JP2016512523A - 高粘性液体キャリアを含む注射用制御放出組成物 - Google Patents

高粘性液体キャリアを含む注射用制御放出組成物 Download PDF

Info

Publication number
JP2016512523A
JP2016512523A JP2016501226A JP2016501226A JP2016512523A JP 2016512523 A JP2016512523 A JP 2016512523A JP 2016501226 A JP2016501226 A JP 2016501226A JP 2016501226 A JP2016501226 A JP 2016501226A JP 2016512523 A JP2016512523 A JP 2016512523A
Authority
JP
Japan
Prior art keywords
composition
pharmaceutically active
active agent
administration
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2016501226A
Other languages
English (en)
Japanese (ja)
Inventor
ライト、ジェレミー・シー
タムラズ、ウィルマ
レオナルド、ジョン・ジェイ
ギブソン、ジョン・ダブリュー
ブランハム、キース・イー
スジョベック、ステファニア
ボイド、ブルックス
ルビノ、クリストファー・エム
Original Assignee
デュレクト コーポレーション
デュレクト コーポレーション
ゾジェニックス インコーポレイテッド
ゾジェニックス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デュレクト コーポレーション, デュレクト コーポレーション, ゾジェニックス インコーポレイテッド, ゾジェニックス インコーポレイテッド filed Critical デュレクト コーポレーション
Publication of JP2016512523A publication Critical patent/JP2016512523A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016501226A 2013-03-11 2014-03-11 高粘性液体キャリアを含む注射用制御放出組成物 Withdrawn JP2016512523A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361776336P 2013-03-11 2013-03-11
US61/776,336 2013-03-11
US201361798874P 2013-03-15 2013-03-15
US61/798,874 2013-03-15
US201361824827P 2013-05-17 2013-05-17
US61/824,827 2013-05-17
PCT/US2014/023397 WO2014164754A1 (en) 2013-03-11 2014-03-11 Injectable controlled release composition comprising high viscosity liquid carrier

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018226302A Division JP6758577B2 (ja) 2013-03-11 2018-12-03 高粘性液体キャリアを含む注射用制御放出組成物

Publications (1)

Publication Number Publication Date
JP2016512523A true JP2016512523A (ja) 2016-04-28

Family

ID=50439501

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016501226A Withdrawn JP2016512523A (ja) 2013-03-11 2014-03-11 高粘性液体キャリアを含む注射用制御放出組成物
JP2018226302A Expired - Fee Related JP6758577B2 (ja) 2013-03-11 2018-12-03 高粘性液体キャリアを含む注射用制御放出組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018226302A Expired - Fee Related JP6758577B2 (ja) 2013-03-11 2018-12-03 高粘性液体キャリアを含む注射用制御放出組成物

Country Status (10)

Country Link
US (5) US9737605B2 (enExample)
EP (1) EP2986278A1 (enExample)
JP (2) JP2016512523A (enExample)
CN (3) CN109602692B (enExample)
AU (2) AU2014249008B2 (enExample)
BR (1) BR112015022023B1 (enExample)
CA (1) CA2903769A1 (enExample)
EA (1) EA033537B1 (enExample)
HK (1) HK1220628A1 (enExample)
WO (1) WO2014164754A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019526532A (ja) * 2016-06-30 2019-09-19 デュレクト コーポレーション デポー製剤
JP2021165310A (ja) * 2015-12-23 2021-10-14 ニューカナ パブリック リミテッド カンパニー ヌクレオシド薬剤のアミド亜リン酸エステル誘導体の製剤
JP2022548616A (ja) * 2019-09-13 2022-11-21 メドインセルル エス．エー． 薬物送達製剤

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
TW201334791A (zh) * 2011-11-23 2013-09-01 杜瑞克公司 輻射滅菌之可生物降解之藥物遞送組合物
WO2014164754A1 (en) 2013-03-11 2014-10-09 Durect Corporation Injectable controlled release composition comprising high viscosity liquid carrier
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN104007070B (zh) * 2014-06-19 2015-04-15 中国石油大学(华东) 用于矿物样品检测的自动观测装置
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
CN113633609B (zh) * 2016-09-09 2023-08-04 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) 抗寄生虫药物原位固化缓释注射剂及其制备方法
EP3600258A1 (en) 2017-03-20 2020-02-05 Teva Pharmaceuticals International GmbH Sustained release olanzapine formulaitons
US10806789B2 (en) 2017-05-12 2020-10-20 The LIV Group Inc. Composition for enhanced absorption of supplements
AU2018379992B2 (en) 2017-12-05 2022-07-21 Sunovion Pharmaceuticals Inc. Nonracemic mixtures and uses thereof
CN112236138B (zh) 2017-12-05 2024-05-31 赛诺维信制药公司 晶体形式及其制备方法
CA3142355A1 (en) 2019-06-04 2020-12-10 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
WO2021011891A1 (en) * 2019-07-18 2021-01-21 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
WO2021011896A1 (en) * 2019-07-18 2021-01-21 Durect Corporation Long-acting formulations and vehicles
CA3169718A1 (en) * 2020-03-18 2021-09-23 Reid M. Rubsamen Injectable formulation of poly(lactic-co-glycolic (plga)) microspheres encapsulating siltuximab
CN113349829B (zh) * 2021-04-27 2022-07-26 四川大学华西医院 一种肿瘤积液取样送检装置
WO2023126867A1 (en) * 2021-12-31 2023-07-06 Orbicular Pharmaceutical Technologies Private Limited Self-administration injection device for risperidone
CN117618336B (zh) * 2024-01-26 2024-04-12 山东齐都药业有限公司 K-5a2原位凝胶制剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515669A (ja) * 2005-11-17 2009-04-16 ゾゲニクス インコーポレーティッド 無針注射による粘性製剤の送達方法
JP2010527926A (ja) * 2007-05-18 2010-08-19 デュレクト コーポレーション 改良されたデポー製剤

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859996A (en) 1973-07-18 1975-01-14 Mizzy Inc Multi-dose injector
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4421508A (en) 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
DE3115375A1 (de) 1981-04-16 1982-11-11 Hoechst Ag, 6000 Frankfurt Kolbenpumpe fuer nadellose injektionsgeraete
DE3115376A1 (de) 1981-04-16 1982-12-16 Hoechst Ag, 6000 Frankfurt Nadelloses injektionsgeraet
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
HU186718B (en) 1983-06-29 1985-09-30 Radelkis Electrokemiai Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin
US4891225A (en) 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4913699A (en) 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
JPH0284962A (ja) 1988-06-14 1990-03-26 Vci Corp 負圧圧着無針注射器
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
AU6550990A (en) 1989-11-09 1991-05-16 Bioject, Inc. Needleless hypodermic injection device
JPH0456736A (ja) 1990-06-22 1992-02-24 Ngk Insulators Ltd 金属溶湯用フィルターカートリッジ
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
EP0556276A1 (en) 1990-11-09 1993-08-25 Sy-Quest International Limited Needleless hypodermic jet injector device
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
JP3145742B2 (ja) 1991-09-19 2001-03-12 日東電工株式会社 ゴム系感圧性接着剤とその接着シ―ト
DE69230524T2 (de) 1991-10-22 2000-05-18 Yasuhiro Koike Optische faser mit brechungsindexverteilung und verfahren zur herstellung
EP0669128B1 (en) 1992-11-17 2000-01-05 Yoshitomi Pharmaceutical Industries, Ltd. Sustained-release microsphere containing antipsychotic and process for producing the same
NZ260909A (en) 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
ATE254939T1 (de) 1993-07-31 2003-12-15 Aradigm Corp Nadelloser injektor
US5643605A (en) 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
ATE212830T1 (de) 1993-11-19 2002-02-15 Alkermes Inc Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel
US6681810B2 (en) 1994-12-20 2004-01-27 Aradigm Corporation Filling device for a needleless injector cartridge
GB9425642D0 (en) 1994-12-20 1995-02-22 Weston Medical Ltd Filling device
GB9504878D0 (en) 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5968542A (en) 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
EP2314272A1 (en) 1995-06-22 2011-04-27 Minnesota Mining And Manufacturing Company Stable hydroalcoholic compositions
GB9525757D0 (en) 1995-12-16 1996-02-14 Weston Medical Ltd Needleless injector drug capsule and filling method
GB9602605D0 (en) 1996-02-09 1996-04-10 Weston Medical Ltd Injection aid
HUP9902128A3 (en) 1996-04-02 2000-01-28 Weston Medical Ltd Eye Method filling a drug capsule and article produced thereby
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
ES2183172T3 (es) 1996-05-07 2003-03-16 Alkermes Inc Procedimiento para la preparacion de microparticulas.
JP4346696B2 (ja) 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
NL1004059C2 (nl) 1996-09-18 1998-03-19 Plastic Moulding Appliances B Samenstel van houder en breeksluiting en werkwijze voor de vervaardiging daarvan.
JP2001501571A (ja) 1996-09-25 2001-02-06 ウェストン メディカル リミテッド 成形可能な物質から物品を作るための方法および装置
ATE318580T1 (de) 1996-12-20 2006-03-15 Alza Corp Gelzusammensetzungen und verfahren
US6258059B1 (en) 1997-02-06 2001-07-10 Weston Medical Limited Injection aid
US6179583B1 (en) 1997-02-25 2001-01-30 Weston Medical Limited Metered fluid delivery device
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
DE50112157D1 (de) 2000-01-11 2007-04-19 Roland Bodmeier Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel
JP2004511431A (ja) 2000-06-28 2004-04-15 アトゥル・ジェイ・シュクラ 生物活性物質を含む生分解性ビヒクルおよび送達システム
DE10035889A1 (de) 2000-07-24 2002-02-14 Lohmann Therapie Syst Lts Medizinischer Haftkleber mit einem Gehalt an Zucker-Estern
DE10044545A1 (de) 2000-09-05 2002-04-04 Roland Bodmeier Retardpartikeldispersion
EP1335704A2 (en) 2000-11-16 2003-08-20 Durect Corporation Implant dosage form and use thereof for the delivery of a cholesterol lowering agent
GB0102386D0 (en) 2001-01-31 2001-03-14 Weston Medical Ltd Method for filling needless injector capsules
DE60231862D1 (de) 2001-02-23 2009-05-20 Genentech Inc Erodierbare polymere zur injektion
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
WO2002076344A1 (en) 2001-03-23 2002-10-03 Durect Corporation Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space
GB0112324D0 (en) 2001-05-21 2001-07-11 Croda Int Plc Compounds
JP2003063954A (ja) 2001-08-24 2003-03-05 Saitama Daiichi Seiyaku Kk リザーバー型貼付剤
GB0125506D0 (en) 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
NZ533434A (en) 2001-11-14 2006-11-30 Alza Corp Thixotropic gel composition for injectable deposition
ATE507816T1 (de) 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
AU2002359407B2 (en) 2001-11-14 2008-02-28 Durect Corporation Catheter injectable depot compositions and uses thereof
US20040258731A1 (en) 2001-11-21 2004-12-23 Tsuyoshi Shimoboji Preparation approriate for cartilage tissue formation
GB0127942D0 (en) 2001-11-21 2002-01-16 Weston Medical Ltd Needleless injector drug capsule and a method for filing thereof
GB0206560D0 (en) 2002-03-20 2002-05-01 Glaxo Group Ltd Novel device
TWI314464B (en) 2002-06-24 2009-09-11 Alza Corp Reusable, spring driven autoinjector
US20040109893A1 (en) 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
TWI353854B (en) 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
CN1684663A (zh) 2002-07-31 2005-10-19 阿尔萨公司 可注射的多模式聚合物储库组合物以及其用途
AU2003257994A1 (en) 2002-07-31 2004-02-16 Alza Corporation Injection device providing automatic needle retraction
CA2500908A1 (en) 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
US7368126B2 (en) 2002-11-06 2008-05-06 Guohua Chen Controlled release depot formulations
US7005225B2 (en) 2002-11-12 2006-02-28 Samsung Electronics Company Organosol including amphipathic copolymeric binder having crystalline material, and use of the organosol to make dry tones for electrographic applications
EP2218448B1 (en) 2002-12-13 2015-09-23 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
US7231945B2 (en) 2002-12-18 2007-06-19 Zogenix, Inc. Method of proof testing glass
WO2004094415A1 (en) 2003-04-22 2004-11-04 Synthon B.V. Risperidone monohydrochloride
US20050079202A1 (en) 2003-05-30 2005-04-14 Guohua Chen Implantable elastomeric depot compositions and uses thereof
WO2005021046A1 (en) 2003-09-01 2005-03-10 Fh Faulding & Co Ltd Compositions and methods for delivery of biologically active agents
US20050281879A1 (en) 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US20050106214A1 (en) 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
MY158342A (en) 2003-11-14 2016-09-30 Novartis Ag Pharmaceutical composition
EP1689465A4 (en) 2003-12-05 2011-10-12 Zogenix Inc DEVICE FOR DELIVERY OF A NEEDLELESS INJECTOR USED FOR DRUG DELIVERY
KR101242486B1 (ko) 2004-01-12 2013-03-13 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 장기 전달을 위한 제형 및 그의 이용 방법
WO2005089670A1 (en) 2004-03-15 2005-09-29 Durect Corporation Pharmaceutical compositions for administration to a sinus
IS7290A (is) 2004-05-28 2005-11-29 Actavis Group Lyfjasamsetningar sem innihalda risperidone
GB0412866D0 (en) 2004-06-09 2004-07-14 Novartis Ag Organic compounds
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
CA2637569C (en) 2006-01-18 2013-01-08 Yuhua Li Pharmaceutical compositions with enhanced stability
EP3202814B1 (en) 2007-02-15 2019-10-16 Tolmar Therapeutics, Inc. Low burst poly-(lactide/glycolide) and methods to produce polymers
CN101678125A (zh) 2007-04-03 2010-03-24 特里梅里斯公司 用于递送抗病毒肽治疗剂的新制剂
EP2152315B1 (en) 2007-05-25 2016-01-06 Indivior UK Limited Sustained delivery formulations of risperidone compounds
WO2009100222A1 (en) 2008-02-08 2009-08-13 Qps Llc Non-polymeric compositions for controlled drug delivery
US8877225B2 (en) * 2008-06-03 2014-11-04 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
EP2394664B1 (en) 2010-05-31 2016-06-01 Laboratorios Farmaceuticos Rovi, S.A. Antipsychotic injectable depot composition
EP2529756B1 (en) 2011-05-31 2021-05-19 Laboratorios Farmaceuticos Rovi, S.A. Risperidone and/or Paliperidone implant formulation
SI2394663T1 (sl) 2010-05-31 2022-02-28 Laboratorios Farmaceuticos Rovi, S.A. Sestave za injicirane biološko razgradljive vsadke in situ
CN105748402B (zh) * 2010-11-24 2022-06-03 杜雷科特公司 生物可降解的药物递送组合物
WO2014164754A1 (en) 2013-03-11 2014-10-09 Durect Corporation Injectable controlled release composition comprising high viscosity liquid carrier
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009515669A (ja) * 2005-11-17 2009-04-16 ゾゲニクス インコーポレーティッド 無針注射による粘性製剤の送達方法
JP2010527926A (ja) * 2007-05-18 2010-08-19 デュレクト コーポレーション 改良されたデポー製剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. MATER. SCI. MATER. MED., 2012, VOL.23, NO.2, PP.443-455, JPN6017044703, ISSN: 0003852203 *
J. PHARM. SCI., 2007, VOL.96, NO.12, PP.3252-3262, JPN6017044705, ISSN: 0003852204 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021165310A (ja) * 2015-12-23 2021-10-14 ニューカナ パブリック リミテッド カンパニー ヌクレオシド薬剤のアミド亜リン酸エステル誘導体の製剤
JP7648458B2 (ja) 2015-12-23 2025-03-18 ニューカナ パブリック リミテッド カンパニー ヌクレオシド薬剤のアミド亜リン酸エステル誘導体の製剤
JP2019526532A (ja) * 2016-06-30 2019-09-19 デュレクト コーポレーション デポー製剤
JP7051721B2 (ja) 2016-06-30 2022-04-11 デュレクト コーポレーション デポー製剤
JP2022088568A (ja) * 2016-06-30 2022-06-14 デュレクト コーポレーション デポー製剤
JP2022548616A (ja) * 2019-09-13 2022-11-21 メドインセルル エス．エー． 薬物送達製剤
JP7661312B2 (ja) 2019-09-13 2025-04-14 メドインセルル エス．エー． 薬物送達製剤
JP2025106353A (ja) * 2019-09-13 2025-07-15 メドインセルル エス．エー． 薬物送達製剤

Also Published As

Publication number Publication date
EA033537B1 (ru) 2019-10-31
AU2019201172B2 (en) 2020-07-16
US20190255179A1 (en) 2019-08-22
CN105163719B (zh) 2019-03-08
CN109602692A (zh) 2019-04-12
JP6758577B2 (ja) 2020-09-23
US20180036412A1 (en) 2018-02-08
EP2986278A1 (en) 2016-02-24
CN115804749A (zh) 2023-03-17
WO2014164754A1 (en) 2014-10-09
CN105163719A (zh) 2015-12-16
US20210015924A1 (en) 2021-01-21
BR112015022023B1 (pt) 2022-12-06
CN109602692B (zh) 2022-11-04
BR112015022023A2 (pt) 2020-10-20
AU2014249008A1 (en) 2015-10-01
EA201591560A1 (ru) 2016-07-29
US9737605B2 (en) 2017-08-22
US11285217B2 (en) 2022-03-29
US20160038596A1 (en) 2016-02-11
US10226532B2 (en) 2019-03-12
AU2014249008B2 (en) 2018-12-06
US20220280646A1 (en) 2022-09-08
AU2019201172A1 (en) 2019-03-07
CA2903769A1 (en) 2014-10-09
JP2019048884A (ja) 2019-03-28
HK1220628A1 (zh) 2017-05-12

Similar Documents

Publication Publication Date Title
JP6758577B2 (ja) 高粘性液体キャリアを含む注射用制御放出組成物
US9572812B2 (en) Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
US10028957B2 (en) Depot formulations
EP3999046A1 (en) Long-acting formulations and vehicles

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170303

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171128

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180222

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180807

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20190108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20190108