JP2016512960A5 - - Google Patents
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- Publication number
- JP2016512960A5 JP2016512960A5 JP2015560341A JP2015560341A JP2016512960A5 JP 2016512960 A5 JP2016512960 A5 JP 2016512960A5 JP 2015560341 A JP2015560341 A JP 2015560341A JP 2015560341 A JP2015560341 A JP 2015560341A JP 2016512960 A5 JP2016512960 A5 JP 2016512960A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cells
- talen
- gene
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 108020004414 DNA Proteins 0.000 claims 8
- 108010042407 Endonucleases Proteins 0.000 claims 8
- 102000004533 Endonucleases Human genes 0.000 claims 8
- 108010073062 Transcription Activator-Like Effectors Proteins 0.000 claims 8
- 206010064571 Gene mutation Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 238000010459 TALEN Methods 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 4
- 208000016361 genetic disease Diseases 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 101150056204 COL7A1 gene Proteins 0.000 claims 3
- 101100496573 Homo sapiens COL7A1 gene Proteins 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 102100024335 Collagen alpha-1(VII) chain Human genes 0.000 claims 2
- 101000909498 Homo sapiens Collagen alpha-1(VII) chain Proteins 0.000 claims 2
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 230000003007 single stranded DNA break Effects 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 1
- 230000007035 DNA breakage Effects 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 108010026638 endodeoxyribonuclease FokI Proteins 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000002518 glial effect Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 210000005265 lung cell Anatomy 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019021260A JP6893945B2 (ja) | 2013-03-01 | 2019-02-08 | Ｔａｌｅｎに基づく遺伝子修正 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771735P | 2013-03-01 | 2013-03-01 | |
| US61/771,735 | 2013-03-01 | ||
| PCT/US2014/019322 WO2014134412A1 (en) | 2013-03-01 | 2014-02-28 | Talen-based gene correction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019021260A Division JP6893945B2 (ja) | 2013-03-01 | 2019-02-08 | Ｔａｌｅｎに基づく遺伝子修正 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512960A JP2016512960A (ja) | 2016-05-12 |
| JP2016512960A5 true JP2016512960A5 (enExample) | 2017-03-30 |
| JP6480874B2 JP6480874B2 (ja) | 2019-03-13 |
Family
ID=51428832
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560341A Expired - Fee Related JP6480874B2 (ja) | 2013-03-01 | 2014-02-28 | Ｔａｌｅｎに基づく遺伝子修正 |
| JP2019021260A Expired - Fee Related JP6893945B2 (ja) | 2013-03-01 | 2019-02-08 | Ｔａｌｅｎに基づく遺伝子修正 |
| JP2021015441A Pending JP2021088565A (ja) | 2013-03-01 | 2021-02-03 | Ｔａｌｅｎに基づく遺伝子修正 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019021260A Expired - Fee Related JP6893945B2 (ja) | 2013-03-01 | 2019-02-08 | Ｔａｌｅｎに基づく遺伝子修正 |
| JP2021015441A Pending JP2021088565A (ja) | 2013-03-01 | 2021-02-03 | Ｔａｌｅｎに基づく遺伝子修正 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9393257B2 (enExample) |
| EP (2) | EP2961262B1 (enExample) |
| JP (3) | JP6480874B2 (enExample) |
| AU (2) | AU2014223243B2 (enExample) |
| CA (1) | CA2902954A1 (enExample) |
| ES (1) | ES2750550T3 (enExample) |
| WO (1) | WO2014134412A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9850497B2 (en) * | 2013-11-04 | 2017-12-26 | Regents Of The University Of Minnesota | Gene targeting methods and tools |
| JP2017510542A (ja) * | 2014-01-31 | 2017-04-13 | ファクター バイオサイエンス インコーポレイテッド | 核酸生成及び送達のための方法及び製品 |
| EP3220926B1 (en) | 2014-11-17 | 2024-12-25 | Adicet Therapeutics, Inc. | Engineered gamma delta t-cells |
| EP3543339A1 (en) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN104726495B (zh) * | 2015-03-25 | 2018-06-19 | 西北农林科技大学 | 一种基于talen介导的基因打靶敲除山羊blg的载体及重组细胞 |
| WO2016161207A1 (en) | 2015-03-31 | 2016-10-06 | Exeligen Scientific, Inc. | Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism |
| US11845928B2 (en) | 2015-05-04 | 2023-12-19 | Tsinghua University | Methods and kits for fragmenting DNA |
| JP2018515123A (ja) | 2015-05-18 | 2018-06-14 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| US20180296600A1 (en) * | 2015-10-27 | 2018-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of epidermolysis bullosa by injection of autologous collagen vii overexpressing leukocytes |
| EP3377637B1 (en) | 2016-04-08 | 2020-03-18 | Krystal Biotech, LLC | Compositions for use in methods for the treatment of wounds, disorders, and diseases of the skin |
| MX2018013864A (es) | 2016-05-12 | 2019-06-10 | Adicet Bio Inc | Métodos para la expansión selectiva de poblaciones de células t gama y composicicones de estas. |
| EP3494138A1 (en) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN109803977B (zh) | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
| IL292551B2 (en) | 2016-10-07 | 2023-10-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| US20210187022A1 (en) | 2016-12-21 | 2021-06-24 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| WO2018140497A1 (en) | 2017-01-25 | 2018-08-02 | Efimov Igor R | Apparatus and methods for in vitro preclinical human trials |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| WO2018154413A1 (en) * | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders |
| JP7402503B2 (ja) | 2017-06-14 | 2023-12-21 | テクニスチェ ユニベルシタト ドレスデン | デザイナーｄｎａ組換え酵素を利用したゲノムを遺伝的に改変するための方法及び手段 |
| EP3643316A4 (en) | 2017-06-19 | 2021-01-20 | National University Corporation Hokkaido University | TREATMENT PRODUCTS FOR EPIDERMOLYSIS BULLOSA |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| CA3082818A1 (en) | 2017-11-15 | 2019-05-23 | Adicet Bio Inc. | Methods for selective expansion of .delta.3 .gamma..delta. t-cell populations and compositions thereof |
| CA3094345A1 (en) | 2018-04-12 | 2019-10-17 | Krystal Biotech, Inc. | Compositions and methods for the treatment of autosomal recessive congenital ichthyosis |
| EP3781677A4 (en) | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| CN119523873A (zh) | 2018-04-27 | 2025-02-28 | 克里斯托生物技术股份有限公司 | 用于美容性应用的编码一种或多种美容蛋白的重组核酸 |
| EP3806961A4 (en) | 2018-05-11 | 2022-10-19 | Memorial Sloan Kettering Cancer Center | T LYMPHOCYTE RECEPTORS TARGETING PIK3CA MUTATIONS AND THEIR USES |
| US20210337753A1 (en) | 2018-06-07 | 2021-11-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization | Methods of regenerating and transforming cannabis |
| EP3802839A1 (en) | 2018-06-07 | 2021-04-14 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) | Nucleic acid constructs and methods of using same |
| US12497593B2 (en) | 2018-09-07 | 2025-12-16 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| JP7562515B2 (ja) | 2018-09-24 | 2024-10-07 | クリスタル バイオテック インコーポレイテッド | ネザートン症候群の治療のための組成物及び方法 |
| EP3887395A4 (en) | 2018-11-30 | 2022-07-27 | Intima Bioscience, Inc. | METHODS FOR IDENTIFICATION OF IMMUNOMODULATORY GENES |
| EP3890757A1 (en) | 2018-12-03 | 2021-10-13 | Adicet Bio Inc. | Methods for selective in vivo expansion of gamma delta t-cell populations and compositions thereof |
| MX2021008832A (es) | 2019-02-08 | 2021-09-08 | Krystal Biotech Inc | Composiciones y metodos para la administracion de polipeptidos cftr. |
| CN113906047B (zh) | 2019-04-05 | 2025-02-14 | 根路径基因组学公司 | 用于t细胞受体基因组装的组合物和方法 |
| US20220259617A1 (en) | 2019-06-13 | 2022-08-18 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| WO2020257684A1 (en) | 2019-06-20 | 2020-12-24 | University Of Massachusetts | Compositions and methods for improved gene editing |
| CA3144054A1 (en) | 2019-06-20 | 2020-12-24 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting pik3ca mutations and uses thereof |
| CN114450265B (zh) | 2019-07-03 | 2024-12-24 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| JP7708737B2 (ja) | 2019-07-18 | 2025-07-15 | ユニバーシティー オブ ロチェスター | 細胞の細胞型選択的免疫保護 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| MX2022002613A (es) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Metodos y composiciones para la integracion del genoma. |
| CA3172449A1 (en) | 2020-03-27 | 2021-09-30 | Erik Hans MANTING | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| KR20230033647A (ko) | 2020-06-30 | 2023-03-08 | 멘두스 비.브이. | 난소암 백신에서 백혈병 유래 세포의 용도 |
| MX2023001028A (es) | 2020-07-24 | 2023-04-24 | Massachusetts Gen Hospital | Particulas similares a virus potenciadas y metodos de uso de las mismas para suministro a celulas. |
| IL301021A (en) | 2020-09-01 | 2023-05-01 | 64 X Inc | Mammalian cells and methods for engineering the same |
| KR20230088833A (ko) | 2020-10-23 | 2023-06-20 | 루트패스 제노믹스, 인크. | T-세포 수용체 식별을 위한 조성물 및 방법 |
| EP4277933A4 (en) | 2021-01-14 | 2024-12-11 | Senti Biosciences, Inc. | SECRETABLE PAYLOAD REGULATION |
| US12397055B2 (en) | 2021-01-22 | 2025-08-26 | Mendus B.V. | Methods of tumor vaccination |
| KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
| CA3213789A1 (en) | 2021-04-02 | 2022-10-06 | Krystal Biotech, Inc. | Viral vectors for cancer therapy |
| WO2022241029A1 (en) | 2021-05-11 | 2022-11-17 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US11753677B2 (en) | 2021-11-10 | 2023-09-12 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| CN119677842A (zh) | 2022-03-17 | 2025-03-21 | 科士华(南京)生物技术有限公司 | 人工合成肿瘤浸润淋巴细胞 |
| WO2024039576A2 (en) | 2022-08-19 | 2024-02-22 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting ras mutations and uses thereof |
| CN120769907A (zh) | 2022-11-18 | 2025-10-10 | 京都府公立大学法人 | 用于线粒体自噬诱导的组合物及其用途 |
| WO2025128981A1 (en) | 2023-12-14 | 2025-06-19 | Sohm, Inc. | Compositions and methods for genome editing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040161817A1 (en) | 2001-06-04 | 2004-08-19 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| KR102110725B1 (ko) * | 2009-12-10 | 2020-05-13 | 리전츠 오브 더 유니버스티 오브 미네소타 | Ｔａｌ 이펙터-매개된 ｄｎａ 변형 |
| US9650647B2 (en) * | 2010-09-06 | 2017-05-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between XA10 and AVRXA10 |
| DK2638163T3 (en) * | 2010-11-12 | 2017-07-24 | Massachusetts Gen Hospital | POLYCOMB-ASSOCIATED NON-CODING RNAs |
| AU2012312260B2 (en) | 2011-09-21 | 2017-08-31 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of transgene expression |
-
2014
- 2014-02-28 CA CA2902954A patent/CA2902954A1/en not_active Abandoned
- 2014-02-28 WO PCT/US2014/019322 patent/WO2014134412A1/en not_active Ceased
- 2014-02-28 JP JP2015560341A patent/JP6480874B2/ja not_active Expired - Fee Related
- 2014-02-28 EP EP14756449.6A patent/EP2961262B1/en active Active
- 2014-02-28 EP EP19180371.7A patent/EP3567104A1/en not_active Withdrawn
- 2014-02-28 US US14/193,037 patent/US9393257B2/en not_active Expired - Fee Related
- 2014-02-28 ES ES14756449T patent/ES2750550T3/es active Active
- 2014-02-28 AU AU2014223243A patent/AU2014223243B2/en not_active Ceased
-
2016
- 2016-06-15 US US15/182,773 patent/US10172880B2/en not_active Expired - Fee Related
-
2018
- 2018-10-31 US US16/176,073 patent/US10973844B2/en not_active Expired - Fee Related
-
2019
- 2019-02-08 JP JP2019021260A patent/JP6893945B2/ja not_active Expired - Fee Related
-
2020
- 2020-01-16 AU AU2020200307A patent/AU2020200307A1/en not_active Abandoned
-
2021
- 2021-02-03 JP JP2021015441A patent/JP2021088565A/ja active Pending
- 2021-03-04 US US17/191,864 patent/US20210187006A1/en not_active Abandoned
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