CA2095858A1 - Needleless hypodermic jet injector device - Google Patents
Needleless hypodermic jet injector deviceInfo
- Publication number
- CA2095858A1 CA2095858A1 CA002095858A CA2095858A CA2095858A1 CA 2095858 A1 CA2095858 A1 CA 2095858A1 CA 002095858 A CA002095858 A CA 002095858A CA 2095858 A CA2095858 A CA 2095858A CA 2095858 A1 CA2095858 A1 CA 2095858A1
- Authority
- CA
- Canada
- Prior art keywords
- capsule
- gas
- vial
- injector device
- jet injector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A needleless, three-shot, variable dose jet injector (1) comprises a body portion (2) having a passageway (5) and a trigger (7), a cylinder portion (11) onto which a medicament vial (17) can be screwed in order to vary the dose to be applied and a piston head (16) movable within the cylinder portion (11) to move a plunger (15) into the vial (17). The vial (17) has a bore (20) containg the medicament which exits through an orifice (19) under pressure from a plug (21) moving under actuation from the plunger (15). The piston head (16) is caused to move by the release of gas from one (28) of three chambers in a gas capsule (27) through an exit port (43) into the passageway (5) due to the trigger (7) opening a valve (31). The passageway (5) is arranged so as to only align with the exit port and valve of one of the three chambers at a time, so that, by rotating the capsule (27), three shots of gas can be provided in a single capsule.
Description
WO 92/08508 _ 1 _ r t~',P"~ PCr/AU!)1/0()514 EDLElESS HYPODERMIC J~ ~F~R DEVICE
Backqround QF the Inventio~
This inventlon relates to a needleless hypodermic jet injector device and, more partlcularly, to such a device which lncludes a disposable gas powered plunger and a disposable medicament vlal.
S For many years it has been the practice to deposit medicaments into the hypoderma by the use of a dev~ce includ~ng a tubular needle connected to a reservoir of medicament incorporating a piston. The needle was lnserted throu~h the ep7der~1s lnto th~ hypoderma and the medicament ~as dlscharged by movlng the p7ston along the reservoir. Such dev~ces have several problems. F~rstly, the penetrat~on o~ the needle ls a possible tause for 7nfect7On and there ls patient res7stance to the discomfort associated wlth the insertion o~ the needle.
It has been known to provide d~sposable injector devices, which are used once and then thrown away. Such devices have use ln administratlon of, for example, local anaesthetic, lnsulln and the like.
In particular, the diabetes sufferer has to endure the pain and inconvenience of frequent hypoderm~c needle ~njections to administer the insulin used ~n the con~rol of dlabetes.
In the case of the diabetes sufferer, it is deslrable to have a presterillsed, d7sposable dev~ce for s7ngle and mult~ple (lnsulin~
7n~ection use, that has lts own power source while being small and llght enough for the user to carry dur7ng the day. The dev7ce should be such that the user can vary the selected dose conveniently and accuratPly and lt should be conven7ently and safely operated.
Z5 The dlabetes sufferer n~eds to in~ect on at 1 ast one and up to three occaslons dal1y, 7nsul~n at a dosage varylng ~rom less than 0.1 mill~l7tres up to a maxlmum o~ 0O3 m711711tres.
Gas and spr7ng operated jet ln~ection devices have b~en lnvented as alternatives to the needle dev~ces. In ~he gas operated devlce, llquid med1eament ls dlscharged from a reservolr through a port as a spray by a p~ston moved along the reservolr by sub~ect~ng it to a force created by the sudden release of gas. These dev7ces have the obvlous advan~ages u that there 7s no sk1n penetration hence no d~scom~ort and no posslbility of ~nfect1On. In addltlon, they are more easlly used by persons of ltmited s~ll. -The rommon fornls o~ gas devlee co~pr~se a holder to whlch lscoupled a contalner of med~cament ~n a manner al~gn~ng ~t w~th ~he piston to be gas operated and which provides means to hold a gas ~lled eapsule , ~ST-TUT. SilC-T _ ~ , . . .. , ., .. , ... .. , . ~ , . .. i . . . ... , .. . ~ .. . . . . .. . .... ..
Wo 92/08508 ~ ' p~r/Au~J1/oo514 _ in the holder. By puncturing the capsule the gas is released into a cylinder and the piston therein is driven into the container to discharge the medicament through a port in the container.
Such an arrangement has several disadvantages. For example, the holder, as provided, is a relatively la7ge member and is complex having to prov~de securement means for the med~cament container and the gas capsule. It has to provlde a plston mounting arrangement and means to releasably ho1d the gas capsule in a gas tlght manner and puncture the gas capsule. In short, the device is large and complex and correspondingly expens7ve.
One existlng needleless injection dev~ce is descr~bed ln US Patent No. 4,680,027 to Parsons et al. It employs a disposable syringe that is filled by the user with a selected amount of medlcat~on. Then a separate power supply mechanism is attached to the lnstr~ment and trlggered to drive a plunger against the med~cation. This produces a h~gh pressure jet for in~ectlon purposes.
Although effective ln many respects, the separate power supply mechanism reduces the portabillty and convenience of the Parsons device.
Consequently lt 7s des~rahle to have a needleless ln~ectlon system that overcomes thls conc~rn.
US Patent No. 41596,556 describes a hypodermic injection apparatus hav~ng a spr~ng-loaded f1ring mechanlsm that operates to release carbon dlox~de from a capsule. Thls propels the capsule and a plunger toward a discharge aperture to discharge medicatlon through the aperture.
However, in heing self cocking, reloadable, and reusable the device ls somewhat compl~cated.
US Patent No. 3,688,765 descr1bes another devtce that is intended for portable use. However, lt uses a syringe in the form of a prefilled, sealed, ampoule that precludes dosage select~on a~ ~he t~me of use In 30 addition, the detachable syringe, disposable carbon diox~de unit and re-usable pressur~s~ng unit rspresent three separate components w1th whlch the user must contend.
: 5~ r~5e ~5~ Qn ~ The present 1nvention, therefore, seeks t~ provide a simple and easy to use dlsposable, needleless, syr~n~e, whlch reduces at least some of the above dlsadvantages and wh~ch can be eas~ly use~ to ca~er ~or the needs of the d~abetes suff~rer.
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W092/08~08 _ 3_ ~ Y~ '`'o PCr/~U~)~/00~14 Accordingly, in one aspect the invention provides a disposable, needleless hypodermic jet injector device for introducing a llquid into a pat1entt the liquid being contained in a vial which includes a hollow body having an orlfice end through which the l~quid exlts from withln the vial, and a vlal plug movably mounted within the hollow body and operable to push the liquid out through said orifice end, said device comprising a body portion having a first end including means for ad~ustably receiving said vial and a second end including means for recelving a gas capsule, the gas capsule having a plural~ty of independent, pressurlsed gas-contain~ng chambers, each chamber havlng an openable exit port in an end of the capsule receivable within the device, the body port~on further comprising a first part, adjacent said flrst end, includlng a cylinder containing a piston movable wlthin said cylinder, said piston being provlded w~th a plston rod extending towards said first end for engaging w~th the vlal plug to cause movement thereof when the piston ~s moved in the cylinder, and a second part, adjacent said second end, lnclud~ng a passage extend~ng from the first part to a part of said second end, the remainder of the second end be~ng closed, for cooperating w~th each of . .
the openable exit ports, ~n turn, and tr~gger means arranged for opening the one of the openable exlt ports which cooperates with the passage for causlng gas to exit from the respective chamber, flow through the passage and cause the p~ston to move thereby cauxlng the p~ston rod and vial plug to be moved.
Preferably, the means ~or receiving the vial compr~ses a mountlng means for rece~vlng and mount~ng the vial in an ad~ustable fashion so that the dose dellvered therefrom can be ad~usted according ~o volume of liquid to be del1vered. In a pre~erred embodiment, the mounting means comprlses a threaded recess w1th wh~ch an ~xternal thread vn the v~al can cooperate so that the via1 can be threaded long~tudlnally along the recess to adjust the volume of llquid prov~ding the dose. Preferably, the mountlng means includes one or more detent means for engaging the vlal at one or more positions correspond~ng to particular predetermined doses.
In one prefelred e~bodlment, the means for recelving the gas capsule compr~se~ a thread for cooperat~ng w~th a matching thread on the gas capsule. Preferably, the passage is open at a restricted part of the second end for cooperat~ng with only one o~ ~he openable ex~t ports o~
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w 0 92/08s08 ,~ ; Pcr/Au9l/00514 ~
the capsule. In a preferred embodiment, the means for receiving the gas capsule allows the gas capsule and the passage opening at the second end to be relatively moved, for example rotated, so as to bring each of the openable ex~t ports, in turn, into cooperation with the passage opening.
Preferably, the passage opening takes up a thlrd of thQ area of the second end, the gas capsule having three gas chambers, each having an openable exit port ln one respective thlrd of the end of the capsu1e, the capsule be~ng rotatable to bring each exlt port lnto cooperation wlth the passage openlng, ln turn. Preferably, the means for recelving the gas 10 capsule includes detent means at each of the posltions at wh~ch an exlt port is in cooperation with the passage opening.
The trigger means preferably comprlses a finger portion on the outside of the body port~on, a longitudinal trlgger port~on within the passage and a connecting portion connectlng the f~nger portion and the 15 trigger port~on and extending through a longl~udinal aper~ure in the wall of the body portion. The trlgger ~eans is preferably longltudlnally movable wlthln the aperture such that the trigger portlon moves withln the passage, an end of tr~gger port~on reachlng the second end of the body port~on so as to engage and open the openable exit port of the gas 20 capsule when the trigger means has been moved towards the second end. A
bias~ng means preferably blases the trlgger means towards the flrst end of the device.
In a second aspect of the present ~nvent1On, there ls prov~ded a gas capsule havlng a plurality of ~ndependent, pressurised gas-containing 25 chambers, each chamber having an openable exit port in an end of the capsule for cooper~tion, ~n turn, w~th an open~ng ~n an inJector dev~ce.
r - Preferably, the end of the capsule ls cireul ar and the exit ports are equally clrcumferentially spaced therein. Preferably, the chambers are long1tudinally extending in the capsule. In one preferred 30 embod1ment, three chambers are provlded; although any number could be used.
The end of the capsule is preferably provided wlth a thread for cooperating w1th a matching thread on the ~njector device. The openable ex~t ports are preferably prov~ded with valve means whlch can be opened 35 by a trlgger ~eans on the lnjector dev~ce. r It wlll be apparent, therefore, that the tr~gger means dlrectly releases eompressed gas, stored ~n the capsule, from each capsule ., . i, ,; . ~. ~ ' ' :
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WO ~2/08508 _ 5 _ ~ PCI-/AU"I/OU514 chamber, one at a time. By rotating the capsule, each of the three gas charges can be released.
The gas pressure acts upon the piston to drivé the piston rod which in turn acts upon the plug in the vial to eject the selected dosage of medication through an orlfice in the discharge end of the vial section.
Brief Description ~ The Dr~wings One embodiment of the invention will now be more fully described, by way of example, with reference to the drawings, of which:
Figure 1 ~s a cross-sectional view of an lnjector devlce accord~ng ~o the invention wlth a vlal and gas capsule attached thereto;
Figure 2 ls a cross-sectional view of a trigger used in the injector device along line A-A of Figure l;
Figure 3 ~s a cross-sectional view of the body port~on o~ the device along line B-B of Figure l; and Figure 4 is a cross-sectional view of the gas capsule along l~ne C-C of Figure 1.
~etailed D~scription of A Pref~rr~d Emb~d~m~n~
As illustrated ~n the drawings, the an ~n~eetor device 1 according to one embodiment of the lnvention comprises a cyllndrieal body portton 2 having an external thread section 3 at one end, an internal thread section 4 at the other end, and a passage 5 extending longitudinally thro~gh the body port~on 2 between the two ends. The passageway 5 at the other end ~s o~ substantially the same ~dth as the ~nternal diameter of the internal threaded sect~on 4, but, at the first end, is of reduced .
25 cross-sectlonal area, as shown ln Figure 3, so as to cover only a third sector of the lnternal diameter of the body portion 2.
Body portlon 4 ~s also provided w~th a slot 6 ln wh~ch trigger 7 is assembled into and moves slidably within body portion 2. Tr~gger 7, as shown in F19ure 2, lncludes finger portlcn 8 arranged outside body portion 4, tr~gger plunger 9 arranged within passageway 5 and trigger stem lO conneet~ng the finger.portion 8 and ~he ~rigger plunger 9 through slot 6. The slot 6 is longltudinal so as to allow long1tud~nal movement oF'the flnger'portion 8.to cause..longitudinal..movement of the trlgger plunger 9 within passageway S. ' ' ~ ..
35 :: '; Threaded onto the lnternal''thread section 4 o~ body portion 2 1s ' 'cyl~nder port1On 11 havtng a longltudinal bore 12.thereln ex~ending from passageway 5 to an ~nternally threaded end sec~ion 13. A shoulder 14 ~s provided ~n the bore 12 adjaeent th~ internally ~hreaded end section 13.
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w 0 92to8so~ 8~"'" t~ pcr/~u~1/oo5l4 Cylinder portlon 11 is attached to body portion 2 by screwing the cylinder portion into the body internal thread section 4 until a shoulder 25 on outside of cylinder portion 11 engag~s body end ~ace 26.
The shoulder 14 serves as a piston stop, as will be descrlbed later, and a guide for a plunger 15 having a piston head 16 sealingly sl~d~bly mounted in the cylinder bore 12. There is a gas exhaust port 46 in the wall of the cyllnder port~on 11 ln communication w~th the bore 12.
A 17qu7d medlcament vial 17 is provided as a fitment for the device. The v~al 17 has a vial thread section 18 enabling 7t to be screwed into the cylinder thread section 13. The vial has an or7fice 19 at its fore end and the orifice 19 7s sealed by a seal that will yield when pressure is applied to liquid medicament housed 1n a bore 20 of vial 12. Pressure is applied to the medicament by a plug 21 slidably housed ln the vial bore 20.
1~ The exterior of the vial 17 is marked in any su7table manner to indicate fractions of the capac7ty of the vial bore 20. For example there may be external markings on the vial to divide the bore length ~nto five sect~ons each of Y mls.
By threading the v1al 17 into the cyl7nder portion 11, the markings on the v~al 17 will pass by a datum mark on the cyl~nder portion 11, for example an end face 22 of the cyllnder portion 11 could be such a mark.
~etent means ~s pre~erably prov~ded whereby the detent is releasably engaged each time a graduat~on on the vlal 17 is allgned w1~h the datum mark. In this way the vial 17 can be releasably locked 7n a des1red 25 posttlon.
By ax1ally movlng the vial 17 (as a result of rotat~ng ~t) the position of the v~al 17 relativ~ to the end 24 of the plunger 15 : changes. ~hen the vial 17 7s ~ully "ln" the maxlmum amount o~ the :.
med1eament wlll be e~ect~d. By thread7ng the v~al 17 "out", the amount ~0 of medlcament e~ected w~ll be reduced.
- `. It ~ill be noted that, as illustrated, the plunger i5 ~s ln its zero position when al7gned with the end face 22 of the cyllnder portion `11. The stroke o~ the;pis~on head l6 ls llm~ted to ~he distance "X" and therefore when the vial 17 ls threaded fully:into the cylinder portion 11 -35: so that the:end fat:e 23 of v1al l7 engages the end o~ the threaded sett10n of the cyl7nder psrtlon 11, the plug Zl will be ad~acen~ the end 24 of th~ plunger 15.
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W O 92/08508 _ 7 _ -~ Pcr/Au9l/oos-l4 The maximum stroke of the plug 21 is slightly greater than "X". It follows that when the piston head 16 moves the distance "X", the plug 21 will move the same distance and subs~antially the whole of the medicament in the vial 17 wlll be ejected, If the! vial 17 is moved "out" of the cyl~nder portion 11, the plunger end 24 will be spaced from the plug 21 and although the plunger 15 will move "X", the plug 21 ~ill move less than "X".
A gas capsule 27 comprising three longitudlnal chambers 28, 29, 30 and three valves 31, 32, 33 arranged at exit ports ~3, 4~, ~5 of ~he respective long~tudlnal chambers 28, 29, 30, ls attached to body port~on 24 by screwing an internal thread section 34 onto the body external thread section 3 until an end face 35 of the capsule 27 approaches an end face 36 of the body external thread section 34 and capsule pins 37, 38, 39 provided on the capsule end face 35 engage detents 40, 41, 42 provlded on the body end ~ace 36. As shown in F~gure 4, ~he three longitudlnal chambers each take up a third sector of the capsule 27 and the detents are arranged so that only one of the valves 31, 31, 33 is aligned wlth the end of the passageway 5 in body port~on 2.
As tr19ger 7 ls moved slidably along slot 6 in body port~on 2 towards eapsule 27, the trigger plunger 9 moves through passageway 5 to operate on the one of the valves 31, 32, 33 wh~ch ~s allgned w~th the passageway 5 to rel~ase the gas pressure ~rom the correspondlng one of the chambers 28, 29, 30 and allow gas ~o travel through passageway 5 ln body port~on 2 and lnto cyi~nder portion 11, drlving p1ston head 16 and 25 plunger 15 into v1al 17 and dtsplae~ng p7ug 21 and the contents of v~al 17 in the form of a h~gh pressure ~et through the orifice 19.
The gas ln the chambers 28, ~9, 30 ~s released by ~he trigger plunger 9 enter1ng through exlt ports 43, 44, 45 and openlng valves 31, 32, 33.
The three detents 40, 41, ~2 on b~dy ~nd ~ace 36 and the three correspondlng capsule pins 37, 38, 39 on capsule end face 35 ensure th~t alignment of tr1gger plunger 9 and exi~ por~s q3, 44, 45 ~s malntalned ~n only three posslble positlons.
It 1s presently intended that the devic.e will be made substant~ally completely ~rom thermosett~ng plas~le matPri al s ~ u s i ng the ~iection mouldlng process.
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WO 92/(~X508 _ ~ _ PCr/~U91/0051 OperatlQnal~ equence In an operational sequence, a v~al 17 would be fitted to the device 1 and the amount of med~cament to be ejected would be chosen by the degree to which the vial 17 is threaded into the cylinder portion 11.
The device would be positioned wil:h the or~fice 19 over the part o~
the user where the "inject~on" is to take place.
As ~he trigger 7 is slldably moved along the body portion 2, the trigger plunger 9 would enter one of the exit ports 43, 44, 45, opening the correspond~ng one of valves 31, 32, 33, and thereby releaslng gas from the correspond~ng one of chambers 28, 2~, 30.
The gas travels through body port~on Z, dr~ving p~ston head 16 and plunger 15 the distance "X" until plston head 16 engages the cylinder shoulder 14. At this time the exhaust psrt 46 w~ll be uncovered and the gas behind the piston head 16 escapes to atmosphere.
Whilst the p~ston head 16 is advancing ~he plunger end face 2 would be dr~ving the plug 21 along the vial bore 20 causing the medicament therein to e~ect through orifice 19.
Depending on the amount the vial 17 1s threaded into the cylinder portion 11, the plug Zl w~ll move the d~stance "X" or a fraction of that distance and tne amount of med kament e~ected will vary accordingly.
~hilst a presently preferred embodiment of the ~nvention has been described hereinbefore ~t ~s to be understo~d that var~ations can De made to the spec1f~c embodlment descrlbed w~thout departing from the invent1Ye concept. By way of example only:
The manner ln wh1ch the piston 9 i5 regulated ~n its travel can be other than ~s dlsclosed.
The manner ~n whlch thP cartridge chamber valves are open~d can be other than as descr~bed.
The manner ~n whlch the gas under pressure ln the cartridge chambers ls sealed can be other than as described.
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Backqround QF the Inventio~
This inventlon relates to a needleless hypodermic jet injector device and, more partlcularly, to such a device which lncludes a disposable gas powered plunger and a disposable medicament vlal.
S For many years it has been the practice to deposit medicaments into the hypoderma by the use of a dev~ce includ~ng a tubular needle connected to a reservoir of medicament incorporating a piston. The needle was lnserted throu~h the ep7der~1s lnto th~ hypoderma and the medicament ~as dlscharged by movlng the p7ston along the reservoir. Such dev~ces have several problems. F~rstly, the penetrat~on o~ the needle ls a possible tause for 7nfect7On and there ls patient res7stance to the discomfort associated wlth the insertion o~ the needle.
It has been known to provide d~sposable injector devices, which are used once and then thrown away. Such devices have use ln administratlon of, for example, local anaesthetic, lnsulln and the like.
In particular, the diabetes sufferer has to endure the pain and inconvenience of frequent hypoderm~c needle ~njections to administer the insulin used ~n the con~rol of dlabetes.
In the case of the diabetes sufferer, it is deslrable to have a presterillsed, d7sposable dev~ce for s7ngle and mult~ple (lnsulin~
7n~ection use, that has lts own power source while being small and llght enough for the user to carry dur7ng the day. The dev7ce should be such that the user can vary the selected dose conveniently and accuratPly and lt should be conven7ently and safely operated.
Z5 The dlabetes sufferer n~eds to in~ect on at 1 ast one and up to three occaslons dal1y, 7nsul~n at a dosage varylng ~rom less than 0.1 mill~l7tres up to a maxlmum o~ 0O3 m711711tres.
Gas and spr7ng operated jet ln~ection devices have b~en lnvented as alternatives to the needle dev~ces. In ~he gas operated devlce, llquid med1eament ls dlscharged from a reservolr through a port as a spray by a p~ston moved along the reservolr by sub~ect~ng it to a force created by the sudden release of gas. These dev7ces have the obvlous advan~ages u that there 7s no sk1n penetration hence no d~scom~ort and no posslbility of ~nfect1On. In addltlon, they are more easlly used by persons of ltmited s~ll. -The rommon fornls o~ gas devlee co~pr~se a holder to whlch lscoupled a contalner of med~cament ~n a manner al~gn~ng ~t w~th ~he piston to be gas operated and which provides means to hold a gas ~lled eapsule , ~ST-TUT. SilC-T _ ~ , . . .. , ., .. , ... .. , . ~ , . .. i . . . ... , .. . ~ .. . . . . .. . .... ..
Wo 92/08508 ~ ' p~r/Au~J1/oo514 _ in the holder. By puncturing the capsule the gas is released into a cylinder and the piston therein is driven into the container to discharge the medicament through a port in the container.
Such an arrangement has several disadvantages. For example, the holder, as provided, is a relatively la7ge member and is complex having to prov~de securement means for the med~cament container and the gas capsule. It has to provlde a plston mounting arrangement and means to releasably ho1d the gas capsule in a gas tlght manner and puncture the gas capsule. In short, the device is large and complex and correspondingly expens7ve.
One existlng needleless injection dev~ce is descr~bed ln US Patent No. 4,680,027 to Parsons et al. It employs a disposable syringe that is filled by the user with a selected amount of medlcat~on. Then a separate power supply mechanism is attached to the lnstr~ment and trlggered to drive a plunger against the med~cation. This produces a h~gh pressure jet for in~ectlon purposes.
Although effective ln many respects, the separate power supply mechanism reduces the portabillty and convenience of the Parsons device.
Consequently lt 7s des~rahle to have a needleless ln~ectlon system that overcomes thls conc~rn.
US Patent No. 41596,556 describes a hypodermic injection apparatus hav~ng a spr~ng-loaded f1ring mechanlsm that operates to release carbon dlox~de from a capsule. Thls propels the capsule and a plunger toward a discharge aperture to discharge medicatlon through the aperture.
However, in heing self cocking, reloadable, and reusable the device ls somewhat compl~cated.
US Patent No. 3,688,765 descr1bes another devtce that is intended for portable use. However, lt uses a syringe in the form of a prefilled, sealed, ampoule that precludes dosage select~on a~ ~he t~me of use In 30 addition, the detachable syringe, disposable carbon diox~de unit and re-usable pressur~s~ng unit rspresent three separate components w1th whlch the user must contend.
: 5~ r~5e ~5~ Qn ~ The present 1nvention, therefore, seeks t~ provide a simple and easy to use dlsposable, needleless, syr~n~e, whlch reduces at least some of the above dlsadvantages and wh~ch can be eas~ly use~ to ca~er ~or the needs of the d~abetes suff~rer.
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W092/08~08 _ 3_ ~ Y~ '`'o PCr/~U~)~/00~14 Accordingly, in one aspect the invention provides a disposable, needleless hypodermic jet injector device for introducing a llquid into a pat1entt the liquid being contained in a vial which includes a hollow body having an orlfice end through which the l~quid exlts from withln the vial, and a vlal plug movably mounted within the hollow body and operable to push the liquid out through said orifice end, said device comprising a body portion having a first end including means for ad~ustably receiving said vial and a second end including means for recelving a gas capsule, the gas capsule having a plural~ty of independent, pressurlsed gas-contain~ng chambers, each chamber havlng an openable exit port in an end of the capsule receivable within the device, the body port~on further comprising a first part, adjacent said flrst end, includlng a cylinder containing a piston movable wlthin said cylinder, said piston being provlded w~th a plston rod extending towards said first end for engaging w~th the vlal plug to cause movement thereof when the piston ~s moved in the cylinder, and a second part, adjacent said second end, lnclud~ng a passage extend~ng from the first part to a part of said second end, the remainder of the second end be~ng closed, for cooperating w~th each of . .
the openable exit ports, ~n turn, and tr~gger means arranged for opening the one of the openable exlt ports which cooperates with the passage for causlng gas to exit from the respective chamber, flow through the passage and cause the p~ston to move thereby cauxlng the p~ston rod and vial plug to be moved.
Preferably, the means ~or receiving the vial compr~ses a mountlng means for rece~vlng and mount~ng the vial in an ad~ustable fashion so that the dose dellvered therefrom can be ad~usted according ~o volume of liquid to be del1vered. In a pre~erred embodiment, the mounting means comprlses a threaded recess w1th wh~ch an ~xternal thread vn the v~al can cooperate so that the via1 can be threaded long~tudlnally along the recess to adjust the volume of llquid prov~ding the dose. Preferably, the mountlng means includes one or more detent means for engaging the vlal at one or more positions correspond~ng to particular predetermined doses.
In one prefelred e~bodlment, the means for recelving the gas capsule compr~se~ a thread for cooperat~ng w~th a matching thread on the gas capsule. Preferably, the passage is open at a restricted part of the second end for cooperat~ng with only one o~ ~he openable ex~t ports o~
!
w 0 92/08s08 ,~ ; Pcr/Au9l/00514 ~
the capsule. In a preferred embodiment, the means for receiving the gas capsule allows the gas capsule and the passage opening at the second end to be relatively moved, for example rotated, so as to bring each of the openable ex~t ports, in turn, into cooperation with the passage opening.
Preferably, the passage opening takes up a thlrd of thQ area of the second end, the gas capsule having three gas chambers, each having an openable exit port ln one respective thlrd of the end of the capsu1e, the capsule be~ng rotatable to bring each exlt port lnto cooperation wlth the passage openlng, ln turn. Preferably, the means for recelving the gas 10 capsule includes detent means at each of the posltions at wh~ch an exlt port is in cooperation with the passage opening.
The trigger means preferably comprlses a finger portion on the outside of the body port~on, a longitudinal trlgger port~on within the passage and a connecting portion connectlng the f~nger portion and the 15 trigger port~on and extending through a longl~udinal aper~ure in the wall of the body portion. The trlgger ~eans is preferably longltudlnally movable wlthln the aperture such that the trigger portlon moves withln the passage, an end of tr~gger port~on reachlng the second end of the body port~on so as to engage and open the openable exit port of the gas 20 capsule when the trigger means has been moved towards the second end. A
bias~ng means preferably blases the trlgger means towards the flrst end of the device.
In a second aspect of the present ~nvent1On, there ls prov~ded a gas capsule havlng a plurality of ~ndependent, pressurised gas-containing 25 chambers, each chamber having an openable exit port in an end of the capsule for cooper~tion, ~n turn, w~th an open~ng ~n an inJector dev~ce.
r - Preferably, the end of the capsule ls cireul ar and the exit ports are equally clrcumferentially spaced therein. Preferably, the chambers are long1tudinally extending in the capsule. In one preferred 30 embod1ment, three chambers are provlded; although any number could be used.
The end of the capsule is preferably provided wlth a thread for cooperating w1th a matching thread on the ~njector device. The openable ex~t ports are preferably prov~ded with valve means whlch can be opened 35 by a trlgger ~eans on the lnjector dev~ce. r It wlll be apparent, therefore, that the tr~gger means dlrectly releases eompressed gas, stored ~n the capsule, from each capsule ., . i, ,; . ~. ~ ' ' :
... . .
WO ~2/08508 _ 5 _ ~ PCI-/AU"I/OU514 chamber, one at a time. By rotating the capsule, each of the three gas charges can be released.
The gas pressure acts upon the piston to drivé the piston rod which in turn acts upon the plug in the vial to eject the selected dosage of medication through an orlfice in the discharge end of the vial section.
Brief Description ~ The Dr~wings One embodiment of the invention will now be more fully described, by way of example, with reference to the drawings, of which:
Figure 1 ~s a cross-sectional view of an lnjector devlce accord~ng ~o the invention wlth a vlal and gas capsule attached thereto;
Figure 2 ls a cross-sectional view of a trigger used in the injector device along line A-A of Figure l;
Figure 3 ~s a cross-sectional view of the body port~on o~ the device along line B-B of Figure l; and Figure 4 is a cross-sectional view of the gas capsule along l~ne C-C of Figure 1.
~etailed D~scription of A Pref~rr~d Emb~d~m~n~
As illustrated ~n the drawings, the an ~n~eetor device 1 according to one embodiment of the lnvention comprises a cyllndrieal body portton 2 having an external thread section 3 at one end, an internal thread section 4 at the other end, and a passage 5 extending longitudinally thro~gh the body port~on 2 between the two ends. The passageway 5 at the other end ~s o~ substantially the same ~dth as the ~nternal diameter of the internal threaded sect~on 4, but, at the first end, is of reduced .
25 cross-sectlonal area, as shown ln Figure 3, so as to cover only a third sector of the lnternal diameter of the body portion 2.
Body portlon 4 ~s also provided w~th a slot 6 ln wh~ch trigger 7 is assembled into and moves slidably within body portion 2. Tr~gger 7, as shown in F19ure 2, lncludes finger portlcn 8 arranged outside body portion 4, tr~gger plunger 9 arranged within passageway 5 and trigger stem lO conneet~ng the finger.portion 8 and ~he ~rigger plunger 9 through slot 6. The slot 6 is longltudinal so as to allow long1tud~nal movement oF'the flnger'portion 8.to cause..longitudinal..movement of the trlgger plunger 9 within passageway S. ' ' ~ ..
35 :: '; Threaded onto the lnternal''thread section 4 o~ body portion 2 1s ' 'cyl~nder port1On 11 havtng a longltudinal bore 12.thereln ex~ending from passageway 5 to an ~nternally threaded end sec~ion 13. A shoulder 14 ~s provided ~n the bore 12 adjaeent th~ internally ~hreaded end section 13.
.
w 0 92to8so~ 8~"'" t~ pcr/~u~1/oo5l4 Cylinder portlon 11 is attached to body portion 2 by screwing the cylinder portion into the body internal thread section 4 until a shoulder 25 on outside of cylinder portion 11 engag~s body end ~ace 26.
The shoulder 14 serves as a piston stop, as will be descrlbed later, and a guide for a plunger 15 having a piston head 16 sealingly sl~d~bly mounted in the cylinder bore 12. There is a gas exhaust port 46 in the wall of the cyllnder port~on 11 ln communication w~th the bore 12.
A 17qu7d medlcament vial 17 is provided as a fitment for the device. The v~al 17 has a vial thread section 18 enabling 7t to be screwed into the cylinder thread section 13. The vial has an or7fice 19 at its fore end and the orifice 19 7s sealed by a seal that will yield when pressure is applied to liquid medicament housed 1n a bore 20 of vial 12. Pressure is applied to the medicament by a plug 21 slidably housed ln the vial bore 20.
1~ The exterior of the vial 17 is marked in any su7table manner to indicate fractions of the capac7ty of the vial bore 20. For example there may be external markings on the vial to divide the bore length ~nto five sect~ons each of Y mls.
By threading the v1al 17 into the cyl7nder portion 11, the markings on the v~al 17 will pass by a datum mark on the cyl~nder portion 11, for example an end face 22 of the cyllnder portion 11 could be such a mark.
~etent means ~s pre~erably prov~ded whereby the detent is releasably engaged each time a graduat~on on the vlal 17 is allgned w1~h the datum mark. In this way the vial 17 can be releasably locked 7n a des1red 25 posttlon.
By ax1ally movlng the vial 17 (as a result of rotat~ng ~t) the position of the v~al 17 relativ~ to the end 24 of the plunger 15 : changes. ~hen the vial 17 7s ~ully "ln" the maxlmum amount o~ the :.
med1eament wlll be e~ect~d. By thread7ng the v~al 17 "out", the amount ~0 of medlcament e~ected w~ll be reduced.
- `. It ~ill be noted that, as illustrated, the plunger i5 ~s ln its zero position when al7gned with the end face 22 of the cyllnder portion `11. The stroke o~ the;pis~on head l6 ls llm~ted to ~he distance "X" and therefore when the vial 17 ls threaded fully:into the cylinder portion 11 -35: so that the:end fat:e 23 of v1al l7 engages the end o~ the threaded sett10n of the cyl7nder psrtlon 11, the plug Zl will be ad~acen~ the end 24 of th~ plunger 15.
. . . .
. - - , , . . i : . : . . . .
.: , . . . ~ .... ~ . . ,, ;
W O 92/08508 _ 7 _ -~ Pcr/Au9l/oos-l4 The maximum stroke of the plug 21 is slightly greater than "X". It follows that when the piston head 16 moves the distance "X", the plug 21 will move the same distance and subs~antially the whole of the medicament in the vial 17 wlll be ejected, If the! vial 17 is moved "out" of the cyl~nder portion 11, the plunger end 24 will be spaced from the plug 21 and although the plunger 15 will move "X", the plug 21 ~ill move less than "X".
A gas capsule 27 comprising three longitudlnal chambers 28, 29, 30 and three valves 31, 32, 33 arranged at exit ports ~3, 4~, ~5 of ~he respective long~tudlnal chambers 28, 29, 30, ls attached to body port~on 24 by screwing an internal thread section 34 onto the body external thread section 3 until an end face 35 of the capsule 27 approaches an end face 36 of the body external thread section 34 and capsule pins 37, 38, 39 provided on the capsule end face 35 engage detents 40, 41, 42 provlded on the body end ~ace 36. As shown in F~gure 4, ~he three longitudlnal chambers each take up a third sector of the capsule 27 and the detents are arranged so that only one of the valves 31, 31, 33 is aligned wlth the end of the passageway 5 in body port~on 2.
As tr19ger 7 ls moved slidably along slot 6 in body port~on 2 towards eapsule 27, the trigger plunger 9 moves through passageway 5 to operate on the one of the valves 31, 32, 33 wh~ch ~s allgned w~th the passageway 5 to rel~ase the gas pressure ~rom the correspondlng one of the chambers 28, 29, 30 and allow gas ~o travel through passageway 5 ln body port~on 2 and lnto cyi~nder portion 11, drlving p1ston head 16 and 25 plunger 15 into v1al 17 and dtsplae~ng p7ug 21 and the contents of v~al 17 in the form of a h~gh pressure ~et through the orifice 19.
The gas ln the chambers 28, ~9, 30 ~s released by ~he trigger plunger 9 enter1ng through exlt ports 43, 44, 45 and openlng valves 31, 32, 33.
The three detents 40, 41, ~2 on b~dy ~nd ~ace 36 and the three correspondlng capsule pins 37, 38, 39 on capsule end face 35 ensure th~t alignment of tr1gger plunger 9 and exi~ por~s q3, 44, 45 ~s malntalned ~n only three posslble positlons.
It 1s presently intended that the devic.e will be made substant~ally completely ~rom thermosett~ng plas~le matPri al s ~ u s i ng the ~iection mouldlng process.
.,. . ~ ,. ... .. .., ~. ....
i , , :: . - . . ;
: , ..
WO 92/(~X508 _ ~ _ PCr/~U91/0051 OperatlQnal~ equence In an operational sequence, a v~al 17 would be fitted to the device 1 and the amount of med~cament to be ejected would be chosen by the degree to which the vial 17 is threaded into the cylinder portion 11.
The device would be positioned wil:h the or~fice 19 over the part o~
the user where the "inject~on" is to take place.
As ~he trigger 7 is slldably moved along the body portion 2, the trigger plunger 9 would enter one of the exit ports 43, 44, 45, opening the correspond~ng one of valves 31, 32, 33, and thereby releaslng gas from the correspond~ng one of chambers 28, 2~, 30.
The gas travels through body port~on Z, dr~ving p~ston head 16 and plunger 15 the distance "X" until plston head 16 engages the cylinder shoulder 14. At this time the exhaust psrt 46 w~ll be uncovered and the gas behind the piston head 16 escapes to atmosphere.
Whilst the p~ston head 16 is advancing ~he plunger end face 2 would be dr~ving the plug 21 along the vial bore 20 causing the medicament therein to e~ect through orifice 19.
Depending on the amount the vial 17 1s threaded into the cylinder portion 11, the plug Zl w~ll move the d~stance "X" or a fraction of that distance and tne amount of med kament e~ected will vary accordingly.
~hilst a presently preferred embodiment of the ~nvention has been described hereinbefore ~t ~s to be understo~d that var~ations can De made to the spec1f~c embodlment descrlbed w~thout departing from the invent1Ye concept. By way of example only:
The manner ln wh1ch the piston 9 i5 regulated ~n its travel can be other than ~s dlsclosed.
The manner ~n whlch thP cartridge chamber valves are open~d can be other than as descr~bed.
The manner ~n whlch the gas under pressure ln the cartridge chambers ls sealed can be other than as described.
' ' :, ' ' ' ' . . :
.. . . . . . . . .
. , ., , ... . ~ ~. ,,
Claims (19)
1. A disposable, needleless hypodermic jet injector device for use with a gas capsule having a plurality of independent, pressurised gas-containing chambers, each chamber having an openable exit port in an end of the capsule receivable within the device, for introducing a liquid into a patient, the liquid being contained in a vial which includes a hollow body having an orifice end through which the liquid exits from within the vial, and a vial plug movably mounted within the hollow body and operable to push the liquid out through said orifice end, said device comprising a body portion having a first end including means for receiving said vial and a second end including means for receiving the gas capsule, the body portion further comprising a first part, adjacent said first end, including a cylinder containing a piston movable within said cylinder, said piston being provided with a piston rod extending towards said first end for engaging with the vial plug to cause movement thereof when the piston is moved in the cylinder, and a second part, adjacent said second end, including a passage extending from the first part to a part of said second end, the remainder of the second end being closed, for cooperating with each of the openable exit ports, in turn, and trigger means arranged for opening the one of the openable exit ports which cooperates with the passage for causing gas to exit from the respective chamber, flow through the passage and cause the piston to move thereby causing the piston rod and vial plug to be moved.
2. A jet injector device according to claim 1, wherein the means for receiving the vial comprises a mounting means for receiving and mounting the vial in an adjustable fashion so that the dose delivered therefrom can be adjusted according to volume of liquid to be delivered.
3. A jet injector device according to claim 2, wherein the mounting means comprises a threaded recess with which an external thread on the vial can cooperate so that the vial can be threaded longitudinally along the recess to adjust the volume of liquid providing the dose.
4. A jet injector device according to claim 3, wherein the mounting means includes one or more detent means for engaging the vial at one or more positions corresponding to particular predetermined doses.
5. A jet injector device according to any preceding claim, wherein the means for receiving the gas capsule comprises a thread for cooperating with a matching thread on the gas capsule.
6. A jet injector device according to any preceding claim, wherein the passage is open at a restricted part of the second end for cooperating with only one of the openable exit ports of the capsule.
7. A jet injector device according to claim 6, wherein the means for receiving the gas capsule allows the gas capsule and the passage opening at the second end to be relatively moved so as to bring each of the openable exit ports, in turn, into cooperation with the passage opening.
8. A jet injector device according to claim 6, wherein the gas capsule and the passage opening at the second end can be relatively rotated so as to bring each of the openable exit ports, in turn, into cooperation with the passage opening.
9. A jet injector device according to any one of claims 6 to 8, wherein the passage opening takes up a third of the area of the second end, the gas capsule having three gas chambers, each having an openable exit port in one respective third of the end of the capsule, the capsule being rotatable to bring each exit port into cooperation with the passage opening, in turn.
10. A jet Injector device according to any one of claims 6 to 9, wherein the means for receiving the gas capsule includes detent means at each of the positions at which an exit port is in cooperation with the passage opening.
11. A jet injector device according to any preceding claim, wherein the trigger means comprises a finger portion on the outside of the body portion, a longitudinal trigger portion within the passage and a connecting portion connecting the finger portion and the trigger portion and extending through a longitudinal aperture in the wall of the body portion.
12. A jet injector device according to claim 11, wherein the trigger means is longitudinally movable within the aperture such that the trigger portion moves within the passage, an end of trigger portion reaching the second end of the body portion so as to engage and open the openable exit port of the gas capsule when the trigger means has been moved towards the second end.
13. A jet injector device according to claim 12, further comprising a biasing means for biasing the trigger means towards the first end of the device.
14. A gas capsule having a plurality of independent, pressurised gas-containing chambers, each chamber having an openable exit port in an end of the capsule for cooperation, in turn, with an opening in an injector device.
15. A gas capsule according to claim 14, wherein the end of the capsule is circular and the exit ports are equally circumferentially spaced therein.
16. A gas capsule according to either claim 14 or claim 15, wherein the chambers are longitudinally extending in the capsule.
17. A gas capsule according to any one of claims 14 to 16, wherein three chambers are provided.
18. A gas capsule according to any one of claims 14 to 17, wherein the end of the capsule is provided with a thread for cooperating with a matching thread on the injector device.
19. A gas capsule according to any one of claims 14 to 18, wherein the openable exit ports are provided with valve means which can be opened by a trigger means on the injector device.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPK3301 | 1990-11-09 | ||
| AUPK330190 | 1990-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2095858A1 true CA2095858A1 (en) | 1992-05-10 |
Family
ID=3775061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002095858A Abandoned CA2095858A1 (en) | 1990-11-09 | 1991-11-11 | Needleless hypodermic jet injector device |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0556276A1 (en) |
| CA (1) | CA2095858A1 (en) |
| WO (1) | WO1992008508A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8221347B2 (en) | 2004-12-01 | 2012-07-17 | Acushot, Inc. | Needle-free injector |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9118204D0 (en) * | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| RU2179864C2 (en) * | 1993-07-31 | 2002-02-27 | Вестон Медикал Лимитед | Needleless injector |
| FR2718357B1 (en) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Improvements made to a needleless jet injection device. |
| US5542920A (en) * | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
| DE19820172A1 (en) * | 1997-09-30 | 2005-01-27 | Wolfgang Wagner | Injection arrangement for inserting a diagnostic carrier or medicament beneath a patient's skin has a compressed gas source and a valve closure for controlling the release of the gas that is used to inject a substance |
| DE10010123A1 (en) | 2000-03-03 | 2001-09-20 | Boehringer Ingelheim Int | Needle-less injector for liquids comprises a tensioning system, an energy storing spring, a hollow piston in a cylinder, and a nozzle |
| CN103071209A (en) | 2005-11-17 | 2013-05-01 | 周吉尼克斯股份有限公司 | Delivery of viscous formulations by needle-free injection |
| CA2700205A1 (en) | 2007-09-24 | 2009-04-02 | Pulse Needlefree Systems, Inc. | Needle free injector with dose adjustment assembly |
| EP2273880B1 (en) | 2008-04-28 | 2014-12-31 | Zogenix, Inc. | Novel formulations for treatment of migraine |
| CN104958813A (en) | 2010-09-15 | 2015-10-07 | 周吉尼克斯股份有限公司 | Needle free injectors and design parameters thereof that optimize injection performance |
| EP2986278A1 (en) | 2013-03-11 | 2016-02-24 | DURECT Corporation | Injectable controlled release composition comprising high viscosity liquid carrier |
| FR3057169B1 (en) * | 2016-10-11 | 2022-04-01 | Crossject | INJECTION NOZZLE FOR NEEDLELESS INJECTION DEVICE |
| DE202018102738U1 (en) * | 2018-05-16 | 2018-09-10 | Ira Yasmin Lehmann | Needle-free injection system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2547099A (en) * | 1948-03-11 | 1951-04-03 | Becton Dickinson Co | Injection device and ampoule |
| US2653605A (en) * | 1951-03-22 | 1953-09-29 | Jr George N Hein | Injection device and ampoule |
| AT278499B (en) * | 1967-04-14 | 1970-02-10 | Orszagos Koolaj Gazipari | Cartridge for storing pressurized gas and method of making the cartridge |
| US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
| US3714943A (en) * | 1970-12-01 | 1973-02-06 | H Yanof | Medicament injectors |
| US3853125A (en) * | 1971-10-05 | 1974-12-10 | W Clark | Disposable needleless injector |
| US3802430A (en) * | 1972-06-30 | 1974-04-09 | L Arnold | Disposable pyrotechnically powered injector |
| US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| JPH01198561A (en) * | 1987-11-16 | 1989-08-10 | Medhi Tek Internatl Ltd | Liquid injection apparatus |
| AU6550990A (en) * | 1989-11-09 | 1991-05-16 | Bioject, Inc. | Needleless hypodermic injection device |
-
1991
- 1991-11-11 CA CA002095858A patent/CA2095858A1/en not_active Abandoned
- 1991-11-11 EP EP91920413A patent/EP0556276A1/en not_active Withdrawn
- 1991-11-11 WO PCT/AU1991/000514 patent/WO1992008508A1/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8221347B2 (en) | 2004-12-01 | 2012-07-17 | Acushot, Inc. | Needle-free injector |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0556276A1 (en) | 1993-08-25 |
| WO1992008508A1 (en) | 1992-05-29 |
| EP0556276A4 (en) | 1994-03-23 |
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| EEER | Examination request | ||
| FZDE | Dead |