CA2902954A1 - Talen-based gene correction - Google Patents
Talen-based gene correction Download PDFInfo
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- CA2902954A1 CA2902954A1 CA2902954A CA2902954A CA2902954A1 CA 2902954 A1 CA2902954 A1 CA 2902954A1 CA 2902954 A CA2902954 A CA 2902954A CA 2902954 A CA2902954 A CA 2902954A CA 2902954 A1 CA2902954 A1 CA 2902954A1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| PCT/US2014/019322 WO2014134412A1 (en) | 2013-03-01 | 2014-02-28 | Talen-based gene correction |
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| CA2902954A Abandoned CA2902954A1 (en) | 2013-03-01 | 2014-02-28 | Talen-based gene correction |
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| US9850497B2 (en) * | 2013-11-04 | 2017-12-26 | Regents Of The University Of Minnesota | Gene targeting methods and tools |
| JP2017510542A (ja) * | 2014-01-31 | 2017-04-13 | ファクター バイオサイエンス インコーポレイテッド | 核酸生成及び送達のための方法及び製品 |
| EP3220926B1 (en) | 2014-11-17 | 2024-12-25 | Adicet Therapeutics, Inc. | Engineered gamma delta t-cells |
| EP3543339A1 (en) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| CN104726495B (zh) * | 2015-03-25 | 2018-06-19 | 西北农林科技大学 | 一种基于talen介导的基因打靶敲除山羊blg的载体及重组细胞 |
| WO2016161207A1 (en) | 2015-03-31 | 2016-10-06 | Exeligen Scientific, Inc. | Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into a genome of a cell or organism |
| US11845928B2 (en) | 2015-05-04 | 2023-12-19 | Tsinghua University | Methods and kits for fragmenting DNA |
| JP2018515123A (ja) | 2015-05-18 | 2018-06-14 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| US20180296600A1 (en) * | 2015-10-27 | 2018-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of epidermolysis bullosa by injection of autologous collagen vii overexpressing leukocytes |
| EP3377637B1 (en) | 2016-04-08 | 2020-03-18 | Krystal Biotech, LLC | Compositions for use in methods for the treatment of wounds, disorders, and diseases of the skin |
| MX2018013864A (es) | 2016-05-12 | 2019-06-10 | Adicet Bio Inc | Métodos para la expansión selectiva de poblaciones de células t gama y composicicones de estas. |
| EP3494138A1 (en) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN109803977B (zh) | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
| IL292551B2 (en) | 2016-10-07 | 2023-10-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| CN110520530A (zh) | 2016-10-18 | 2019-11-29 | 明尼苏达大学董事会 | 肿瘤浸润性淋巴细胞和治疗方法 |
| AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| US20210187022A1 (en) | 2016-12-21 | 2021-06-24 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| WO2018140497A1 (en) | 2017-01-25 | 2018-08-02 | Efimov Igor R | Apparatus and methods for in vitro preclinical human trials |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| WO2018154413A1 (en) * | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders |
| JP7402503B2 (ja) | 2017-06-14 | 2023-12-21 | テクニスチェ ユニベルシタト ドレスデン | デザイナーｄｎａ組換え酵素を利用したゲノムを遺伝的に改変するための方法及び手段 |
| EP3643316A4 (en) | 2017-06-19 | 2021-01-20 | National University Corporation Hokkaido University | TREATMENT PRODUCTS FOR EPIDERMOLYSIS BULLOSA |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| CA3082818A1 (en) | 2017-11-15 | 2019-05-23 | Adicet Bio Inc. | Methods for selective expansion of .delta.3 .gamma..delta. t-cell populations and compositions thereof |
| CA3094345A1 (en) | 2018-04-12 | 2019-10-17 | Krystal Biotech, Inc. | Compositions and methods for the treatment of autosomal recessive congenital ichthyosis |
| EP3781677A4 (en) | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
| CN119523873A (zh) | 2018-04-27 | 2025-02-28 | 克里斯托生物技术股份有限公司 | 用于美容性应用的编码一种或多种美容蛋白的重组核酸 |
| EP3806961A4 (en) | 2018-05-11 | 2022-10-19 | Memorial Sloan Kettering Cancer Center | T LYMPHOCYTE RECEPTORS TARGETING PIK3CA MUTATIONS AND THEIR USES |
| US20210337753A1 (en) | 2018-06-07 | 2021-11-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization | Methods of regenerating and transforming cannabis |
| EP3802839A1 (en) | 2018-06-07 | 2021-04-14 | The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) | Nucleic acid constructs and methods of using same |
| US12497593B2 (en) | 2018-09-07 | 2025-12-16 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| JP7562515B2 (ja) | 2018-09-24 | 2024-10-07 | クリスタル バイオテック インコーポレイテッド | ネザートン症候群の治療のための組成物及び方法 |
| EP3887395A4 (en) | 2018-11-30 | 2022-07-27 | Intima Bioscience, Inc. | METHODS FOR IDENTIFICATION OF IMMUNOMODULATORY GENES |
| EP3890757A1 (en) | 2018-12-03 | 2021-10-13 | Adicet Bio Inc. | Methods for selective in vivo expansion of gamma delta t-cell populations and compositions thereof |
| MX2021008832A (es) | 2019-02-08 | 2021-09-08 | Krystal Biotech Inc | Composiciones y metodos para la administracion de polipeptidos cftr. |
| CN113906047B (zh) | 2019-04-05 | 2025-02-14 | 根路径基因组学公司 | 用于t细胞受体基因组装的组合物和方法 |
| US20220259617A1 (en) | 2019-06-13 | 2022-08-18 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| WO2020257684A1 (en) | 2019-06-20 | 2020-12-24 | University Of Massachusetts | Compositions and methods for improved gene editing |
| CA3144054A1 (en) | 2019-06-20 | 2020-12-24 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting pik3ca mutations and uses thereof |
| CN114450265B (zh) | 2019-07-03 | 2024-12-24 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| JP7708737B2 (ja) | 2019-07-18 | 2025-07-15 | ユニバーシティー オブ ロチェスター | 細胞の細胞型選択的免疫保護 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| MX2022002613A (es) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Metodos y composiciones para la integracion del genoma. |
| CA3172449A1 (en) | 2020-03-27 | 2021-09-30 | Erik Hans MANTING | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| KR20230033647A (ko) | 2020-06-30 | 2023-03-08 | 멘두스 비.브이. | 난소암 백신에서 백혈병 유래 세포의 용도 |
| MX2023001028A (es) | 2020-07-24 | 2023-04-24 | Massachusetts Gen Hospital | Particulas similares a virus potenciadas y metodos de uso de las mismas para suministro a celulas. |
| IL301021A (en) | 2020-09-01 | 2023-05-01 | 64 X Inc | Mammalian cells and methods for engineering the same |
| KR20230088833A (ko) | 2020-10-23 | 2023-06-20 | 루트패스 제노믹스, 인크. | T-세포 수용체 식별을 위한 조성물 및 방법 |
| EP4277933A4 (en) | 2021-01-14 | 2024-12-11 | Senti Biosciences, Inc. | SECRETABLE PAYLOAD REGULATION |
| US12397055B2 (en) | 2021-01-22 | 2025-08-26 | Mendus B.V. | Methods of tumor vaccination |
| KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
| CA3213789A1 (en) | 2021-04-02 | 2022-10-06 | Krystal Biotech, Inc. | Viral vectors for cancer therapy |
| WO2022241029A1 (en) | 2021-05-11 | 2022-11-17 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US11753677B2 (en) | 2021-11-10 | 2023-09-12 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| CN119677842A (zh) | 2022-03-17 | 2025-03-21 | 科士华(南京)生物技术有限公司 | 人工合成肿瘤浸润淋巴细胞 |
| WO2024039576A2 (en) | 2022-08-19 | 2024-02-22 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting ras mutations and uses thereof |
| CN120769907A (zh) | 2022-11-18 | 2025-10-10 | 京都府公立大学法人 | 用于线粒体自噬诱导的组合物及其用途 |
| WO2025128981A1 (en) | 2023-12-14 | 2025-06-19 | Sohm, Inc. | Compositions and methods for genome editing |
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| US9650647B2 (en) * | 2010-09-06 | 2017-05-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between XA10 and AVRXA10 |
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| AU2012312260B2 (en) | 2011-09-21 | 2017-08-31 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of transgene expression |
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