JP2016508726A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016508726A5 JP2016508726A5 JP2015558982A JP2015558982A JP2016508726A5 JP 2016508726 A5 JP2016508726 A5 JP 2016508726A5 JP 2015558982 A JP2015558982 A JP 2015558982A JP 2015558982 A JP2015558982 A JP 2015558982A JP 2016508726 A5 JP2016508726 A5 JP 2016508726A5
- Authority
- JP
- Japan
- Prior art keywords
- hepatocytes
- stem cells
- item
- hepatocyte
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003494 hepatocyte Anatomy 0.000 claims description 52
- 238000000034 method Methods 0.000 claims description 52
- 210000000130 stem cell Anatomy 0.000 claims description 35
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims description 10
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims description 10
- 102100035961 Hematopoietically-expressed homeobox protein HHEX Human genes 0.000 claims description 10
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims description 10
- 101001021503 Homo sapiens Hematopoietically-expressed homeobox protein HHEX Proteins 0.000 claims description 10
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims description 10
- 101000666775 Homo sapiens T-box transcription factor TBX3 Proteins 0.000 claims description 10
- 101000819074 Homo sapiens Transcription factor GATA-4 Proteins 0.000 claims description 10
- 102100038409 T-box transcription factor TBX3 Human genes 0.000 claims description 10
- 102100021380 Transcription factor GATA-4 Human genes 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 10
- 238000004114 suspension culture Methods 0.000 claims description 10
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims description 8
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 claims description 8
- 238000012258 culturing Methods 0.000 claims description 8
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 8
- 108010088751 Albumins Proteins 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 6
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical class C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 claims description 6
- 229940124647 MEK inhibitor Drugs 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 102000005427 Asialoglycoprotein Receptor Human genes 0.000 claims description 4
- 102000003638 Glucose-6-Phosphatase Human genes 0.000 claims description 4
- 108010086800 Glucose-6-Phosphatase Proteins 0.000 claims description 4
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 claims description 4
- 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 claims description 4
- 108010066327 Keratin-18 Proteins 0.000 claims description 4
- 108010070511 Keratin-8 Proteins 0.000 claims description 4
- 102000004140 Oncostatin M Human genes 0.000 claims description 4
- 108090000630 Oncostatin M Proteins 0.000 claims description 4
- 108700008625 Reporter Genes Proteins 0.000 claims description 4
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims description 4
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims description 4
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims description 4
- 108010006523 asialoglycoprotein receptor Proteins 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 230000000144 pharmacologic effect Effects 0.000 claims description 4
- 230000002110 toxicologic effect Effects 0.000 claims description 4
- 231100000759 toxicological effect Toxicity 0.000 claims description 4
- DVKQVRZMKBDMDH-UUOKFMHZSA-N 8-Br-cAMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br DVKQVRZMKBDMDH-UUOKFMHZSA-N 0.000 claims description 2
- 101150037123 APOE gene Proteins 0.000 claims description 2
- 101710187578 Alcohol dehydrogenase 1 Proteins 0.000 claims description 2
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 claims description 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 2
- 102100029470 Apolipoprotein E Human genes 0.000 claims description 2
- 102100021723 Arginase-1 Human genes 0.000 claims description 2
- 101710129000 Arginase-1 Proteins 0.000 claims description 2
- 102000007990 Organic Anion Transporters Human genes 0.000 claims description 2
- 108010089503 Organic Anion Transporters Proteins 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 210000000941 bile Anatomy 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 238000001784 detoxification Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 230000000877 morphologic effect Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 239000002676 xenobiotic agent Substances 0.000 claims description 2
- 230000002034 xenobiotic effect Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768301P | 2013-02-22 | 2013-02-22 | |
| US61/768,301 | 2013-02-22 | ||
| PCT/US2014/017588 WO2014130770A1 (en) | 2013-02-22 | 2014-02-21 | Hepatocyte production via forward programming by combined genetic and chemical engineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016508726A JP2016508726A (ja) | 2016-03-24 |
| JP2016508726A5 true JP2016508726A5 (enExample) | 2016-12-01 |
Family
ID=50336502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558982A Pending JP2016508726A (ja) | 2013-02-22 | 2014-02-21 | 組み合わせた遺伝的および化学的操作によるフォワードプログラミングを介した肝細胞の産生 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140242595A1 (enExample) |
| EP (1) | EP2958992A1 (enExample) |
| JP (1) | JP2016508726A (enExample) |
| CN (1) | CN105229144A (enExample) |
| AU (1) | AU2014218807A1 (enExample) |
| CA (1) | CA2901747A1 (enExample) |
| IL (1) | IL240747A0 (enExample) |
| WO (1) | WO2014130770A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CN104830906B (zh) * | 2014-02-12 | 2018-09-04 | 北京维通达生物技术有限公司 | 一种重编程获得功能性人肝脏实质细胞的方法 |
| SG11201704291QA (en) | 2014-11-26 | 2017-06-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| EP3543339A1 (en) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US10006084B2 (en) | 2015-04-30 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| JP6937513B2 (ja) * | 2015-09-11 | 2021-09-22 | 国立研究開発法人理化学研究所 | 転写因子結合部位特異的なｄｎａ脱メチル化方法 |
| US10093903B2 (en) | 2015-10-19 | 2018-10-09 | FUJIFILM Cellular Dynamics, Inc. | Production of virus-receptive pluripotent stem cell (PSC)-derived hepatocytes |
| WO2017117333A1 (en) | 2015-12-30 | 2017-07-06 | Cellular Dynamics International, Inc. | Microtissue formation using stem cell-derived human hepatocytes |
| CA2983930C (en) * | 2016-04-15 | 2023-05-02 | Sakura Finetek U.S.A., Inc. | Methods to reduce evaporation during elevated temperature |
| CN109803977B (zh) | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
| CN108060120B (zh) * | 2016-11-07 | 2022-11-04 | 云南济慈再生医学研究院有限公司 | 用于分化的细胞重编程的小分子化合物组合、试剂盒及应用 |
| AU2017363142B2 (en) * | 2016-11-16 | 2024-05-30 | Allele Biotechnology & Pharmaceuticals, Inc. | Induction of hepatocytes by stem cell differentiation with RNA |
| WO2019070888A1 (en) * | 2017-10-03 | 2019-04-11 | Children's Hospital And Clinics Of Minnesota | VECTORS AND METHODS OF USE |
| MA51753A (fr) * | 2018-02-05 | 2020-12-16 | Audentes Therapeutics Inc | Éléments de régulation de la transcription et utilisations associées |
| CN110055217B (zh) * | 2019-01-29 | 2021-03-30 | 中国人民解放军军事科学院军事医学研究院 | 获得巨核细胞及血小板的方法 |
| WO2021003462A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN111004770B (zh) * | 2019-09-25 | 2022-08-23 | 中国人民解放军军事科学院军事医学研究院 | 功能性肝细胞诱导方法及其专用三维诱导培养基和应用 |
| EP4061400A4 (en) * | 2019-11-20 | 2024-01-10 | Cornell University | Generation of kidney glomerular specific endothelial cells and methods of use |
| CN114480253B (zh) * | 2022-01-30 | 2023-02-28 | 深圳市三启生物技术有限公司 | 多能干细胞定向诱导分化为肝细胞的培养基及培养方法和用途 |
| CN114480495A (zh) * | 2022-02-14 | 2022-05-13 | 深圳市三启生物技术有限公司 | 一种alb融合蛋白的表达方法及其应用 |
| WO2025096798A2 (en) * | 2023-10-31 | 2025-05-08 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5510254A (en) | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| DK0412700T3 (da) | 1989-08-03 | 1998-04-06 | Univ California | Fremgangsmåde til isolering af føtale cytrophoblastceller |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| WO1991018087A1 (en) | 1990-05-16 | 1991-11-28 | Baylor College Of Medicine | A permanent human hepatocyte cell line and its use in a liver assist device (lad) |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| EP0652965A1 (en) | 1992-07-27 | 1995-05-17 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
| US5935849A (en) | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US7410773B2 (en) | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| US5837670A (en) | 1995-04-18 | 1998-11-17 | Hartshorn; Richard Timothy | Detergent compositions having suds suppressing properties |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US20030040038A1 (en) | 1997-08-22 | 2003-02-27 | Steven F. Dowdy | Inducible regulatory system and use thereof |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| ES2317707T3 (es) | 1998-12-07 | 2009-04-16 | Duke University | Metodo de aislamiento de celulas troncales. |
| DE60001229T2 (de) | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| AR029803A1 (es) | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
| US7351813B2 (en) | 2000-06-20 | 2008-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Liver-specific gene expression cassettes, and methods of use |
| JP2004501664A (ja) | 2000-06-30 | 2004-01-22 | ボード・オブ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | 標的化薬剤送達のための腫瘍組織を浸潤する細胞特異的な内部移行ペプチドの単離 |
| US20030082561A1 (en) | 2000-07-21 | 2003-05-01 | Takashi Sera | Zinc finger domain recognition code and uses thereof |
| WO2002040468A1 (en) | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Compounds |
| GB0102668D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| ATE438708T1 (de) | 2001-11-15 | 2009-08-15 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| CA2478374C (en) | 2002-03-13 | 2009-01-06 | Eli M. Wallace | N3 alkylated benzimidazole derivatives as mek inhibitors |
| DE10224242A1 (de) | 2002-05-29 | 2003-12-11 | Max Delbrueck Centrum | Frog Prince, ein Transposonvektor für den Gentransfer bei Wirbeltieren |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| US7407776B2 (en) | 2003-09-19 | 2008-08-05 | Sangamo Biosciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| EP1783205B1 (en) | 2004-06-18 | 2024-02-21 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| CN101627112A (zh) * | 2006-06-28 | 2010-01-13 | 堪萨斯大学 | 将来自脐带基质的干细胞分化为肝细胞谱系细胞 |
| JP5797551B2 (ja) | 2008-04-22 | 2015-10-21 | フエー・イー・ベー・フエー・ゼツト・ウエー | 肝特異的核酸調節要素ならびにその方法および用途 |
| US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| EP3260534A1 (en) * | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| WO2011130402A2 (en) * | 2010-04-13 | 2011-10-20 | Cellular Dynamics International, Inc. | Hepatocyte production by forward programming |
| AU2010363437B2 (en) * | 2010-11-01 | 2015-11-19 | Kabushiki Kaisha Maghouse | Soil improvement device |
| US20130071931A1 (en) * | 2011-08-02 | 2013-03-21 | National Cancer Center | Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby |
-
2014
- 2014-02-21 CN CN201480022500.3A patent/CN105229144A/zh active Pending
- 2014-02-21 CA CA2901747A patent/CA2901747A1/en not_active Abandoned
- 2014-02-21 US US14/186,620 patent/US20140242595A1/en not_active Abandoned
- 2014-02-21 WO PCT/US2014/017588 patent/WO2014130770A1/en not_active Ceased
- 2014-02-21 JP JP2015558982A patent/JP2016508726A/ja active Pending
- 2014-02-21 EP EP14711342.7A patent/EP2958992A1/en not_active Withdrawn
- 2014-02-21 AU AU2014218807A patent/AU2014218807A1/en not_active Abandoned
-
2015
- 2015-08-20 IL IL240747A patent/IL240747A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016508726A5 (enExample) | ||
| Yiangou et al. | Human pluripotent stem cell-derived endoderm for modeling development and clinical applications | |
| Hu et al. | Long-term expansion of functional mouse and human hepatocytes as 3D organoids | |
| JP2019004912A5 (enExample) | ||
| Lindsley et al. | Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs | |
| Lis et al. | Conversion of adult endothelium to immunocompetent haematopoietic stem cells | |
| Costello et al. | The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation | |
| Wang et al. | Defined and scalable generation of hepatocyte-like cells from human pluripotent stem cells | |
| Moretti et al. | Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification | |
| Kramer et al. | Generation of differentiating and long-living intestinal organoids reflecting the cellular diversity of canine intestine | |
| Schwartz et al. | Pluripotent stem cell-derived hepatocyte-like cells | |
| EP2956538B1 (en) | Bioengineered liver constructs and methods relating thereto | |
| Goldman et al. | KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development | |
| Hussain et al. | Side population cells derived from adult human liver generate hepatocyte-like cells in vitro | |
| JP2016127847A5 (enExample) | ||
| JP2009545302A5 (enExample) | ||
| Cuvellier et al. | In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo engraftment | |
| Luo et al. | Pluripotent stem cell-derived hepatocyte-like cells: induction methods and applications | |
| Medvinsky et al. | On human development: lessons from stem cell systems | |
| Domingo-Reines et al. | Hoxa9 and EGFP reporter expression in human Embryonic Stem Cells (hESC) as useful tools for studying human development | |
| Hookway et al. | Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis | |
| CN108004201B (zh) | 一种成熟的多能干细胞来源肝脏细胞的获取方法 | |
| JP6486619B2 (ja) | 薬物評価用細胞及び薬物評価方法 | |
| Sakai et al. | Alkoxyresorufin O-dealkylase assay using a rat hepatocyte spheroid microarray | |
| Hee Hong et al. | Generation of hepatic progenitor cells from the primary hepatocytes of nonhuman primates using small molecules |