JP2016513478A5 - - Google Patents
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- Publication number
- JP2016513478A5 JP2016513478A5 JP2016503216A JP2016503216A JP2016513478A5 JP 2016513478 A5 JP2016513478 A5 JP 2016513478A5 JP 2016503216 A JP2016503216 A JP 2016503216A JP 2016503216 A JP2016503216 A JP 2016503216A JP 2016513478 A5 JP2016513478 A5 JP 2016513478A5
- Authority
- JP
- Japan
- Prior art keywords
- cell culture
- culture medium
- insulin
- cystine
- copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 64
- 238000000034 method Methods 0.000 claims 57
- 239000006143 cell culture medium Substances 0.000 claims 49
- 102000004877 Insulin Human genes 0.000 claims 32
- 108090001061 Insulin Proteins 0.000 claims 32
- 229940125396 insulin Drugs 0.000 claims 32
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 31
- 229960003067 cystine Drugs 0.000 claims 31
- 229960000397 bevacizumab Drugs 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 21
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 20
- 229940108928 copper Drugs 0.000 claims 20
- 229910052802 copper Inorganic materials 0.000 claims 20
- 239000010949 copper Substances 0.000 claims 20
- 210000004962 mammalian cell Anatomy 0.000 claims 16
- 238000004113 cell culture Methods 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 10
- 238000012258 culturing Methods 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 239000002609 medium Substances 0.000 claims 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000001186 cumulative effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361801247P | 2013-03-15 | 2013-03-15 | |
| US61/801,247 | 2013-03-15 | ||
| PCT/US2014/029758 WO2014145091A1 (en) | 2013-03-15 | 2014-03-14 | Cell culture media and methods of antibody production |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019112773A Division JP2019193643A (ja) | 2013-03-15 | 2019-06-18 | 細胞培養培地及び抗体を産生する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016513478A JP2016513478A (ja) | 2016-05-16 |
| JP2016513478A5 true JP2016513478A5 (cg-RX-API-DMAC7.html) | 2017-04-13 |
Family
ID=51537877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503216A Pending JP2016513478A (ja) | 2013-03-15 | 2014-03-14 | 細胞培養培地及び抗体を産生する方法 |
| JP2019112773A Pending JP2019193643A (ja) | 2013-03-15 | 2019-06-18 | 細胞培養培地及び抗体を産生する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019112773A Pending JP2019193643A (ja) | 2013-03-15 | 2019-06-18 | 細胞培養培地及び抗体を産生する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9441035B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2968544A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2016513478A (cg-RX-API-DMAC7.html) |
| KR (1) | KR102202476B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN105246510A (cg-RX-API-DMAC7.html) |
| AR (1) | AR095348A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015022529A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2903589A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1213179A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX366112B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2015144020A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014145091A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL264336B2 (en) | 2009-08-11 | 2024-02-01 | Genentech Inc | Production of proteins in cell culture medium without glutamine |
| KR102007930B1 (ko) | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
| AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
| EP3534949A4 (en) * | 2016-11-07 | 2020-07-22 | Seattle Genetics, Inc. | DISTRIBUTION OF GENETICALLY MODIFIED CYSTEINE HAIRDRESSES |
| GB201708655D0 (en) * | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| EP3727629A1 (en) | 2017-12-22 | 2020-10-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| CN108823267B (zh) * | 2018-06-25 | 2020-05-08 | 深圳市菲鹏生物制药股份有限公司 | 调节cho-k1表达系统所分泌抗体的酸性峰含量的方法 |
| CA3201327A1 (en) * | 2020-12-08 | 2022-06-16 | Partner Therapeutics, Inc. | Manufacture of granulocyte macrophage-colony stimulating factor |
| EP4267616A1 (en) * | 2020-12-22 | 2023-11-01 | Novartis AG | Methods for reducing the oxidation level of cysteine residues in a secreted recombinantly-expressed protein during cell culture |
| TW202309087A (zh) * | 2021-05-03 | 2023-03-01 | 德商百靈佳殷格翰國際股份有限公司 | 製備spesolimab之方法 |
| EP4493710A1 (en) * | 2022-04-06 | 2025-01-22 | Kashiv Biosciences, LLC | An improved cell culture process for production of protein |
| WO2024099551A1 (en) * | 2022-11-09 | 2024-05-16 | Infors Ag | Incubator avoiding condensation |
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-
2014
- 2014-03-14 JP JP2016503216A patent/JP2016513478A/ja active Pending
- 2014-03-14 CA CA2903589A patent/CA2903589A1/en not_active Abandoned
- 2014-03-14 US US14/211,467 patent/US9441035B2/en active Active
- 2014-03-14 EP EP14763258.2A patent/EP2968544A4/en not_active Withdrawn
- 2014-03-14 KR KR1020157029225A patent/KR102202476B1/ko active Active
- 2014-03-14 MX MX2015011781A patent/MX366112B/es active IP Right Grant
- 2014-03-14 AR ARP140101052A patent/AR095348A1/es unknown
- 2014-03-14 HK HK16101113.2A patent/HK1213179A1/zh unknown
- 2014-03-14 BR BR112015022529A patent/BR112015022529A2/pt not_active Application Discontinuation
- 2014-03-14 RU RU2015144020A patent/RU2015144020A/ru not_active Application Discontinuation
- 2014-03-14 WO PCT/US2014/029758 patent/WO2014145091A1/en not_active Ceased
- 2014-03-14 CN CN201480027392.9A patent/CN105246510A/zh active Pending
-
2015
- 2015-09-11 US US14/852,382 patent/US20160102141A1/en not_active Abandoned
-
2016
- 2016-07-29 US US15/224,113 patent/US20170051049A1/en not_active Abandoned
-
2019
- 2019-06-18 JP JP2019112773A patent/JP2019193643A/ja active Pending
- 2019-10-18 US US16/657,844 patent/US20200291103A1/en not_active Abandoned
- 2019-11-15 US US16/685,798 patent/US20200347122A1/en not_active Abandoned
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