JP2016508987A5 - - Google Patents
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- Publication number
- JP2016508987A5 JP2016508987A5 JP2015551117A JP2015551117A JP2016508987A5 JP 2016508987 A5 JP2016508987 A5 JP 2016508987A5 JP 2015551117 A JP2015551117 A JP 2015551117A JP 2015551117 A JP2015551117 A JP 2015551117A JP 2016508987 A5 JP2016508987 A5 JP 2016508987A5
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- cancer
- therapy
- composition
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000014150 Interferons Human genes 0.000 claims 19
- 108010050904 Interferons Proteins 0.000 claims 19
- 229940079322 interferon Drugs 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 238000011319 anticancer therapy Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000012377 drug delivery Methods 0.000 claims 3
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 238000001815 biotherapy Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000004876 tela submucosa Anatomy 0.000 claims 2
- 206010006002 Bone pain Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 238000010317 ablation therapy Methods 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 238000002663 nebulization Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229940126703 systemic medication Drugs 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749570P | 2013-01-07 | 2013-01-07 | |
| US61/749,570 | 2013-01-07 | ||
| US201361779711P | 2013-03-13 | 2013-03-13 | |
| US61/779,711 | 2013-03-13 | ||
| PCT/CN2014/070212 WO2014106492A2 (en) | 2013-01-07 | 2014-01-07 | Methods and compositions for treatment of bone, skin, subcutaneous, mucosal and/or submucosal cancer by percutaneous and/or transmucosal administration of interferon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066723A Division JP2020105223A (ja) | 2013-01-07 | 2020-04-02 | インターフェロンの経皮及び／又は経粘膜投薬による骨ガン、皮膚癌、皮下腫瘍、粘膜癌及び／又は粘膜下腫瘍を治療する方法と組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508987A JP2016508987A (ja) | 2016-03-24 |
| JP2016508987A5 true JP2016508987A5 (enExample) | 2017-02-09 |
Family
ID=51062515
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551117A Pending JP2016508987A (ja) | 2013-01-07 | 2014-01-07 | インターフェロンの経皮及び／又は経粘膜投薬による骨ガン、皮膚癌、皮下腫瘍、粘膜癌及び／又は粘膜下腫瘍を治療する方法と組成物 |
| JP2015551113A Pending JP2016506413A (ja) | 2013-01-07 | 2014-01-07 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
| JP2019190263A Pending JP2020023547A (ja) | 2013-01-07 | 2019-10-17 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
| JP2020066723A Pending JP2020105223A (ja) | 2013-01-07 | 2020-04-02 | インターフェロンの経皮及び／又は経粘膜投薬による骨ガン、皮膚癌、皮下腫瘍、粘膜癌及び／又は粘膜下腫瘍を治療する方法と組成物 |
| JP2021200049A Pending JP2022031331A (ja) | 2013-01-07 | 2021-12-09 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551113A Pending JP2016506413A (ja) | 2013-01-07 | 2014-01-07 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
| JP2019190263A Pending JP2020023547A (ja) | 2013-01-07 | 2019-10-17 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
| JP2020066723A Pending JP2020105223A (ja) | 2013-01-07 | 2020-04-02 | インターフェロンの経皮及び／又は経粘膜投薬による骨ガン、皮膚癌、皮下腫瘍、粘膜癌及び／又は粘膜下腫瘍を治療する方法と組成物 |
| JP2021200049A Pending JP2022031331A (ja) | 2013-01-07 | 2021-12-09 | 空間配置が変化した組換えインターフェロンを用いる腫瘍治療の方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20160022778A1 (enExample) |
| EP (3) | EP3895725A3 (enExample) |
| JP (5) | JP2016508987A (enExample) |
| KR (4) | KR20210077005A (enExample) |
| CN (2) | CN104902917A (enExample) |
| AU (2) | AU2014204386B2 (enExample) |
| CA (2) | CA2897335A1 (enExample) |
| HK (2) | HK1216394A1 (enExample) |
| TW (3) | TW201427681A (enExample) |
| WO (2) | WO2014106459A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201427681A (zh) * | 2013-01-07 | 2014-07-16 | Superlab Far East Ltd | 用空間構象改變的重組干擾素治療腫瘤的方法 |
| EP3294321B1 (en) * | 2015-05-12 | 2024-07-31 | Superlab Far East Limited | Methods of determining interferon having direct inhibitory effects on tumors and uses thereof |
| US10906985B2 (en) * | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| CN108721603B (zh) * | 2017-04-14 | 2020-11-13 | 中国医学科学院基础医学研究所 | 干扰素α-1a在制备用于治疗癌症的药物中的用途 |
| KR101880015B1 (ko) * | 2017-12-08 | 2018-07-19 | 아주대학교산학협력단 | 인터페론 감마를 유효성분으로 함유하는 신경섬유육종 예방 또는 치료용 조성물 |
| CA3121000A1 (en) * | 2018-11-27 | 2020-06-04 | The Children's Hospital Of Philadelphia | Compositions and methods for treating cancer |
| US20220251605A1 (en) * | 2019-06-14 | 2022-08-11 | The Brigham And Women's Hospital, Inc. | Membrane attack complexes and uses thereof |
| CN111658779A (zh) * | 2020-06-22 | 2020-09-15 | 四川大学华西医院 | 治疗新型冠状病毒肺炎的联合用药物 |
| JP2024504340A (ja) * | 2021-01-21 | 2024-01-31 | シャーメン アモイトップ バイオテック カンパニー， リミテッド | 癌の再発を予防する方法及び組合せ医薬 |
| CN117255695A (zh) * | 2021-01-21 | 2023-12-19 | 厦门特宝生物工程股份有限公司 | 一种基于干扰素的癌症治疗方法和药物组合 |
| US11759434B2 (en) * | 2022-02-03 | 2023-09-19 | Sytheon Limited | Methods and compositions for treating melanoma and non-melanoma skin cancers |
| CN114533706B (zh) * | 2022-02-15 | 2022-10-14 | 深圳市利云德生物技术有限公司 | 一种用于防治呼吸道疾病的雾化吸入制剂及其应用 |
| WO2024076973A1 (en) * | 2022-10-04 | 2024-04-11 | Brown University | Compositions and methods of delivering large proteins |
| WO2024186193A1 (ko) * | 2023-03-08 | 2024-09-12 | 인제대학교 산학협력단 | 국소적 방사선 치료에서 전신성 항암 치료를 위한 조성물 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2005169A (en) * | 1932-08-27 | 1935-06-18 | Rowe Andrew Reed | Casting metal ingots |
| US4672108A (en) | 1981-12-07 | 1987-06-09 | Hoffmann-La Roche Inc. | Crystalline human leukocyte interferon |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4681930A (en) | 1983-09-20 | 1987-07-21 | Hoffmann-La Roche Inc. | Immune interferon and a method for its extraction and purification |
| SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| US4846782A (en) * | 1986-03-14 | 1989-07-11 | Schering Corporation | Treatment of cancer with interferon and radiotherapy |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| WO1993000951A1 (en) | 1991-07-02 | 1993-01-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
| RU2054180C1 (ru) | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
| AU4829593A (en) | 1992-09-23 | 1994-04-12 | Fisons Plc | Inhalation device |
| NZ257056A (en) | 1992-10-19 | 1996-08-27 | Dura Pharma Inc | Dry powder inhaler: housing with mixing chamber and impeller |
| AU5883694A (en) | 1993-01-19 | 1994-08-15 | Glaxo Group Limited | Device |
| US5441734A (en) | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
| CA2180260A1 (en) * | 1993-12-29 | 1995-07-06 | Dennis M. Brown | Methods and compositions for the treatment of a host with a cellular proliferative disease |
| TW426523B (en) | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
| US5480640A (en) | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
| EP0861321B1 (en) | 1995-10-13 | 2006-05-31 | President And Fellows Of Harvard College | Phosphopantetheinyl transferases and uses thereof |
| GB9526100D0 (en) | 1995-12-20 | 1996-02-21 | Intersurgical Ltd | Nebulizer |
| US5972331A (en) | 1995-12-22 | 1999-10-26 | Schering Corporation | Crystalline interferon alpha for pulmonary delivery and method for producing the same |
| DE69617754T2 (de) | 1996-01-03 | 2002-08-08 | Glaxo Group Ltd., Greenford | Inhalator |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US5980884A (en) | 1996-02-05 | 1999-11-09 | Amgen, Inc. | Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon |
| US5921447A (en) | 1997-02-13 | 1999-07-13 | Glaxo Wellcome Inc. | Flow-through metered aerosol dispensing apparatus and method of use thereof |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| US6087478A (en) | 1998-01-23 | 2000-07-11 | The Rockefeller University | Crystal of the N-terminal domain of a STAT protein and methods of use thereof |
| CN1062565C (zh) | 1998-06-29 | 2001-02-28 | 深圳九先生物工程有限公司 | 重组人α型复合干扰素及其制备方法和用途 |
| US6833256B1 (en) | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| JP3983985B2 (ja) | 2000-03-22 | 2007-09-26 | 株式会社東芝 | ＭｘＡタンパク質の多型遺伝子およびその使用 |
| IL155741A0 (en) | 2000-11-03 | 2003-12-23 | Pbl Biomedical Lab | Interferons, uses and compositions related thereto |
| US20060035327A1 (en) * | 2001-02-28 | 2006-02-16 | Guangwen Wei | Recombinant super-compound interferon and uses thereof |
| CN1245215C (zh) | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
| US8551469B2 (en) * | 2001-02-28 | 2013-10-08 | Superlab Far East Limited | Treatment of tumors and viral diseases with recombinant interferon alpha |
| FR2823764B1 (fr) | 2001-04-24 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides du gene ifn alpha-17 |
| CN1375502A (zh) | 2001-10-25 | 2002-10-23 | 南京药科大学 | 聚乙二醇修饰重组人干扰素 |
| EP1477164B1 (en) | 2002-02-19 | 2012-06-06 | Hisamitsu Pharmaceutical Co. Inc. | Percutaneous absorption type plaster |
| US7537803B2 (en) | 2003-04-08 | 2009-05-26 | New Jersey Institute Of Technology | Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process |
| US20110142887A1 (en) * | 2009-12-15 | 2011-06-16 | Immunovative Therapies Ltd. | Methods and compositions for liquidation of tumors |
| MY141751A (en) * | 2003-08-28 | 2010-06-30 | Sichuan Biotechnology Res Ct | Recombinant super-compound interferon |
| US7585647B2 (en) * | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
| ES2528218T3 (es) * | 2003-08-28 | 2015-02-05 | Superlab Far East Limited | Usos de interferones con estructura espacial modificada |
| CN101001644B (zh) * | 2003-08-28 | 2011-09-21 | 辉阳科技美国公司 | 空间构象改变的干扰素及其应用 |
| KR20060130009A (ko) * | 2003-08-28 | 2006-12-18 | 휴이양테크 (유에스에이), 인크. | 변경된 공간 구조를 갖는 인터페론의 용도 |
| FR2862541B1 (fr) * | 2003-11-21 | 2007-04-20 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques |
| WO2005067963A1 (en) | 2003-12-23 | 2005-07-28 | Intermune, Inc. | Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens |
| US20080102114A1 (en) * | 2004-04-23 | 2008-05-01 | Panduranga Rao Koritala | Microparticles and Nanoparticles for the Transmucosal Delivery of Therapeutic and Diagnostic Agents |
| CN1740197B (zh) | 2004-08-26 | 2010-05-12 | 辉阳科技美国公司 | 具有全新空间构象且功效增强的重组干扰素、其制备方法及应用 |
| EP1868636A4 (en) * | 2005-03-09 | 2012-03-28 | Guangwen Wei | USE OF RECOMBINANT SUPERCOMPOSE INTERFERONS |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101247821B (zh) | 2005-06-03 | 2013-01-23 | Ambrx公司 | 经改良人类干扰素分子和其用途 |
| WO2007065303A1 (en) | 2005-12-09 | 2007-06-14 | Beijing Kangbeide Pharmaceutical Technology Development Co., Ltd. | Transdermal patch containing isosorbide dinitrate and bisoprolol |
| US7964574B2 (en) | 2006-08-04 | 2011-06-21 | Baxter International Inc. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| US8095213B1 (en) | 2007-05-31 | 2012-01-10 | Purdue Pharma L.P. | Transdermal patch |
| ES2336873B1 (es) * | 2007-11-07 | 2011-01-24 | Proyecto De Biomedicina Cima, S.L. | Composicion farmaceutica para el tratamiento de cancer. |
| JP2012522055A (ja) * | 2009-03-30 | 2012-09-20 | セルリアン・ファーマ・インコーポレイテッド | ポリマー‐薬剤抱合体、粒子、組成物、および関連する使用方法 |
| ES2413255T3 (es) | 2009-04-09 | 2013-07-16 | Lga Biotecnologie Srl | Determinación de la eficacia de 5-ASA en la prevención y/o el tratamiento de CRC mediante el análisis de la expresión génica |
| CN102101886A (zh) | 2009-12-18 | 2011-06-22 | 四川辉阳生命工程股份有限公司 | 构象改变的重组干扰素晶体、其三维结构及应用 |
| AU2011310664B2 (en) | 2010-09-27 | 2016-02-18 | Zestagen, S.A. | Compositions and methods for treating neoplasia |
| MX360254B (es) * | 2011-03-10 | 2018-10-26 | Pfizer | Combinacion de terapias inmunomoduladoras local y sistemica para tratamiento mejorado del cancer. |
| US20130184437A9 (en) | 2011-06-08 | 2013-07-18 | Guangwen Wei | Design and use of new recombinant interferons with altered spatial configuration and three-dimensional structure |
| HK1202240A1 (en) | 2011-11-14 | 2015-09-25 | 戊瑞治疗有限公司 | Methods of treating cancer |
| US20130273527A1 (en) * | 2012-04-13 | 2013-10-17 | Superlab Far East Limited | Method for inducing cell senescence by recombinant interferon with altered spatial configuration |
| CN104703620A (zh) * | 2012-07-20 | 2015-06-10 | 拉筹伯大学 | 诊断和治疗方法 |
| TW201427681A (zh) | 2013-01-07 | 2014-07-16 | Superlab Far East Ltd | 用空間構象改變的重組干擾素治療腫瘤的方法 |
| JP6768507B2 (ja) | 2013-11-13 | 2020-10-14 | スーパーラブ ファー イースト リミテッドＳｕｐｅｒｌａｂ Ｆａｒ Ｅａｓｔ Ｌｉｍｉｔｅｄ | 腫瘍に対して直接抑制作用を有するインターフェロンの同定方法、及びその使用 |
-
2014
- 2014-01-06 TW TW103100470A patent/TW201427681A/zh unknown
- 2014-01-06 TW TW108107884A patent/TWI726291B/zh active
- 2014-01-06 TW TW103100472A patent/TWI718086B/zh not_active IP Right Cessation
- 2014-01-07 US US14/759,410 patent/US20160022778A1/en not_active Abandoned
- 2014-01-07 KR KR1020217018383A patent/KR20210077005A/ko not_active Ceased
- 2014-01-07 KR KR1020217016953A patent/KR20210069127A/ko not_active Ceased
- 2014-01-07 WO PCT/CN2014/000019 patent/WO2014106459A2/en not_active Ceased
- 2014-01-07 EP EP21161499.5A patent/EP3895725A3/en active Pending
- 2014-01-07 KR KR1020157021350A patent/KR20150103284A/ko not_active Ceased
- 2014-01-07 JP JP2015551117A patent/JP2016508987A/ja active Pending
- 2014-01-07 HK HK16104396.4A patent/HK1216394A1/zh unknown
- 2014-01-07 CA CA2897335A patent/CA2897335A1/en not_active Abandoned
- 2014-01-07 AU AU2014204386A patent/AU2014204386B2/en active Active
- 2014-01-07 CA CA2897312A patent/CA2897312C/en active Active
- 2014-01-07 JP JP2015551113A patent/JP2016506413A/ja active Pending
- 2014-01-07 AU AU2014204368A patent/AU2014204368B2/en active Active
- 2014-01-07 KR KR1020157021423A patent/KR20150139824A/ko not_active Ceased
- 2014-01-07 HK HK16102577.9A patent/HK1214528A1/zh unknown
- 2014-01-07 WO PCT/CN2014/070212 patent/WO2014106492A2/en not_active Ceased
- 2014-01-07 CN CN201480003935.3A patent/CN104902917A/zh active Pending
- 2014-01-07 EP EP14735427.8A patent/EP2941264B1/en active Active
- 2014-01-07 US US14/759,483 patent/US20150352188A1/en not_active Abandoned
- 2014-01-07 CN CN201480003898.6A patent/CN104994866A/zh active Pending
- 2014-01-07 EP EP14735273.6A patent/EP2941266B1/en active Active
-
2018
- 2018-07-18 US US16/038,704 patent/US20180326012A1/en not_active Abandoned
- 2018-07-25 US US16/044,582 patent/US10874716B2/en active Active
-
2019
- 2019-10-17 JP JP2019190263A patent/JP2020023547A/ja active Pending
-
2020
- 2020-04-02 JP JP2020066723A patent/JP2020105223A/ja active Pending
- 2020-12-29 US US17/136,656 patent/US12109250B2/en active Active
-
2021
- 2021-12-09 JP JP2021200049A patent/JP2022031331A/ja active Pending
- 2021-12-13 US US17/548,598 patent/US20220339255A1/en active Pending
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