP 2016502370A JP 2016513688 A5 JP2016513688 A5 JP 2016513688A5

Authority

JP

Japan

Prior art keywords

composition

kit according

disease

set formed

effective amount

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 10
• 239000000178 monomer Substances 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 229910052799 carbon Inorganic materials 0.000 claims 3
• 208000019693 Lung disease Diseases 0.000 claims 2
• 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 150000002016 disaccharides Chemical class 0.000 claims 2
• 150000002772 monosaccharides Chemical class 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 1
• 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 1
• WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 241000589513 Burkholderia cepacia Species 0.000 claims 1
• 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 206010041925 Staphylococcal infections Diseases 0.000 claims 1
• 241000191967 Staphylococcus aureus Species 0.000 claims 1
• 241001147693 Staphylococcus sp. Species 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 238000012387 aerosolization Methods 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000000304 alkynyl group Chemical group 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 1
• 229960003644 aztreonam Drugs 0.000 claims 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
• AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
• 229960002626 clarithromycin Drugs 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• -1 cycloheteroalkyl Chemical group 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
• 239000006199 nebulizer Substances 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 239000003306 quinoline derived antiinfective agent Substances 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1