JP2016510054A5 - - Google Patents
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- JP2016510054A5 JP2016510054A5 JP2015560654A JP2015560654A JP2016510054A5 JP 2016510054 A5 JP2016510054 A5 JP 2016510054A5 JP 2015560654 A JP2015560654 A JP 2015560654A JP 2015560654 A JP2015560654 A JP 2015560654A JP 2016510054 A5 JP2016510054 A5 JP 2016510054A5
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- Prior art keywords
- fibrosis
- liver
- burns
- systemic
- ischemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010064930 Age-related macular degeneration Diseases 0.000 claims 8
- 206010016654 Fibrosis Diseases 0.000 claims 8
- 230000004761 fibrosis Effects 0.000 claims 8
- 208000007788 Acute Liver Failure Diseases 0.000 claims 4
- 206010000804 Acute hepatic failure Diseases 0.000 claims 4
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 206010003210 Arteriosclerosis Diseases 0.000 claims 4
- 210000000988 Bone and Bones Anatomy 0.000 claims 4
- 206010007554 Cardiac failure Diseases 0.000 claims 4
- 208000005846 Cardiomyopathy Diseases 0.000 claims 4
- 206010012601 Diabetes mellitus Diseases 0.000 claims 4
- 208000007342 Diabetic Nephropathy Diseases 0.000 claims 4
- 206010061835 Diabetic nephropathy Diseases 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 4
- 208000008069 Geographic Atrophy Diseases 0.000 claims 4
- 208000007565 Gingivitis Diseases 0.000 claims 4
- 208000010412 Glaucoma Diseases 0.000 claims 4
- 206010051920 Glomerulonephropathy Diseases 0.000 claims 4
- 206010019280 Heart failure Diseases 0.000 claims 4
- 206010019641 Hepatic cirrhosis Diseases 0.000 claims 4
- 206010019695 Hepatic neoplasm Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 4
- 208000002260 Keloid Diseases 0.000 claims 4
- 210000001117 Keloid Anatomy 0.000 claims 4
- 208000001083 Kidney Disease Diseases 0.000 claims 4
- 210000004185 Liver Anatomy 0.000 claims 4
- 208000002780 Macular Degeneration Diseases 0.000 claims 4
- 208000010125 Myocardial Infarction Diseases 0.000 claims 4
- 208000003067 Myocardial Ischemia Diseases 0.000 claims 4
- 206010029149 Nephropathy Diseases 0.000 claims 4
- 206010029151 Nephropathy Diseases 0.000 claims 4
- 206010069385 Ocular ischaemic syndrome Diseases 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 208000005069 Pulmonary Fibrosis Diseases 0.000 claims 4
- 206010037660 Pyrexia Diseases 0.000 claims 4
- 206010063837 Reperfusion injury Diseases 0.000 claims 4
- 208000004644 Retinal Vein Occlusion Diseases 0.000 claims 4
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 4
- 206010039580 Scar Diseases 0.000 claims 4
- 206010042953 Systemic sclerosis Diseases 0.000 claims 4
- 206010044390 Transient ischaemic attack Diseases 0.000 claims 4
- 206010052779 Transplant rejections Diseases 0.000 claims 4
- 206010046851 Uveitis Diseases 0.000 claims 4
- 231100000836 acute liver failure Toxicity 0.000 claims 4
- 201000001320 atherosclerosis Diseases 0.000 claims 4
- 201000008031 cardiomyopathy Diseases 0.000 claims 4
- 230000001684 chronic Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000001969 hypertrophic Effects 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 230000001537 neural Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 201000002793 renal fibrosis Diseases 0.000 claims 4
- 231100000241 scar Toxicity 0.000 claims 4
- 230000037387 scars Effects 0.000 claims 4
- 201000009594 systemic scleroderma Diseases 0.000 claims 4
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 1
Claims (4)
- 疼痛、アテローム性動脈硬化症、加齢黄斑変性症、糖尿病性網膜症、緑内障、網膜静脈閉塞、未熟児網膜症、眼虚血症候群、地図状萎縮、糖尿病、炎症、炎症性腸疾患、虚血−再灌流傷害、急性肝不全、肝線維症、肺線維症、腎線維症、全身性線維症、急性移植片拒絶反応、慢性移植腎症、糖尿病性腎症、糸球体腎症、心筋症、心不全、心筋虚血、心筋梗塞、全身性硬化症、熱傷、火傷、肥厚性瘢痕、ケロイド、歯肉炎、発熱、肝臓の硬変又は腫瘍、骨量の制御、神経変性、筋萎縮性側索硬化症、多発性硬化症、卒中、一過性脳虚血発作又はブドウ膜炎の治療又は予防のための、請求項1〜13のいずれか一項に記載の化合物の使用。
- 疼痛、アテローム性動脈硬化症、加齢黄斑変性症、糖尿病性網膜症、緑内障、網膜静脈閉塞、未熟児網膜症、眼虚血症候群、地図状萎縮、糖尿病、炎症、炎症性腸疾患、虚血−再灌流傷害、急性肝不全、肝線維症、肺線維症、腎線維症、全身性線維症、急性移植片拒絶反応、慢性移植腎症、糖尿病性腎症、糸球体腎症、心筋症、心不全、心筋虚血、心筋梗塞、全身性硬化症、熱傷、火傷、肥厚性瘢痕、ケロイド、歯肉炎、発熱、肝臓の硬変又は腫瘍、骨量の制御、神経変性、筋萎縮性側索硬化症、多発性硬化症、卒中、一過性脳虚血発作又はブドウ膜炎の治療又は予防のための医薬の調製のための、請求項1〜13のいずれか一項に記載の化合物の使用。
- 疼痛、アテローム性動脈硬化症、加齢黄斑変性症、糖尿病性網膜症、緑内障、網膜静脈閉塞、未熟児網膜症、眼虚血症候群、地図状萎縮、糖尿病、炎症、炎症性腸疾患、虚血−再灌流傷害、急性肝不全、肝線維症、肺線維症、腎線維症、全身性線維症、急性移植片拒絶反応、慢性移植腎症、糖尿病性腎症、糸球体腎症、心筋症、心不全、心筋虚血、心筋梗塞、全身性硬化症、熱傷、火傷、肥厚性瘢痕、ケロイド、歯肉炎、発熱、肝臓の硬変又は腫瘍、骨量の制御、神経変性、筋萎縮性側索硬化症、多発性硬化症、卒中、一過性脳虚血発作又はブドウ膜炎の治療又は予防のための、請求項1〜13のいずれか一項に記載の化合物。
- 疼痛、アテローム性動脈硬化症、加齢黄斑変性症、糖尿病性網膜症、緑内障、網膜静脈閉塞、未熟児網膜症、眼虚血症候群、地図状萎縮、糖尿病、炎症、炎症性腸疾患、虚血−再灌流傷害、急性肝不全、肝線維症、肺線維症、腎線維症、全身性線維症、急性移植片拒絶反応、慢性移植腎症、糖尿病性腎症、糸球体腎症、心筋症、心不全、心筋虚血、心筋梗塞、全身性硬化症、熱傷、火傷、肥厚性瘢痕、ケロイド、歯肉炎、発熱、肝臓の硬変又は腫瘍、骨量の制御、神経変性、筋萎縮性側索硬化症、多発性硬化症、卒中、一過性脳虚血発作又はブドウ膜炎の治療又は予防のための方法であって、それを必要とする患者に有効量の請求項1〜13のいずれか一項に定義される化合物を投与することを含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13158233.0 | 2013-03-07 | ||
EP13158233 | 2013-03-07 | ||
PCT/EP2014/054107 WO2014135507A1 (en) | 2013-03-07 | 2014-03-04 | Novel pyrazol derivatives |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018229203A Division JP2019055986A (ja) | 2013-03-07 | 2018-12-06 | 新規ピラゾール誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016510054A JP2016510054A (ja) | 2016-04-04 |
JP2016510054A5 true JP2016510054A5 (ja) | 2017-04-06 |
JP6514119B2 JP6514119B2 (ja) | 2019-05-15 |
Family
ID=47827068
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015560654A Active JP6514119B2 (ja) | 2013-03-07 | 2014-03-04 | 新規ピラゾール誘導体 |
JP2018229203A Pending JP2019055986A (ja) | 2013-03-07 | 2018-12-06 | 新規ピラゾール誘導体 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018229203A Pending JP2019055986A (ja) | 2013-03-07 | 2018-12-06 | 新規ピラゾール誘導体 |
Country Status (35)
Country | Link |
---|---|
US (2) | US9512132B2 (ja) |
EP (1) | EP2964646B1 (ja) |
JP (2) | JP6514119B2 (ja) |
KR (2) | KR102217297B1 (ja) |
CN (1) | CN105143220B (ja) |
AR (1) | AR094978A1 (ja) |
AU (1) | AU2014224784B2 (ja) |
BR (1) | BR112015020795B1 (ja) |
CA (1) | CA2897513C (ja) |
CL (1) | CL2015002387A1 (ja) |
CR (1) | CR20150447A (ja) |
CY (1) | CY1118950T1 (ja) |
DK (1) | DK2964646T3 (ja) |
EA (1) | EA027935B1 (ja) |
ES (1) | ES2629751T3 (ja) |
HK (1) | HK1213258A1 (ja) |
HR (1) | HRP20170919T1 (ja) |
HU (1) | HUE034831T2 (ja) |
IL (1) | IL240327B (ja) |
LT (1) | LT2964646T (ja) |
MA (1) | MA38403A1 (ja) |
MX (1) | MX363727B (ja) |
MY (1) | MY176797A (ja) |
NZ (1) | NZ710052A (ja) |
PE (1) | PE20151539A1 (ja) |
PH (1) | PH12015501843A1 (ja) |
PL (1) | PL2964646T3 (ja) |
PT (1) | PT2964646T (ja) |
RS (1) | RS56148B1 (ja) |
SG (1) | SG11201507168XA (ja) |
SI (1) | SI2964646T1 (ja) |
TW (1) | TWI609866B (ja) |
UA (1) | UA118666C2 (ja) |
WO (1) | WO2014135507A1 (ja) |
ZA (1) | ZA201505073B (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2897513C (en) * | 2013-03-07 | 2021-03-16 | F. Hoffmann-La Roche Ag | Pyrazol derivatives |
PT2978755T (pt) | 2013-03-26 | 2018-02-26 | Hoffmann La Roche | Novos derivados de piridina |
NZ712030A (en) | 2013-05-02 | 2021-03-26 | Hoffmann La Roche | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
EP2991987B1 (en) | 2013-05-02 | 2018-05-23 | F.Hoffmann-La Roche Ag | Purine derivatives as cb2 receptor agonists |
DK3483163T3 (da) | 2013-09-06 | 2021-08-30 | Hoffmann La Roche | Triazolo[4,5-d]pyrimidinderivater som cb2-receptorantagonister |
EP3268366A1 (en) * | 2015-03-13 | 2018-01-17 | AbbVie Inc. | (indazol-4-yl)hexahydropyrrolopyrrolones and method of use |
WO2016191935A1 (en) * | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
UA123834C2 (uk) | 2016-06-23 | 2021-06-09 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ З АФІННІСТЮ ДО КАНАБІНОЇДНИХ РЕЦЕПТОРІВ ТИПУ 2 |
JP7090037B2 (ja) | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
JP7090036B2 (ja) | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
EP3475281A1 (en) | 2016-06-23 | 2019-05-01 | H. Hoffnabb-La Roche Ag | Novel [1,2,31triazolo[4,5-d]pyrimidine derivatives |
EP3950920A4 (en) | 2019-03-25 | 2023-02-01 | Nikon Corporation | DEVICE AND METHOD FOR CELL MANIPULATION |
IL301285A (en) | 2020-09-10 | 2023-05-01 | Precirix N V | A portion of an antibody against FAP |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2980677A (en) * | 1961-04-18 | Certificate of correction | ||
WO2001058869A2 (en) * | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
EP1492784A4 (en) | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
DE10219435A1 (de) * | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
WO2009051705A1 (en) | 2007-10-18 | 2009-04-23 | Merck & Co., Inc. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
WO2010118367A2 (en) * | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
WO2014005968A1 (en) | 2012-07-04 | 2014-01-09 | F. Hoffmann-La Roche Ag | Novel adamantyl derivatives as cannabinoid receptor 2 agonists |
SI2928882T1 (sl) | 2012-12-07 | 2017-05-31 | F. Hoffmann-La Roche Ag | Pirazinski derivati kot agonisti receptorja CB2 |
EP2928867B1 (en) | 2012-12-07 | 2017-08-09 | F. Hoffmann-La Roche AG | Pyridine-2-amides useful as cb2 agonists |
DK2928868T3 (en) | 2012-12-07 | 2017-10-23 | Hoffmann La Roche | Pyridine-2-amides which can be used as CB2 agonists |
SG10201800170YA (en) | 2012-12-07 | 2018-02-27 | Hoffmann La Roche | Novel pyridine derivatives |
CA2897513C (en) * | 2013-03-07 | 2021-03-16 | F. Hoffmann-La Roche Ag | Pyrazol derivatives |
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2014
- 2014-03-04 CA CA2897513A patent/CA2897513C/en active Active
- 2014-03-04 NZ NZ710052A patent/NZ710052A/en unknown
- 2014-03-04 RS RS20170653A patent/RS56148B1/sr unknown
- 2014-03-04 JP JP2015560654A patent/JP6514119B2/ja active Active
- 2014-03-04 KR KR1020157024230A patent/KR102217297B1/ko active IP Right Grant
- 2014-03-04 PT PT147095905T patent/PT2964646T/pt unknown
- 2014-03-04 MY MYPI2015702926A patent/MY176797A/en unknown
- 2014-03-04 HU HUE14709590A patent/HUE034831T2/en unknown
- 2014-03-04 BR BR112015020795-2A patent/BR112015020795B1/pt active IP Right Grant
- 2014-03-04 LT LTEP14709590.5T patent/LT2964646T/lt unknown
- 2014-03-04 UA UAA201509653A patent/UA118666C2/uk unknown
- 2014-03-04 MX MX2015011534A patent/MX363727B/es active IP Right Grant
- 2014-03-04 MA MA38403A patent/MA38403A1/fr unknown
- 2014-03-04 KR KR1020217003979A patent/KR102369407B1/ko active IP Right Grant
- 2014-03-04 CN CN201480012444.5A patent/CN105143220B/zh active Active
- 2014-03-04 EP EP14709590.5A patent/EP2964646B1/en active Active
- 2014-03-04 SG SG11201507168XA patent/SG11201507168XA/en unknown
- 2014-03-04 PL PL14709590T patent/PL2964646T3/pl unknown
- 2014-03-04 SI SI201430259T patent/SI2964646T1/sl unknown
- 2014-03-04 WO PCT/EP2014/054107 patent/WO2014135507A1/en active Application Filing
- 2014-03-04 DK DK14709590.5T patent/DK2964646T3/en active
- 2014-03-04 AU AU2014224784A patent/AU2014224784B2/en active Active
- 2014-03-04 PE PE2015001840A patent/PE20151539A1/es active IP Right Grant
- 2014-03-04 EA EA201591624A patent/EA027935B1/ru not_active IP Right Cessation
- 2014-03-04 ES ES14709590.5T patent/ES2629751T3/es active Active
- 2014-03-05 AR ARP140100693A patent/AR094978A1/es active IP Right Grant
- 2014-03-06 TW TW103107745A patent/TWI609866B/zh active
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2015
- 2015-07-15 ZA ZA2015/05073A patent/ZA201505073B/en unknown
- 2015-08-03 IL IL240327A patent/IL240327B/en active IP Right Grant
- 2015-08-20 PH PH12015501843A patent/PH12015501843A1/en unknown
- 2015-08-26 CL CL2015002387A patent/CL2015002387A1/es unknown
- 2015-08-27 CR CR20150447A patent/CR20150447A/es unknown
- 2015-09-03 US US14/844,991 patent/US9512132B2/en active Active
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2016
- 2016-02-04 HK HK16101304.1A patent/HK1213258A1/zh unknown
- 2016-10-24 US US15/332,398 patent/US9694012B2/en active Active
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2017
- 2017-06-14 HR HRP20170919TT patent/HRP20170919T1/hr unknown
- 2017-06-16 CY CY20171100638T patent/CY1118950T1/el unknown
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2018
- 2018-12-06 JP JP2018229203A patent/JP2019055986A/ja active Pending
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